KR100760148B1 - Cosmetic composition for stabilizing alpha-lipoic acid - Google Patents

Abstract

A cosmetic composition for stabilizing alpha-lipoic acid is provided to maintain effects for a long period of time by preventing changes of smell and color of alpha-lipoic acid caused by binding with thiol, thereby being useful for skin whitening, skin wrinkle prevention, oxidation inhibition and body sliming. A cosmetic composition comprises: 0.01-20 wt.% of alpha-lipoic acid; 0.1-30 wt.% of polyol as a stabilizer of alpha-lipoic acid selected from propylene glycol, glycerin, 1,3-butylene glycol, 1,3-butandiol and sorbitol; and 0.01-10 wt.% of non-ionic surfactant selected from POE(polyoxyethylene) sorbitan fatty acid ester, POE alkyl ether, POE hydrogenated ester oil, POE(10) octyldodecyl ether, POE(15) octyldodecyl ether, POE(20) octyldodecyl ether, POE(30) octyldodecyl ether, POE(15) glyceryl monostearate, POE(20) glyceryl monostearate, POE(25) glyceryl monostearate and POE(30) glyceryl monostearate, and is formulated as skin, lotion, cream, foundation or essence.

Description

Cosmetic composition which stabilized alpha-lipoic acid {COSMETIC COMPOSITION FOR STABILIZING ALPHA-LIPOIC ACID}

The present invention relates to a cosmetic composition stabilized alpha-lipoic acid, and more particularly, by mixing a polyol and a nonionic surfactant in a constant ratio to prevent the destabilization of the alpha-lipoic acid, such as odor, discoloration, etc. It relates to a cosmetic composition.

Alpha-lipoic acid has various names such as thioctic acid, 6,8-dithiooctanoic acid and 1,2-diethylene-3 pentanoic acid. Alpha-lipoic acid is known to not only have the effect of treating the symptoms associated with diabetes, but also plays an important role in maintaining a healthy state of antioxidants in the body. In addition, glutathione and vitamins C, E, etc. are known to have the action of promoting the production. Recently, the Journal of Biological Chemistry , α-lipoic acid inhihits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways, vol 278, No. 37, 2003, 34823-34833), inhibiting the increase of vascular lipids (Korean Patent Publication No. 10-2004-0067312), as a preventive and therapeutic agent for vascular diseases, and as a weight loss food and an obesity food. It is attracting attention.

On the other hand, alpha-lipoic acid has low solubility characteristics in aqueous solutions used in cosmetics, has a problem of discoloration and discoloration by dissolving and discoloring as thiols under daylight or over time, and a problem of high odor due to sulfur component. There was a difficulty in using it as a cosmetic ingredient. That is, alpha-lipoic acid has been limited in practical applications because of its low stability against discoloration and odor, despite its excellent efficacy, and various studies have been conducted to protect its stability.

As a method of stabilizing alpha-lipoic acid, which has been carried out so far, as a specific example, it is contained in a porous polymer such as cyclodexrtrin and stabilized (Korean Patent Publication No. 10-2005-0039927), or an encapsulation method using solid lipid nanoparticles. (Souto EB, Muller RH, Gohla S., J. Microencapsul . 2005, Sep; 22 (6), 581-92A, Novel approach based on lipid nanoparticles (SLN) for topical delivery of alpha-lipoic acid). ).

However, due to various environmental factors, it was very difficult to solve the stability problems such as the specific odor, discoloration, and discoloration of alpha-lipoic acid by the aforementioned method.

Therefore, the present inventors have studied a method for stabilizing alpha-lipoic acid to solve the above problems, by using a mixture of polyols and nonionic surfactants in a constant ratio to solve the stability problems such as discoloration, discoloration The present invention has been accomplished by finding a method that can

It is an object of the present invention to provide a mixed cosmetic composition stabilized by preventing alpha-lipoic acid from being destabilized by odor and discoloration in the cosmetic composition.

