KR100257293B1 - Method for manufacturing porous polymer particle - Google Patents

Abstract

PURPOSE: Provided is a method for manufacturing porous polymer particles at low cost which are useful for medical as well as industrial purposes by attaching a substituent group to the polymer particles. CONSTITUTION: Porous polymer particles are manufactured by the next steps: i) mixing mediators such as hydrophobic and hydrophilic monovinyl monomers, dispersion stabilizer, initiator, divinyl monomers, diluent, distilled water, and sheathe polymers in solution; ii) swelling the sheathe polymers uniformly dispersed in the solution with the diluent to dissolve the mediators; iii) heating the solution for polymerization; and iv) washing the mediators with organic solvent and water to eliminate unreacted monomers, sheathe, diluent, and dispersion stabilizer.

Description

Method of producing porous polymer particles

The present invention relates to a method for producing porous polymer particles. More particularly, the present invention relates to a method for producing porous polymer particles having precisely controlled particle sizes and uniform particle sizes.

In general, polymers having a spherical morphology have a large specific surface area and thus can provide a sufficient reaction site when applied as an enzyme immobilizing agent or a catalyst carrier, and are easy to handle with low viscosity and relatively easy to functionalize by introducing a substituent. Therefore, it is applied to various fields according to the physical and chemical properties of polymer particles.

In addition, the spherical polymer may be used as an electrophotographic toner, a cap-controller for liquid crystal display panels, standard particles of a cooler counter and additives for cosmetics if the particles have a particle size of several micrometers to several tens of micrometers and the particle size distribution is monodisperse. Can be.

In particular, polymers having a spherical morphology, uniform size, and porous structure on the particle surface have applications such as column fillers, carriers for adsorptive separation of proteins, and chelate resins for adsorptive separation of heavy metals and ionic materials.

Research into such polymers has been conducted in the early days for materials having relatively hard and chemically stable properties such as polystyrene, and in order to synthesize polymers having excellent separation ability and durability and pressure resistance, polymer porosity and particle size And there is a need to be able to adjust the particle size distribution properly.

Polymeric materials used as column fillers are commercially available, including hydrophobic polymers such as styrene-divinylbenzene copolymers and hydrophilic polymers such as acrylamide-methylenebisacrylamide copolymers. However, in Korea, the polymerization process technology such as monomer, diluent, stabilizer selection, reaction temperature and agitation rate, etc. affecting the synthesis of polymer material for separation is still not properly established and imported from abroad.

Therefore, research to develop column fillers and polymers for adsorptive separation, which have excellent separation ability, durability and chemical resistance, is required. In recent years, water quality and environmental pollution problems caused by heavy metals have emerged seriously. There is also increasing interest in metal chelate resins that can selectively separate.

In general, the polymer can be prepared by emulsion polymerization, suspension polymerization, dispersion polymerization, precipitation polymerization and seed polymerization, and the polymer obtained by each polymerization method has different physical properties such as particle size, particle size distribution and molecular weight.

Emulsion polymerization generally uses a solvent (water), a water-soluble initiator, and an emulsifier to form a micelle having a hydrophilic / hydrophobic portion in a solution, and monomers insoluble in the solvent are dissolved into the hydrophobic portion of the micelle to perform polymerization. The polymer obtained at this time produces a high degree of polymerization of monodisperse microparticles, while having a wide molecular weight distribution. The particle size can be controlled to some extent by the concentration of the emulsifier and the initiator, but small particles of 1 μm or less are usually obtained. In addition, it is difficult to remove the emulsifier contained in the polymer after the reaction, and when the polymer particles are synthesized by the emulsion polymerization method without using the emulsifier, slightly larger particles can be obtained, but the particle size distribution has a disadvantage.

Suspension polymerization usually uses water as a solvent and vigorously stirs the monomer and the initiator which are insoluble in the solvent. The initiator melts into the monomer and is dispersed in the solvent in the form of small droplets. The polymerization takes place in monomer droplets and the resulting polymer is obtained as particles without melting in a solvent.

