KR101434841B1 - 2-치환-8-알킬-7-옥소-7,8-디하이드로피리도[2,3-ｄ] 피리미딘-6-카르보니트릴 및 이의 용도 - Google Patents

2-치환-8-알킬-7-옥소-7,8-디하이드로피리도[2,3-ｄ] 피리미딘-6-카르보니트릴 및 이의 용도 Download PDF

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Publication number: KR101434841B1
Authority: KR; South Korea
Prior art keywords: compound; cancer; formula; oxo; amino
Prior art date: 2010-08-05

Application number

KR1020137004979A

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English (en)

Korean (ko)

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KR20130098314A (ko

Inventor

이. 프렘쿠마르 레디

엠.브이. 라마나 레디

Original Assignee

템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-08-05

Filing date

2011-07-21

Publication date

2014-08-29

2011-07-21 Application filed by 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 filed Critical 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션

2013-09-04 Publication of KR20130098314A publication Critical patent/KR20130098314A/ko

2014-08-29 Application granted granted Critical

2014-08-29 Publication of KR101434841B1 publication Critical patent/KR101434841B1/ko

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

KR1020137004979A 2010-08-05 2011-07-21 2-치환-8-알킬-7-옥소-7,8-디하이드로피리도[2,3-ｄ] 피리미딘-6-카르보니트릴 및 이의 용도 KR101434841B1 (ko)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US37094610P	2010-08-05	2010-08-05
US61/370,946		2010-08-05
PCT/US2011/044807 WO2012018540A1 (en)	2010-08-05	2011-07-21	2-substituted-8-alkyl-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidine-6-carbonitriles and uses thereof

Publications (2)

Publication Number	Publication Date
KR20130098314A KR20130098314A (ko)	2013-09-04
KR101434841B1 true KR101434841B1 (ko)	2014-08-29

Family

ID=45559737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1020137004979A KR101434841B1 (ko)	2010-08-05	2011-07-21	2-치환-8-알킬-7-옥소-7,8-디하이드로피리도[2,3-ｄ] 피리미딘-6-카르보니트릴 및 이의 용도

Country Status (17)

Country	Link
US (1)	US8987267B2 (ja)
EP (1)	EP2600719B1 (ja)
JP (1)	JP5512894B2 (ja)
KR (1)	KR101434841B1 (ja)
CN (1)	CN103200822B (ja)
AU (1)	AU2011286282B2 (ja)
BR (1)	BR112013002375B1 (ja)
CA (1)	CA2807498C (ja)
DK (1)	DK2600719T3 (ja)
EA (1)	EA022527B1 (ja)
ES (1)	ES2525866T3 (ja)
IL (1)	IL224555A (ja)
MX (1)	MX2013001427A (ja)
NZ (1)	NZ606281A (ja)
PL (1)	PL2600719T3 (ja)
PT (1)	PT2600719E (ja)
WO (1)	WO2012018540A1 (ja)

