KR101347807B1 - Compositions for Preventing or Treating Pulmonary Disease or Obesity - Google Patents
Compositions for Preventing or Treating Pulmonary Disease or Obesity Download PDFInfo
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- KR101347807B1 KR101347807B1 KR1020120025986A KR20120025986A KR101347807B1 KR 101347807 B1 KR101347807 B1 KR 101347807B1 KR 1020120025986 A KR1020120025986 A KR 1020120025986A KR 20120025986 A KR20120025986 A KR 20120025986A KR 101347807 B1 KR101347807 B1 KR 101347807B1
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- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Abstract
본 발명의 조성물은 (a) 쑥, 구기자, 오미자, 마늘, 은행, 엿기름, 무, 메주콩, 현미쌀, 배, 생강, 당귀 및 질경이를 포함하는 주재료, (b) 설탕 및 (c) 물을 포함하는 폐질환 또는 비만의 억제 또는 치료용 조성물에 관한 것이다. 본 발명의 조성물은 우수한 가래 억제 효과를 가져 폐질환의 예방 또는 치료 효과를 가지며, 체중을 감소시켜 비만으로 야기되는 각종 질환의 예방 및 개선 효과가 있다. 또한, 본 발명의 조성물은 천연물질을 유효 성분으로 하여 세포독성 및 피부 부작용이 없어 식품 및 약제학적 조성물에 안전하게 적용할 수 있다.The composition of the present invention comprises (a) a main ingredient comprising wormwood, wolfberry, schisandra chinensis, garlic, ginkgo, malt, radish, soybean, brown rice, pear, ginger, donkey and plantain, (b) sugar and (c) water It relates to a composition for inhibiting or treating lung disease or obesity. The composition of the present invention has an excellent effect of inhibiting sputum, has a prophylactic or therapeutic effect of lung disease, and has the effect of preventing and improving various diseases caused by obesity by reducing weight. In addition, the composition of the present invention can be safely applied to food and pharmaceutical compositions because there is no cytotoxicity and skin side effects using a natural substance as an active ingredient.
Description
본 발명은 (a) 쑥, 구기자, 오미자, 마늘, 은행, 엿기름, 무, 메주콩, 현미쌀, 배, 생강, 당귀 및 질경이를 포함하는 주재료, (b) 설탕 및 (c) 물을 포함하는 폐질환 또는 비만의 억제 또는 치료용 조성물에 관한 것이다.
The present invention comprises (a) a main ingredient comprising mugwort, wolfberry, schizandra, garlic, ginkgo, malt, radish, soybean, brown rice, pear, ginger, donkey and plantain, (b) sugar and (c) waste A composition for inhibiting or treating a disease or obesity.
폐는 폐포 세포가 있어서 모세혈관을 통해서 이산화탄소와 산소가 교환된다. 정맥으로부터 심장의 우심방으로 들어온 여러 가지 독성물질을 함유한 피는 폐동맥으로 들어간 후 폐포의 모세혈관을 통해서 산소를 흡수하고, 대신 노폐물을 비롯한 이산화탄소를 내보게 된다. 이렇게 깨끗해진 피가 심장의 좌심방, 좌심실을 거쳐 동맥으로 들어가서 온몸으로 퍼지게 된다. 따라서, 폐포에 유독가스가 유입될 경우 폐질환을 일으킬 뿐 아니라 혈액의 농도 유지에도 영향을 미치게 된다.The lungs have alveolar cells that exchange carbon dioxide and oxygen through capillaries. Blood containing various toxic substances from the vein into the right atrium of the heart enters the pulmonary artery and then absorbs oxygen through the capillaries of the alveoli and instead emits carbon dioxide, including waste products. This cleared blood enters the arteries through the left atrium, the left ventricle, and spreads throughout the body. Therefore, when toxic gas is introduced into the alveoli, not only causes lung disease but also affects the concentration of blood.
즉, 자동차에서 뿜어져 나오는 아황산가스, 대기 중의 먼지, 황사, 담배연기 등은 이러한 메카니즘을 통해서 폐를 병들게 하고 혈액을 산성화하여 질병을 발생시키게 된다.That is, sulfurous acid gas emitted from the car, dust in the air, yellow dust, tobacco smoke, etc., causes the lungs to become sick through this mechanism and acidify the blood to cause disease.
이러한 폐질환 증상 중 하나인 가래를 제거하기 위한 기술로서 대한민국 특허공개공보 제2002-0083782호에는 살구씨, 피마자, 차조기, 박하 및 용뇌 추출물을 유효 성분으로 함을 특징으로 하는 코막힘 해소 및 가래소거용 오일에 대해서 개시되어 있다.
As a technique for removing sputum, one of the symptoms of lung disease, Korean Patent Publication No. 2002-0083782 discloses apricot seed, castor, perilla, peppermint, and sputum elimination, which are characterized by eliminating nasal congestion. A solvent oil is disclosed.
한편, 비만은 여러 가지 요인으로 발병하는 일반적인 질병으로 고지혈증, 지방간, 동맥경화, 심맥질환, 고혈압 또는 당뇨병 등의 여러 가지 합병증을 수반하며, 최근 식생활의 서구화로 인해 심각한 사회적인 문제로 대두되고 있다.On the other hand, obesity is a common disease that is caused by a number of factors, including various complications such as hyperlipidemia, fatty liver, arteriosclerosis, cardiovascular disease, hypertension or diabetes, and has recently emerged as a serious social problem due to westernization of diet.