However, when an soluble initiator is used in the solvent, the polymerization takes place at the interface between the monomer droplet and the solvent (surface of the droplet), which is called dispersion polymerization. In addition, gelatin, starch, ethyl cellulose, polyvinyl alcohol, and the like are used as dispersion stabilizers to prevent incorporation of monomer droplets and to make suspension and dispersion uniform and stable.

Suspension polymerization results in the formation of a porous structure in which pores are developed on the particle surface by phase separation of copolymers formed during polymerization in the reaction system. Therefore, the selection of the diluent used in the polymerization system determines the pore structure of the obtained polymer particles. It is an important factor.

Dispersion polymerization requires that polymer particles precipitate on the solvent while monomers, initiators, and stabilizers react in the starting medium, optionally requiring solvents that can be used to bind the monomers and dispersion stabilizers used. However, as the reaction proceeds, the polymer particles are nucleated and the initiator and monomer are partitioned between the solvent and the polymer phase. The amount of the mediator involved in each phase is determined by the choice of solvent, reaction temperature and several other factors.

The formation of the polymer depends on the number of aggregates which are brought in at the beginning of the reaction since the initial aggregates produced in the initial stage of polymerization determine the number of nuclei formed. The nuclei formed are subsequently grown into spherical particles of larger particle size depending on the amount of monomer used, and the final particle size and particle size distribution are mainly added to maintain the amount of monomer used and colloidal stability of the growing particles. Determined by the role of stabilizers.

The particle size control in suspension and dispersion polymerization depends on (1) the solubility of the monomer-polymer (2) the composition of the reactants (3) the reaction temperature (4) the solvent media, etc. as a function of thermodynamic or kinematic factors. The reaction temperature affects thermodynamic factors such as solubility as well as the rate of decomposition of the initiator that determines the molecular weight, polymerization rate, and particle nucleus of the resulting polymer.

Since the monomer is part of the solvent system and the concentration of monomer in the medium is constantly reduced when polymerization takes place, the role of monomer in the polymerization process is more important than the role of solvent. However, the role of these mediators in the solvent system is very complicated in their interrelationships. In the early stages of polymerization, the monomer phases are physically decomposed into small, three-dimensionally stabilized droplets of micrometer size, and thus have a wide particle size distribution because they are polymerized by radical initiation.

Such suspension polymerization and dispersion polymerization can not control the molecular weight of the polymer, there is a disadvantage that the particle size and the monomer used are limited.

Precipitation polymerization method is a polymerization method in which a polymer produced by a polymerization method without using an emulsifier or a dispersion stabilizer is precipitated after polymerization without dissolving in a solvent in a homogeneous solution in which monomers and an initiator are dissolved. Micron (μm) sized particles can be obtained, but the particle size distribution is wide, and as polymers are synthesized, large aggregates or agglomerates are more likely to occur than large particles. In addition, polymers of narrow molecular weight distribution can be obtained, but high molecular weight particles are difficult to obtain.

British Polymer Journal (Brit. Polym. J., 14,131, 1982) is a spray polymerization method using alcohol as a solvent and quaternary ammonium salts as a dispersant for the preparation of relatively uniform polymer particles having a size of 1 탆 to 6 탆. Has been described.

In addition, the Journal of Polymer Science Polymer Letter (J. Polym. Sci. Polym. Lett, Ed., 23, 103, 1985) has polymicronized particles having a size of several micrometers using nonionic cellulose derivatives as spray stabilizers in various solvents. It was described with respect to the manufacturing method of.

On the other hand, Korean Patent 95-10230 (KR) has described a new precipitation polymerization method to swell the first synthesized cross-linked polymer in a solvent in order to obtain a monodisperse polymer gel of fine particles and to incorporate the monomer secondary in a limited space.

However, spherical polymer particles having a size of several micrometers to several tens of micrometers or more can be obtained by the emulsion polymerization, suspension polymerization, dispersion polymerization, and precipitation polymerization methods, but it is impossible to control the molecular weight, and the molecular weight distribution is wide and used. There is a problem that possible solvents and monomers are limited.