In order to achieve the above object, in the present invention, in the cosmetic composition comprising alpha-lipoic acid, 0.1 to 30% by weight of polyol and 0.01 to 10% by weight of nonionic surfactant based on the total weight of the composition as a stabilizer of alpha-lipoic acid It provides a cosmetic composition comprising a.

Hereinafter, the present invention will be described in detail.

The alpha-lipoic acid used in the composition of the present invention is not particularly limited, but is alpha-lipoic acid and dehydrolyzed dihydrolipoic acid (DHLA, dihydrolipoic acid). have.

The amount of such alpha-lipoic acid added is preferably 0.01 to 20% by weight based on the total weight of the composition.

In the cosmetic composition of the present invention, the mixed system of the polyol and the nonionic surfactant is preferably contained in an amount of 0.1 to 40% by weight based on the total weight of the composition. When used in less than 0.1% by weight can not prevent destabilization, such as discoloration, discoloration, such as alpha-lipoic acid, if it exceeds 40% by weight is not suitable for cosmetics such as odor, discoloration, solubility, crystallization.

Moreover, in the cosmetic composition of this invention, it is preferable that the mixing ratio of a polyol and a nonionic surfactant is 1-7: 1-5, and it is more preferable that it is 6-7: 1-2.

The polyol used in the cosmetic composition of the present invention may be at least one member selected from the group consisting of propylene glycol, glycerin, 1,3-butylene glycol, 1,3-butanediol and sorbitol.

The nonionic surfactants include POE (polyoxyethylene) sorbitan fatty acid esters, POE alkyl ethers (LA), POE hydrogenated ester oils, POE (10) octyldodecyl ethers, POE (15) octyldodecyl ethers, POE ( 20) octyldodecyl ether, POE (30) octyldodecyl ether, POE (15) glyceryl monostearate, POE (20) glyceryl monostearate, POE (25) glyceryl monostearate and POE (30) ) Glyceryl monostearate may be at least one selected from the group consisting of.

On the other hand, the cosmetic composition of the present invention may be formed of any one formulation selected from the group consisting of skin, lotion, cream, foundation and essence.

Hereinafter, an Example is given and this invention is demonstrated concretely. However, these examples are provided to more fully explain the present invention to those skilled in the art, and may be modified in many different forms and should be construed as limited to the scope of the present invention. It should not be.

Example  1 to 9 and Comparative example  1 to 6

The lotion was prepared with the composition shown in Table 1 below. In Table 1 the units are weight percent.

Raw material name Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Cholesteryl ester 2.0 2.0 2.0 2.0 2.0 Cetostearyl alcohol 0.8 0.8 0.8 0.8 0.8 Stearic acid 1.0 1.0 1.0 1.0 1.0 Squalane 8.0 8.0 8.0 8.0 8.0 Purified Jojoba Oil 4.0 4.0 4.0 4.0 4.0 Octyldodecanol 2.0 2.0 2.0 2.0 2.0 Polysorbate 1.0 1.0 1.0 1.0 1.0 Sesquioleic acid sorbitan 0.5 0.5 0.5 0.5 0.5 Carboxyvinyl Polymer 0.2 0.2 0.2 0.2 0.2 Triethanolamine 0.3 0.3 0.3 0.3 0.3 antiseptic Quantity Quantity Quantity Quantity Quantity Spices Quantity Quantity Quantity Quantity Quantity Pigment Quantity Quantity Quantity Quantity Quantity Propylene glycol 10 10 10 10 Twin 80 5 10 20 10 Alpha lipoic acid One One One One One Purified water Total 100 Total 100 Total 100 Total 100 Total 100

To the essence was prepared in the composition shown in Table 2. In Table 2, the unit is weight percent.

Raw material name Example 4 Example 5 Example 6 Comparative Example 3 Comparative Example 4 ethanol 6.0 6.0 6.0 6.0 6.0 Methylparaben 0.1 0.1 0.1 0.1 0.1 Polyacrylic acid 5.0 5.0 5.0 5.0 5.0 Hydroxyethylcellulose 0.1 0.1 0.1 0.1 0.1 Carboxyethylcellulose 0.1 0.1 0.1 0.1 0.1 Triethanolamine 0.2 0.2 0.2 0.2 0.2 Ethylene oxide 0.3 0.3 0.3 0.3 0.3 antiseptic 5.0 5.0 5.0 5.0 5.0 Spices Quantity Quantity Quantity Quantity Quantity Propylene glycol 10 10 10 10 Twin 80 5 10 20 10 Alpha lipoic acid One One One One One Purified water Total 100 Total 100 Total 100 Total 100 Total 100

To prepare a cream with the composition shown in Table 3. In Table 3, the unit is weight percent.

