KR101225094B1 - Braiding machine, braiding method and supporting scaffold for regenerating articular cartilage produced thereby - Google Patents
Braiding machine, braiding method and supporting scaffold for regenerating articular cartilage produced thereby Download PDFInfo
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- KR101225094B1 KR101225094B1 KR1020100094352A KR20100094352A KR101225094B1 KR 101225094 B1 KR101225094 B1 KR 101225094B1 KR 1020100094352 A KR1020100094352 A KR 1020100094352A KR 20100094352 A KR20100094352 A KR 20100094352A KR 101225094 B1 KR101225094 B1 KR 101225094B1
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- braiding
- orientation
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- braid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The present invention relates to a braiding machine, comprising: a frame; A braiding bed disposed in the frame such that a plurality of carriers capable of drawing each braid is arranged, and the braids are twisted together to form a braid in the process of turning the carriers into a cross; A drive source connected to the braids by a wire and capable of advancing the braided braid at a predetermined speed; And an orientation yarn supply member provided in the frame to supply the orientation yarn in a direction perpendicular to the direction of travel of the knitted fabric so as to interpose the orientation yarn into the braid.
Description
The present invention relates to a braiding machine, a braiding method and a support for articular cartilage regeneration produced by the braiding machine, and more particularly, a braiding machine capable of inserting an orientation yarn in the braiding direction of a knitted fabric, a braiding method and It relates to a support for articular cartilage regeneration produced thereby.
In general, cartilage tissue that forms the joints of vertebrates is not normally regenerated in vivo once damaged. Arthritis is the most representative degenerative disease and most frequently occurs in an aging society. According to a recent report from the Korean medical community, 80% of patients over 55 years old and nearly 70% of people over 50 years old have degenerative arthritis, and about a quarter of them show clinical symptoms.
Currently known methods for treating damaged articular cartilage include chondroplasty, osteochondraltransplantation, and autolaugous chondrocyte transplantation.
Cartilage surgery is the most commonly used method, and arthroscopy, a representative method, inserts an arthroscopy with a small camera into the joint cavity through a small hole of less than 1 cm and enters the joint through a TV monitor. It is a method of performing diagnosis and surgery simultaneously while enlarging observation. However, cartilage surgery does not have a satisfactory effect in terms of function because fibro-cartilage is mainly produced rather than hyaline cartilage required for actual joints.
Osteochondral transplantation has been successful in some patients by harvesting the cartilage and the subchondral cartilage that has already been produced in the patient's normal area and transplanting it through a suitable hole drilled in the damaged cartilage. . However, osteochondral transplantation is difficult to call a complete treatment because there is a gap between the transplanted site and the original tissue, and it can be performed only in patients who are capable of autolaugous transplantation. Can't.
Self-derived chondrocyte transplantation has recently emerged as a new treatment based on tissue engineering for the treatment of damaged articular cartilage. The technology was first studied at the Hospital for Joint Disease in New York and was developed at the University of Gothenburg and Sahlgrenska University Hospital in Sweden.
Self-derived chondrocyte transplantation is to obtain cartilage cells enough to treat cartilage defects by collecting and removing cartilage cells that are not used in the cartilage areas of patients with damaged knee joint cartilage. It is a method of restoring the joint cartilage of the patient by implanting the cartilage defects of the patient. Compared to osteochondral grafting, the transplanted cartilage cells multiply directly within the damaged area and fill the damaged area, so that the transplanted area and the normal area are relatively well fused, and there is a high possibility of regenerating supercartilage. However, surgery is required when the chondrocytes are harvested and when the chondrocytes cultured in vitro are transplanted back to the joint cartilage injuries. Thus, the patient suffers from pain, sequelae and economic burden by two operations. The procedure is also complicated and tricky.
In addition to the aforementioned surgical treatments, research has been actively conducted for regeneration of damaged cartilage into normal cartilage for the past several decades. As a result of these studies, methods such as multiple perforation, microfracture, abrasion, periosteum or cartilage transplantation have been attempted for the repair of defects of articular cartilage, but most of them are repaired only to fibrous cartilage. The healing effect was very limited. Autologous or allogeneic cartilage transplantation is also performed, but it is difficult to perform due to limitation of donor or donor. Therefore, regeneration of damaged cartilage into tissues that are histologically and biomechanically similar to the original cartilage is very important in terms of preventing and treating cartilage damage or defects.
Meanwhile, with the development of cartilage cells or mesenchymal stem cells (MSCs), advanced methods of cell transplantation and various in vitro histological cartilage using various supports have been developed. Lee, CR, et al., Tissue Eng., 6: 555, 2000, Li, WJ, et al., Biomaterials, 26: 599, 2005.