In addition, since the particle size distribution is polydisperse, when used as a column filler, there are disadvantages such as deterioration of column efficiency, pressure drop, and shortening of life due to fine particles, and poor reproducibility when used as an immobilizing agent for enzymes and antibodies in the biomedical field. .

Although several methods have been proposed for obtaining monodisperse polymer particles as described above, it is difficult to obtain uniform polymer particles of several micrometers to tens of micrometers or more, and the selection of monomers and solvents is limited.

Therefore, in order to synthesize monodisperse porous polymer particles of several micrometers to tens of micrometers or more, it is necessary to grow uniform seed particles having a size of μm synthesized by emulsion polymerization method to a required size with a suitable solvent to a required size. Required.

Accordingly, an object of the present invention is to provide a method for preparing a polymer particle having a porous structure in which the size of the particle can be precisely adjusted by solving the above problems and the particle size is uniform.

1 is a photograph showing the polymer produced in Preparation Example 1 by an electron microscope.

2 is a photograph showing an electron microscope of the polymer prepared in Preparation Example 2. FIG.

3 is a photograph showing an electron microscope of the polymer prepared in Preparation Example 3. FIG.

4 is a photograph showing an electron microscope of the polymer prepared in Preparation Example 4. FIG.

FIG. 5 is a photograph showing an electron microscope of the polymer particles prepared in Example 1. FIG.

6 is a photograph showing an electron microscope of the polymer particles prepared in Example 6.

Figure 7 is a photograph showing the electron micrograph of the polymer particles prepared in Example 11.

The present invention is to uniformly disperse and mix the media such as divinyl monomer, diluent, distilled water and the seed polymer as hydrophobic and hydrophilic monovinyl monomer, dispersion stabilizer, oil phase initiator, crosslinking agent in a solution using an ultrasonic wave generator Swelling the seed polymer uniformly dispersed in the solution by a dispersion stabilizer to a predetermined size with a diluent and a monomer to dissolve the media into the swollen seed, and bringing the solution to a temperature at which the reaction can occur. A porous polymer particle having a uniform particle size consisting of heating to cause a polymerization reaction and washing with an organic solvent and water to complete the polymerization reaction and to remove unreacted monomers, seeds, diluents and dispersion stabilizers. It is a manufacturing method of.

Hereinafter, the present invention will be described in detail.

The production method of the present invention uses a monodisperse linear or crosslinked seed polymer synthesized by emulsion polymerization, and swells the seed with a monomer and a diluent to increase particle size and uniform particle size distribution. It is a polymerization method which synthesize | combines.

Swelling the seed polymer through monomers and diluents is a useful material that is almost insoluble in water, and since the diluent is an organic solvent, it is not mixed with water. Thus, the diluent can dissolve the seed polymer and monomer. Hydrophobic monomers, such as butyl methacrylate and divinylbenzene, melt into the swollen seeds by mixing well with each other to swell the seeds. The extent to which the seed swells is thus determined by the amount of diluent and monomer added.

However, hydrophilic monomers such as acrylonitrile and vinylpyridine can be used using a method of reducing the solubility of the monomers in water using an electrolyte such as sodium chloride. It is important to reduce the solubility of the monomer because the monomers are dissolved in water and polymerized so that spherical particles are not obtained but are obtained in the form of agglomerates.

The polymer particles synthesized by the manufacturing method can be obtained as core-shell type or porous polymer particles having a large specific surface area, and the particle size distribution is monodisperse, thus eliminating the necessity of classification according to particle size. Because of the economic and reproducibility of the experiment.

In the above, the seed polymer is swellable with respect to the monomer, and the particle size is preferably about 0.1㎛ to 10㎛.

In the above, the monovinyl monomer used as a medium is styrene, methyl methacrylate, ethyl methacrylate, butyl methacrylate, glycidyl methacrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate , Lauryl acrylate, lauryl methacrylate, stearyl acrylate, stearyl methacrylate, butadiene, methyl acrylate, ethyl acrylate, glycidyl acrylate, butyl acrylate, vinyl acetate, vinyl pyridine, vinyl And vinyl monomers having hydrophilic and hydrophobic properties such as chloride, acrylic acid, acrylamide, or acrylonitrile.