Raw material name Example 7 Example 8 Example 9 Comparative Example 5 Comparative Example 6 Microstalin lead 2.0 2.0 2.0 2.0 2.0 Cetostearyl alcohol 0.8 0.8 0.8 0.8 0.8 Stearic acid 1.0 1.0 1.0 1.0 1.0 Squalane 8.0 8.0 8.0 8.0 8.0 Glycerin Stearate 4.0 4.0 4.0 4.0 4.0 Octyldodecanol 2.0 2.0 2.0 2.0 2.0 Polysorbate 1.0 1.0 1.0 1.0 1.0 Sesquioleate sorbitan 0.5 0.5 0.5 0.5 0.5 Liquid paraffin 0.2 0.2 0.2 0.2 0.2 Octyldodecyl Myristate 0.3 0.3 0.3 0.3 0.3 Spices Quantity Quantity Quantity Quantity Quantity Pigment Quantity Quantity Quantity Quantity Quantity Propylene glycol 10 10 10 10 Twin 80 5 10 20 10 Alpha lipoic acid One One One One One Purified water Total 100 Total 100 Total 100 Total 100 Total 100

Effect Test Example 1 Test for Deodorant and Discoloration

In order to test the stability against discoloration and discoloration of the cosmetic compositions prepared in the above Examples and Comparative Examples, each composition was stored in 400 g of a transparent glass container for 3 months at room temperature, and then the discoloration and discoloration of 20 people were measured. It was confirmed. The results are shown in Tables 4 and 5 below.

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Initial value Odor One 0 One 0 One One One One One Discoloration degree 0 0 0 0 0 0 0 0 0 3 months later Odor One One One One One One One One One Discoloration degree 0 0 0 One One 0 One One 0 6 months later Odor One One One One One One One One One Discoloration degree One 0 0 0 One One 2 One One

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Initial value Odor One One One One One One Discoloration degree 0 0 One 0 One 0 3 months later Odor One One 4 One 4 4 Discoloration degree 3 2 2 One 2 One 6 months later Odor 2 2 4 3 4 4 Discoloration degree 4 4 3 3 3 3

In the table above, the criteria are as follows:

(1) discoloration degree

0: no change, 1: very little change, 2: little change, 3: little change,

4: severely changed, 5: extremely severe.

(2) the degree of odor

0: no change, 1: very little change, 2: little change, 3: little change,

4: severely changed, 5: extremely severe.

As shown in the results of Tables 4 and 5, the cosmetic compositions of Examples 1 to 9 stabilized alpha-lipoic acid with a polyol and a nonionic surfactant are more stable against discoloration and discoloration than the cosmetic compositions of Comparative Examples 1 to 6. Do. Therefore, the effects of lipoic acid whitening, wrinkle removal, antioxidant, slimming and the like are expected.

In order to confirm the above results more quantitatively, the residual amount of alpha-lipoic acid in the Example and Comparative Example compositions was measured using high performance liquid chromatography (HPLC). The results are shown in the following Tables 6 and 7. The values in Tables 6 and 7 are HPLC analysis alpha-lipoic acid residual percentages.

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Initial value 100 100 100 100 100 100 100 100 100 3 months later 98 95 90 94 96 95 94 93 98 6 months later 90 92 85 70 80 83 86 89 85

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Initial value 100 100 100 100 100 100 3 months later 80 78 66 83 82 80 6 months later 57 62 50 45 40 58

As shown in Tables 6 and 7, it can be seen that the alpha-lipoic acid content is higher in the cosmetic composition prepared in Example than in Comparative Example.

