KR100814196B1 - Skin external preparations and cosmetics containing inositol derivatives - Google Patents

Abstract

The present invention relates to a formulation applied from the outside to the skin containing an inositol derivative in which inositol and a saccharide are bonded. An object of the present invention is to provide an external preparation for skin that can be applied to the skin without the sense of particle, provides sufficient wetness and has the effect of keeping the skin healthy.

Inositol, sugars, external skin preparations, monosaccharides, oligosaccharides, glucose, cosmetics

Description

Skin external preparations and cosmetics containing inositol derivatives {A SKIN CARE AND COSMETIC PREPARATION CONTAINING AN INOSITOL DERIVATIVE}

<Cross Reference of Related Application>

This application is directed to US Patent Law 35 U.S.C. United States Patent Act 35 U.S.C., filed on Provisional Application No. 60 / 558,551, filed April 2, 2004, filed under Section 111 (b). US Patent Law 35 U.S.C., which claims priority under section 119 (e) (1). An application filed under the provision of section 111 (a).

The present invention relates to an external preparation for skin containing an inositol derivative in which inositol and a sugar are combined. More specifically, the present invention relates to a skin external preparation and a cosmetic having an effect of keeping the skin healthy.

Inositol is one of the constituents of phytin, and it is known that rice bran contains about 10% of this phytin. Rice bran extract contains fats and oils, vitamin B and minerals, in addition to inositol. Therefore, rice bran extract has been used in skin cosmetics to provide oil, moisture, and nutrients to the skin, improve wetting and moisturizing properties, and prevent elasticity degradation.

In order to enhance these effects, cosmetics containing a polysaccharide extracted from rice bran as an active ingredient, or cosmetics containing a water-soluble antioxidant obtained from rice bran are known (see, for example, Patent Documents 1 and 2).

Moreover, since the extract from rice bran has a unique smell, cosmetics etc. which are added as a component without an odor by selectively extracting only inositol from rice bran or obtained by chemical synthesis are also known (see Patent Document 3, for example). .

Furthermore, in order to prevent stickiness of cosmetics, the cosmetics containing inositol which is a sugar alcohol are also known (for example, refer patent document 4).

Although inositol is synthesized in the human body, the compound is treated as a member of vitamins because the required amount cannot be synthesized. It is said that phystol has physiological activities such as preventing cirrhosis and fatty liver, preventing atherosclerosis, and promoting growth. As the use method, what is contained in a drink other than cosmetics, etc. are known (for example, refer patent document 5).

On the other hand, various sugar modified compounds have recently been able to be produced. Inositol is also used as a biochemical reagent or bacteria growth promoting substance by converting to gluco oligosaccharide (see Patent Document 6, for example).

<Patent Documents of Prior Art>

<Patent Document 1> Japanese Unexamined Patent Publication No. 64-66106

<Patent Document 2> Japanese Patent Application Laid-Open No. 2-53705

<Patent Document 3> Japanese Unexamined Patent Publication No. 10-114641

<Patent Document 4> Japanese Unexamined Patent Publication No. 2002-161015

<Patent Document 5> Japanese Patent Application Laid-Open No. 7-330643

<Patent Document 6> Japanese Unexamined Patent Publication No. 63-196596

<Start of invention>

Although rice bran is useful as a source of inositol, the external preparation for skin containing rice bran has a unique odor due to its unique smell, which is a drawback. Although fragrance is added to mask odors, there is a problem that the difference in the personal preference of the fragrance or the possibility of adversely affecting the skin due to the stimulation of the fragrance is also great.

In addition, rice bran extract also has the drawback that often insoluble ingredients are precipitated in the external preparation for the skin, resulting in a grainy skin. Although pure extracts and chemical compounds of inositol are inhibited from infiltration of insoluble components, they are not necessarily useful as active ingredients blended into external preparations for skin in terms of adhesion and affinity to lipid-rich skin surfaces. As such, the use of rice bran extract and chemical compound in combination with an external preparation for skin is not sufficient.

An object of the present invention is to solve the above problems and drawbacks by providing an external preparation for skin and a cosmetic containing an inositol derivative. More specifically, an object of the present invention is to provide an external preparation for skin and a cosmetic containing inositol to which saccharides are bound.

As a result of earnestly examining in order to solve the said subject, since the derivative which modified inositol into the saccharide was excellent in solubility, it discovered that precipitation of an insoluble component is suppressed even if it contains in skin external preparations. In addition, the external preparation for skin is significantly improved in the wetness and feel of the skin because the adhesion and affinity to the skin is significantly improved. The present invention has been completed based on this finding.

That is, the present invention relates to the following.

(1) A skin external preparation containing an inositol derivative in which inositol and a saccharide are bonded.

(2) The skin external preparation according to the above (1), wherein the saccharide is a monosaccharide and / or an oligosaccharide.

(3) The external preparation for skin according to the above (2), wherein the monosaccharide and / or oligosaccharide contains glucose as a structural unit.

(4) The external preparation for skin according to any one of (1) to (3), wherein the inositol constituting the inositol derivative is myo-inositol.

(5) The skin external preparation according to any one of (1) to (4), wherein the content of the inositol derivative in which the inositol and the saccharide are bonded is 0.01 to 50% by mass of the preparation.

(6) Cosmetics containing the external preparation for skin as described in any one of said (1)-(5).

Inositol derivatives used in the present invention are compounds in which sugars and inositol are combined.

There is no particular restriction on the saccharide used in the present invention. Examples of the sugar include mannitol, sorbitol, xylitol, maltitol, erythritol, pentaerythritol, glucose, sucrose, fructose, lactose, maltose, xylose, trehalose, α-cyclodextrin, β-cyclodextrin, γ- Cyclodextrin, etc. are mentioned.

Of these sugars, monosaccharides, oligosaccharides and mixtures thereof are preferred. In particular, oligosaccharides containing glucose and / or glucose as structural units are preferred.

Inositol used in the present invention is a cyclic hexavalent alcohol represented by C ₆ H ₆ (OH) ₆ , and nine stereoisomers exist. Any isomer may be used in the present invention. Among these inositol isomers, myo-inositol is particularly preferable. Inositol used in the present invention can be extracted from rice bran or synthesized by chemical synthesis or fermentation.

