KR100308491B1 - Composition for growthing hair - Google Patents

Abstract

The present invention relates to a hair growth composition, and more particularly, to a hair growth composition comprising plant extracts and vitamins as an active ingredient.

The present invention a) sesame flower extract; And b) a hair growth composition comprising tretinoin (retinoic acid) as an active ingredient. The composition may further comprise c) a vitamin or vitamin precursor selected from the group consisting of vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, nicotinic acid, pantothenic acid, biotin, and folic acid; , d) pine needle extract and ginseng extract may further comprise at least one extract selected from the group consisting of.

The composition of the present invention inhibits 5-reducing enzymes in the body so that DHT is not formed in the metabolic process of testosterone and helps the hair metabolism by cell regeneration in the functioning of epithelial tissues of the human body. Hair growth compositions that can be used for treatment.

Description

Hair Growth Composition {COMPOSITION FOR GROWTHING HAIR}

[Industrial use]

The present invention relates to a hair growth composition, and more particularly, to a hair growth composition comprising plant extracts and vitamins as an active ingredient.

[Prior art]

Human hair consists of a protein called keratin, which is the protein that makes up nails and toenails. Our visible hair consists of three layers of tissue that form from a `` hair follicle '' shaped like a bag about 4 mm below the skin. The outermost layer is a thin, hard, scaly protective layer that does not show color. The middle layer is the thickest, hair-bearing structure that determines whether the hair is straight or humped, and the color of the hair. The innermost layer is the layer of living cells that nourish hair growth.

There is a papilla in the hair follicle, where small blood vessels are distributed to provide the nutrients needed for hair growth, and the side of the teat has a seborrheic gland that provides shine to the hair. This growth of hair follicles is under the influence of 'testosterone', where the hairs of the armpits and the genitals are particularly sensitive to the hormone and appear first in puberty than other body hair. On the other hand, the hair of the head is affected by 'dihydrotestosterone (DHT)', a derivative of male hormone.

Hair follicles are originally formed in the prenatal period, and no new hair follicles are formed after childbirth. The numbers remain the same even in adults, but decrease in later life. The first hair to appear during fetal periods is called lanugo hair, which falls off in the mother's womb in about eight months. After birth is vellus hair, thin, light, colorless and within 2 cm in size. This hair can also be seen in the anterior head when androgenetic alopecia progresses. During puberty, cilia are transformed into terminal hair, turning into thick, strong, colored hair.

The growth of the Virgin is influenced by male hormones. In the case of male alopecia, DHT affects the formation of soft hair and eventually causes hair loss. The head usually has an average of 100,000 virgins, which repeat their creation and disappearance with periodic changes in growth, degeneration, and resting phases.

In addition, hair is affected by various factors such as age, season, race, physiological factors, stress, and disease, and usually 50-100 normal 'degenerative hair loss' occurs every day. Normal hair growth is about 2 to 6 years and growth continues at this time, with growth rates of 4 to 6 mm per month. The growth rate is fastest when it is hot and late when it is cold. Hair loss occurs more frequently in autumn and winter than in spring and summer. Hair growth is usually most active between the ages of 15 and 30, and gradually degenerates at age 40 and 50. After age 50, natural hair loss begins to occur due to aging, and hair loss accelerates after 70 years.

Meanwhile, the types, causes and treatment of hair loss are as follows.

The most common complaints of alopecia are subjective and conceptual. Of course, there are cases of obvious hair loss and lesions, but there are no obvious lesions, and the number of complaints is not counted objectively or the appearance of hair is observed without complaints. In other words, the number of hair is reduced, the hair is thinner or smaller, or sometimes breaks easily and breaks, which is often the case. Therefore, when you have hair loss, it is important to accurately assess your current hair condition and to understand your physical and mental health in general.

These alopecia are classified into alopecia areata, resting alopecia, growing alopecia, scalp disease and androgenetic alopecia, looking at them as follows.