Effect Test Example 2 Stability Test Over Time

In order to determine the stability over time of the cosmetic compositions prepared in Examples 1 to 9 and Comparative Examples 1 to 6, each composition was placed in a transparent glass container of 400 g each at room temperature (25 ° C.), high temperature (45 ° C.), After storage in daylight and freeze-thaw chamber (45 ℃ to -10 ℃, 24 hours cycle), the results measured using a colorimeter (Model Σ 80, Nippon D Enshoku) are shown in Table 8 and 9 is shown.

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Room temperature, 6 months Δ0 Δ1 Δ1 Δ1 Δ1 Δ0 Δ0 Δ1 Δ1 45 ℃, 6 months Δ0 Δ1 Δ2 Δ1 Δ2 Δ1 Δ1 Δ2 Δ1 Daylight, 6 months Δ2 Δ2 Δ1 Δ1 Δ2 Δ1 Δ2 Δ2 Δ2 45 ~ -10 ℃, 6 months Δ1 Δ2 Δ1 Δ2 Δ2 Δ2 Δ2 Δ2 Δ2

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Room temperature, 6 months Δ3 Δ3 Δ3 Δ3 Δ3 Δ3 45 ℃, 6 months Δ3 Δ3 Δ3 Δ3 Δ3 Δ4 Daylight, 6 months Δ4 Δ4 Δ4 Δ4 Δ4 Δ4 45 ~ -10 ℃, 6 months Δ3 Δ4 Δ3 Δ4 Δ3 Δ4

* Judgment criteria: Amount of change = the amount of change in colorimeter measurement compared to the control.

Δ0: almost no change,

Δ1: very slightly changed,

Δ2: slightly changed,

Δ3: change a lot,

Δ4: very much changed.

As shown in the results of Tables 8 and 9, the cosmetic compositions of Examples 1 to 9 stabilized alpha-lipoic acid with polyols and nonionic surfactants have higher storage stability over time than the cosmetic compositions of Comparative Examples 1 to 6. You can check it. That is, as a result of quantitatively confirming the content of the remaining alpha-lipoic acid by high performance liquid chromatography (HPLC), the cosmetics of Examples 1 to 9 have almost 100% stability over time at room temperature, high temperature, sunlight and freeze-thaw conditions. Although it was stable, it confirmed that it was not stable in the case of Comparative Examples 1-6.

As described above, the cosmetic composition of the present invention prevents the alpha-lipoic acid, which is effective in whitening, wrinkles, antioxidants, slimming, etc. in the composition to prevent destabilization, such as odors, odors, etc., so that the long-term effect can be maintained. It can be usefully used as a cosmetic composition, such as wrinkles, antioxidants, slimming.

Claims (7)

A cosmetic composition comprising alpha-lipoic acid, wherein the composition is selected from the group consisting of propylene glycol, glycerin, 1,3-butylene glycol, 1,3-butanediol, and sorbitol based on the total weight of the composition as a stabilizer of alpha-lipoic acid. 0.1-30% by weight or more of polyols, and POE (polyoxyethylene) sorbitan fatty acid ester, POE alkyl ether (LA), POE hydrogenated ester oil, POE (10) octyldodecyl ether, POE (15) octyldodecyl ether , POE (20) octyldodecyl ether, POE (30) octyldodecyl ether, POE (15) glyceryl monostearate, POE (20) glyceryl monostearate, POE (25) glyceryl monostearate and POE (30) A cosmetic composition comprising 0.01 to 10% by weight of at least one nonionic surfactant selected from the group consisting of glyceryl monostearate. The cosmetic composition according to claim 1, wherein the amount of alpha-lipoic acid added is 0.01 to 20% by weight based on the total weight of the composition. The cosmetic composition according to claim 1, wherein the mixing amount of the polyol and the nonionic surfactant is 0.1 to 40% by weight based on the total weight of the composition. The cosmetic composition according to claim 1, wherein the mixing ratio of the polyol and the nonionic surfactant is from 1 to 7: 1 to 5. delete delete The cosmetic composition according to claim 1, which is a skin, lotion, cream, foundation or essence.