Inositol derivatives are compounds in which sugars such as monosaccharides or oligosaccharides are bonded to the hydroxyl group of inositol. The saccharide may be bonded to one or more of the six hydroxyl groups of inositol, and is typically bonded to one hydroxyl group. In the inositol derivative used in the present invention, a plurality of inositols may be bonded to one sugar.

There is no restriction | limiting in particular in the synthesis | combining method of these inositol derivatives, The method known conventionally can be applied. For example, inositol and cyclodextrin, which is a kind of oligosaccharide, can be reacted in the presence of cyclodextrin glucanotransferase to bind a sugar or oligosaccharide with an inositol residue (Japanese Patent Laid-Open No. 63-196596). In addition, glucosylated inositol derivatives can be obtained using glucosyl phosphite as a sugar donor (Japanese Patent Laid-Open No. Hei 6-298783).

As a blending method of the inositol derivative in which the inositol and the saccharide are combined into the external preparation for skin, a method of mixing the inositol derivative with the external preparation for skin as a solid, powder, or semisolid, a method for mixing the derivative with the external preparation for the skin as an aqueous solution, alcohols, or other suitable substances As a solution of a solvent, the method of mixing a derivative with an external preparation for skin, and the method of mixing or adding a derivative with an external preparation for skin by a well-known method are mentioned, However, it is not specifically limited to this.

Inositol derivatives used in the present invention can be isolated as white powder form. Moreover, the aqueous solution of the derivative obtained during a manufacturing process can also be mix | blended with the external preparation for skin.

The compounding amount of the inositol derivative in which inositol and saccharide are combined is not particularly limited as long as it is suitable for external skin preparations or cosmetics. It is preferable to mix | blend a derivative in the quantity of 0.01 mass%-50 mass%, More preferably, it is 0.1 mass%-10 mass%. If the compounding quantity of the said inositol derivative is in the said range, the skin external preparation produced | generated will have sufficient texture, such as a moisturizing feeling in skin, and a viscosity is suitable. Therefore, the function of the external preparation for skin is fully exhibited.

The topical skin preparation used in the present invention is not particularly limited, but includes a cosmetic, a cleaning agent, a bath and a soap that directly contact the skin. It is especially preferable to use it as a cosmetic.

In general terms, a skin external preparation refers to any kind of preparation that can come into contact with the skin when in use, regardless of the gender and age of the user. These external preparations include, for example, skin milk, skin cream, foundation cream, massage cream, cleansing cream, shaving cream, cleansing foam, skin lotion, lotion, pack, lipstick, ball touch, eye shadow, nail polish, soap, body shampoo , Hand soaps, shampoos, rinses, hair tonics, treatments, hair creams, hair sprays, hair restorers, wool, hair dyes, hair barbers, hair loss agents, toothpastes, mouthwashes, permanent wave agents, ointments and bathing agents.

Use forms of the topical skin preparation may be solid, semisolid, liquid and gas. The form of the external preparation for skin is not particularly limited, but may be in the form of powder, granules, tablets, gels and foams.

The external preparation for skin of the present invention is a component other than the inositol derivative to which saccharides are bound, and if necessary, may contain a component generally used for the external preparation for skin within the range that does not impair the effects of the present invention.

Such components include the following, for example.

Earthworm, α-olefin oligomer, hard isoparaffin, hard isoparaffin, squalene, squalane, synthetic squalane, vegetable squalane, ceresin, paraffin, polyethylene powder, polybutene, microcrystalline wax, liquid isoparaffin, liquid paraffin, mineral oil And hydrocarbons such as petrolatum;

Natural waxes such as jojoba oil, carnauba wax, candelilla wax, rice bran wax, shellac, lanolin, mink oil wax, sperm, sugar cane, diesel, beeswax and montan wax;

Avocado oil, almond oil, olive oil, extra virgin olive oil, sesame oil, rice bran oil, rice oil, rice germ oil, corn germ oil, safflower oil, soybean oil, corn oil, rapeseed oil, persic oil, palm kernel oil, palm oil , Castor oil, sunflower oil, high oleic sunflower oil, grape seed oil, cottonseed oil, palm oil, hydrogenated palm oil, tallow, hydrogenated oil, horse oil, mink oil, egg yolk oil, egg yolk fat oil, rosehip oil, kukui oil nut oil), evening primrose oil, wheat germ oil, peanut oil, camellia oil, baby camellia oil, cacao butter, beeswax, beef bone fat, shellfish oil, pork fat, horse fat, sheep fat, shea butter, macadamia nut oil And natural fats and oils such as meadowfoam oil;

Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, γ-linolenic acid, isostearic acid, 12-hydroxystearic acid, undecylenic acid and palm oil fatty acids;

Higher alcohols such as isostearyl alcohol, octyldodecanol, hexyldecanol, cholesterol, phytosterol, lauryl alcohol, myristyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, behenyl alcohol and cetostearyl alcohol ;

Alkyl glyceryl ethers such as batyl alcohol, chimil alcohol, ceracyl alcohol and isostearyl glyceryl ether;

Myristic acid isopropyl, butyl myristic acid, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, linoleic acid isopropyl, cetyl acid hexyl, hexyl laurate, isooctyl myristate , Myristic acid decyl, myristic acid myristyl, myristic acid cetyl, myristic octadecyl, palmitic acid cetyl, stearic acid stearyl, decyl oleic acid, oleic oleic acid, ricinolic acid cetyl, isostearyl laurate , Myristic acid isotridecyl, myristic acid isocetyl, myristic acid isostearyl, myristic acid octyldodecyl, palmitic acid 2-ethylhexyl, palmitic acid isocetyl, palmitic acid isostearyl, stearic acid 2-ethylhexyl acid, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl lysanoate, ethyl isostearate, isopropyl isostearate, cetyl 2-ethylhexanoate, 2-ethyl Acid cetostearyl, 2-ethylhexanoic acid stearyl, hexyl isostearic acid, dioctanoic acid ethylene glycol, dioleic acid ethylene glycol, dicaprylic acid propylene glycol, di (caprylic acid capric acid) propylene glycol, dicapric acid Propylene glycol, propylene glycol dioleate, neopentyl glycol dicapric acid, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, glyceryl tri (caprylic acid capric acid) , Tri (caprylic acid, capric acid, stearic acid) glyceryl, triundecyl glyceryl, triisopalmitate glyceryl, triisostearic acid glyceryl, tri-2-ethylhexanoic acid trimethylolpropane, triiso Stearic acid trimethylolpropane, tetra-2-ethylhexanoic acid pentaerythryl, tetramyritic acid pentaerythryl, tetraisostearic acid pentaerythryl, tetraisostearic acid di Riseryl, octyldodecyl neopentanoic acid, isocetyl octanoate, isostearyl octanoate, isopropyl hexapentyl, 2-ethylhexyl dimethyloctanoic acid, hexyldecyl dimethyl, octyldodecyl dimethyloctanoate, 2-ethylhexyl isopalmitate Isostearic acid isocetyl, isostearic acid isostearyl, isostearic acid octyldodecyl, lactic acid lauryl, lactic acid myristyl, lactic acid cetyl, lactic acid octyldodecyl, citrate triethyl, acetyl triethyl citrate, acetyl tributyl citrate , Trioctyl citrate, triisocetyl citrate, trioctyl citrate citrate, diisostearyl malic acid, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, adipic acid diisopropyl, adipic acid di Isobutyl, dioctyl adipic acid, diheptyl undecyl adipic acid, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, chole isostearic acid Steryl, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, 12-stearoylhydroxystearate isocetyl, 12-stea Loylhydroxystearate stearyl, 12-stearoylhydroxystearate isostearyl, polyoxyethylene (3) polyoxypropylene (1) cetyl ether, polyoxyethylene (3) polyoxypropylene (1 Esters such as isocetyl ether, isononanoic acid isononyl, isononanoic acid octyl, isononanoic acid tridecyl and isononanoic acid isotridecyl;