Alopecia areata usually occurs suddenly in the scalp of one to two circular hair loss. In addition to the scalp, it can be seen on beard, eyebrows, pubic hair, etc. In severe cases, hair loss may occur all over the body. The cause is not yet known, but it is thought to be caused by autoimmune mechanisms, and genetic and mental (particularly stress) causes. Although it may heal naturally, it is a good idea to treat it if symptoms persist for more than three months or progress further. The most common treatment is intra-lesional injection of corticosteroids and treatment of immune response.

In the stage of alopecia areata, 50 to 100 alopecia hair loss occurs in a normal adult. If the number of hair loss is greater than the normal alopecia, a lot of cases can be found. The causes are as follows.

The first is drug use, including anticoagulants, antidepressants, antihypertensives, gastric ulcers, anti-arthritis agents, anticonvulsants, vitamin A derivatives (acne treatments), contraceptives, etc. If you are experiencing hair loss problems while using these drugs, try another agent that has the same effect.

Second is excessive diet, hair loss can occur if there is anemia due to lack of protein or iron due to excessive diet.

Third, stress or fever, severe infectious diseases, chronic diseases, major surgery, etc. These cases can cause hair loss within about 3 months of the cause.

Fourth, hyperthyroidism or hypothyroidism can cause hair loss.

In most cases, hair growth is restored after about six months if the causative irritation disappears.

Growing alopecia is a condition in which hair follicles in the growing stage are acutely severely damaged and more than 80% to 90% of the hair falls out rapidly, and chemotherapy and X-ray irradiation are used to treat malignant tumors. In this case, the hair follicle will recover within a few weeks after the administration of the causative agent is good, but the regenerated hair is thin and growth can be seen in many cases.

Scalp disease may show partial hair loss in seborrheic scalpitis, fungal disease, scleroderma, lupus, nymphitis, tumor, syphilis (3rd stage). Seborrheic scalp infection is the most common of the above diseases and is similar to that of alopecia areata. Seborrheic scalp infections often occur with androgenetic alopecia because this phenomenon is also affected by seborrheic glands by DHT.

In many cases, androgenetic alopecia starts from the sides of the forehead and goes up to the 'M-' shape, leading to hair loss at the forehead. At the same time, it is a common phenomenon that the hair experiences thinning, smallness and loss of power along with hair loss.

Androgenetic alopecia is affected by three factors: age, genetic factors and DHT.

The mechanisms by which these factors cause androgenetic alopecia are as follows.

Testosterone in the body is converted to the DHT form by a 5-reduction enzyme during metabolism, which acts on the hair follicles with a male hair loss genetic factor, causing the hair follicles to contract and eventually die off or form a small downy hair. It will result in the remaining. Therefore, if 5-reductase is inhibited, DHT is not formed during the metabolism of male hormones, but male hormones are normally maintained, so male sexual characteristics are maintained but hair loss is prevented.

Using this principle, the rationale for preventing male alopecia can be established.

Propecia is a drug that is based on the above theory and has recently been marketed by US drug company Merck. The drug has been reported to have prevented hair loss by 86% and hair growth in 66% of the groups taken.

But the disadvantage of Propecia

a) take a continuous dose,

b) relatively expensive

c) minor side effects such as decreased libido and erectile dysfunction

There is a problem.

Another hair loss preventer recognized by the US FDA is Minoxidil, which is a topical drug that has some effectiveness (20-30%) in young, oily, and flaky areas. In other cases, the effect is not very good.

Alopecia in women is much higher than normal people think, and about two-thirds of women experience it once in their lifetime. The types of female hair loss include the following types of female hair loss and pregnancy hair loss.

Female alopecia is similar to male alopecia, and hair loss occurs gradually with age, but unlike men, hair loss occurs in general without any form. It usually occurs from 25 to 30 years old, and the hair grows thinner and shorter, and it is noticed by feeling thinning of the garma area. 50% of hair loss in adult women does not have this hair loss, but unfortunately no cure, hair loss is permanent and genetic.

Hair loss due to pregnancy can occur during pregnancy or at the end of 6 months, and in many cases it is almost recoverable, but there are some cases of permanent hair loss.

