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KR101225094B1 - Braiding machine, braiding method and supporting scaffold for regenerating articular cartilage produced thereby - Google Patents

Braiding machine, braiding method and supporting scaffold for regenerating articular cartilage produced thereby Download PDF

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Publication number
KR101225094B1
KR101225094B1 KR1020100094352A KR20100094352A KR101225094B1 KR 101225094 B1 KR101225094 B1 KR 101225094B1 KR 1020100094352 A KR1020100094352 A KR 1020100094352A KR 20100094352 A KR20100094352 A KR 20100094352A KR 101225094 B1 KR101225094 B1 KR 101225094B1
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Prior art keywords
braiding
orientation
yarn
braid
frame
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KR1020100094352A
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Korean (ko)
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KR20120032817A (en
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유웅열
안현철
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서울대학교산학협력단
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30756Cartilage endoprostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof

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  • Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

The present invention relates to a braiding machine, comprising: a frame; A braiding bed disposed in the frame such that a plurality of carriers capable of drawing each braid is arranged, and the braids are twisted together to form a braid in the process of turning the carriers into a cross; A drive source connected to the braids by a wire and capable of advancing the braided braid at a predetermined speed; And an orientation yarn supply member provided in the frame to supply the orientation yarn in a direction perpendicular to the direction of travel of the knitted fabric so as to interpose the orientation yarn into the braid.

Description

Brading machine, braiding method and supporting scaffold for regenerating articular cartilage produced thereby

The present invention relates to a braiding machine, a braiding method and a support for articular cartilage regeneration produced by the braiding machine, and more particularly, a braiding machine capable of inserting an orientation yarn in the braiding direction of a knitted fabric, a braiding method and It relates to a support for articular cartilage regeneration produced thereby.

In general, cartilage tissue that forms the joints of vertebrates is not normally regenerated in vivo once damaged. Arthritis is the most representative degenerative disease and most frequently occurs in an aging society. According to a recent report from the Korean medical community, 80% of patients over 55 years old and nearly 70% of people over 50 years old have degenerative arthritis, and about a quarter of them show clinical symptoms.

Currently known methods for treating damaged articular cartilage include chondroplasty, osteochondraltransplantation, and autolaugous chondrocyte transplantation.

Cartilage surgery is the most commonly used method, and arthroscopy, a representative method, inserts an arthroscopy with a small camera into the joint cavity through a small hole of less than 1 cm and enters the joint through a TV monitor. It is a method of performing diagnosis and surgery simultaneously while enlarging observation. However, cartilage surgery does not have a satisfactory effect in terms of function because fibro-cartilage is mainly produced rather than hyaline cartilage required for actual joints.

Osteochondral transplantation has been successful in some patients by harvesting the cartilage and the subchondral cartilage that has already been produced in the patient's normal area and transplanting it through a suitable hole drilled in the damaged cartilage. . However, osteochondral transplantation is difficult to call a complete treatment because there is a gap between the transplanted site and the original tissue, and it can be performed only in patients who are capable of autolaugous transplantation. Can't.

Self-derived chondrocyte transplantation has recently emerged as a new treatment based on tissue engineering for the treatment of damaged articular cartilage. The technology was first studied at the Hospital for Joint Disease in New York and was developed at the University of Gothenburg and Sahlgrenska University Hospital in Sweden.

Self-derived chondrocyte transplantation is to obtain cartilage cells enough to treat cartilage defects by collecting and removing cartilage cells that are not used in the cartilage areas of patients with damaged knee joint cartilage. It is a method of restoring the joint cartilage of the patient by implanting the cartilage defects of the patient. Compared to osteochondral grafting, the transplanted cartilage cells multiply directly within the damaged area and fill the damaged area, so that the transplanted area and the normal area are relatively well fused, and there is a high possibility of regenerating supercartilage. However, surgery is required when the chondrocytes are harvested and when the chondrocytes cultured in vitro are transplanted back to the joint cartilage injuries. Thus, the patient suffers from pain, sequelae and economic burden by two operations. The procedure is also complicated and tricky.