Methyl polysiloxane, methylphenyl polysiloxane, methylhydrogen polysiloxane, methyl cyclopolysiloxane, octamethyl cyclotetrasiloxane, decamethyl cyclopentasiloxane, dodecamethyl cyclohexasiloxane, octamethyl trisiloxane, decamethyl tetrasiloxane, tetradecamethyl hexasiloxane, High polymerization methyl polysiloxane, dimethyl siloxane / methyl (polyoxyethylene) siloxane / methyl (polyoxypropylene) siloxane copolymer, dimethyl siloxane / methyl (polyoxyethylene) siloxane copolymer, dimethyl siloxane / methyl (polyoxypropylene) siloxane air Silicone oils such as copolymer, dimethyl siloxane / methyl cetyloxysiloxane copolymer, dimethyl siloxane / methyl stearoxysiloxane copolymer, polyether modified silicone, alcohol modified silicone, alkyl modified silicone and amino modified silicone;

Ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, pentanediol, glycerol, diglycerol, polyglycerol, isoprene glycol, 1,3-butylene glycol, 3-methyl Polyhydric alcohols such as -1,3-butanediol, 1,3-butanediol, 1,2-pentanediol and 1,2-hexanediol;

Sugars such as mannitol, sorbitol, xylitol, maltitol, erythritol, pentaerythritol, glucose, sucrose, fructose, lactose, maltose, xylose and trehalose;

Sodium alginate, carrageenan, agar, purselane, guar gum, queen's seed, konjac met, tamarind gum, tara gum, dextrin, starch, locust bean gum, arabic gum, garty gum, karaya gum, tragacanth gum, Arabinogalactan, pectin, quince, chitosan, starch, curdlan, xanthan gum, gellan gum, cyclodextrin, dextran, pullulan, microcrystalline cellulose, methylcellulose, ethylcellulose, hydroxyethyl cellulose, hydrate Hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxy starch, cationic cellulose, starch phosphate, cationic guar gum, carboxymethyl / hydroxypropylated guar gum, hydroxypropylated guar gum, albumin, casein, Gelatin, sodium polyacrylate, polyacrylic amide, carboxyvinyl polymer, polyethyleneimine, high polymerization polyethylene glycol, Livinyl alcohol, polyvinylpyrrolidone, polyvinyl ether, polyacrylamide, acrylic acid copolymer, methacrylic acid copolymer, maleic acid copolymer, vinylpyridine copolymer, ethylene / acrylic acid copolymer, vinylpyrrolidone polymer, Vinylalcohol / vinylpyrrolidone copolymers, nitrogen substituted acrylamide polymers, amino modified silicones, cationic polymers, dimethylacrylic ammonium polymers, acrylic acid based anionic polymers, methacrylic acid based anionic polymers, modified silicones, acrylic acid or methacrylic acid alkyls polymers, such as (C _{10 ~30)} copolymers, and polyoxyethylene / polyoxypropylene copolymer;

Alcohols such as ethanol, isopropyl alcohol, 1-butanol, 2-butanol and benzyl alcohol;