Hair loss that is common to other women is about 50 to 100 hair loss a day in normal women. When the number of hair loss is higher than the normal hair loss, looking for the cause can often reveal the cause. The case is as follows.

The first is medications, which include anticoagulants, antidepressants, antihypertensive drugs, gastric ulcers, antiarthritis agents, anticonvulsants, vitamin A derivatives (acne medications), contraceptives, etc. If hair loss problems occur while using these drugs, hair loss may be encouraged.

Second is excessive diet, hair loss can occur if there is anemia due to lack of protein or iron deficiency.

Third is the case of stress or fever, severe infectious diseases, chronic diseases, major surgery, hair loss can occur within about three months of the cause.

Fourth, hair loss may occur in hyperthyroidism or hypothyroidism.

In most cases, hair growth is restored after about six months if the causative irritation disappears.

In consideration of the problems of the prior art, the present invention inhibits 5-reducing enzymes in the body so that DHT is not formed in the metabolic process of androgen hormones, and metabolism of hair by cell regeneration in the function of epithelial tissues It is an object of the present invention to provide a hair growth composition that can be used to treat androgenetic alopecia.

Another object of the present invention is to provide a hair growth composition which is more fundamentally hair growth and promoting effect.

[Means for solving the problem]

The present invention to achieve the above object,

a) sesame flower extract; And

b) tretinoin (retinoic acid)

It provides a hair growth composition comprising a.

The sesame flower extract is preferably an extract prepared by extracting 100 parts by weight of sesame flowers with 500 to 1000 parts by weight of a methanol solution of 30 to 100% by weight methanol.

[Action]

Hereinafter, the present invention will be described in detail.

In the present invention, the use of the sesame flower extract and tretinoin is due to the hair growth synergistic effect that did not appear when used alone.

In addition, by including a variety of vitamins and vitamin precursors to aid in human metabolism can further promote the hair growth function of the composition exhibiting the synergistic effect.

Sesame flower extract of a) is to extract the active ingredient by collecting only the flower part of the sesame in order to suppress the 5-reductase in the body so that DHT is not formed in the metabolic process of male hormone. The content in the composition is preferably 0.1 to 10% by weight, the content of 0.1% by weight or less is low hair growth effect, the content of 10% by weight or more is not as effective as the content.

The tretinoin of b) is also called retinoic acid (retinoic acid), and plays a role in helping the hair metabolism by regenerating cells as vitamin A necessary for the function of epithelial tissues of the human body. The content of tretinoin is preferably 0.01 to 2% by weight. The content of 0.01 wt% or less has a low hair growth effect, and the content of 2 wt% or more is not as effective as the content. In particular, the content in the composition of the tretinoin of b) and the vitamin or vitamin precursor of c) is effective at a total of 0.1 to 10% by weight, and beyond this range there is no hair growth synergistic effect and promoting effect.

Various vitamin and vitamin precursor components which may be further included in the composition comprising the sesame flower extract and tretinoin having the synergistic effect are vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, nicotinic acid, pantothenic acid, biotin or Folic acid and the like, and these may be used by selecting one or more kinds.

Vitamin B1 helps the cells grow, and the proper growth of the vitamin B1 first, the cells grow normally.

Vitamin B2 is also called Riboflavin, which plays an important role in the metabolism of the soft tissues of the human body. In addition to the role of replacing the oxygen in other parts of the tissue also helps the assimilation and metabolism of starch and sugar. Several scientific studies have reported that vitamin B2 does not give luster and smooth hair injuries change the cycle of new hair growth and start hair loss.

Vitamin B6, also known as pyridoxine, is a deficiency in animal testing that can interfere with hair growth. At the same time, scaly dermatitis is caused by malnutrition. This vitamin B6 helps the body work with protein, fat and carbohydrates. In addition, it is important to help hematopoiesis and maintain the function of skin, nerves and muscles.

Vitamin C has been used as an antioxidant of the present invention, also known as anti-bleeding factor and inhibits the tendency for blood to easily leak out of capillaries. The action of this vitamin is further enhanced by the presence of bioflaving. The connective tissue that binds the skin cells together is called collagen. Vitamin C is a vitamin necessary for the formation of collagen. It is known as a vitamin that has protection against bacterial infectious diseases, and also has a function of inhibiting the overproduction of histamine in the body. Vitamin C is also a quick way to heal trauma, helping to absorb iron from the intestines.