비만은 현대화에 따라 급격하게 증가하였기 때문에 많은 학자들이 현대화의 병(disease of civilization)이라고 결론을 내리고 있으며(배만종 등, 고려인삼학회지, 14(3):404-415(1990)), 이외에도 당뇨병과 같은 위험한 질환을 유발할 수 있는 잠재적인 요인으로 생각되고 있다. 비만을 감소시켜서 각종 성인병의 발병률을 감소시키기 위한 연구가 지속되고 있는데, 보다 효과적인 비만 해소를 위해서 운동과 함께 식이요법이 연구되었고, 특히 식사요법이 중요한 요인으로 부각되면서 다이어트와 관련된 건강식품 또는 비만치료제에 대한 관심이 높아지고 있다.Because obesity has increased rapidly with modernization, many scholars have concluded that it is the disease of civilization (Bae Jong Jong et al., Journal of the Korean Ginseng Society, 14 (3): 404-415 (1990)). It is thought to be a potential cause of the same dangerous disease. Research has been conducted to reduce the incidence of various adult diseases by reducing obesity. In order to more effectively relieve obesity, dietary therapy was studied along with exercise. There is a growing interest in.
그러나, 현재 비만치료제로서 이용되고 있는 올리스타트(orlistat)는 지방변, 장내가스 발생, 복부팽만감 등의 부작용이 있고, 시부트라민(sibutramine)은 두통, 구갈, 식욕부진, 불면, 변비 등의 부작용이 알려져 있다. 또한, 올리스타트는 비타민 E와 비타민 D의 흡수를 억제하고, 펜터민(phentermine)과 시부트라민은 심박수 증가, 심계항진 또는 현기증을 초래하는 부작용이 있다. However, orlistat, which is currently used as an anti-obesity agent, has side effects such as fatty stool, intestinal gas generation, and bloating. Sibutramine has side effects such as headache, dry mouth, anorexia, insomnia, and constipation. . In addition, orlistat inhibits absorption of vitamin E and vitamin D, and phentermine and sibutramine have side effects that lead to increased heart rate, palpitations, or dizziness.
상기와 같은 비만 문제를 해결하기 위해 종래에 화학 합성 화합물을 이용한 항비만 관련 조성물(그 예로서, 대한민국 공개특허 제1999-0036207호)들이 개발되었으나, 합성 화합물이라는 이유로 일반 소비자에게 거부감뿐만 아니라 복용 시 불쾌감을 주는 경우가 많았다.
In order to solve the problem of obesity, anti-obesity-related compositions (eg, Korean Patent Laid-Open Publication No. 1999-0036207) using a chemical synthetic compound have been developed in the past, but because of the synthetic compound, it is not only rejected by the general consumer when taken Often it was unpleasant.
이에, 본 발명자들은 생약제 등 천연식물을 주재료로 하여 가래 억제 효과를 통한 폐질환 예방 또는 치료 효과를 나타내면서 비만 억제 효과도 나타낼 수 있는 조성물 개발의 필요성을 인식하였다.
Accordingly, the present inventors have recognized the necessity of developing a composition capable of suppressing obesity while showing the effect of preventing or treating lung disease through the effect of suppressing phlegm, using natural plants such as herbal medicines as main ingredients.
본 발명자들은 천연식물을 대상으로 효과적이고 안전한 폐질환 또는 비만의 억제 또는 치료용 조성물을 개발하고자 노력하였다. 그 결과, (a) 쑥, 구기자, 오미자, 마늘, 은행, 엿기름, 무, 메주콩, 현미쌀, 배, 생강, 당귀 및 질경이를 포함하는 주재료, (b) 설탕 및 (c) 물을 포함하는 조성물을 제조한 결과, 우수한 가래 억제 효과 및 비만과 관련된 체중 감소에 우수한 효과를 가짐을 확인함으로써, 본 발명을 완성하였다.The present inventors have tried to develop effective and safe composition for suppressing or treating lung disease or obesity in natural plants. As a result, a composition comprising (a) a main ingredient comprising wormwood, wolfberry, schizandra, garlic, ginkgo, malt, radish, soybean, brown rice, pear, ginger, donkey and plantain, (b) sugar and (c) water As a result of the preparation, the present invention was completed by confirming that it had an excellent effect on suppressing phlegm and weight loss associated with obesity.
따라서, 본 발명의 목적은 폐질환 또는 비만의 억제 또는 치료용 조성물을 제공하는데 있다.
Accordingly, it is an object of the present invention to provide a composition for inhibiting or treating lung disease or obesity.
본 발명의 다른 목적 및 이점은 하기의 발명의 상세한 설명 및 청구범위에 의해 보다 명확하게 된다.
Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention and claims.