In addition to the aforementioned surgical treatments, research has been actively conducted for regeneration of damaged cartilage into normal cartilage for the past several decades. As a result of these studies, methods such as multiple perforation, microfracture, abrasion, periosteum or cartilage transplantation have been attempted for the repair of defects of articular cartilage, but most of them are repaired only to fibrous cartilage. The healing effect was very limited. Autologous or allogeneic cartilage transplantation is also performed, but it is difficult to perform due to limitation of donor or donor. Therefore, regeneration of damaged cartilage into tissues that are histologically and biomechanically similar to the original cartilage is very important in terms of preventing and treating cartilage damage or defects.

Meanwhile, with the development of cartilage cells or mesenchymal stem cells (MSCs), advanced methods of cell transplantation and various in vitro histological cartilage using various supports have been developed. Lee, CR, et al., Tissue Eng., 6: 555, 2000, Li, WJ, et al., Biomaterials, 26: 599, 2005.

Scaffolds that provide a three-dimensional culture environment affect the ultimate quality of tissue engineered cartilage tissue as well as the proliferation and differentiation of inoculated cells. Currently, various materials derived from synthetic or natural materials are used as suitable supports. These supports are used in various forms such as sponges, gels, fibers and microbeads (Honda, MJ, et al., J. Oral Maxillofac Surg., 62: 1510, 2004, Griogolo, B., et. al., Biomaterials, 22: 2417, 2001, Chen, G., et al., J. Biomed.Mater.Res.A, 67: 1170, 2003, Kang, SW, et al., Tissue Eng., 11: 438, 2005), the most commonly used among them is a porous structure capable of improving cell adhesion and maintaining a high rate of surface tension with respect to volume. However, this structure also has a problem that can not be clinically applied because it can not produce high-quality histological cartilage, although some applications have been successfully reported in vivo and in vitro (in vitro). In addition, these supports in the prior art had a limitation because it cannot fully mimic the mechanical properties of natural cartilage.

On the other hand, these conventional supports are manufactured by a well-known braiding machine, which can only insert the orientation yarn in the same direction as the direction of travel of the braid, and is a plane perpendicular to the direction of travel of the braid. There was a problem in that it was impossible to insert an alignment yarn for reinforcing properties in another axial direction perpendicular to the alignment yarn.

SUMMARY OF THE INVENTION The present invention has been made to overcome the above-mentioned problems, and it is a technical object of the present invention to provide a braiding machine capable of simultaneously forming the orientation yarns on the braiding direction of the braid and the direction perpendicular thereto, that is, two axes.

According to an exemplary embodiment of the present invention for achieving the above object, a braiding machine includes a frame; A braiding bed disposed in the frame such that a plurality of carriers capable of withdrawing each braid is arranged and the braids are twisted together to form a braid in the process of turning the carriers into a cross; A drive source connected to the braids by a wire and capable of advancing the braided braid at a predetermined speed; And an orientation yarn supply member provided in the frame to supply the orientation yarn in a direction perpendicular to the direction in which the knitted fabric is interposed to interpose the orientation yarn into the braid.

Preferably, the alignment yarn supply member includes: an orientation yarn supply unit installed on the frame so as to be reciprocally movable and having the alignment yarn at one end thereof; And a hook member provided in the frame so as to face the orientation yarn supply section so that the orientation yarn supplied by the orientation yarn supply section is caught.

Preferably, the hook member comprises: a back plate installed on the frame; And a hook plate, in which a plurality of hooks are arranged at predetermined intervals so that the orientation yarns can be caught and can be moved by a predetermined distance with respect to the back plate.

Preferably, the orientation yarn supply unit: a guide block installed in the frame; And a needle having a through hole through which the guide yarn can be penetrated and moved through the braided material while being guided and moved by the guide block.

Preferably, at least one of the braids has a second orientation yarn which penetrates and advances the braid without twisting each other.

Preferably, the braided and oriented yarns are formed of strands of a plurality of fine fibers.

Preferably, each of the fibers is made by Poly Glycolic Acid (PGA) or Poly Lactic-co-Glycolic Acid (PLGA).

A braiding method according to a preferred embodiment of the present invention for achieving the above object, the step of (a) braiding a plurality of partial surveys to each other; And (b) inserting an orientation yarn on a plane orthogonal to the braiding direction of the braids.

Preferably, step (a) comprises simply advancing at least one of the plurality of knitting yarns in the braiding direction without twisting each other.