Palm oil fatty acid potassium, palm oil fatty acid sodium, palm oil fatty acid triethanolamine, potassium laurate, sodium laurate, lauric acid triethanolamine, myristic acid potassium, myristic acid sodium, myristic acid isopropanolamine, potassium palmitate, Sodium palmitate, isopropanolamine, isopropanolamine, potassium stearate, sodium stearate, triethanolamine, potassium stearate, sodium oleate, castor oil fatty acid sodium, zinc undecylenate, zinc laurate, zinc myristic acid, Magnesium myristic acid, zinc palmitate, zinc stearate, calcium stearate, magnesium stearate, aluminum stearate, calcium myristic acid, magnesium myristic acid, aluminum dimyrate, aluminum isostearate, polyoxyethylene la Uryl ether acetic acid, polyoxyethylene lauryl ether sodium acetate, poly Oxyethylene tridecyl ether acetic acid, sodium polyoxyethylene tridecyl ether acetate, sodium stearoyl lactate, sodium isostaroyl lactate, lauroyl sarcosine sodium, palm oil fatty acid sarcosine, palm oil fatty acid sarcosine sodium, palm oil fatty acid sarco Cin triethanolamine, lauroyl sarcosine, lauroyl sarcosine potassium, lauroyl sarcosine triethanolamine, oleyl sarcosine, myristoyl sarcosine sodium, sodium stearoyl glutamate, palm oil fatty acid acyl glutamic acid, palm oil fatty acid Potassium acylglutamate, palm oil fatty acid sodium acylglutamate, palm oil fatty acid acylglutamic acid triethanolamine, lauroyl acylglutamic acid, lauroyl potassium acylglutamate, lauroyl sodium acylglutamate, lauroyl acylglutamic acid triethanolamine, myristoyl acyl glutamate , Myri Toyl Acyl Glutamate, Sodium Myristoyl Acyl Glutamate, Stearoyl Acyl Glutamic Acid, Stearoyl Acyl Glutamate, Disodium Steayl Acyl Glutamate, Sodium Cured Uji Fatty Acid Acyl Glutamate, Palm Oil Fatty Acid / Cure Uji Fatty Acid Acyl Glutamate, Palm oil fatty acid methylalanine sodium, lauroyl methylalanine, lauroyl methylalanine sodium, lauroylmethylalanine triethanolamine, myristoyl methylalanine sodium, lauroylmethyl taurine sodium, palm oil fatty acid methyltaurine potassium, palm oil fatty acid methyl Taurine sodium, palm oil fatty acid methyltaurine magnesium, myristoyl methyltaurine sodium, palmitoyl methyltaurine sodium, stearoyl methyltaurine sodium, oleoyl methyltaurine sodium, alkanesulfonic acid sodium, tetradecenesulfonic acid sodium, sulfosuccinate dioctyl sodium, Sulfo Disodium succinate, palm oil fatty acid ethyl ester sodium sulfonate, sodium lauryl sulfate, lauryl sulfate triethanolamine, sodium cetyl sulfate, alkyl (11,13,15) triethanolamine, alkyl (12,13) sodium sulfate, alkyl (12,13) triethanolamine sulfate, alkyl (12,14,16) ammonium sulfate, alkyl (12,13) sulfate ethanolamine, alkyl (12-14) sulfate triethanolamine, alkyl (12-15) triethanolamine , Palm oil alkyl magnesium triethanolamine, ammonium lauryl sulfate, potassium lauryl sulfate, magnesium lauryl sulfate, monoethanolamine lauryl sulfate, diethanolamine lauryl sulfate, sodium myristyl sulfate, sodium stearyl sulfate, oleyl sulfate Sodium, oleyl sulfate triethanolamine, polyoxyethylene lauryl ether sulfate sodium sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene (1) alkyl (11, 13, 15) ether Sodium sulfate, polyoxyethylene (1) alkyl (11,13,15) ether triethanolamine sulfate, polyoxyethylene (3) alkyl (11-15) ether sodium sulfate, polyoxyethylene (2) alkyl (12,13) Ether sodium sulfate, polyoxyethylene (3) alkyl (12-14) ether sodium sulfate, polyoxyethylene (3) alkyl (12-15) ether sodium sulfate, polyoxyethylene (2) laurylether sodium sulfate, polyoxy Sodium ethylene (3) myristyl ether sodium sulfate, higher fatty acid alkanolamide sodium sulfate, lauryl phosphate, sodium lauryl phosphate, cetyl phosphate, cetyl phosphate diethanolamine, polyoxyethylene oleyl ether phosphoric acid, polyoxyethylene lauryl Ether phosphoric acid, polyoxyethylene lauryl ether phosphate, polyoxyethylene cetyl ether phosphoric acid, polyoxyethylene cetyl ether sodium phosphate, polyoxyethylene stearyl ether phosphoric acid, polyoxyethylene oleyl Tere phosphate, polyoxyethylene oleyl ether sodium phosphate, polyoxyethylene alkylphenyl ether phosphoric acid, polyoxyethylene alkylphenyl ether sodium phosphate, polyoxyethylene alkylphenyl ether phosphate triethanolamine, polyoxyethylene octylether phosphoric acid, polyoxyethylene ( 10) alkyl (12,13) ether phosphoric acid, polyoxyethylene alkyl (12-15) ether phosphoric acid, polyoxyethylene alkyl (12-16) ether phosphoric acid, polyoxyethylene laurylether phosphoric acid triethanolamine and polyoxyethylene oleyl Anionic surfactants such as ether phosphate diethanolamine;

Dioctylamine, dimethylstearylamine, trilaurylamine, diethylaminoethylamide stearate, lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, cetyltrimethylammonium saccharin, stearyltrimethylammonium chloride Alkyl (20-22) trimethylammonium, lauryl trimethylammonium bromide, alkyl (16,18) trimethylammonium, stearyl trimethylammonium bromide, stearyltrimethylammonium saccharin, alkyl chloride (28) trimethylammonium chloride, di (polyoxy Ethylene) oleylmethylammonium (2EO), dipolyoxyethylenestearylmethylammonium chloride, polyoxyethylene (1) polyoxypropylene (25) diethylmethylammonium chloride, tri (polyoxyethylene) stearylammonium chloride (5EO ), Distearyl dimethylammonium chloride, dialkyl chloride (12-15) dimethylammonium, dialkyl chloride (12-18) dimethylammonium, Dialkyl Ammonium Chloride (14-18) Dimethyl Ammonium Chloride, Dicoyl Dimethyl Ammonium Chloride, Dicetyl Dimethyl Ammonium Chloride, Isostearyl Lauryl Dimethyl Ammonium Chloride, Benzalkonium Chloride, Myristyl Dimethyl Benzyl Ammonium Chloride, Lauryl Dimethyl (Ethyl Benzyl) Ammonium chloride, stearyldimethylbenzylammonium chloride, laurylpyridinium chloride, cetylpyridinium chloride, lauroylcolaminoformylmethylpyridinium chloride, stearoylcolaminoformylmethylpyridinium chloride, alkyl isoquinolium bromide, methyl chloride Cationic surfactants such as benzetonium and benzetonium chloride;

2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, alkyldiaminoethylglycine hydrochloride, lauryldiaminoethylglycine sodium, undecylhydroxyethylimidazoliumbetaine sodium, undecyl -N-carboxymethylimidazolium betaine, palm oil fatty acid acyl-N-carboxyethyl-N-hydroxyethylethylenediamine disodium, palm oil fatty acid acyl-N-carboxyethoxyethyl-N-carboxyethylethylenediamine disodium, Palm oil fatty acid acyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine disodium, sodium laurylaminopropionate, sodium laurylaminodipropionate, laurylaminopropionic acid triethanolamine, palm oil fatty acid acyl-N-carboxyethyl-N -Hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid betaine, palm oil alkyldimethylaminoacetic acid betaine, stearyldimethylaminoa Betaine acid, stearyl dimethylbetaine sodium, palm oil fatty acid amidopropylbetaine, palm oil fatty acid amidopropylbetaine, lauric acid amide propylacetic acid betaine, ricinoleic acid amidopropylbetaine, stearyldihydrate Amphoteric surfactants such as oxyethyl betaine and laurylhydroxysulfo betaine;