The monovinyl monomer is added in the range of 0.01 to 50% by weight.

As another medium, the divinyl monomer as a crosslinking agent is divinylbenzene, ethylene glycol dimethacrylate, methylenebisacrylamide, methylenebismethacrylamide, divinyl methacrylate, divinyl acrylate, ethylene glycol divinyl ether , Acrylic acid anhydride or methacrylic anhydride.

Polymerization initiators include azo compounds such as azobisisobutyronitrile and azobisdimethylvaleronitrile or cumene hydroperoxide, t-butyl hydroperoxide, dicumyl peroxide, di-t-butyl peroxide, benzoyl peroxide and Peroxides such as lauroin peroxide and the like.

Dispersion stabilizers are used to improve the dispersibility of the seed polymer particles in the solvent and are selected from nonionic surfactants, anionic surfactants, cationic surfactants or amphoteric surfactants.

As the diluent, nonpolar solvents such as toluene, xylene, carbon tetrachloride, isoamyl alcohol or cyclohexane are used.

The seed polymer is styrene, -Methyl styrene, methyl methacrylate, ethyl methacrylate, butyl methacrylate, glycidyl methacrylate, hydroxyethyl acrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, lauryl acryl Latex, lauryl methacrylate, stearyl acrylate, stearyl methacrylate, methyl acrylate, ethyl acrylate, glycidyl acrylate, butyl acrylate, vinyl acetate, vinyl pyridine, vinyl chloride, acrylic acid, acrylamide Or acrylonitrile and the like.

The seed polymer is added in the range of 0.001 to 50% by weight.

In addition, the weight ratio of the monovinyl monomer to the seed polymer is preferably in the range of 1.0 to 100.

In addition, the weight ratio of the divinyl monomer to the monovinyl monomer is preferably in the range of 0.01 to 10.

In addition, the weight ratio of the diluent to the monovinyl monomer is preferably in the range of 0.1 to 10.

In addition, the seed polymerization can obtain polymer particles having particle size and characteristics suitable for the purpose according to the swelling conditions, the type, amount of the monomer and the concentration of the crosslinking agent, and can synthesize polymer particles having a porous structure with an increased surface area. Many applications are expected.

Hereinafter, the present invention will be described in more detail with reference to Examples.

[Production Example 1]

Dissolve 5.0 g of polyvinylpyrrolidone and 1.0 g of sodium dioctylsulfosuccinate in 200 ml of a mixture of ethanol / distilled water in a four-necked flask equipped with a stirrer, reflux cooler, nitrogen gas inlet, and a thermometer. Styrene polymer is produced by adding 0.15 g of azobisisobutyronitrile and reacting at 200 to 400 rpm for 4 hours at 50 to 70 캜.

The polymer obtained by the reaction was centrifuged, washed several times with methanol and dried to obtain 30 g of fine polymer particles having a uniform particle size. As shown in FIG. 1, the shape of the polymer observed under an electron microscope showed that the particle size was 1.0 μm, and the particle size distribution had a very narrow monodisperse form (FIG. 1).

[Production Example 2]

Dissolve 3.0 g of polyvinylpyrrolidone and 1.0 g of sodium dioctylsulfosuccinate in 200 ml of a mixture of ethanol / distilled water in a four-neck flask equipped with a stirrer, reflux condenser, nitrogen gas inlet, and a thermometer. Styrene polymer is produced by adding 0.15 g of azobisisobutyronitrile and reacting at 200 to 400 rpm for 4 hours at 50 to 70 캜.

The polymer obtained by the reaction was centrifuged, washed several times with methanol and dried to obtain 30 g of fine polymer particles having a uniform particle size. As shown in FIG. 2, the shape of the polymer observed by the electron microscope showed that the particle size was 1.5 μm, and the particle size distribution had a very narrow monodisperse form (FIG. 2).

[Manufacture example 3]

Dissolve 2.0 g of polyvinylpyrrolidone and 1.0 g of sodium dioctylsulfosuccinate in 200 ml of ethanol in a four-necked flask equipped with a stirrer, reflux cooler, nitrogen gas inlet, and a thermometer, and then 30.0 g of styrene and azobisisobuty. Styrene polymer is produced by adding 0.15 g of ronitrile and reacting at 200 to 400 rpm for 4 hours at 50 to 70 캜.