Preferably, step (a) comprises the steps of: arranging the plurality of braids such that the braided braid forms a plurality of layers; And step (b) varies the number of respective orientation yarns inserted between the plurality of layers.

According to the present invention, there is provided a support for articular cartilage regeneration produced by the braiding method.

The braiding machine, the braiding method and the support structure for articular cartilage regeneration according to the present invention have the following effects.

First, by adding a process or structure for inserting the orientation yarn in a direction orthogonal to the braiding direction of the braid in the known braiding machine and method, it is possible to enhance the physical properties of the braided braid.

Second, when the additional orientation yarns are added so as not to be twisted with each other in the same direction as the braiding direction of the braid, the physical properties in the braiding direction of the braid can be reinforced.

Third, the cartilage regeneration support braided by the braiding machine and the method according to the present invention is simulated to correspond to the actual structure of the cartilage in each axial direction (in the biaxial direction) in the process of braiding the braids alternately. In order to simulate the physical cartilage properties of the actual cartilage because the structure of the woven yarn of the volume necessary for the woven structure. In addition, it is possible to provide a more flexible support structure for cartilage regeneration by adjusting the thickness or the number of cross-sections of the alignment yarns.

BRIEF DESCRIPTION OF THE DRAWINGS The drawings appended hereto illustrate a preferred embodiment of the present invention and, together with the following detailed description, serve as an illustrative role to better understand the spirit of the present invention. It should not be construed as limited to matters.
Figure 1 is a schematic diagram showing a braiding machine in a preferred embodiment of the present invention.
2 is a conceptual diagram schematically showing a braiding method according to a braiding machine according to a preferred embodiment of the present invention.
3 is a conceptual diagram schematically showing a braiding method according to a braiding machine according to a preferred embodiment of the present invention.
4 is a real picture schematically showing a support for articular cartilage regeneration produced by a braiding machine according to a preferred embodiment of the present invention.
FIG. 5 is an enlarged schematic perspective view showing the configuration of the support for cartilage regeneration according to FIG. 4, as viewed from the XZ plane. FIG.
FIG. 6 is an enlarged schematic perspective view of the configuration of the support for cartilage regeneration according to FIG. 4, as viewed from the YZ plane. FIG.
FIG. 7 is a diagram showing an X-direction tensile result according to computer simulation of the support for cartilage regeneration shown in FIGS. 4 to 6.
FIG. 8 is a diagram illustrating a Y-direction tensile result according to computer simulation of the support for cartilage regeneration shown in FIGS. 4 to 6.

Hereinafter, a braiding machine according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.

1 is a schematic view showing a braiding machine according to a preferred embodiment of the present invention, Figures 2 and 3 schematically show a braiding method by a braiding machine according to a preferred embodiment of the present invention, respectively Conceptual diagrams.

1 to 3, a braiding machine 200 according to a preferred exemplary embodiment of the present invention is a component of a generally known brader and an orientation yarn supply member additionally installed in the brader. 250.

A typical brader is a braiding bed 230 in which a plurality of rollers 212 are installed, a braiding bed 230 in which carriers 220 are arranged to withdraw each braid 10, and a braided piece. It is provided with the drive source 240 which can pull the sculpture 100 by the wire 214 at a predetermined speed.

The frame 210 extends from the base 211 on which the braiding bed 230 is installed, the vertical plate 213 installed to protrude a predetermined distance from the base 211, and extends from the vertical plate 213. And horizontal plates 215 spaced apart from each other.

The braiding bed 230 is for forming the knitted fabric 100 by twisting the braids 10 in the process of turning the carriers 220 to the church, each carrier 220 is a plane A semi-circular structure with a structure that is moved radially and semicircularly in phase or may be a matrix structure in which the respective carriers 220 can be moved in an orthogonal direction on a plane. The driving of the carriers 220 located on the braiding bed 230 may utilize a plurality of gears (not shown) or an actuator (not shown) that includes a hydraulic or pneumatic cylinder. Each carrier 220 is wound with unwinding probes 10 wound on a bobbin not shown.

The driving source 240 is for advancing the braided braid 100 and functions as a take-up motor capable of rotating discontinuously (optionally) at a predetermined speed (braiding speed). The drive source 240 may advance the braid 100 by rotating the take-up roller 216 on which the end of the wire 214 is fixed.