Polyoxyethylene (10) alkyl (12,13) ether, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene (3,7,12 ) Alkyl (12-14) ether, polyoxyethylene tridecyl ether, polyoxyethylene myristyl ether, polyoxyethylene-sec-alkyl (14) ether, polyoxyethylene isocetyl ether, polyoxyethylene cetostearyl ether, Polyoxyethylene (2,10,20) isostearyl ether, polyoxyethylene oleylcetyl ether, polyoxyethylene (20) aralkyl ether, polyoxyethylene octyldodecyl ether, polyoxyethylene behenyl ether, polyoxy Ethylene octylphenyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene dinonylphenyl ether, polyoxyethylene (1) polyoxypropylene (1,2,4,8) cetyl ether, polyox Cyethylene (5) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene (10) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene (20) polyoxypropylene (1,2,4,8) cetyl ether, polyoxyethylene polyoxypropylene lauryl ether, polyoxyethylene (3) polyoxypropylene (34) stearyl ether, polyoxyethylene (4) polyoxypropylene (30) Stearyl Ether, Polyoxyethylene (34) Polyoxypropylene (23) Stearyl Ether, Polyoxyethylene Polyoxypropylene Cetyl Ether, Polyoxyethylene Polyoxypropylene Decyltetradecyl Ether, Monolauric Acid Polyethylene Glycol, Monostearic Acid Ethylene glycol, monostearic acid polyethylene glycol, monooleic acid polyethylene glycol, ethylene glycol fatty acid ester, self-emulsifying monostearic acid ethylene glycol, dilauric acid diethylene glycol, in advance Polyethylene glycol acid, polyethylene glycol palmitic acid, diethylene glycol stearate, polyethylene glycol self-emulsifying monostearate (2), polyethylene glycol isostearic acid, ethylene glycol dioctanoate, diethylene glycol dilauric acid, dilauric acid Polyethylene glycol, dipalmitate polyethylene glycol (150), distearate ethylene glycol, distearate diethylene glycol, distearate polyethylene glycol, dioleate ethylene glycol, dioleate polyethylene glycol, diricinoleate polyethylene glycol, mono Lauric acid polyoxyethylene (20) sorbitan, monopalmitate polyoxyethylene (20) sorbitan, monostearate polyoxyethylene (6) sorbitan, monostearate polyoxyethylene (20) sorbitan, tri Stearic acid polyoxyethylene (20) sorbitan, monooleic acid polyoxyethylene (6) Junior, polyoxyethylene (20) sorbitan, trioleic acid polyoxyethylene (20) sorbitan, polyoxyethylene (20) palm oil fatty acid sorbitan, monolaurate polyoxyethylene (10-80) sorbitan, Tristearic acid polyoxyethylene sorbitan, isostearic acid polyoxyethylene (20) sorbitan, tristearic acid polyoxyethylene (150) sorbitan, polyoxyethylene castor oil, polyoxyethylene hardened castor oil, polyoxyethylene ( 10) Cured castor oil, Polyoxyethylene (20) Cured castor oil, Polyoxyethylene (40) Cured castor oil, Polyoxyethylene (50) Cured castor oil, Polyoxyethylene (60) Cured castor oil, Lipophilic monostearate Acid glyceryl, lipophilic glycerol monooleate, glyceryl self-emulsifying monostearate, palm oil fatty acid glyceryl, glycerol laurate, glyceryl myristic acid, isostearic acid Glyceryl, glyceryl ricinoleate, glyceryl monohydroxystearate, glyceryl oleate, glycerol linoleic acid, glyceryl erucic acid, glyceryl behenate, wheat germ oil fatty acid glycerides, safflower oil fatty acid glyceryl, hydrogenated Soybean fatty acid glyceryl, saturated fatty acid glycerides, cottonseed oil fatty acid glyceryl, monoisostearic acid monomyritic glyceryl, monotalo fatty acid glycerides, monoglyceryl lanolin fatty acids, sesquioleic acid glyceryl, glycerol distearate, di Glycerol isostearic acid, glyceryl diaraic acid, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan monostearate, sorbitan mono monostearate, sorbitan sesquistearic acid , Sesquioleic acid sorbitan, tristearate sorbitan, trioleic acid sorbitan, palm oil fatty acid Sorbitan, isostearic acid sorbitan, sesquiisostearic acid sorbitan, distearate sorbitan, isopalmitate diglyceryl, monolauric poly (4-10) glyceryl, monomyritic poly (10 ) Glyceryl, monostearic acid poly (2-10) glyceryl, monoisostearic acid poly (2-10) glyceryl, monooleic acid poly (2-10) glyceryl, sesquioleic acid diglyceryl, diisostearate Acid poly (2-10) glyceryl, distearic acid poly (6-10) glyceryl, triisostearic acid diglyceryl, tristearic acid poly (10) glyceryl, trioleic acid poly (10) glyceryl, tetra Isostearic acid poly (2) glyceryl, pentastearic acid decaglyceryl, pentaoleic acid poly (6-10) glyceryl, heptastearic acid poly (10) glyceryl, decastearate decaglyceryl, decaoleic acid poly (10 ) Glyceryl, condensation lishi Nooleic acid poly (6) glyceryl, sucrose fatty acid ester, sucrose palm oil fatty acid ester, alkyl glucoside, palm oil alkyldimethylamine oxide, lauryldimethylamine oxide, dihydroxyethyllauryldimethylamine oxide, stearyl Nonionic surfactants such as dimethylamine oxide, oleyldimethylamine oxide and polyoxyethylene palm oil alkyldimethylamine oxide;

Saponin, lecithin, soybean phospholipid, hydrogenated soybean phospholipid, soybean lysolipid, hydrogenated soybean lysophospholipid, egg yolk lecithin, hydrogenated egg yolk lysophosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingophospholipid, sphingomyelin, ganglio Natural surfactants such as seed, bile acid, cholic acid, deoxycholic acid, sodium cholate, sodium deoxycholic acid, spiculisporic acid, rhamnolipid, trehalose lipid, sopolorilipid and mannoserythritol lipid;