The polymer obtained by the reaction was centrifuged, washed several times with methanol and dried to obtain 30 g of fine polymer particles having a uniform particle size. As shown in FIG. 4, the shape of the polymer observed under an electron microscope showed that the particle size was 2.0 μm, and the particle size distribution had a very narrow monodisperse form (FIG. 3).

[Production Example 4]

Dissolve 1.5 g of polyvinylpyrrolidone and 1.0 g of sodium dioctylsulfosuccinate in 200 ml of ethanol in a four-necked flask equipped with a stirrer, reflux cooler, nitrogen gas inlet, and a thermometer, and then 30.0 g of styrene and azobisisobuty. Styrene polymer is produced by adding 0.15 g of ronitrile and reacting at 200 to 400 rpm for 4 hours at 50 to 70 캜.

The polymer obtained by the reaction was centrifuged, washed several times with methanol and dried to obtain 30 g of fine polymer particles having a uniform particle size. As shown in FIG. 4, the shape of the polymer observed under an electron microscope showed that the particle size was 3.5 μm, and the particle size distribution had a very narrow monodisperse form (FIG. 4).

Example 1

The polystyrene particles prepared in Preparation 1 were dispersed in a concentration of 0.05 g / ml in an aqueous 1.0 wt% polyvinyl alcohol solution, and a predetermined amount of the dispersed polystyrene was placed in a four-necked flask equipped with a mechanical stirrer, a reflux cooler, a nitrogen gas inlet device, and a thermometer. Of a mixed solution of butyl methacrylate, divinylbenzene, 2,2'-azobisdimethylvaleronitrile and toluene / isoamyl alcohol (oil layer), sodium dioctylsulfosuccinate and 1.0 wt% polyvinyl alcohol Prepare a mixed solution (aqueous layer). The mixed solution of the oil layer is added to the mixed solution of the aqueous layer and dispersed with an ultrasonic generator for about 1 hour while cooling with ice water until a white uniform suspension is obtained. While observing the shape of the dispersed remains with an optical microscope, using a dropping funnel is slowly dropped into the reactor for about 3 hours. Reaction mixture

The mixture was left for 24 hours with stirring at 200 rpm to 400 rpm to observe swelled styrene seed particles with a constant size under an optical microscope, and then reacted at 50 ° C. to 70 ° C. for 4 hours to obtain a polymer.

The polymer obtained by the above reaction was washed with distilled water and an organic solvent, filtered through a glass filter and dried to obtain fine polymer particles having a uniform particle shape and a porous structure on the particle surface.

The composition of the mediators used in the polymerization reaction is shown in Table 1, and the shape of particles observed with a scanning electron microscope is shown in FIG. As can be seen from the results shown in FIG. 5, the particles of the polymer obtained in this experiment had uniform particle sizes, and the average particle size was 2.8 μm, and the surface of the particles had a porous structure. (Figure 5)

Example 2

The polymer particles were obtained by experiment using the same method as the polymerization conditions used in Example 1 and changing the weight ratio of the added monomer / side. The results are shown in Table 1-a.

Example 3

Using the same method as the polymerization conditions used in Example 1 and experimenting while changing the weight ratio of the added monovinyl monomer and divinyl monomers to obtain a polymer particle. The results are shown in Table 1-b.

Example 4

The polymer particles were obtained by experiment using the same method as the polymerization conditions used in Example 1 and changing the type of the added diluent (organic solvent). The results are shown in Table 1-c.

Example 5

Using the same method as the polymerization conditions used in Example 1 and experimenting while changing the weight ratio of the added monomer / diluent (organic solvent) to obtain a polymer particle. The results are shown in Table 1-d.