본 발명의 일 양태에 따르면, 본 발명은 (a) 쑥, 구기자, 오미자, 마늘, 은행, 엿기름, 무, 메주콩, 현미쌀, 배, 생강, 당귀 및 질경이를 포함하는 주재료, (b) 설탕 및 (c) 물을 포함하고, 상기 (a) 주재료는 쑥 100 중량부에 대하여 구기자 5-15 중량부, 오미자 5-15 중량부, 마늘 1-10 중량부, 은행 1-10 중량부, 엿기름 1-10 중량부, 무 1-10 중량부, 메주콩 1-10 중량부, 현미쌀 1-10 중량부, 배 1-10 중량부, 생강 1-10 중량부, 당귀 1-10 중량부 및 질경이 10-30 중량부를 포함하는 것을 특징으로 하는 폐질환 또는 비만의 억제 또는 치료용 조성물을 제공한다.
According to an aspect of the present invention, the present invention provides a composition comprising (a) mugwort, wolfberry, schizandra, garlic, ginkgo, malt, radish, soybean, brown rice, pear, ginger, donkey and plantain, (b) sugar and (c) water, wherein (a) the main ingredient is 5-15 parts by weight of goji berry, 5-15 parts by weight of Schisandra chinensis, 1-10 parts by weight of garlic, 1-10 parts by weight of ginkgo, malt 1 -10 parts by weight, 1-10 parts by weight of radish, 1-10 parts by weight of soybeans, 1-10 parts by weight of brown rice, 1-10 parts by weight of pears, 1-10 parts by weight of ginger, 1-10 parts by weight of donkey, and plantain 10 It provides a composition for inhibiting or treating lung disease or obesity, comprising -30 parts by weight.
본 발명자들은 천연식물을 대상으로 효과적이고 안전한 폐질환 또는 비만의 억제 또는 치료용 조성물을 개발하고자 노력하였다. 그 결과, (a) 쑥, 구기자, 오미자, 마늘, 은행, 엿기름, 무, 메주콩, 현미쌀, 배, 생강, 당귀 및 질경이를 포함하는 주재료, (b) 설탕 및 (c) 물을 포함하는 조성물을 제조한 결과, 우수한 가래 억제 효과 및 비만과 관련된 체중 감소에 우수한 효과를 가짐을 확인하였다.
The present inventors have tried to develop effective and safe composition for suppressing or treating lung disease or obesity in natural plants. As a result, a composition comprising (a) a main ingredient comprising wormwood, wolfberry, schizandra, garlic, ginkgo, malt, radish, soybean, brown rice, pear, ginger, donkey and plantain, (b) sugar and (c) water As a result of the preparation, it was confirmed to have an excellent effect on suppressing phlegm and weight loss associated with obesity.
본 발명은 (a) 쑥, 구기자, 오미자, 마늘, 은행, 엿기름, 무, 메주콩, 현미쌀, 배, 생강, 당귀 및 질경이를 포함하는 주재료, (b) 설탕 및 (c) 물을 포함한다.The present invention includes (a) main ingredients including mugwort, wolfberry, schizandra, garlic, ginkgo, malt, radish, soybean, brown rice, pear, ginger, donkey and plantain, (b) sugar and (c) water.
본 발명에 이용되는 "쑥"은 국화과에 속하는 다년생 풀로서, 그것은 식용과 약용으로 구분되며, 항균, 혈액응고, 자궁수축, 기관지확장 또는 해열작용 등이 있다고 알려져 있다. 또한, 쑥의 약효 성분은 치네올, 콜린, 유칼리프톨, 아데닌, 모노기닌, 아르테미신 등으로 밝혀져 있으며, 강한 정혈(淨血), 해독, 활혈, 강장, 강정, 소염, 진통, 면역, 이뇨, 지혈, 식욕증진 등의 효과가 있는 것으로 알려져 있으며, 치네올이라는 정유(精油) 성분으로 인해 독특한 향기를 발생시키는데, 이는 몸에 유익한 역할을 하며 살균 및 살충력을 나타낸다고 알려져 있다."Mugweed" used in the present invention is a perennial grass belonging to the Asteraceae, which is divided into edible and medicinal, and is known to have antibacterial, blood coagulation, uterine contraction, bronchial dilatation or antipyretic effect. In addition, the active ingredients of mugwort have been identified as cineol, choline, eucalyptol, adenine, monoginine, artemisine, etc., and strong congestion, detoxification, blood circulation, tonic, gangjeong, anti-inflammatory, analgesic, immunity, diuresis It is known that the effects of hemostasis, appetite, etc., due to the essential oil component (Cineol) generates a unique scent, which is known to play a beneficial role in the body and exhibit sterilization and insecticides.
본 발명에 이용되는 "구기자"는 달걀 모양 또는 긴 타원 모양이고 길이 1.5-2.5 cm인 식물로 7월부터 붉게 익어 7-11월 하순에 수확하고, 종류로는 재래종을 비롯하여 청양종, 일본과 중국에서 들여온 일본1호, 중국1호 등이 있으며, 특징으로는 단백질, 지방, 당질, 칼슘, 인, 철분, 베타인, 루틴, 비타민(A, B1, B2, C) 등이 들어 있어 흡수가 빠르다. 그리고, 강장제, 해열제로 쓰고 간기능 보호 작용이 뛰어나고 부작용이 별로 없는 것으로 알려져 있으며, 시력을 좋게 하고 당뇨병 등의 성인병을 예방하며 폐와 신장의 기능을 좋게 한다고 알려져 있다."Golgija" used in the present invention is an egg-shaped or long oval-shaped plant 1.5-2.5 cm long, ripened red from July, harvested in late July-November, and includes varieties including Cheongyang species, Japan and China. Japan No. 1 and China No. 1 imported from China, and the protein, fat, sugar, calcium, phosphorus, iron, betaine, rutin, vitamins (A, B1, B2, C), etc. . In addition, it is known that it is used as a tonic and antipyretic, and has excellent liver function protection effect and little side effects. It is known to improve vision and prevent adult diseases such as diabetes and improve lung and kidney function.