Vitamin D maintains the balance of calcium in the body and may play an important role in the metabolism of phosphorus and the substitution of oxygen in the body.

Vitamin E also plays an indispensable factor in muscle tissue and vasculature throughout the body, and a lack of this vitamin can cause red blood cells to become very resistant and clogged blood vessels.

Nicotinic acid aids in the blood circulation, has the trade name Niacin and is one of the vitamin B complexes. This chemical is necessary for the normal functioning of the skin, liver, nerves and blood circulation tissues. It is also necessary for the assimilation of starch and carbohydrates.

Pantothenic acid was used as a substance necessary to maintain the normal function of the adrenal gland as well as to act as an anti-dermatitis factor factor necessary for maintaining skin health.

Biotin acts to stimulate cell development, and it has been known in animal experiments that the lack of this material inhibits hair growth.

Folic acid is known to stimulate bone marrow and cell molecules, to help the liver to work properly, and to help the use of fat in human tissues.

As another plant extract of the present invention, it may further include at least one plant extract selected from the group consisting of pine needle extract and ginseng extract. In the case of including them, 0.1 to 20% by weight of the sesame flower extract of a) is preferably included in the composition. The content of 20% by weight or more does not appear as effective as the content. The pine needle extract or ginseng extract may act as a biological vitality, protein enzymes, antioxidants, and the like, as the various components contained in each extract are known, hair growth effect of the composition showing the synergistic effect of the present invention by a complex action It is estimated that can be promoted more. These extracts can be used without being affected by the vitamins or vitamin precursors of c).

The present invention will be described in more detail with reference to the following examples. However, the examples are only for illustrating the present invention and are not limited thereto.

EXAMPLE

Among the raw materials used in the following examples, ginseng extract and ginkgo extract are products of 'Abb's Herb Company', pine needle extract, balm mint extract and oat extract are products of 'Herbal Resources Inc', polyvinyl Pyrrolidone K-90 and K-30 are products of GAF Co.

Example 1

(Sesame Flower Extract Preparation 1)

200 g of dried sesame flower powder are soaked in 1.2 L methanol for 2 weeks.

The mixture was refluxed for 3 hours and then cooled to filter the solution, and the remainder was reextracted twice in the same way with 1 liter of methanol. Each filtrate was mixed and concentrated in a 500 ml rotary evaporator.

This concentrated solution was added to 2.5 liters of distilled acetone, and the precipitate formed was separated and purified with acetone. The precipitate was evaporated under reduced pressure for 3 hours and then stored in a dryer. Yield was 18 g.

Example 2

(Sesame Flower Extract Preparation 2)

Soak 1 kg powdered sesame seeds in 6 L methanol for 2 weeks.

The mixture was refluxed for 8 hours and then cooled to filter the solution, the remainder was reextracted twice in the same way with 1 liter of methanol. Each filtrate was mixed and concentrated in a 500 ml rotary evaporator.

This concentrated solution was added to distilled 2.5 liter ethyl ether and the precipitate formed was separated and purified with ethyl ether. This precipitate was evaporated under reduced pressure for 3 hours and then dried. The material which was not dissolved in the ethyl ether was dissolved in 3 L of water again, and the precipitate was evaporated under reduced pressure after 3 days and dried. The two dry powders were mixed well and stored in a dryer. Yield 30 g.

Example 3

(Sesame Flower Extract Preparation 3)

300 g of dried sesame flower powder is soaked in 2.2 L methanol for 2 weeks.

The mixture was refluxed for 4 hours and then cooled to filter the solution using Amberlite IRN 77 cation exchange resin and the remainder was reextracted twice with 1 L of methanol in the same manner. Each filtrate was mixed and concentrated in a 500 ml rotary evaporator.

This concentrated solution was added to 2.5 liters of distilled acetone and the precipitate formed was separated and purified with acetone. The precipitate was evaporated under reduced pressure for 3 hours and then stored in a drier. Yield was 12 g.