Example 6

The polystyrene particles prepared in Preparation Example 1 were dispersed in a 1.0 wt% polyvinyl alcohol (hereinafter referred to as PVA) aqueous solution at a concentration of 0.05 g / ml, and a predetermined amount of the dispersed polystyrene was agitated, reflux cooler, nitrogen gas inlet apparatus, and temperature rP. Was added to a four-necked flask, and a mixed solution of acrylonitrile, ethylene glycol dimethacrylate, 2,2'-azobisdimethylvaleronitrile, and toluene (oil layer), 1.0 wt% aqueous polyvinyl alcohol solution, and 22.0 wt. Prepare a mixed solution of aqueous NaCl solution (aqueous layer).

The mixed solution of the oil layer is added to the mixed solution of the aqueous layer and dispersed with an ultrasonic generator for about 1 hour while cooling with ice water until a white uniform suspension is obtained. While observing the shape of the dispersed remains with an optical microscope, the dropping funnel is slowly dropped into the reactor for about 3 hours. Reaction mixture

The styrene seed particles swelled to a constant size by standing at 200rpm to 400rpm for 24 hours were observed under an optical microscope and then reacted at 50 ° C to 70 ° C for 4 hours to obtain a polymer.

The polymer obtained in the reaction was washed with distilled water and an organic solvent, filtered through a glass filter and dried to obtain fine polymer particles having a uniform particle shape and a porous structure on the particle surface.

In the polymerization reaction, the ratio of the mediators in the solution is shown in Table 2, and the shape of the particles observed with the scanning electron microscope is shown in FIG. As can be seen from the results shown in FIG. 6, the polymer obtained in this experiment had a uniform particle size, an average particle size of 5.2 μm, and the surface of the particle had a porous structure. 6

Example 7

Using the same method as the polymerization conditions used in Example 6, experiments were carried out while varying the weight ratio of the added monomer / side to obtain polymer particles. The results are shown in Table 2-a.

Example 8

Using the same method as the polymerization conditions used in Example 6, experiments were carried out while varying the weight ratio of the added monovinyl monomer / divinyl monomer to obtain polymer particles. The results are shown in Table 2-b.

Example 9

The polymer particles were obtained by experimenting using the same method as the polymerization conditions used in Example 6 while changing the type of the added diluent (organic solvent).

Example 10

Using the same method as the polymerization conditions used in Example 6, experiments were carried out while varying the ratio of the added monomer / diluent (organic solvent) to obtain polymer particles.

Example 11

The polystyrene particles prepared in Preparation Example 1 were dispersed in a 1.0 wt% polyvinyl alcohol solution at a concentration of 0.05 g / ml, and a predetermined amount of the dispersed polystyrene was added to a four-necked flask equipped with a stirrer, a reflux cooler, a nitrogen gas inlet apparatus, and a thermometer. A mixed solution (oil layer) of 4-vinylpyridine, divinylbenzene, 2,2'-azobisdimethylvaleronitrile and toluene / isoamyl alcohol was prepared and sodium dioctylsulfosuccinate, 1.0 wt% aqueous polyvinyl alcohol solution and 22.0 A mixed solution (aqueous layer) of a wt% aqueous NaCl solution is prepared.

The mixed solution of the oil layer is added to the mixed solution of the aqueous layer and dispersed with an ultrasonic generator for about 1 hour while cooling with ice water until a white uniform suspension is obtained. While observing the shape of the dispersed remains with an optical microscope, using a dropping funnel is slowly dropped into the reactor for about 3 hours. The reaction mixture was left at 200 rpm to 400 rpm for 24 hours to observe swelled styrene seed particles with a constant size under an optical microscope, and then reacted for 4 hours at 50 ° C to 70 ° C to obtain a polymer.

The polymer obtained in the reaction was washed with distilled water and an organic solvent, filtered through a glass filter and dried to obtain fine polymer particles having a uniform particle shape and a porous structure on the particle surface.

In the polymerization reaction, the ratio of the mediators in the solution is shown in Table 3, and the shape of the particles observed by the scanning electron microscope is shown in FIG. As can be seen from the results shown in FIG. 7, the polymer obtained in this experiment had uniform particle size, an average particle size of 3.7 μm, and the surface of the particle had a porous structure. 7

As shown in Table 1a-d and Table 2 ac, the Seed polymerization is performed in a relatively simple manner by uniform homogeneous polymer particles having particle size and characteristics suitable for the purpose according to the type and amount of the seed polymer, monomer, diluent and the like. You can get along.