본 발명에 이용되는 "오미자(Schizandrae Fructus)"는 오미자과의 오미자( Schizandra chinesis BAILL)의 성숙과실을 건조한 것으로, 거담, 진해, 정천, 청혈, 검한, 생진지갈, 보신, 양오장 등의 효능이 있는 것으로 알려져 있다. Schizandrae used in the present invention Fructus ) is a dried fruit of Schizandra chinesis BAILL of Schizandra chinesis BAILL, and is known to have an effect of expectoration, Jinhae, Cheonje, Cheonghyeol, Black, Saengjigal, Bosin and Yangjang.
본 발명에 이용되는 "당귀(Angelica gigantis radix)"는 미나리(Umbelliferae)과에 속한 다년생 초목으로 토당귀(Angelica gigas Nakai, 참당귀)와 일당귀(Angelica acutiloba Kitagawa, 왜당귀) 및 중국당귀(Angelica sinensis)를 일컫는 한약재로, 냉증, 빈혈과 같은 부인과 질환에 주로 쓰이며 혈행을 수월하게 하며 조혈 및 혈류의 개선 효과가 있는 것으로 알려져 있다."Angelica (Angelica used in the present invention gigantis radix ) is a perennial vegetation belonging to the Umbelliferae family, Angelica gigas Nakai , Angelica Angelica and Angelica Angelica acutiloba Kitagawa , Japanese Angelica and Angelica sinensis ) is a Chinese medicine, commonly used for gynecological diseases such as cold and anemia, and is known to have an effect of improving hematopoiesis and blood flow.
본 발명에 이용되는 "질경이(Plantago asiatica)"는 질경이과(Plantaginaceae)에 속하는 다년생 초본으로 우리나라, 중국 및 일본 등의 동아시아와 중앙아시아 등지에 자생하는 약초로 노방초라고 할 만큼 생명력이 강하고 번식력이 우수하다. 꽃이 필 때의 전초를 말린 것을 차전초(車前草), 씨를 차전자(車前子)라 하며 한방에서는 강력한 이뇨제로 신장염, 방광염 및 요도염들에 널리 사용되어 왔으며, 무기질, 단백질, 비타민류 및 다당류 등이 많이 함유되어 있으며, 이들 성분들은 항염증작용에 관여하는 것으로 알려져 있다. Plantago used in the present invention asiatica ) "is a perennial herb belonging to Plantaginaceae . It is a herb that grows in East Asia and Central Asia such as Korea, China, and Japan. Chajeoncho and seeds are called chajeon, and herbal medicine is a powerful diuretic, widely used in nephritis, cystitis and urethritis, and contains a lot of minerals, proteins, vitamins and polysaccharides. They are known to be involved in anti-inflammatory action.
질경이의 주요 생리활성 성분으로 이리도이드 글리코사이드(iridoid glycoside)인 오큐빈(aucubin)과 플란타글루코사이드(plantaglucoside), 각종 스테롤(sterol)류, 아데닌(adenin), 콜린(choline), 점액질(mucilage) 및 각종 지방산이 함유되어 있는 것으로 밝혀져 있으며, 항균작용, 담즙 분비작용, 간독성 방어 작용 및 혈압 강하 작용 등이 보고된 바 있다.
The main bioactive components of plantain are iridoid glycosides, acubin and plantaglucoside, various sterols, adenine, choline and mucilage And it has been found that contains a variety of fatty acids, antibacterial action, bile secretion action, hepatotoxic defense action and blood pressure lowering action has been reported.
바람직한 구현예로서, 본 발명의 조성물에 포함되는 (a) 주재료는 쑥 100 중량부에 대하여 구기자 5-15 중량부, 오미자 5-15 중량부, 마늘 1-10 중량부, 은행 1-10 중량부, 엿기름 1-10 중량부, 무 1-10 중량부, 메주콩 1-10 중량부, 현미쌀 1-10 중량부, 배 1-10 중량부, 생강 1-10 중량부, 당귀 1-10 중량부 및 질경이 10-30 중량부를 포함하고, 보다 바람직하게는 쑥 100 중량부에 대하여 구기자 8-12 중량부, 오미자 8-12 중량부, 마늘 3-7 중량부, 은행 3-7 중량부, 엿기름 3-7 중량부, 무 3-7 중량부, 메주콩 3-7 중량부, 현미쌀 3-7 중량부, 배 3-7 중량부, 생강 3-7 중량부, 당귀 3-7 중량부 및 질경이 15-25 중량부를 포함한다.As a preferred embodiment, the main material (a) included in the composition of the present invention is 5-15 parts by weight of goji berry, 5-15 parts by weight of Schizandra chinensis, 1-10 parts by weight of garlic, 1-10 parts by weight of ginkgo , 1-10 parts by weight of malt, 1-10 parts by weight of radish, 1-10 parts by weight of soybean, 1-10 parts by weight of brown rice, 1-10 parts by weight of pear, 1-10 parts by weight of ginger, 1-10 parts by weight of donkey And it is 10-30 parts by weight of plantain, more preferably 8-12 parts by weight of wolfberry, 8-12 parts by weight of Schisandra chinensis, 3-7 parts by weight of garlic, 3-7 parts by weight of ginkgo, malt 3 -7 parts by weight, 3-7 parts by weight of radish, 3-7 parts by weight of soybeans, 3-7 parts by weight of brown rice, 3-7 parts by weight of pears, 3-7 parts by weight of ginger, 3-7 parts by weight of donkey, and plantain 15 -25 parts by weight.