Meanwhile, the driving method of the carriers 220, the driving speed of the driving source 240, the braiding angle, and the like in the braiding bed 230 for the braiding operation may be appropriately selected according to the type of the braid 100. It will be understood by those skilled in the art that the detailed description thereof will be omitted.

The orientation yarn supply member 250 is for interposing the orientation yarn (second alignment yarn 30 of the above-described embodiment) into the knitted fabric 100 as necessary during the braiding process of the knitted fabric 100. , The structure capable of supplying the orientation yarn 30 in a direction perpendicular to the traveling direction of the braided article 100.

The alignment yarn supply member 250 is installed to the frame 210 so as to reciprocate, and the orientation yarn supply unit 252 and the orientation yarn that can be supplied into the braid 100 while moving the orientation yarn 30 at one end The hook member 254 is provided on the frame 210 so as to face the orientation yarn supply unit 252 so that the orientation yarn 30 supplied by the supply unit 252 is caught. The orientation yarn supply unit 252 is guided by the guide block 256 and the guide block 256 installed on the vertical plate 213 to move forward through the braided article 100 while reciprocating, and the orientation yarn 30 is caught. And a needle moving device (not shown) including a needle 258 having a through hole 258a formed at its tip, and a motor for reciprocating the needle 258 with respect to the guide block 256. The hook member 254 is a back plate 217 installed to extend from the horizontal plate 215 to face the vertical plate 213, a plurality of hooks 251 arranged at predetermined intervals so that the alignment yarn 30 can be caught. ) And a hook driving device (not shown) for moving the hook plate 253 and the hook plate 253 as needed, which is movable with respect to the back plate 217. Here, the moving speed and / or spacing of the hook plate 253 with respect to the back plate 217 is preferably linked to the moving speed of the braid 100, that is, the rotational speed of the drive source 240, if necessary It will be understood by those skilled in the art that the speed of movement of the hook plate 253 can be adjusted.

As shown in FIGS. 2 and 3, after the needle 258 of the orientation yarn supply 252 is guided by the guide block 256 and passes through the braid 100 of the alignment yarn 30 in a row. When the needles 258 are returned to their original positions by hooking the alignment yarns 30 to the corresponding hooks 251 of the hook plate 253, two rows of alignment yarns 30 are positioned inside the knitted fabric 100. .

In a preferred alternative embodiment, where braid 100 produced by braiding machine 200 is a multi-layered structure, the orientation yarn supply member 250 is provided with a braided material to correspond to the multi-layered braid. A plurality of needles 258 corresponding to each layer of the layer 100, and the hooks 251 provided on the hook plate 253 also have a plurality of hook collars (not shown) corresponding to the respective needles 258. )

Meanwhile, the carriers 220 installed in the braiding bed 230 may be divided into first carriers 222 and second carriers 224. Here, the first carriers 222 move over the braiding bed 230 in a predetermined pattern for the twisting of the braids 10, which may be twisted alternately with each other, for example in the form of a right or left helix. Can be. In addition, the second carriers 224 are intended to function as the first alignment yarn 20 of the above-described embodiment, and are simply penetrated through the braid 100 without being twisted with the other braids 10. And move on the braiding bed 230 in a pattern different from the cycling pattern of the first carrier 222. That is, the first carriers 222 are moved at a predetermined period on the braiding bed 230 so that the braids 10 can be twisted with each other, but the second carriers 224 are moved with the first carriers 222. Driven so as not to interfere, it is simply advanced in the braiding direction without being twisted with the adjacent braid 10.

A braiding method for a support structure for articular cartilage regeneration in accordance with a preferred exemplary embodiment of the present invention comprises a plurality of braiding using the above-described braiding machine or another kind of braiding machine known or known in the future. Braiding the fields 10 to each other, and inserting the orientation yarns 30 on a plane orthogonal to the braiding direction of the braids 10.

Here, the braiding step includes simply advancing at least one of the plurality of knitting yarns in the braiding direction without twisting each other with the other knitting yarns 10.

The braiding step also includes appropriately placing the plurality of braids 10 so that the braided braid 100 can form a plurality of layers.