Example 4

(Hair growth composition of lotion formulation)

Based on the conventional lotion formulation, sesame flower extract prepared in Example 1, tretinoin, vitamin or vitamin precursor biotin, nicotinic acid and vitamin B1, plant extracts containing ginseng extract as a plant extract It was prepared by mixing in a conventional lotion manufacturing method.

ingredient Kinds Composition (% by weight) Sesame Flower Extract Example 1 Extract One Vitamin A Tretinoin 0.03 Vitamin or Vitamin Precursor Biotin nicotinic acid vitamin B1 0.050.10.2 Plant extracts Ginseng Extract 0.8 Etc Disodium dietate trisodium citrate cetylisooctanate glycerol 2-ethylhexanoate cetyl alcohol vaseline oatmeal extract glyceryl monostearate polyoxyethylene (60) cast oil carboxyvinyl polymer gum xanthan potassium hydroxide glycerol propylene glycol glycol salis Silicate copper glyconate manganese glyconate ethyl paraben distilled water 0.010.02102210.61.51.30.20.050.061030.70.010.010.2 balance Sum 100

Example 5

(Regrowth composition of cream formulation)

Cream formulation of Table 2 comprising sesame flower extract, tretinoin, vitamin or vitamin precursor B1, B6 (pyridoxine hydrochloride) and E as a plant extract, pine needle extract as a plant extract, based on a conventional cream formulation Hair regrowth composition was prepared by mixing in a conventional cream preparation method.

ingredient Kinds Composition (% by weight) Sesame Flower Extract Example 2 Extract One Vitamin A Tretinoin 0.03 Vitamin or Vitamin Precursor Vitamin B2 Hydrochloride Pyridoxine Vitamin E 0.40.515 Plant extracts Pine needle extract One Etc Glycerol tri2-ethylhexanoate isopropyl myristate ascorbic acid vaseline butyl paraben propyl parabenglycerol monooleate oatmeal extract diglycerol diisostearate polyethylene dioleate (molecular weight 400) glycerine cellulose powder dipropylene glycol glycol salicylate Glyconate Manganese Glyconate disodium dietate triethanolamine distilled water 870.320.10.130.52110150.50.020.010.010.02 Sum 100

Example 6

(Hair Regrowth Composition of Emulsion Formulation)

Biotin, Pantothenic Acid, Vitamin B2 (Riboflavin), B6 (Pyridoxine) and E, Ginseng Extract as Plant Extract The hair growth composition of the emulsion formulation of Table 3 was prepared by mixing in a conventional emulsion preparation method.

ingredient Kinds Composition (% by weight) Sesame Flower Extract Example 3 Extract 1.2 Vitamin A Tretinoin 0.025 Vitamin or Vitamin Precursor Biotin pantothenic acid vitamin B2 (riboflavin) vitamin B6 (pyridoxine hydrochloride) vitamin E 0.020.40.060.50.4 Plant extracts Ginseng Extract 2 Etc Hyaluronic acid tetraethanolamine edtate ethanol glycerin propylene glycol oatmeal extract carboxyvinyl polymer potassium hydroxide methyl parabencetanol petrolatum isopropyl myristate glyceryl monostearate polyoxyethylene (25) cetyl ether 0.1121030.70.30.10.12.52522 Sum 100

Example 7

(Hair Regrowth Composition of Essence Formulation)

Sesame flower extract prepared in Example 1 based on a conventional essence formulation, tretinoin, B2 as a vitamin or vitamin precursor, a hair extract composition of the essence formulation of the following Table 4 containing a pine needle extract as a plant extract It was prepared by mixing.

ingredient Kinds Composition (% by weight) Sesame Flower Extract Example 1 Extract 0.7 Vitamin A Tretinoin 0.025 Vitamin or Vitamin Precursor Vitamin B2 0.8 Plant extracts Pine needle extract 6 Etc Carboxyvinyl polymer glycerin propylene glycol sodium lactate triethanolamine polyoxyethylene (60) cast oil bank extract chestnut extract oatmeal extract squalane alpha-tocopherol methyl paraben ethyl alcohol glycol salicylate copper glyconate manganese glyconate distilled water 0.4550.053.80.50.710.70.50.30.260.60.010.01 Sum 100