본 발명의 조성물에 상기 주재료가 상기 함량을 가지는 경우에, 아래 실시예에서 명확히 확인되는 바와 같이, 우수한 가래 억제 효과 및 항비만 효과를 가진다.
When the main material has the above content in the composition of the present invention, as clearly shown in the following examples, it has an excellent sputum inhibiting effect and an anti-obesity effect.
본 발명의 바람직한 구현예에 따르면, 본 발명의 조성물은 (a) 주재료 및 (b) 설탕이 중량비 1 : 1로 포함된다.According to a preferred embodiment of the present invention, the composition of the present invention comprises (a) the main material and (b) sugar in a weight ratio of 1: 1.
본 발명의 다른 바람직한 구현예에 따르면, 본 발명의 조성물은 (a) 주재료 및 (b) 설탕이 (c) 물과 중량비 1 : 4로 포함된다.According to another preferred embodiment of the present invention, the composition of the present invention comprises (a) the main ingredient and (b) sugar in (c) water and weight ratio 1: 4.
본 발명의 조성물에 상기 (a) 주재료 및 (b) 설탕이 (c) 물과 상기 중량비로 포함되는 경우에 우수한 가래 억제 효과 및 항비만 효과를 가진다.When (a) the main material and (b) the sugar are included in the composition of the present invention in (c) water and the weight ratio, it has an excellent sputum inhibiting effect and an anti-obesity effect.
본 발명의 조성물의 제조는 상기 함량으로 주재료, 설탕 및 물을 포함하며, 우선, 상기 주재료를 물로 세척하여 물기를 제거한 다음, 설탕과 상기 전처리한 주재료를 중량비 1 : 1로 혼합하여 주재료를 설탕에 7일 동안 재워서 숙성시킨 다음, 상기 재운 숙성물에 물을 중량비 1 : 4로 혼합하고 100-200℃의 불로 3-5시간 동안 가열하여 제조한다.
The preparation of the composition of the present invention comprises the main material, sugar and water in the above content, first, the main material is washed with water to remove water, and then the sugar and the pretreated main material in a weight ratio of 1: 1 to mix the main material in sugar After aging for 7 days, the mixture is prepared by mixing water at a weight ratio of 1: 4 with the lysed aging product and heating it for 3-5 hours with a fire at 100-200 ° C.
본 발명의 조성물은 폐질환 또는 비만의 억제 또는 치료 효과를 가진다.The composition of the present invention has an inhibitory or therapeutic effect on lung disease or obesity.
본 발명의 바람직한 구현예에 따르면, 상기 폐질환의 억제 또는 치료는 가래 억제이다.According to a preferred embodiment of the invention, the suppression or treatment of the lung disease is sputum suppression.
또한, 본 발명의 조성물은 체중 증가를 억제하고 비만을 개선하는 효과가 높아 비만을 예방 및 개선하는 데에 유용하며, 결국 각종 성인병 및 대사증후군으로 야기된 질환을 개선하는 데에 유효하다.
In addition, the composition of the present invention has a high effect of inhibiting weight gain and improving obesity, and thus is useful for preventing and improving obesity, and is effective for ameliorating diseases caused by various adult diseases and metabolic syndrome.
본 발명의 조성물은 식품 또는 약제학적 조성물로 제조될 수 있다.The composition of the present invention may be prepared as a food or pharmaceutical composition.
본 발명의 조성물이 식품 조성물로 제조되는 경우, 상술한 본 발명의 조성물뿐만 아니라, 식품 제조 시에 통상적으로 첨가되는 성분을 포함하며, 예를 들어, 단백질, 탄수화물, 지방, 영양소, 조미제 및 향미제를 포함한다. 상술한 탄수화물의 예는 모노사카라이드, 예를 들어, 포도당, 과당 등; 디사카라이드, 예를 들어, 말토스, 슈크로스, 올리고당 등; 및 폴리사카라이드, 예를 들어, 덱스트린, 사이클로덱스트린 등과 같은 통상적인 당 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 향미제로서 천연 향미제 [타우마틴, 스테비아 추출물(예를 들어, 레바우디오시드 A, 글리시르히진 등)] 및 합성 향미제(사카린, 아스파르탐 등)를 사용할 수 있다.When the composition of the present invention is made of a food composition, it includes not only the composition of the present invention as described above, but also components commonly added in the preparation of food, and include, for example, proteins, carbohydrates, fats, nutrients, seasonings and flavors. Include the first. Examples of the above-mentioned carbohydrates are monosaccharides such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, oligosaccharides and the like; And sugars such as conventional sugars such as polysaccharides such as dextrin, cyclodextrin and the like and xylitol, sorbitol, erythritol. As the flavoring agent, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be used.