The orientation yarn insertion step may configure different numbers of orientation yarns 30 inserted between the plurality of layers 12, 14, 16, 18 of the knitted fabric 10.

4 is a real picture schematically showing a support for articular cartilage regeneration braided by a braiding machine according to a preferred embodiment of the present invention, and FIGS. 5 and 6 are enlarged views of the structure of the support shown in FIG. As a schematic perspective view, FIG. 5 is a view from the XZ plane and FIG. 6 is a view from the YZ plane.

4 to 6, the articular cartilage regeneration support 100 according to a preferred exemplary embodiment of the present invention is a joint articular cartilage regeneration support structure 100 according to a preferred exemplary embodiment of the present invention is a damaged joint A kind of scaffold or preform that can simulate the properties of cartilage tissue, and can be twisted alternately in multiple directions at a predetermined braiding angle α to form a four-layer structure. Multiple yarns 10, a plurality of first alignment yarns 20 interposed substantially linearly between the yarns 10 in the same direction as the direction in which the yarns 10 are twisted (Y-direction) And a plurality of second alignment yarns 30 interposed substantially linearly between the braids 10 in the X-direction substantially perpendicular to the first alignment yarns 20. Here, although the plurality of knitting yarns 10 are twisted adjacent to each other, each of the first alignment yarns 20 and the second alignment yarns 30 may be pressed by the adjacent knitting yarns 10. Since it is not a twisted relationship with the other biases 10 can be seen in a straight form. In addition, each of the braids 10 and the first and second alignment yarns 20 and 30 is composed of a bundle of thinner tows, each of which is subjected to a force in the braiding process of the support structure 100. The cross section of is deformed into an elliptical shape.

Articular cartilage regeneration support structure 100 according to a preferred exemplary embodiment of the present invention has a structure similar to the actual cartilage by being composed of four layers. That is, the support structure 100 is composed of first to fourth layers 12, 14, 16, 18 arranged sequentially from the proximal end to the distal end. These four layers 12, 14, 16, 18 are all formed by braids 10, the first layer 12 being the end plate of the actual cartilage, the second layer ( 14 represents the radial zone of the actual cartilage, the third layer 16 represents the transitional zone of the actual cartilage, and the fourth layer 18 represents the tangential zone of the actual cartilage, respectively. Form.

The braids 10 are arranged in the same volume as a whole in each layer according to the braiding method, whereas in the case of the first alignment yarn 20 and the second alignment yarn 30, the physical properties of the actual joints are substantially the same. For simplicity, it is inserted between the layers 12, 14, 16, 18 of the cartilage support structure 100. Thus, the volume of the first alignment yarns 20 and / or the second alignment yarns 30 disposed in each layer of the multilayer structure is different for each layer. The difference in volume is determined by the number or cross sectional area of the orientation yarns 20, 30.

In the present embodiment, the volume of the first alignment yarns 20 and / or the second alignment yarns 30 gradually increases from one layer to another in the multilayer structure. The first alignment yarns 20 and the second alignment yarns 30 are not disposed in any one outermost layer of the multilayer structure, that is, the first layer 12. This is because the end plate portion of the actual cartilage structure is the weakest structure.

The braided yarn 10, the first oriented yarns 20 and the second oriented yarns 30 are formed of a plurality of strands of fine fibers, each of which is biocompatible and biodegradable Poly Glycolic Acid (PGA) or PLGA ( Poly Lactic-co-Glycolic Acid). PGA consists of a single component, PLGA consists of a copolymer of PGA and PLA. These PGAs and PLGAs are both US FDA approved materials, and the use of PLGA allows for easy control of decomposition time and physical properties.

Single component PGA has good physical properties but has a high rate of decomposition and is good for use by surgeons due to the pH change according to glycolic acid, but may have problems in use for internal organs. In comparison, PLA is slightly degraded in physical properties but slower in decomposition than PGA, and its byproduct lactic acid has less effect on the human body.

The fibers used in the support structure 100 according to this embodiment are PGA, PGA: PGA: PLA = 90: 10. The reason for using these materials is that the surgeon currently commercialized has such a composition.