Scaffolds that provide a three-dimensional culture environment affect the ultimate quality of tissue engineered cartilage tissue as well as the proliferation and differentiation of inoculated cells. Currently, various materials derived from synthetic or natural materials are used as suitable supports. These supports are used in various forms such as sponges, gels, fibers and microbeads (Honda, MJ, et al., J. Oral Maxillofac Surg., 62: 1510, 2004, Griogolo, B., et. al., Biomaterials, 22: 2417, 2001, Chen, G., et al., J. Biomed.Mater.Res.A, 67: 1170, 2003, Kang, SW, et al., Tissue Eng., 11: 438, 2005), the most commonly used among them is a porous structure capable of improving cell adhesion and maintaining a high rate of surface tension with respect to volume. However, this structure also has a problem that can not be clinically applied because it can not produce high-quality histological cartilage, although some applications have been successfully reported in vivo and in vitro (in vitro). In addition, these supports in the prior art had a limitation because it cannot fully mimic the mechanical properties of natural cartilage.
On the other hand, these conventional supports are manufactured by a well-known braiding machine, which can only insert the orientation yarn in the same direction as the direction of travel of the braid, and is a plane perpendicular to the direction of travel of the braid. There was a problem in that it was impossible to insert an alignment yarn for reinforcing properties in another axial direction perpendicular to the alignment yarn.
SUMMARY OF THE INVENTION The present invention has been made to overcome the above-mentioned problems, and it is a technical object of the present invention to provide a braiding machine capable of simultaneously forming the orientation yarns on the braiding direction of the braid and the direction perpendicular thereto, that is, two axes.
According to an exemplary embodiment of the present invention for achieving the above object, a braiding machine includes a frame; A braiding bed disposed in the frame such that a plurality of carriers capable of withdrawing each braid is arranged and the braids are twisted together to form a braid in the process of turning the carriers into a cross; A drive source connected to the braids by a wire and capable of advancing the braided braid at a predetermined speed; And an orientation yarn supply member provided in the frame to supply the orientation yarn in a direction perpendicular to the direction in which the knitted fabric is interposed to interpose the orientation yarn into the braid.
Preferably, the alignment yarn supply member includes: an orientation yarn supply unit installed on the frame so as to be reciprocally movable and having the alignment yarn at one end thereof; And a hook member provided in the frame so as to face the orientation yarn supply section so that the orientation yarn supplied by the orientation yarn supply section is caught.
Preferably, the hook member comprises: a back plate installed on the frame; And a hook plate, in which a plurality of hooks are arranged at predetermined intervals so that the orientation yarns can be caught and can be moved by a predetermined distance with respect to the back plate.
Preferably, the orientation yarn supply unit: a guide block installed in the frame; And a needle having a through hole through which the guide yarn can be penetrated and moved through the braided material while being guided and moved by the guide block.
Preferably, at least one of the braids has a second orientation yarn which penetrates and advances the braid without twisting each other.
Preferably, the braided and oriented yarns are formed of strands of a plurality of fine fibers.
Preferably, each of the fibers is made by Poly Glycolic Acid (PGA) or Poly Lactic-co-Glycolic Acid (PLGA).
A braiding method according to a preferred embodiment of the present invention for achieving the above object, the step of (a) braiding a plurality of partial surveys to each other; And (b) inserting an orientation yarn on a plane orthogonal to the braiding direction of the braids.
Preferably, step (a) comprises simply advancing at least one of the plurality of knitting yarns in the braiding direction without twisting each other.
Preferably, step (a) comprises the steps of: arranging the plurality of braids such that the braided braid forms a plurality of layers; And step (b) varies the number of respective orientation yarns inserted between the plurality of layers.
According to the present invention, there is provided a support for articular cartilage regeneration produced by the braiding method.
The braiding machine, the braiding method and the support structure for articular cartilage regeneration according to the present invention have the following effects.
First, by adding a process or structure for inserting the orientation yarn in a direction orthogonal to the braiding direction of the braid in the known braiding machine and method, it is possible to enhance the physical properties of the braided braid.
Second, when the additional orientation yarns are added so as not to be twisted with each other in the same direction as the braiding direction of the braid, the physical properties in the braiding direction of the braid can be reinforced.