예컨대, 본 발명의 식품 조성물이 드링크제로 제조되는 경우에는 본 발명의 유효 성분 이외에 구연산, 액상과당, 설탕, 포도당, 초산, 사과산, 과즙, 두충 추출액, 대추 추출액 등을 추가로 포함시킬 수 있다.
For example, when the food composition of the present invention is prepared with a drink, citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, fruit juice, tofu extract, jujube extract and the like may be further included in addition to the active ingredient of the present invention.
본 발명의 조성물이 약제학적 조성물로 제조되는 경우, 본 발명의 약제학적 조성물은 약제학적으로 허용되는 담체를 포함한다. 본 발명의 약제학적 조성물에 포함되는 약제학적으로 허용되는 담체는 제제 시에 통상적으로 이용되는 것으로서, 락토스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 전분, 아카시아 고무, 인산칼슘, 알기네이트, 젤라틴, 규산칼슘, 미세결정성 셀룰로스, 폴리비닐피롤리돈, 셀룰로스, 물, 시럽, 메틸셀룰로스, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 스테아르산 마그네슘 및 미네랄 오일 등을 포함하나, 이에 한정되는 것은 아니다. 본 발명의 약제학적 조성물은 상기 성분들 이외에 윤활제, 습윤제, 감미제, 향미제, 유화제, 현탁제, 보존제 등을 추가로 포함할 수 있다. 적합한 약제학적으로 허용되는 담체 및 제제는 Remington's Pharmaceutical Sciences (19th ed., 1995)에 상세히 기재되어 있다.When the composition of the present invention is manufactured from a pharmaceutical composition, the pharmaceutical composition of the present invention includes a pharmaceutically acceptable carrier. Pharmaceutically acceptable carriers included in the pharmaceutical compositions of the present invention are those commonly used in the preparation, such as lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, calcium phosphate, alginate, gelatin, Calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methylcellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, and the like It doesn't happen. The pharmaceutical composition of the present invention may further contain a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, etc. in addition to the above components. Suitable pharmaceutically acceptable carriers and formulations include, but are not limited to, Remington's Pharmaceutical Sciences (19th ed., 1995).
본 발명의 약제학적 조성물은 경구 또는 비경구 투여(예컨대, 정맥내 투여, 복강내 투여, 근육내 투여, 피하 투여 또는 국부 투여)할 수 있다.The pharmaceutical compositions of the invention may be oral or parenteral (eg, intravenous, intraperitoneal, intramuscular, subcutaneous or topical).
본 발명의 약제학적 조성물의 적합한 투여량은 제제화 방법, 투여 방식, 환자의 연령, 체중, 성, 병적 상태, 음식, 투여 시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하게 처방될 수 있다. 한편, 본 발명의 약제학적 조성물의 투여량은 바람직하게는 1일 당 100-600 mg/kg(체중)이다.The appropriate dosage of the pharmaceutical composition of the present invention may vary depending on factors such as the formulation method, administration method, age, body weight, sex, pathological condition, food, administration time, administration route, excretion rate, . On the other hand, the dosage of the pharmaceutical composition of the present invention is preferably 100-600 mg / kg body weight per day.
본 발명의 약제학적 조성물은 당해 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있는 방법에 따라 약제학적으로 허용되는 담체 및/또는 부형제를 이용하여 제제화함으로써 단위 용량 형태로 제조되거나 또는 다용량 용기 내에 내입시켜 제조될 수 있다. 이때, 제형은 산제, 과립제, 정제, 캅셀제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 연고, 크림 등의 외용제, 좌제 및 멸균 주사용액 등을 비롯하여 약제학적 제제에 적합한 어떠한 형태로든 사용할 수 있으며, 분산제 또는 안정화제를 추가적으로 포함할 수 있다.
The pharmaceutical compositions of the present invention may be prepared in unit dose form by formulating with a pharmaceutically acceptable carrier and / or excipient according to methods which can be easily carried out by those skilled in the art. Or by incorporating into a multi-dose container. In this case, the formulation may be used in any form suitable for pharmaceutical preparations, including powders, granules, tablets, capsules, suspensions, emulsions, syrups, oral formulations such as aerosols, external preparations such as ointments, creams, suppositories, and sterile injectable solutions. It may further include a dispersant or stabilizer.
