KR100490365B1 - Cosmetics including nanovesicle - Google Patents

Abstract

The present invention relates to a cosmetic composition containing a nano vesicle containing an active substance, having a size of 100 nm to 150 nm with a phospholipid as a main component, and more particularly, using a lecithin as a main component of the vesicle to form a vesicle to form a water-soluble Nano-vesicles with particle diameters of 100 nm to 150 nm are prepared by capturing oil-soluble physiologically active substances into head groups and alkyl groups, respectively, and improving skin elasticity and improving skin moisturizing sustainability over time. It relates to a cosmetic composition containing a.

Description

Cosmetic composition containing cosmetic nano vesicles {Cosmetics including nanovesicle}

The present invention relates to a cosmetic composition containing a nano-vesicle containing a water-soluble and fat-soluble active substance consisting of a phospholipid as a main component, 100nm ~ 150nm, more specifically phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, It is manufactured by collecting vesicles using lecithin containing phosphatiic acid to collect water-soluble physiologically active substances and oil-soluble physiologically active substances into head groups and alkyl groups, respectively, to improve skin elasticity and to maintain skin moisture over time. The present invention relates to a cosmetic composition containing a nano vesicle having a particle size of 100 nm to 150 nm containing an active substance having an enhanced effect.

Vesicles containing phospholipids generally consist of a closed bilayer of circular or oval shape, and a spherical membrane containing water inside a spherical membrane made of a molecular bilayer into which water can enter. It has a structure with space.

Biofilms have a molecular bilayer structure such as vesicles, and since these vesicles can be a very simple model system, biological organisms are used to form vesicles using extracted lipid molecules. Used.

A vesicle composed of naturally occurring or synthetically obtained phospholipids is called a liposome. The phospholipid is dispersed in water and spontaneously forms a 2-molecular membrane due to the molecular structure of the phospholipid.

Phospholipids are amphoteric and have anionic or zwither ion polar molecular groups and two nonpolar fat-soluble chains with varying degrees of unsaturation of about 16 hydrocarbons.

Vesicles containing these phospholipids are classified into three types according to their size and shape.

The multi-layered membrane vesicle (MLV: MultiLamella Vesicle) and the monolayer vesicle (ULV: Unilamella Vesicle) with several layers of lipid 2 molecules overlap, and the ULV is large-unilamella (LUV: Large Unilamella) Vesicle and Small Unilamella Vesicle (SUV).

Its size is 400 ~ 3500nm for MLV and 100 ~ 1000nm for LUV. SUVs range from 20 to 50 nm, with 5-15% active material contained in vesicles, 35-65% for LUV, and 0.5-1.0% for SUV. In terms of stability, the SUV is the best, but the amount of inclusion is extremely low.

Since the difference between these vesicles depends on the manufacturing method of the vesicle, even if the same phospholipid is used, it is important to obtain a vesicle having a desired shape and size by using an appropriate manufacturing method.

The reason for using vesicle using phospholipid as a carrier of effective substance (DDS system) in cosmetics and pharmaceutical fields is that the phospholipid has similar affinity to cell membrane of biological cells, so it has excellent affinity, thus increasing fluidity of biological membrane. The oil-soluble and water-soluble active substance is simultaneously and effectively delivered safely into the cell to impart an effect to a desired site.

Previously, vesicles were made by vesicles made of ceramides and cholesterol, which are intercellular lipids of the stratum corneum, and these substances contain unsaturated fatty acids, which are easily oxidized, and are almost impossible to prepare as poorly soluble substances. .

In addition, when the liposome is prepared by a general stirring method, the particle size is not easy to penetrate itself in the skin state of about 10 mm, and it maintains a dynamic equilibrium, thereby having a fairly unstable defect.

Therefore, the present invention is to solve the above problems, the object of the present invention is to collect and stabilize the water-soluble active ingredient and oil-soluble active ingredient in a certain size of vesicles (100nm ~ 150nm) and excellent skin elasticity improvement effect and moisturizing sustaining effect To provide a cosmetic nanovegicle.