Paraaminobenzoic acid derivatives such as paraaminobenzoic acid, ethyl paraaminobenzoic acid, glyceryl paraaminobenzoic acid, amyl paradimethylaminobenzoic acid and 2-ethylhexyl paradimethylaminobenzoic acid, benzyl cinnamic acid, di-2-methoxycinnamic acid mono-2-ethyl Glyceryl hexanoate, methyl 2,4-diisopropylcinnamic acid, ethyl 2,4-diisopropylcinnamic acid, potassium paramethoxycinnamic acid, sodium paramethoxycinnamic acid, isopropyl paraparacinnamic acid, paramethoxycinnamic acid Cinnamic acid derivatives, such as 2-ethylhexyl, paramethoxycinnamic acid 2-ethoxyethyl, and paraethoxycinnamic acid ethyl, urocanic acid derivatives such as urocanoic acid and ethyl urocanoate, 2,4-dihydroxybenzophenone, 2 , 2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxy-5-sulfobenzophenone sodium, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2- Hydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzo Benzophenone derivatives such as phenone and 2,2'-dihydroxy-4,4'-dimethoxy-5-sulfobenzophenone sodium, ethylene salicylate glycol, 2-ethylhexyl salicylate, phenyl salicylate, benzyl salicylic acid, p salicylic acid salicylic acid derivatives such as -tert-butylphenyl, salicylic acid homomentyl and salicylic acid-3,3,5-trimethylcyclohexyl, 2- (2'-hydroxy-5'-methoxyphenyl) benzotriazole and 4-tert- Ultraviolet absorbers such as butyl-4'-methoxybenzoylmethane;

Kaolin, silicic anhydride, magnesium aluminum silicate, mica, talc, boron nitride, mica, montmorillonite, tricellulose powder, wheat starch, silk powder, corn starch, nitro dye, azo dye, nitroso dye, triphenylmethane dye , Xanthene pigment, quinoline pigment, anthraquinone pigment, indigo pigment, pyrene pigment, phthalocyanine pigment, flavonoid, quinone, porphyrin, water soluble anato, squid ink powder, caramel, guai zulene, gardenia blue pigment Natural pigments such as gardenia yellow, cochinyl, siconin, copper chlorophyllin sodium, paprika pigment, safflower red pigment, safflower yellow pigment, laccaic acid and riboflavin butyric acid, carbon black, iron oxide, black iron oxide, iron oxide, royal blue Ultramarine Blue, Zinc Oxide, Chromium Oxide, Titanium Oxide, Titanium Black Oxide, Zirconium Oxide, Chromium Hydroxide, Alumina, Magnesium Oxide, Barium Sulfate Powders and colorants such as aluminum sulfide, calcium carbonate, lithium cobalt titanate, manganese violet and pearl pigment;

Sinchocho extract, sun medicinal extract, avocado extract, hydrangea leaf extract, vine tea extract, hollyhock extract, arnica extract, oil-soluble arnica extract, almond extract, aloe extract, benzoin extract, ginkgo extract, nettle extract, white iris root extract, fennel Extract, Turmeric Extract, Youngsil Extract, Echinacea Leaf Extract, Golden Leaf Extract, Yellow White Extract, Rhubarb Extract, Barley Extract, Okra Extract, Red Pepper Sprout Extract, Soluble Red Pepper Sprout Extract, Clown Extract, Soluble Clown Extract, Ononis Extract , Watercress extract, orange extract, light water, seaweed extract, persimmon tannin, brown root extract, Valerian extract, boulders extract, chamomile extract, oil-soluble camomile extract, camomile water, oat extract, carrot extract, oil-soluble carrot extract, carrot oil, Evergreen mugwort extract, licorice extract, licorice extract powder, licorice Lavonoid, Cantharis Tink, Raspberry Extract, Kiwi Extract, Cinnabar Extract, Cucumber Extract, Apricot Seed Extract, Queen's Seed Extract, Gardenia Extract, Speckled Root Extract, Red Ginseng Extract, Walnut Peel Extract, Grapefruit Extract, Clematis Extract, brown sugar extract, chlorella extract, mulberry extract, cinnamon extract, gentian extract, vinegar extract, black tea extract, yellow water lily extract, burdock extract, oil-soluble burdock extract, wheat germ extract, hydrolyzed wheat powder, rice bran extract, rice bran fermentation extract, Comfrey Extract, Sessin Extract, Saffron Extract, Soap Paste Extract, Soluble Salvia Extract, Hawthorn Extract, Sancho Extract, Shiitake Extract, Shiitake Extract Powder, Turmeric Extract, Seacon Extract, Soluble Seacon Extract, Perilla Extract, Basswood Extract, Soluble Extract Basswood extract, turmeric extract, peony extract, Yulmu Extract, Ginger Extract, Soluble Ginger Extract, Health Tink, Iris Root Extract, Birch Extract, Soluble Birch Extract, Birch Sap, Honeysuckle Extract, Horsetail Extract, Soluble Horsetail Extract, Scordinin, Stevia Extract, Ivy Extract , Hawthorn extract, elderberry extract, juniper extract, yarrow extract, oil-soluble yarrow extract, spearmint extract, sage extract, oil-soluble sage extract, sage water, mallow extract, celery extract, celery extract, cheongungsu Bitter Extract, Soybean Extract, Jujube Extract, Thyme Extract, Tea Extract, Tea Biscuit Extract, Coconut Extract, Clove Flower Extract, Dermis Extract, Camellia Extract, Centella Extract, Soluble Walnut Extract, Duke Extract, Garza Extract, Pepper Tink, Angelica Extract, Oil Soluble Angelica Extract, Angelica Radix, Glucose Extract Dextrose marigold extract, soy milk powder, peach extract, orange extract, triticale extract, tomato extract, potentilla extract, natto extract, ginseng extract, oil-soluble ginseng extract, garlic extract, wild rose extract, oil-soluble wild rose extract, malt extract, malt root extract, Macmundong Extract, Parsley Extract, Rice Barley Leaf Juice Concentrate, Distilled Peppermint Water, Pungnhahwa Water, Pungwanhwa Extract, Rose Extract, Parietari Extract, Peel Extract, Loquat Leaf Extract, Soluble Loquat Leaf Extract, Kanto Extract, Bokryeong Extract, Lucus Aculeatus Extract, Lucus Aculeatus Extract Powder, Grape Extract, Grape Leaf Extract, Grape Water, Hayflower Extract, Scrubber Extract, Scrubber, Safflower Extract, Soluble Bodhi Tree Extract, Bodhi Tree, Peony Extract, Hop Extract, Soluble Extract Hop extract, pine extract, thistle extract, horse chestnut extract, Oil-soluble horse chestnut extract, Unsweetened tree extract, Melissa extract, Mary rod extract, Peach leaf extract, Oil-soluble peach leaf extract, Bean sprout extract, Cornflower extract, Cornflower water, Eucalyptus extract, Rock extract, Lily extract, Yulmu rice extract Plant extracts such as wormwood extract, wormwood extract, lavender extract, lavender extract, apple extract, ganoderma extract, lettuce extract, lemon extract, self-extracted extract, rose water, rosemary extract, oil-soluble rosemary extract, roman chamomile extract and cucumber extract;

Glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, tryptophan, cystine, cysteine, methylonine, proline, hydroxyproline, aspartic acid, asparagine, glutamic acid, glutamine, arginine, histidine, lysine, γ- Amino acids and peptides such as aminobutyric acid, DL-pyrrolidonecarboxylic acid, ε-aminocaproic acid, hydrolyzed elastin, water-soluble elastin, hydrolyzed collagen, water-soluble collagen, casein, glutathione, wheat peptide, soybean peptide, etc .;

Vitamin As such as retinol, retinal, retinoic acid, retinol acetate and retinol acetate, α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthine, echinenone and Carotenoids such as astaxanthin, vitamin B1 such as thymine, vitamin B2 such as riboflavin, vitamin B6 such as pyridoxine, pyridoxal and pyridoxamine, vitamin B12 such as cyanocobalamin, folate, Nicotinic acid, nicotinic acid amide, pantothenic acid, biotin, L-ascorbic acid, L-ascorbic acid, stearic acid L-ascorbyl, palmitic acid L-ascorbyl, dipalmitic acid L-ascorbyl, tetraisopal Mitrate L-ascorbyl, L-ascorbic acid disodium sulfate, L-ascorbyl magnesium, L-ascorbyl sodium phosphate, L-ascorbic acid-2-glucoside and L-ascorbic acid-2-phosphate Vitamin C, ergocalciferol, etc. Vitamin D such as cholecalciferol, d-α-tocopherol, DL-α-tocopherol, acetate dl-α-tocopherol, succinic acid dl-α-tocopherol, β-tocopherol, γ-tocopherol and d-δ-tocopherol Vitamins such as vitamin E, ubiquinones, vitamin K, carnitine, ferulic acid, γ-orizanol, α-lipoic acid, and orotic acid;

Benzoic acid, sodium benzoate, undecylenic acid, salicylic acid, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetic acid, isopropyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, paraoxybenzoic acid Preservatives such as propyl, benzyl paraoxybenzoate, methyl paraoxybenzoate, methyl paraoxybenzoate sodium, phenoxyethanol, photosensitive 101, photosensitive 201 and photosensitive 401;

Antioxidants such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, erythorbic acid, sodium erythorbate, parahydroxyanisole and octyl gallate;

Metal ion blocking agents such as trisodium ethylenediaminehydroxyethyl triacetate, edetic acid, disodium edate, trisodium edate, tetrasodium edate, sodium citrate, gluconic acid, phytic acid, sodium polyphosphate and sodium metaphosphate;

Humectants such as hyaluronic acid, sodium hyaluronate, sodium chondroitin sulfate, sodium lactate, sodium pyrrolidone carboxylic acid, betaine, lactic acid bacteria culture medium, yeast extract and ceramide;

Anti-inflammatory agents such as glycyrrhizinate, trisodium glycyrrhinate, dipotassium glycyrrhinate, monoammonium glycyrrhinate, β-glycileretinic acid, glycyrrhetinic acid glycerol, glycyrrhetinic acid stearyl, lysozyme chloride, hydrocortisone and allantoin;

PH adjusters such as sodium hydroxide, potassium hydroxide and triethanolamine;

Salts such as sodium chloride, potassium chloride, magnesium chloride and sodium sulfate;

Α-hydroxy acids such as citric acid, glycolic acid, tartaric acid and lactic acid;

Whitening agents such as arbutin, α-arbutin and placental extract;

Angelica Oil, Ylang Ylang Oil, Elemi Oil, Orange Oil, German Chamomile Oil, Roman Chamomile Oil, Cardamom Oil, Iris, Galvanum Oil, Camphor Oil, Carrot Seed Oil, Clary Sage Oil, Grapefruit Oil, Clove Oil, Cinnamon Oil, Coriander Oil, cypress oil, sandalwood oil, cedar wood oil, citronella oil, cinnamon leaf oil, jasmine absolut, juniper berry oil, ginger extract, spearmint oil, sage oil, cedar oil, geranium oil, thyme oil, tea tree oil , Nutmeg, niauli, neroli, pine, basil, peppermint, patchouli, palmarose, fennel, petite grain, pepper, frankincense, vetiver, peppermint, bergamot, benzoin, no Baro Odora Oil, Marjoram Oil, Mandarin Oil, Myrrh Oil, Melissa Oil, Eucalyptus Oil, Citron Oil, Lime Oil, Ravensara Oil, Labandine Oil, Lavender Oil, Linden Oil, Lemon Oil, Lemongrass Oil, Rose Oil, Rosewood Oil , Rosemary oil and rubbish oil Essential oils such as;

Terpenes such as limonene, pinene, terpinene, terpinolene, myrcene and longifolene;

Spices and water.

In addition, the external preparation for skin of the present invention may further contain an existing cosmetic raw material in a general concentration. For example, the second edition of the Cosmetic Ingredients Standard Zhuhai, Japan Fair Western Church edition, 1984 (Yakujinnipposa), the cosmetics ingredients outside the standards, supervised by the Ministry of Health, Welfare and Drug Administration, 1993 (Yakujinnipposa), cosmetic raw materials standards Review of external component standards, supervision of the Ministry of Health, Welfare and Drug Administration, 1993 (Yakujinnipposa), cosmetics classification approval standards, supervised by the Ministry of Health, Welfare and Drug Administration, 1993 (Yakujinnipposa), cosmetics formulation formulation standards, supervision of the Ministry of Health, Welfare and Drug Administration, All cosmetic raw materials described in 1997 (Yakuji Nipposa) and the cosmetic raw material dictionary, 1991 (Nikko Chemicals), etc. can be used.

Effect of the Invention

  By incorporating an inositol derivative in which a saccharide is bound to the external preparation for skin, the external preparation can be applied to the skin without a sense of particles, providing sufficient wetness, and providing an excellent effect of keeping the skin healthy.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated concretely based on an Example. However, the present invention is not limited to these examples. In addition, "%" means "mass%" unless otherwise stated.