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WO2014031571A1 (en) *	2012-08-21	2014-02-27	Icahn School Of Medicine At Mount Sinai	Treatment of viral infections
WO2014151682A1 (en)	2013-03-14	2014-09-25	Icahn School Of Medicine At Mount Sinai	Pyrimidine compounds as kinase inhibitors
AU2015240465B2 (en)	2014-04-04	2020-02-27	Del Mar Pharmaceuticals	Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
AU2015296322B2 (en)	2014-07-26	2019-09-19	Sunshine Lake Pharma Co., Ltd.	2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof
CN104447739B (zh) *	2014-11-07	2016-02-17	郑州泰基鸿诺药物科技有限公司	一种氘代Palbociclib衍生物、制备方法及应用
CN104447743B (zh) *	2014-11-26	2016-03-02	苏州明锐医药科技有限公司	帕博西尼的制备方法
CN104496983B (zh)	2014-11-26	2016-06-08	苏州明锐医药科技有限公司	一种帕博西尼的制备方法
CN104478874B (zh) *	2014-12-08	2016-03-02	新发药业有限公司	一种帕博赛布的制备方法
CN104610254B (zh) *	2015-01-26	2017-02-01	新发药业有限公司	一种帕博赛布的低成本制备方法
CN105111205B (zh) *	2015-09-12	2017-01-04	山东罗欣药业集团股份有限公司	一种帕博西尼的制备方法
JP7044801B2 (ja)	2016-12-16	2022-03-30	シーストーン・ファーマスーティカルズ・（スージョウ）・カンパニー・リミテッド	Ｃｄｋ４／６阻害剤
JP2021514359A (ja)	2018-02-15	2021-06-10	ニューベイション・バイオ・インコーポレイテッドＮｕｖａｔｉｏｎＢｉｏＩｎｃ．	キナーゼ阻害剤としての複素環式化合物
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TWI818930B (zh) *	2018-11-12	2023-10-21	美商昂可諾法治療股份有限公司	8-環戊基-7-側氧基-2-(4-哌嗪-1-基-苯基胺基)-7,8-二氫-吡啶[2,3-d]嘧啶-6-氰基及其用於治療增生性疾病的用途
WO2020101638A1 (en) *	2018-11-12	2020-05-22	Onconova Therapeutics, Inc.	8-cyclopentyl-7-oxo-2-(4-piperazin-1-yl-phenylamino)-7, 8-dihydro-pyrido [2,3-d]pyrimidine-6-carbonitrile and uses thereof in treating proliferative disorders
WO2020140053A1 (en) *	2018-12-28	2020-07-02	Spv Therapeutics Inc.	Cyclin-dependent kinase inhibitors
EP3902801A4 (en) *	2018-12-28	2022-12-14	SPV Therapeutics Inc.	CYCLINE-DEPENDENT KINASE INHIBITORS
CA3145821A1 (en) *	2019-07-02	2021-01-07	Nuvation Bio Inc.	Heterocyclic compounds as kinase inhibitors
WO2021108803A1 (en)	2019-11-26	2021-06-03	Theravance Biopharma R&D Ip, Llc	Fused pyrimidine pyridinone compounds as jak inhibitors
US20230132667A1 (en) *	2020-05-28	2023-05-04	University Of Washington	Drug-like molecules and methods for the therapeutic targeting of viral rna structures
EP4430047A1 (en)	2021-11-08	2024-09-18	Progentos Therapeutics, Inc.	Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
JP2024540529A (ja) *	2021-11-18	2024-10-31	オンコノヴァセラピューティクス，インコーポレイテッド	がんを処置するための方法および組成物
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2011
- 2011-07-21 EP EP11815012.7A patent/EP2600719B1/en active Active
- 2011-07-21 CA CA2807498A patent/CA2807498C/en active Active
- 2011-07-21 ES ES11815012.7T patent/ES2525866T3/es active Active
- 2011-07-21 BR BR112013002375-9A patent/BR112013002375B1/pt active IP Right Grant
- 2011-07-21 DK DK11815012.7T patent/DK2600719T3/da active
- 2011-07-21 KR KR1020137004979A patent/KR101434841B1/ko active IP Right Grant
- 2011-07-21 US US13/813,023 patent/US8987267B2/en active Active
- 2011-07-21 JP JP2013523185A patent/JP5512894B2/ja active Active
- 2011-07-21 AU AU2011286282A patent/AU2011286282B2/en active Active
- 2011-07-21 PT PT118150127T patent/PT2600719E/pt unknown
- 2011-07-21 EA EA201390199A patent/EA022527B1/ru not_active IP Right Cessation
- 2011-07-21 MX MX2013001427A patent/MX2013001427A/es active IP Right Grant
- 2011-07-21 CN CN201180038325.3A patent/CN103200822B/zh active Active
- 2011-07-21 NZ NZ606281A patent/NZ606281A/en unknown
- 2011-07-21 WO PCT/US2011/044807 patent/WO2012018540A1/en active Search and Examination
- 2011-07-21 PL PL11815012T patent/PL2600719T3/pl unknown
2013
- 2013-02-03 IL IL224555A patent/IL224555A/en active IP Right Grant

Patent Citations (2)

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US20080004285A1 (en)	2004-12-30	2008-01-03	De Jonghe Steven C A	Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment
US20090062274A1 (en)	2005-10-07	2009-03-05	Exelixis, Inc	Pyridopyrimidinone inhibitors of pi3kalpha

Also Published As

Publication number	Publication date
WO2012018540A1 (en)	2012-02-09
EP2600719B1 (en)	2014-10-08
ES2525866T3 (es)	2014-12-30
PL2600719T3 (pl)	2015-03-31
NZ606281A (en)	2014-09-26
KR20130098314A (ko)	2013-09-04
CA2807498A1 (en)	2012-02-09
JP5512894B2 (ja)	2014-06-04
US8987267B2 (en)	2015-03-24
BR112013002375B1 (pt)	2020-05-12
JP2013538196A (ja)	2013-10-10
EA201390199A1 (ru)	2013-07-30
IL224555A (en)	2016-03-31
PT2600719E (pt)	2014-12-22
US20130131058A1 (en)	2013-05-23
BR112013002375A2 (pt)	2016-05-24
CA2807498C (en)	2017-02-07
EA022527B1 (ru)	2016-01-29
AU2011286282B2 (en)	2014-08-21
EP2600719A4 (en)	2014-01-01
CN103200822B (zh)	2014-12-24
MX2013001427A (es)	2013-06-13
DK2600719T3 (da)	2014-12-15
EP2600719A1 (en)	2013-06-12
CN103200822A (zh)	2013-07-10
AU2011286282A1 (en)	2013-02-14

Publication	Publication Date	Title
KR101434841B1 (ko)	2014-08-29	2-치환-8-알킬-7-옥소-7,8-디하이드로피리도[2,3-ｄ] 피리미딘-6-카르보니트릴 및 이의 용도
US8765755B2 (en)	2014-07-01	N-containing heterocyclic compounds
KR20190104632A (ko)	2019-09-10	트라이사이클릭 자이라제 억제제
EP1325009B1 (en)	2006-03-08	Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same
AU2002211827A1 (en)	2002-06-27	Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same
ES2747423T3 (es)	2020-03-10	Compuesto de quinoxalina
KR101754664B1 (ko)	2017-07-06	치환된 피리도〔2,3-ｄ〕피리미딘-7(8ｈ)-온스 및 이의 치료 용도
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