Accordingly, the present inventors have repeatedly studied to solve the above problems, liposomes of cosmetic vesicles to a constant size of 100nm ~ 150nm. Phospholipid lecithin and co-stabilizers are vesicleized with polysorbate, propylene glycol, etc. to reduce elution into the substrate by constant temperature and pressure, thereby improving the stability of fat-soluble and water-soluble active ingredients, The present inventors have found that particle size has an effect of improving skin in the application of the product.

Accordingly, it is an object of the present invention to provide a cosmetic vesicle with improved stability and usability by stabilizing a vesicle composed of an oil-soluble active ingredient and a water-soluble active ingredient in a closed bilayer.

Still another object of the present invention is to provide a cosmetic composition containing the cosmetic vesicle.

In order to achieve the above object, a cosmetic composition containing the active material and the nano vesicle according to the present invention is characterized in that it contains a vesicle of 100 nm to 150 nm size in which a water-soluble active material and an oil-soluble active material are stabilized.

The nanovesicles of the present invention were limited and controlled to a size of 100-150 nm, because the particles having a size of 100-150 nm have excellent stability in terms of absorption to the skin or nanovesicle quality itself. If the size is less than 100nm, there is a limit in producing the particle size, there is a concern that irritation in the relationship of skin absorption is difficult to apply to cosmetics, if it exceeds 150nm there is a problem that the absorption in the product is less effective.

The present invention relates to a nano vesicle containing a water-soluble, oil-soluble active substance and the main component of the vesicle is lecithin,

0.1 to 10.0% by weight of lecithin, 0.1 to 10% by weight of caprylic capric triglyceride and polysorbate 60, respectively, based on the total amount of nanovesicle composition, and cosmetic nano veggies having a size of 100 nm to 150 nm It's about the cleats.

In addition, the present invention is a water-soluble and oil-soluble active substance for the cosmetics avocado extract, fumitori extract, carrot extract, bark skin extract, brown root extract, stone root extract, lady's hosttail extract, lady mantil extract, hosttail extract, soybean embryo extract , Wheat germ extract, radish extract, sesame seed extract, cucumber extract, cinnamon extract, ginger extract, ephedra extract, herbal extract, vitamin F and apple seed extract is characterized in that one or two or more selected from the group consisting of .

In addition, the present invention is characterized in that the water-soluble, oil-soluble active substance is contained 0.01% to 20% by weight relative to the total weight of the nanovesicle.

In addition, the present invention relates to a cosmetic composition comprising a cosmetic ingredient and the cosmetic nano vesicle. That is, the cosmetic composition is an avocado extract, a fruit extract, a carrot extract, a bark extract, a root extract, Stone Root Extract, Lady's Hostile Extract, Lady's Mantil Extract, Hostile Extract, Soybean Germ Extract, Wheat Germ Extract, Radish Extract, Charmeda Extract, Cucumber Extract, Cinnamon Extract, Ginger Extract, Ephedra Extract, Herb Extract, Vitamin 0.01 to 20% by weight, 0.1 to 10.0% by weight of lecithin, 0.1 to 10% by weight of triglyceride and polysorbate 60, each containing one or two or more selected from the group consisting of F and apple seed extract And it is characterized by containing a nano-vessel for cosmetics having an average particle diameter of 100nm ~ 150nm.

Hereinafter, the present invention will be described in more detail.

A vesicle having a size of 100 nm to 150 nm according to the present invention is manufactured by the following method.

The lecithin, which is a component of vesicles, is dispersed in a pure aqueous solution, and then heated and mixed to the phase transition temperature of the material.

Lecithin has a liquid crystal phase and a crystal phase depending on the temperature, and the temperature when the phase changes is called a phase transition temperature (TC). The phase transition temperature of the lecithin is 65 ° C. Below TC, it becomes a gel state, and fluidity and permeability are suppressed, and above TC, it becomes a liquid crystal state and fluidity and permeability increase. In addition, the lecithin is easily hydrated and swelled in water above the TC, resulting in different intermolecular interactions. Thus, the nanovesicle of the present invention is prepared above the TC.