Third, the cartilage regeneration support braided by the braiding machine and the method according to the present invention is simulated to correspond to the actual structure of the cartilage in each axial direction (in the biaxial direction) in the process of braiding the braids alternately. In order to simulate the physical cartilage properties of the actual cartilage because the structure of the woven yarn of the volume necessary for the woven structure. In addition, it is possible to provide a more flexible support structure for cartilage regeneration by adjusting the thickness or the number of cross-sections of the alignment yarns.
BRIEF DESCRIPTION OF THE DRAWINGS The drawings appended hereto illustrate a preferred embodiment of the present invention and, together with the following detailed description, serve as an illustrative role to better understand the spirit of the present invention. It should not be construed as limited to matters.
Figure 1 is a schematic diagram showing a braiding machine in a preferred embodiment of the present invention.
2 is a conceptual diagram schematically showing a braiding method according to a braiding machine according to a preferred embodiment of the present invention.
3 is a conceptual diagram schematically showing a braiding method according to a braiding machine according to a preferred embodiment of the present invention.
4 is a real picture schematically showing a support for articular cartilage regeneration produced by a braiding machine according to a preferred embodiment of the present invention.
FIG. 5 is an enlarged schematic perspective view showing the configuration of the support for cartilage regeneration according to FIG. 4, as viewed from the XZ plane. FIG.
FIG. 6 is an enlarged schematic perspective view of the configuration of the support for cartilage regeneration according to FIG. 4, as viewed from the YZ plane. FIG.
FIG. 7 is a diagram showing an X-direction tensile result according to computer simulation of the support for cartilage regeneration shown in FIGS. 4 to 6.
FIG. 8 is a diagram illustrating a Y-direction tensile result according to computer simulation of the support for cartilage regeneration shown in FIGS. 4 to 6.
Hereinafter, a braiding machine according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.
1 is a schematic view showing a braiding machine according to a preferred embodiment of the present invention, Figures 2 and 3 schematically show a braiding method by a braiding machine according to a preferred embodiment of the present invention, respectively Conceptual diagrams.
1 to 3, a
A typical brader is a
The
The
The driving
Meanwhile, the driving method of the
The orientation
The alignment
As shown in FIGS. 2 and 3, after the
In a preferred alternative embodiment, where
Meanwhile, the
A braiding method for a support structure for articular cartilage regeneration in accordance with a preferred exemplary embodiment of the present invention comprises a plurality of braiding using the above-described braiding machine or another kind of braiding machine known or known in the future. Braiding the
Here, the braiding step includes simply advancing at least one of the plurality of knitting yarns in the braiding direction without twisting each other with the
The braiding step also includes appropriately placing the plurality of
The orientation yarn insertion step may configure different numbers of
4 is a real picture schematically showing a support for articular cartilage regeneration braided by a braiding machine according to a preferred embodiment of the present invention, and FIGS. 5 and 6 are enlarged views of the structure of the support shown in FIG. As a schematic perspective view, FIG. 5 is a view from the XZ plane and FIG. 6 is a view from the YZ plane.
4 to 6, the articular
Articular cartilage
The
In the present embodiment, the volume of the
The braided
Single component PGA has good physical properties but has a high rate of decomposition and is good for use by surgeons due to the pH change according to glycolic acid, but may have problems in use for internal organs. In comparison, PLA is slightly degraded in physical properties but slower in decomposition than PGA, and its byproduct lactic acid has less effect on the human body.
The fibers used in the
As the substrate used in the support structure for cartilage regeneration according to the preferred embodiment of the present invention, a gel material such as agarose, fibrin, collage, or the like may be used. Agarose has excellent biocompatibility and is used for DNA electrophoresis. It is dissolved in water and made into a gel. Agarose is liquid at high temperatures and gel-like at room temperature. Agarose is easy to experiment.
In the articular
More specifically, in the present embodiment, the
As described above, comparing the physical property values according to the X, Y direction of the articular cartilage regeneration support structure and the actual articular cartilage according to an exemplary embodiment of the present invention as shown in Table 1 below. Here, the unit of% is the volume ratio (approximate value) of each of the oriented
Compressive strength
(Z-direction)
The tensile strength
0%
(~ 1%)
(~ 2%)
(~ 3%)
Example
0.4383
X
0.9719
13.1188
25.3916
39.0105
Y
0.8092
11.3747
22.0589
33.8414
Comparative example
(Actual cartilage)
0.4-0.8
1-35 (
Knee
)
7 is a diagram showing the X-direction tension results according to the computer simulation of the support for cartilage regeneration according to a preferred embodiment of the present invention.