본 발명의 특징 및 이점을 요약하면 다음과 같다:The features and advantages of the present invention are summarized as follows:
(ⅰ) 본 발명의 조성물은 (a) 쑥, 구기자, 오미자, 마늘, 은행, 엿기름, 무, 메주콩, 현미쌀, 배, 생강, 당귀 및 질경이를 포함하는 주재료, (b) 설탕 및 (c) 물을 포함하고, 상기 (a) 주재료는 쑥 100 중량부에 대하여 구기자 5-15 중량부, 오미자 5-15 중량부, 마늘 1-10 중량부, 은행 1-10 중량부, 엿기름 1-10 중량부, 무 1-10 중량부, 메주콩 1-10 중량부, 현미쌀 1-10 중량부, 배 1-10 중량부, 생강 1-10 중량부, 당귀 1-10 중량부 및 질경이 10-30 중량부를 포함하는 것을 특징으로 하는 폐질환 또는 비만의 억제 또는 치료용 조성물에 관한 것이다.(Iii) The composition of the present invention comprises (a) a main ingredient comprising wormwood, wolfberry, schizandra, garlic, ginkgo, malt, radish, soybean, brown rice, pear, ginger, donkey and plantain, (b) sugar and (c) Water (a) The main material is 5-15 parts by weight of wolfberry, 5-15 parts by weight of Schizandra chinensis, 1-10 parts by weight of garlic, 1-10 parts by weight of ginkgo, 1-10 parts by weight of malt per 100 parts by weight of mugwort 1-10 parts by weight of radish, 1-10 parts by weight of soybeans, 1-10 parts by weight of brown rice, 1-10 parts by weight of pears, 1-10 parts by weight of ginger, 1-10 parts by weight of Angelica, and 10-30 parts by weight of plantain It relates to a composition for inhibiting or treating lung disease or obesity, characterized in that it comprises a part.
(ⅱ) 본 발명의 조성물은 우수한 가래 억제 효과를 가져 폐질환의 예방 또는 치료 효과를 가지며, 체중을 감소시켜 비만으로 야기되는 각종 질환의 예방 및 개선 효과가 있다.(Ii) The composition of the present invention has an excellent effect of inhibiting sputum, has a prophylactic or therapeutic effect of lung disease, and has the effect of preventing and improving various diseases caused by obesity by reducing body weight.
(ⅲ) 또한, 본 발명의 조성물은 천연물질을 유효 성분으로 하여 세포독성 및 피부 부작용이 없어 식품 및 약제학적 조성물에 안전하게 적용할 수 있다.
(Iii) In addition, the composition of the present invention can be safely applied to food and pharmaceutical compositions, since there is no cytotoxicity and skin side effects as a natural substance as an active ingredient.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당 업계에서 통상의 지식을 가진 자에 있어서 자명할 것이다.
Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention more specifically, it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .
실시예Example
제조예: 조성물의 제조Preparation Example: Preparation of Composition
상기 표 1의 재료들(실시예 1, 비교예 1 및 2)을 물로 깨끗이 씻은 다음 물기를 제거하였다. 그 다음, 상기 표 1의 재료와 설탕(흑설탕+황설탕)을 중량비 1 : 1로 혼합하여 7일 동안 떡시루 앉히듯 켜켜이 재었다. 그리고, 상기 설탕에 잰 결과물에 물을 중량비 1 : 4로 첨가하고 약한 불(약 150℃)로 4시간 동안 천천히 가열하여 제조하였다. 그리고, 상기 표 1의 라벨링된 성분들을 이용하여 제조된 조성물을 각각 실시예 1, 비교예 1 및 2로 하여 이하 실험에 이용하였다.
The materials of Table 1 (Example 1, Comparative Examples 1 and 2) were washed with water and then drained. Next, the ingredients of Table 1 and sugar (brown sugar + brown sugar) were mixed in a weight ratio of 1: 1, and then weighed on for 7 days. In addition, water was added to the resultant weighed in a weight ratio of 1: 4, and prepared by slowly heating for 4 hours on a weak fire (about 150 ℃). And the compositions prepared using the labeled components of Table 1 were used in the following experiments as Example 1, Comparative Examples 1 and 2, respectively.
실험예Experimental Example 1: 가래 제거 효과 시험 1: sputum removal effect test
약 10년 이상 흡연으로 인한 가래 환자 10명을 대상으로 본 발명 조성물의 가래 제거 효과를 시험하였다. 본 발명의 조성물 500 ml를 시험 대상으로 하여금 하루에 세 번씩 복용시키고 90일 동안 시험을 실시하였다. 그 결과는 아래 표 1에 정리하였다. 가래 제거 효과는 큰 순으로부터 +++, ++, + 및 (-)로 나타내었다. 가래 제거 효과가 나타나지 않는 경우를 (-)로 나타내었다.Sputum removal effect of the composition of the present invention was tested in 10 sputum patients due to smoking for about 10 years or more. 500 ml of the composition of the present invention were administered to test subjects three times a day and tested for 90 days. The results are summarized in Table 1 below. Sputum elimination effects are shown in the order of +++, ++, + and (-) in descending order. The case where the sputum removal effect does not appear is shown as (-).
상기 표 2에서 볼 수 있듯이, 실시예 1의 본 발명의 조성물은 복용 30일 후 가래 제거 효과가 ++로 나타났고, 60일 이후에는 가래 제거 효과가 +++로 나타나 가래 제거 효과가 우수한데 반해, 비교예 1은 복용 90일 후에, 비교예 2는 복용 60일 이후에 가래 제거 효과가 발생하였고, 비교예 1 및 2의 경우 가래 제거 효과가 발생하더라도 실시예 1의 30일째 가래 제거 효과에 비해 약 절반 정도의 효과만 나타내었다.As can be seen in Table 2, the composition of the present invention of Example 1 was found to have a sputum removal effect ++ after 30 days of administration, after 60 days the sputum removal effect is shown as +++ excellent sputum removal effect On the contrary, Comparative Example 1 had a phlegm removal effect after 90 days of administration and Comparative Example 2 had a sputum removal effect after 60 days of administration. Only about half the effect was shown.