As the substrate used in the support structure for cartilage regeneration according to the preferred embodiment of the present invention, a gel material such as agarose, fibrin, collage, or the like may be used. Agarose has excellent biocompatibility and is used for DNA electrophoresis. It is dissolved in water and made into a gel. Agarose is liquid at high temperatures and gel-like at room temperature. Agarose is easy to experiment.

In the articular cartilage support structure 100 according to the preferred exemplary embodiment of the present invention, the size of the elliptical cross section of one piece of irradiation 10 is about 0.3087 mm in the major axis direction and about 0.1143 mm in the minor axis direction. . Thus, the cross-sectional area of the braid 10 is approximately 0.11085 mm 2 and has a volume of approximately 30% of the total volume of the support structure 100. In addition, the orientation yarns 20 and 30 are inserted between the braids 10 to reinforce the physical properties in the X-direction and / or Y-direction, and each layer is used to simulate the physical natural cartilage properties. The fact that the size or the number of the orientation yarns 20 and 30 arranged for each is different is as described above.

More specifically, in the present embodiment, the first alignment yarn 20 and the second alignment yarn 30 do not exist at all in the first layer 12. In addition, one 1% first alignment yarn 20 and one 1% alignment yarn 30 per unit structure are disposed in the second layer 14, and the third layer 16 is disposed per unit structure. Two 1% first orientation yarns 20 and one 2% orientation yarn 30 are disposed, and the fourth layer 18 has two 1.5% first orientation yarns 20 per unit structure. And one 3% second alignment yarn 30. As such, when the first alignment yarns 20 and the second alignment yarns 30 in the Y and Y directions are added, the ratio of the volume occupied by the fibers (braided and oriented yarns) to the total volume of each layer is The first layer 12 is 30%, the second layer 14 is 32%, the third layer 16 is 34%, and the fourth layer 18 is 36%. Here, the cross section of the 1% oriented yarn is 0.20 × 0.027mm 2 , the cross section of the 1.5% oriented yarn is 0.27 × 0.0030mm 2 , the cross section of the 2% oriented yarn is 0.30 × 0.036mm 2 , and the cross section of the 3% oriented yarn is 0.40 × 0.040mm 2 to be.

As described above, comparing the physical property values according to the X, Y direction of the articular cartilage regeneration support structure and the actual articular cartilage according to an exemplary embodiment of the present invention as shown in Table 1 below. Here, the unit of% is the volume ratio (approximate value) of each of the oriented fibers 20 and 30 fibers, and the corresponding values are Young's Modulus and the unit is MPa.


Compressive strength
(Z-direction)

The tensile strength
First layer (final edition)
0%
Second layer (radial layer)
(~ 1%)
The third floor (transition floor)
(~ 2%)
4th layer (tangential layer)
(~ 3%)

Example

0.4383

X

0.9719

13.1188

25.3916

39.0105

Y

0.8092

11.3747

22.0589

33.8414

Comparative example
(Actual cartilage)

0.4-0.8

1-35 ( Knee )

7 is a diagram showing the X-direction tension results according to the computer simulation of the support for cartilage regeneration according to a preferred embodiment of the present invention.

As shown in Figure 7, the cartilage regeneration support 100 according to the present embodiment can be seen that the force is distributed in the order of blue-green-yellow-red, which is red on the side in the diagram of FIG. It can be seen that since the two parts of the alignment yarns 20 and 30 are present, the alignment yarns 20 and 30 support more force to improve the overall physical properties. The actual property values are collected by analyzing the forces represented by this distribution and analyzing how much force the structure can sustain as a whole.

8 is a diagram showing the Y-direction tension results according to the computer simulation of the support for cartilage regeneration produced by the braiding machine 200 according to a preferred embodiment of the present invention.

As shown in FIG. 8, in the support 100 for cartilage regeneration according to the present embodiment, similar to FIG. 7, there are regions of alignment yarns 20 and 30 in which the upper surface portion of the support 100 is displayed in red.

As can be seen through Figures 7 and 8, corresponding values were changed according to the minute change of the basic structure, the tendency of the basic physical properties is similar to the actual cartilage. In addition to the basic structure of the support 100 that the knitted yarns 10 constitute, the first alignment yarn 20 and the second alignment yarn 30 are added to the basic structure, respectively, so that the physical properties of the actual cartilage can be perfectly simulated. It can be confirmed that.