The vesicles prepared above TC were stirred at the same TC temperature with appropriate concentrations of oils and emulsifiers such as triglycerides, polysorbates, etc., but not so that their respective concentrations exceed 10% by weight. Prepare a vesicle.

In this case, if the stirring time and the stirring speed are long, there is an evaporation of the amount of water, and therefore, an appropriate time and conditions are required. The stirring speed and time is homomixer (Homomixer) 2000rpm, scraper mixer stirring speed 40rpm is preferably prepared in about 10 minutes of time.

By the above method, the first multilayer membrane vesicle is prepared, and then slowly cooled to about 40 ° C. In the process of the first multilayer membrane vesicles at about 40 ° C. at a high pressure (about 600 bar: 8500 psi) at an instant, the multilayer membrane vesicles were prepared by adjusting the particle size of about 100 nm to 150 nm. The condition at this time needs to be repeated 2 to 5 times, preferably 3 times to make the average particle size uniform. In addition, since the cosmetic vesicles are about 40 ° C., it is possible to prevent destabilization of the useful active substance and the water soluble active substance component during the process.

The water-soluble active substance used as an internal wound in the cosmetic vesicle of the present invention is not particularly limited, but avocadofruit extract made of non-timine, albumin, bearberry extract containing urethane, etc., carrot extract made of amino acid components, article It is one or more selected from licorice extract, which is composed mainly of labyridine, and Chada Shima extract, which is composed of minerals, and the oil-soluble active substance is not particularly limited to the water-soluble active substance. acid) is composed of vitamin F, vegetable sterols, tocopherols, apple seed oil composed of fatty acid wax, and the like, and is preferably contained in an amount of 0.1 to 20% by weight of the total weight of nanovesicles. The water-soluble active substance and the oil-soluble active substance have little efficacy and effect when less than 0.01% by weight, and there is a problem in stability when it exceeds 20% by weight. Moreover, even if it added 20 weight% or more, the effect did not increase significantly.

In addition, the material used for manufacturing the cosmetic vesicle of the present invention is preferably lecithin. The lecithin, an amphiphilic substance used to form the vesicles of the present invention, has good solubility compared to conventionally used ceramides, cholesterol, and the like, so that it can be realistically prepared at a phase transition temperature or higher, and also after application of cosmetic skin by controlling the particle size Elasticity improvement effect and moisturizing persistence has the advantage that can be maintained for a long time.

Cosmetic vesicles according to the present invention is applicable to skin care (base cosmetic) products irrespective of the form of the formulation, it is preferable to use dispersed in water-in-oil type products and skins.

In the description of the present invention, the composition of a cosmetic containing nano-vesicles to which an oil-soluble and water-soluble active substance is added is used for various cosmetics, for example, nutrition cream, nutrition liquid, nutrition cosmetic water, packs (wash off type, peel off type). , Sheet type), massage creams, and the like.

In addition, the cosmetic active material nano vesicle according to the present invention can be used in an amount of 0.1 to 30% by weight relative to the total weight of the cosmetic composition, depending on the characteristics of the product when formulated in each cosmetic.

Hereinafter, the cosmetic composition and the method for preparing the same according to the present invention will be described in detail as follows, but the scope of the present invention is not limited by the examples as described.

<Manufacturing method>

The raw materials A) of Table 1 were each exactly weighed and dissolved under heating and stirring at a temperature between 68 and 70 ° C, followed by liquid crystallization for 40 minutes.

B) was added caprylic capric triglyceride and polysorbate 60 to the solution, followed by mixing and stirring at the same temperature for 10 minutes.

After mixing and stirring A) and B), the mixture was cooled to 40 ° C, C) was added at 40 ° C, and mixed and stirred.

After mixing and stirring C), D) was added and mixed and stirred.