As shown in Figure 7, the
8 is a diagram showing the Y-direction tension results according to the computer simulation of the support for cartilage regeneration produced by the
As shown in FIG. 8, in the
As can be seen through Figures 7 and 8, corresponding values were changed according to the minute change of the basic structure, the tendency of the basic physical properties is similar to the actual cartilage. In addition to the basic structure of the
As mentioned above, although this invention was demonstrated by the limited embodiment and drawing, this invention is not limited by this and is within the equal range of a common technical idea in the technical field to which this invention belongs, and a claim to be described below. Of course, various modifications and variations are possible.
10 ...
14 ...
18 ...
30 ...
200 ...
211 ... base (211) 213 ... vertical plate
214 ... wire 215 ... horizontal plate
217 ... back
222 ...
230 ...
250
252 ... Oriented feeder 253 Hook plate
254 ...
258 ... needle
Claims (11)
A braiding bed disposed in the frame such that a plurality of carriers capable of withdrawing each braid is arranged and the braids are twisted together to form a braid in the process of turning the carriers into a cross;
A drive source connected to the braids by a wire and capable of advancing the braided braid at a predetermined speed; And
Braiding machine characterized in that it comprises an orientation yarn supply member provided in the frame to supply the orientation yarn in the direction perpendicular to the direction of travel of the braid in order to interpose the orientation yarn into the braided article (braiding machine) ).
The orientation yarn supply member is:
An orientation yarn supply unit installed on the frame so as to be reciprocated and having one end of the orientation yarns; And
And a hook member provided in the frame so as to face the orientation yarn supply section so that the orientation yarn supplied by the orientation yarn supply section can be caught.
The hook member is:
A back plate installed on the frame; And
And a hook plate arranged with a plurality of hooks arranged at predetermined intervals so that the orientation yarns can be caught and moveable by a predetermined distance relative to the back plate.
The orientation yarn supply unit:
A guide block installed in the frame; And
Braiding machine characterized in that it comprises a needle which is guided by the guide block to move through the braid and move forward and the through hole through which the alignment yarn is formed.
At least one of the braids has a second orientation yarn which penetrates and advances the braid without twisting each other.
Wherein said braided yarn and said oriented yarn are formed of strands of a plurality of fine fibers.
Each fiber is a braiding machine, characterized in that produced by Poly Glycolic Acid (PGA) or Poly Lactic-co-Glycolic Acid (PLGA).
(b) inserting an orientation yarn on a plane orthogonal to the braiding direction of the braids.
The step (a) of the braiding method comprising the step of simply advancing at least one of the plurality of knitting yarns in the braiding direction without twisting each other.
The step (a) comprises the steps of placing the plurality of braids such that the braided braid forms a plurality of layers; And
The step (b) is characterized in that the number of different orientation yarns inserted between the plurality of layers different.
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KR1020100094352A KR101225094B1 (en) | 2010-09-29 | 2010-09-29 | Braiding machine, braiding method and supporting scaffold for regenerating articular cartilage produced thereby |
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KR1020100094352A KR101225094B1 (en) | 2010-09-29 | 2010-09-29 | Braiding machine, braiding method and supporting scaffold for regenerating articular cartilage produced thereby |
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KR101225094B1 true KR101225094B1 (en) | 2013-01-22 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10131010A (en) | 1996-10-01 | 1998-05-19 | Aerospat Soc Natl Ind | Tubular structure of knitting and braiding, its production, apparatus therefor, flat exterior and its production |
JPH11323709A (en) | 1998-05-20 | 1999-11-26 | ▲吉▼田製紐株式会社 | Braider |
KR20040044074A (en) * | 2002-11-18 | 2004-05-27 | 김임선 | Hole braid having double central yarn and braider therefor |
KR20070109537A (en) * | 2006-05-11 | 2007-11-15 | 재단법인서울대학교산학협력재단 | Braided stent and fabrication method thereof |
-
2010
- 2010-09-29 KR KR1020100094352A patent/KR101225094B1/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10131010A (en) | 1996-10-01 | 1998-05-19 | Aerospat Soc Natl Ind | Tubular structure of knitting and braiding, its production, apparatus therefor, flat exterior and its production |
JPH11323709A (en) | 1998-05-20 | 1999-11-26 | ▲吉▼田製紐株式会社 | Braider |
KR20040044074A (en) * | 2002-11-18 | 2004-05-27 | 김임선 | Hole braid having double central yarn and braider therefor |
KR20070109537A (en) * | 2006-05-11 | 2007-11-15 | 재단법인서울대학교산학협력재단 | Braided stent and fabrication method thereof |
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Publication number | Publication date |
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KR20120032817A (en) | 2012-04-06 |
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