가래 제거 효과는 가래 환자의 평소 배출하는 가래 량을 비교하여 평가하였다.
The effect of sputum removal was evaluated by comparing the amount of sputum that is usually released from sputum patients.
실험예Experimental Example 2: 2: 항비만Anti-obesity 효과 시험 Effect test
생후 7주된 ICR 계 수컷 마우스(챨스리버, 일본)를 1주일 동안 예비사육하고 1군 7마리로 비만억제실험에 사용하였다. 동물은 온도 23±1℃, 습도 55±5%, 조명시간 12시간/일(day)로 설정된 항온항실에서 사육하고, 사료에 라보MR(일본농산공업 제조)을 사용하며 물은 자유롭게 섭취할 수 있도록 하였다.Seven-week-old ICR male mice (Higgs River, Japan) were pre-cultured for one week and used in obesity suppression experiments in seven groups of seven. Animals are kept in a constant temperature room set at a temperature of 23 ± 1 ° C, a humidity of 55 ± 5% and an illumination time of 12 hours / day, using Rabo MR (made by Nippon Agricultural Co., Ltd.) for feed, and freely ingesting water. It was made.
상기 실시예 1, 비교예 1 및 2를 시료로 하여, 2주간 100 mg/kg의 농도로 상기 마우스에 경구 투여한 다음 투여 2주 후 체중의 변화를 측정하고 그 결과는 아래 표 3에 정리하였다. 마우스는 투여하기 전날부터 절식(絶食) 상태로 하여 다음 날 강제로 단회(單回) 투여하였다. 그리고, 현재 비만치료제로 이용되고 있는 메트포르민(metformin)(농도: 100 mg/kg)을 양성 대조군으로 이용하였다.Example 1, Comparative Examples 1 and 2 as a sample, the oral administration to the mouse at a concentration of 100 mg / kg for 2 weeks and then measured the change in body weight 2 weeks after administration and the results are summarized in Table 3 below . The mice were fasted from the day prior to administration and were forced to the next day. In addition, metformin (concentration: 100 mg / kg), which is currently used as an obesity agent, was used as a positive control.
(양성대조군)Metformin
(Positive control group)
상기 표 3에 기재된 바와 같이, 실시예 1은 비교예 1, 2 및 메트포르민 투여군(양성대조군)에 비해서 비만억제 효과가 우수하였고, 특히 현재 비만치료제로 이용되고 있는 메트포르민보다도 체중 증가율이 감소하였음을 알 수 있다.
As shown in Table 3, Example 1 was superior to the comparative examples 1, 2 and metformin-administered group (positive control group), the effect of inhibiting obesity, in particular, it was found that the weight gain rate is reduced than metformin currently used as an obesity treatment agent Can be.
이상으로 본 발명의 특정한 부분을 상세히 기술하였는 바, 당 업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the present invention. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.
Claims (5)
(a) a main ingredient comprising wormwood, wolfberry, schizandra, garlic, ginkgo, malt, radish, soybean, brown rice, pear, ginger, donkey and plantain, (b) sugar and (c) water, and (a) ) The main ingredients are 5-15 parts by weight of goji berry, 5-15 parts by weight of Schisandra chinensis, 5-15 parts by weight of Schisandra chinensis, 1-10 parts by weight of garlic, 1-10 parts by weight of ginkgo, 1-10 parts by weight of malt, 1-10 parts by weight of radish. , 1-10 parts by weight of soybeans, 1-10 parts by weight of brown rice, 1-10 parts by weight of pears, 1-10 parts by weight of ginger, 1-10 parts by weight of Angelica, and 10-30 parts by weight of plantain A composition for inhibiting or treating a disease or obesity, wherein the suppression or treatment of the lung disease is sputum suppression.
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| KR20020060671A (en) * | 2002-07-02 | 2002-07-18 | 이혜복 | A composition for preventing a disease in the lung, a method for producing the composition and a method for using the composition |
| JP2004159637A (en) | 2002-11-08 | 2004-06-10 | Eromlife Co Ltd | Dietary composition |
| KR20060094228A (en) * | 2005-02-24 | 2006-08-29 | (주)바이오뉴트리젠 | Food for preventing fatness and hyperlipemia |
| KR100865513B1 (en) | 2007-03-15 | 2008-10-29 | 강화군 | Composition for preventing and treating obesity comprising the alcoholic extract of gang-hwa mugwort |
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| KR20020060671A (en) * | 2002-07-02 | 2002-07-18 | 이혜복 | A composition for preventing a disease in the lung, a method for producing the composition and a method for using the composition |
| JP2004159637A (en) | 2002-11-08 | 2004-06-10 | Eromlife Co Ltd | Dietary composition |
| KR20060094228A (en) * | 2005-02-24 | 2006-08-29 | (주)바이오뉴트리젠 | Food for preventing fatness and hyperlipemia |
| KR100865513B1 (en) | 2007-03-15 | 2008-10-29 | 강화군 | Composition for preventing and treating obesity comprising the alcoholic extract of gang-hwa mugwort |
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