As described above, the method of preparing the porous polymer particles of the present invention can produce the polymer particles in a relatively simple manner at a low cost, and introduce a substituent into the polymer particles by the surface properties and chemical modification of the particles, thereby introducing a polymer having ion adsorption capacity and selectivity. Particles can be prepared.

In addition, since the prepared porous polymer particles have a large surface area, they are widely used in diagnostic medicines, drug carriers, carriers of catalysts and enzymes, and separation and purification of genes, and are particularly applicable to the prevention of environmental pollution by heavy metals, which is a problem due to rapid industrialization. It is expected to be of great industrial value.

Claims (12)

Dispersing and mixing the hydrophobic and hydrophilic monovinyl monomers, dispersion stabilizers, oil phase initiators, and mediators such as divinyl monomers, diluents, distilled water and seed polymers uniformly in a solution using an ultrasonic wave generator, dispersion stabilizers Swelling the seed polymer uniformly dispersed in the solution by a diluent and a monomer to a certain size, dissolving the media into the swollen seed, and heating the solution to a temperature at which the reaction can occur. Method for producing a porous polymer particles having a uniform particle size consisting of the step of causing a reaction, and washing with an organic solvent and water in order to complete the polymerization reaction and remove unreacted monomers, seeds, diluents and dispersion stabilizers. . According to claim 1, wherein the monovinyl monomer is styrene, methyl methacrylate, ethyl methacrylate, butyl methacrylate, glycidyl methacrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate , Lauryl acrylate, lauryl methacrylate, stearyl acrylate, stearyl methacrylate, butadiene, methyl acrylate, ethyl acrylate, glycidyl acrylate, butyl acrylate, vinyl acetate, vinyl pyridine, vinyl A method for preparing porous polymer particles having a uniform particle size comprising chloride, acrylic acid, acrylamide or acrylonitrile. The method of claim 1, wherein the divinyl monomer is divinylbenzene, ethylene glycol methacrylate, methylene bis methacrylate, methylene bis methacrylate, divinyl methacrylate, divinyl acrylate, ethylene glycol divinyl A method for producing porous polymer particles having a uniform particle size comprising ether, acrylic acid anhydride or methacrylic anhydride. The method of claim 1, wherein the polymerization initiator is azo compounds such as azobisisobutyronitrile, azobisdimethylvaleronitrile or cumene hydroperoxide, t-butyl hydroperoxide, dicumyl peroxide, di-t-butylper A method for producing porous polymer particles having a uniform particle size, including peroxides such as oxides, benzoyl peroxides and lauroin peroxides. The method of claim 1, wherein the dispersion stabilizer is a nonionic surfactant, anionic surfactant, cationic surfactant, or amphoteric surfactant. The method of claim 1, wherein the diluent comprises toluene, xylene, carbon tetrachloride, isoamyl alcohol or cyclohexane. The method of claim 1, wherein the seed polymer is styrene, -Methyl styrene, methyl methacrylate, ethyl methacrylate, butyl methacrylate, glycidyl methacrylate, hydroxyethyl acrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, lauryl acryl Latex, lauryl methacrylate, stearyl acrylate, stearyl methacrylate, methyl acrylate, ethyl acrylate, glycidyl acrylate, butyl acrylate, vinyl acetate, vinyl pyridine, vinyl chloride, acrylic acid, acrylamide Or a method for producing a porous polymer particles of uniform particle size comprising acrylonitrile. The method of claim 1, wherein the monomer is added in the range of 0.01 to 50% by weight. The method of claim 1, wherein the seed polymer is added in a range of 0.001 to 50% by weight. The method of claim 1, wherein the weight ratio of the monomer to the seed polymer is 1.0 to 100. The method of claim 1, wherein the weight ratio of the divinyl monomer to the monovinyl monomer is 0.01 to 10. The method of claim 1, wherein the weight ratio of the diluent to the monomer is 0.1 to 10.