The mixed and stirred multi-vesicles were autoclaved at 600 bar (8500 psi) using a high pressure homogenizer APV RANNIE near 40 ° C. to obtain a vesicle having a double layer or more structure having an average size of 100 nm to 150 nm. After the manufacture of vesicles, the particle size of the mastersizer 2000 ( mastersizer 2000, malvern, UK) was used to manage the average particle size to 100-150nm. .

The composition containing the active substance vesicles produced by the method of the present invention can be formulated into various types of cosmetics, for example, nutrition cream, nutrition lotion, nutrition serum, moisturizing skin, packs (fill-off type) and the like. Cosmetic composition and a method for producing the same according to the present invention will be described in detail as follows, but the present invention is not limited by the embodiments as described.

Example 1 Nutrition Cream

The raw material of the nutrient cream by the method of this invention is as Table 2, and the addition unit of a raw material is weight%.

The raw materials 1 to 7 listed in Table 2 were dissolved by heating at 80 ° C., cooled to 40 ° C., and then the raw materials were dissolved at 40 ° C. from 8 to 11, and the two solutions were mixed well. The vesicles are added and homogeneously mixed to make a cosmetic composition (nutrition cream) according to the method of the present invention.

Comparative Example 1

The raw material used is as described in Comparative Example 1 of Table 2, and the production method is the same. At this time, the nano-vesicle containing the active substance is not added.

Experimental Example 1

50 women aged 20 to 40 (25 dry skin, 25 oily skin) to test the nutritional cream containing the active substance nano vesicle (Example 1) and Comparative Example 1 without the active substance nano vesicle ) Was tested for 50 days.

<Evaluation Method>

Evaluation of elasticity improvement effect and skin moisturizing persistence with time was performed, but the evaluation method was 100 points and the average was given to the following grades.

20 points or less: Very bad

40 points or less: Bad.

60 points or less: Normal.

80 points or less: Good.

100 points or less: Very good.

<Evaluation result>

The nutrition cream containing the active substance nano vesicles (Example 1) has a much better result than the nourishing cream containing the active substance nano vesicles (Comparative Example 1). Got.

The results for dry skin are shown in Table 3, and the results for oily skin are shown in Table 4.

As shown in the evaluation results, the nutrition cream was very satisfactory in both the elasticity improvement effect and the improvement effect of the skin moisturizing sustainability over time, whereas the cream of Comparative Example 1 was applied to the nano-vesicle containing cream prepared by the method of the present invention. The effect was found to be inferior.

Especially for dry skin, the effect of the nourishing cream by the method of the present invention showed a better result.

As such, the nanovesicle containing the active substance of the present invention is excellent in the elasticity improvement effect and the moisturizing sustaining effect when formulated with a nourishing cream.

Item Elasticity improvement effect Skin Moisturizing Sustainability Over Time Example 1 96 92 Comparative Example 1 78 74

Item Elasticity improvement effect Skin Moisturizing Sustainability Over Time Example 1 90 88 Comparative Example 1 74 72

Claims (4)

Avocado Extract, Fumitori Extract, Carrot Extract, Bark Extract, Root Extract, Stone Root Extract, Lady's Hostile Extract, Lady's Mantil Extract, Hostile Extract, Soybean Germ Extract, Wheat Germ Extract, Radish Extract, Chamda Extract, Cucumber Extract 0.01-20% by weight of one or two or more selected from the group consisting of extracts, cinnamon extract, ginger extract, ephedra extract, herbal extract, vitamin F and apple seed extract, water-soluble active substance 0.01-20% by weight, lecithin 0.1-10.0% by weight A cosmetic composition containing 0.1 to 10% by weight of triglyceride and polysorbate 60, respectively, and a cosmetic nanovesicle having an average particle diameter of 100 nm to 150 nm. The cosmetic composition of claim 1, wherein the nanovesicle comprises 0.1 to 30% by weight based on the total amount of the cosmetic composition. delete delete