As mentioned above, although this invention was demonstrated by the limited embodiment and drawing, this invention is not limited by this and is within the equal range of a common technical idea in the technical field to which this invention belongs, and a claim to be described below. Of course, various modifications and variations are possible.

10 ... Survey 12 ... The first floor
14 ... 2nd layer 16 ... 3rd layer
18 ... fourth layer 20 ... first orientation yarn
30 ... Second orientation yarn 100 ... Support structure for articular cartilage regeneration
200 ... Brading Machine 210 ... Frame
211 ... base (211) 213 ... vertical plate
214 ... wire 215 ... horizontal plate
217 ... back plate 220 ... carrier
222 ... first carrier 224 ... second carrier
230 ... Brading Bed 240 ... Moving Source
250 directional feeder 251 hook
252 ... Oriented feeder 253 Hook plate
254 ... hook member 256 ... guide block
258 ... needle

Claims (11)

frame;
A braiding bed disposed in the frame such that a plurality of carriers capable of withdrawing each braid is arranged and the braids are twisted together to form a braid in the process of turning the carriers into a cross;
A drive source connected to the braids by a wire and capable of advancing the braided braid at a predetermined speed; And
Braiding machine characterized in that it comprises an orientation yarn supply member provided in the frame to supply the orientation yarn in the direction perpendicular to the direction of travel of the braid in order to interpose the orientation yarn into the braided article (braiding machine) ).
The method of claim 1,
The orientation yarn supply member is:
An orientation yarn supply unit installed on the frame so as to be reciprocated and having one end of the orientation yarns; And
And a hook member provided in the frame so as to face the orientation yarn supply section so that the orientation yarn supplied by the orientation yarn supply section can be caught.
The method of claim 2,
The hook member is:
A back plate installed on the frame; And
And a hook plate arranged with a plurality of hooks arranged at predetermined intervals so that the orientation yarns can be caught and moveable by a predetermined distance relative to the back plate.
The method of claim 2,
The orientation yarn supply unit:
A guide block installed in the frame; And
Braiding machine characterized in that it comprises a needle which is guided by the guide block to move through the braid and move forward and the through hole through which the alignment yarn is formed.
The method of claim 1,
At least one of the braids has a second orientation yarn which penetrates and advances the braid without twisting each other.
The method of claim 1,
Wherein said braided yarn and said oriented yarn are formed of strands of a plurality of fine fibers.
The method according to claim 6,
Each fiber is a braiding machine, characterized in that produced by Poly Glycolic Acid (PGA) or Poly Lactic-co-Glycolic Acid (PLGA).
(a) braiding a plurality of biases into one another; And
(b) inserting an orientation yarn on a plane orthogonal to the braiding direction of the braids.
9. The method of claim 8,
The step (a) of the braiding method comprising the step of simply advancing at least one of the plurality of knitting yarns in the braiding direction without twisting each other.
9. The method of claim 8,
The step (a) comprises the steps of placing the plurality of braids such that the braided braid forms a plurality of layers; And
The step (b) is characterized in that the number of different orientation yarns inserted between the plurality of layers different.
delete
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10131010A (en) 1996-10-01 1998-05-19 Aerospat Soc Natl Ind Tubular structure of knitting and braiding, its production, apparatus therefor, flat exterior and its production
JPH11323709A (en) 1998-05-20 1999-11-26 ▲吉▼田製紐株式会社 Braider
KR20040044074A (en) * 2002-11-18 2004-05-27 김임선 Hole braid having double central yarn and braider therefor
KR20070109537A (en) * 2006-05-11 2007-11-15 재단법인서울대학교산학협력재단 Braided stent and fabrication method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10131010A (en) 1996-10-01 1998-05-19 Aerospat Soc Natl Ind Tubular structure of knitting and braiding, its production, apparatus therefor, flat exterior and its production
JPH11323709A (en) 1998-05-20 1999-11-26 ▲吉▼田製紐株式会社 Braider
KR20040044074A (en) * 2002-11-18 2004-05-27 김임선 Hole braid having double central yarn and braider therefor
KR20070109537A (en) * 2006-05-11 2007-11-15 재단법인서울대학교산학협력재단 Braided stent and fabrication method thereof

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