Example  One

1 g of myo-inositol and 1 g of β-cyclodextrin were dissolved well in 20 mL of 50 mM sodium citrate buffer (pH 5.5). 500 U of cyclodextrin glucanotransferase was added thereto and reacted at 55 ° C. for 48 hours. The resulting reaction was analyzed by LC-MS. The analysis confirmed that β-cyclodextrin was lost in the reaction solution obtained by the reaction of 48 hours. After the reaction, the enzyme was inactivated by boiling the reaction solution for 10 minutes. Next, after cooling this reaction liquid sufficiently, it filtered, and further frozen, and freeze-dried. As a result, 1.2 g of a white powder containing glucosyl inositol (hereinafter, referred to as GI-1) was obtained. LC-MS analysis of GI-1 showed that the number of glucose chains in the glucose chain bound to inositol was 38% for one, 28% for two, 10% for three, 4% for four, and 1% for five. Indicated. In addition, GI-1 is odorless and very soluble in water.

Example  2

The lotion shown in Table 1 was manufactured based on the conventional method (sample 1-1). The lotion was used by ten women aged 20 to 30 years and listened to after use. The results are shown in Table 2. By using Sample 1-1 comprising GI-1, there was no graininess, no peculiar smell, and an increase in wetness of the skin.

Comparative example  1 and 2

The lotion shown in Table 1 was manufactured based on the conventional method (samples 1-2 and 1-3). The sample was tested in the same manner as in Example 2 to hear the listening after use. The results are shown in Table 2.

Example  3

The milk lotion shown in Table 3 was manufactured based on the conventional method (sample 2-1). This milk lotion was used by ten women aged 20 to 30 years, and the post-use impression was listened to. The results are shown in Table 4. By using Sample 2-1 containing GI-1, there was no graininess, no peculiar smell, and an increase in the wetness of the skin.

Comparative example  3 and 4

The milk lotion shown in Table 3 was manufactured based on the conventional method (samples 2-2 and 2-3). The sample was tested in the same manner as in Example 3 and the listening after use was heard. The results are shown in Table 4.

Example  4

10 g of myo-inositol and 10 g of β-cyclodextrin were well dissolved in 200 mL of 50 mM sodium citrate buffer (pH 5.5). 5000 U cyclodextrin glucanotransferase was added thereto and reacted at 55 ° C. for 48 hours. The resulting reaction was analyzed by LC-MS. The analysis confirmed that β-cyclodextrin was lost in the reaction solution obtained by the reaction for 48 hours. After the reaction, the enzyme was inactivated by boiling the reaction solution for 15 minutes. Next, after fully cooling this reaction liquid, it filtered and further freeze-dried after freezing. Thereby, 13.7 g (hereinafter, referred to as GI-2) of a white powder containing glucosyl inositol was obtained. LC-MS analysis of GI-2 indicates that the number of glucose chains in the glucose chain bound to inositol is 42% for one, 30% for two, 9% for three, 3% for four, and 1% for five. It was.

Next, 12 g of GI-2 was dissolved in 5 ml of purified water to provide a sample solution of preparative liquid chromatography. As the conditions for the preparative liquid chromatography, Shodex SUGAR KS-2002 was used as a column, Shodex SUGAR KS-LG was used as a guard column, and purified water was used as an eluent. The flow rate was 5 ml / min, and the column temperature was 80 ° C. . The peaks were monitored by detector RI to selectively collect only peaks of oligosaccharides bound to inositol residues, and fractions were recovered. The recovered liquid was frozen and then freeze dried. This obtained 8.5 g (henceforth GI-3) white powder containing glucosyl inositol. LC-MS analysis of GI-3 shows that the number of glucose chains in the glucose chain bound to inositol is 51% for one, 35% for two, 10% for three, 3% for four, and 1% for five. It was. In addition, GI-3 is odorless and very soluble in water.

Example  5

The lotion shown in Table 5 was manufactured based on the conventional method (sample 3-1). This lotion was applied twice a day for 7 days in the morning and evening to the forearm side of three women aged 30 to 40 years. The keratin moisture content of the morning on the 8th day was tested by measuring conductivity by the high frequency inductance method using an impedance meter (SKICON-200 by IBS). The results are shown in Table 6. The use of Sample 3-1 containing GI-3 showed an improvement in conductivity and an increase in the amount of keratin to increase the wetness of the skin.

Comparative example  5 to 7

The lotion shown in Table 5 was manufactured based on the conventional method (samples 3-2 to 3-4). Samples were tested in the same manner as in Example 5. The results are shown in Table 6.

Example  6

The milk lotion shown in Table 7 was manufactured based on the conventional method (sample 4-1). In the same manner as in Example 5, three women aged 30 to 40 years were applied to the forearm side of the forearm twice a day and evening for seven days. In the morning on day 8, keratin moisture content was tested by measuring conductivity using an impedance meter. These results are shown in Table 8. The use of Sample 4-1 containing GI-3 showed an improvement in conductivity and an increase in the amount of keratin water to increase the wetness of the skin.

Comparative example  8 to 10

The milk lotion shown in Table 7 was manufactured based on the conventional method (Samples 4-2 to 4-4). Samples were tested in the same manner as in Example 5. The results are shown in Table 8.

Example  7

The cream shown in Table 9 was manufactured based on the conventional method (sample 5-1). In the same manner as in Example 5, three women aged 30 to 40 years were applied to the forearm side of the forearm twice a day and evening for seven days. In the morning on day 8, keratin moisture content was tested by measuring conductivity using an impedance meter. These results are shown in Table 10. The use of Sample 5-1 containing GI-3 showed an improvement in conductivity and an increase in the amount of keratin to increase the wetness of the skin.

Comparative example  11 to 13

The cream shown in Table 9 was manufactured based on the conventional method (Samples 5-2 to 5-4). Samples were tested in the same manner as in Example 5. The results are shown in Table 10.

Claims (6)

A skin external preparation comprising inositol and an inositol derivative having a sugar chain having a glucose chain of 1 to 5 glucose. delete delete The external preparation for skin according to claim 1, wherein the inositol constituting the inositol derivative is myo-inositol. The external preparation for skin according to claim 1, wherein the content of the inositol derivative is 0.01 to 50% by mass of the preparation. A cosmetic comprising the external preparation for skin according to any one of claims 1, 4 and 5.