Example 8

(Hair Regrowth Composition of Spray Formulation)

Based on the conventional spray formulation, the sesame flower extract prepared in Example 1, tretinoin, and plant extract were prepared by mixing the hair growth composition of the spray formulation of Table 5 including the ginseng extract by the conventional spray preparation method.

ingredient Kinds Composition (% by weight) Sesame Flower Extract Example 1 Extract 0.9 Vitamin A Tretinoin 0.025 Vitamin or Vitamin Precursor - - Plant extracts Ginseng Extract 0.5 Etc Disodium edium acetate phosphate polyvinyl pyrrolidone K-90 polyvinyl pyrrolidone K-30 polyethylene glycol (molecular weight 1450) benzyl alcohol nicotinic acid ethyl alcohol benzalkonium chloride distilled water 0.02000.09750.25001.00002.50000.25001.50009.60000.0200 Sum 100

Example 9

(Clinical experiment)

The following clinical trials were conducted in 80 male bald patients who have never been treated before.

Those who suffered from serious illness and those who were treated with hormones or hair regrowth were divided into two groups, 60 were treated and 20 were treated as controls, except for this experiment. In comparison, there was no statistical difference.

General data from treatment and control groups division Number of patients Average age Average weight Average baldness Treatment group 60 51.6 65.6 14.0 Control 20 50.7 67.4 12.8

In the treatment group, the lotion type hair growth composition of Example 4 was applied to the bald area once or twice a day for 10 weeks, and the control group included the cream composition except the plant extract and the vitamin in the lotion type hair growth composition of Example 4 for 10 weeks. While applied to the hair loss site 1-2 times a day.

The hair growth effect of each group after 10 weeks is shown in Table 7.

Hair Growth Effect in Treatment and Control Groups division Great usually No change Hair loss No response Treatment group 48% 23% 21% 2% 6% Control 0% 6% 94% - -

The hair growth effect of the hair shown in Table 7 was expressed in the following three stages.

No change: almost no hair grows again.

Normal: It seems to grow little by little.

Excellent: You can see the hair growing back as if full.

As shown in the above results, clinical trials of 80 patients showed that the hair regrowth composition of the present invention increased hair growth in men.

The composition of the present invention inhibits 5-reducing enzymes in the body so that DHT is not formed in the metabolic process of testosterone and helps the hair metabolism by cell regeneration in the functioning of epithelial tissues of the human body. It can be used for treatment.

Claims (9)

a) sesame flower extract; And b) tretinoin A hair growth composition comprising as an active ingredient. The method of claim 1, In the composition c) vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, 1 type from the group consisting of nicotinic acid, pantothenic acid, biotin, and folic acid Vitamins or vitamin precursors selected over Hair growth composition further comprising. The method according to claim 1 or 2, In the composition d) at least one selected from the group consisting of pine needle extract and ginseng extract Extract Hair growth composition further comprising. The method according to any one of claims 1 to 3, Hair growth composition of the content of the sesame flower extract of a) is 0.1 to 10% by weight. The method according to any one of claims 1 to 3, Hair growth composition whose content in the composition of the tretinoin of b) is 0.01-2 weight%. The method of claim 2, Hair growth composition of the c or vitamin precursor of c) is 0.1 to 10% by weight in combination with tretinoin of b). The method of claim 3, wherein A hair growth composition in which the content in the composition of the extract of d) is 0.1-20% by weight in combination with the sesame flower extract of a). The method according to any one of claims 1 to 3, The sesame flower extract of a) is a hair growth composition prepared by extracting 100 parts by weight of sesame flowers with 500 to 1000 parts by weight of an aqueous methanol solution of 30 to 100% by weight methanol. The method according to any one of claims 1 to 3, The hair growth composition wherein the formulation of the hair growth composition is a lotion, cream, emulsion, essence, or spray.