KR100194524B1 - Antifungal Toilet Soap Composition - Google Patents

Abstract

The present invention relates to the preparation of a composition by containing one or two or more antifungal agents selected from iodine propynylbutylcarbamate, thiabendazole and hexaamidine diethionate, keratin exfoliation / softener and pH adjusting agent in a cosmetic soap cleaner. It relates to an antifungal cosmetic soap composition which has a weak acidity similar to the pH of the skin, maintains the stability of the active ingredient, and safely prevents or treats athlete's foot.

Description

[Name of invention]

Antifungal Toilet Soap Composition

Detailed description of the invention

[Purpose of invention]

The present invention relates to an antifungal cosmetic soap composition having a prophylactic and therapeutic effect of athlete's foot by using a conventional cosmetic soap. In more detail, the present invention comprises an antifungal agent, a keratin peeling / softening agent and a pH adjusting agent in the cleaning base of the cosmetic soap using a mixture of the mastication cleaning component and a weak alkaline salt of higher fatty acids, the liquidity of which is similar to the pH of the skin As weakly acidic, the present invention relates to an antifungal cosmetic soap composition that continuously maintains the stability of an active ingredient and safely prevents or treats athlete's foot.

[Technical field to which the invention belongs and the prior art in that field]

In general, Athlete's foot is a kind of fungus that grows in moist, warm, and dirty places such as the human foot, and the skin penetrates the stratum corneum, causing sebum, cracks, odors and itching, and thereby causing a wound. Have

There are many kinds of such athlete's foot, but are classified into three types according to the generation site and type of athlete's foot. Bones are the most common form of athlete's foot and occur well in the 3rd and 4th zones, and show cracks, odors and severe pruritus. The hydrophobic form is characterized by small blisters remaining on the sole and its periphery and severe itching at blister formation. In addition, the keratin type is a chronic refractory type in which the sole of the foot is angled, dried, and cracks occur. Representative athlete's foot causing bacteria are known as T. Mentagrophytes, T. Rubrum, and Epidermophyton Flocosum (E. Floccosum), generally penetrating the skin It is not easy to cure athlete's foot because it breeds.

Folk remedies that are orally transmitted for treating athlete's foot are known to treat athlete's foot by soaking feet in water mixed with vinegar for a long time, but it is not easy to control the concentration, so if the concentration is high, the foot may be burned. There is a risk that this can lead to other complications. In addition, there are a lot of liquid or creamy athlete's foot treatment, but by stopping the treatment due to the discomfort of the drug administration method and the time limit for the therapeutic effect, the athlete's foot recurs easily, it is difficult to cure. In addition, athletes with athlete's foot tend to avoid using cosmetic soap because the athlete's foot is worsened when regular foot soap is used. Since the liquidity of the aqueous soap solution is weakly alkaline, when using soap, the pH of the slightly acidic skin instantly rises, and is restored to its original pH by its acid mentle maintenance. This is known to be active.

[Technical problem to be achieved]

Therefore, the present inventors have studied the characteristics related to athlete's foot as described above. As a result, the continuous and effective treatment of athlete's foot penetrating the stratum corneum is a weakly acidic combination of antifungal agents that can exfoliate / soften the stratum corneum and sterilize the athlete's foot. Technically applied to the cosmetic soap cleaning agent, the present invention was completed by remarking the surprising fact that it is possible to maintain a clean foot state as a daily use of cosmetic soap and to prevent or cure athlete's foot by continuous sterilization of athlete's foot.

[Configuration and Function of Invention]

The present invention relates to a cosmetic soap composition characterized in that it contains 0.1 to 5.0% by weight of antifungal agent, 4.0 to 30.0% by weight of keratin exfoliation / softener and 0.1 to 6.0% by weight of pH adjuster.

The present invention is described in detail as follows.

In the present invention, the cosmetic soap cleaning agent may be used alone or a mixture of the mild alkaline salt of the mild fatty acid and the hypoallergenic cleaning component. The hypoallergenic cleaning component includes one or two or more alkali salts of acyl isethionic acid, acyl sulfosuccinic acid, acyl sacosuccinic acid, acylalkyltauric acid and acyl glutamic acid, wherein the alkali salts are sodium, potassium or triethanolamine. Although mixed may be used, sodium cocoyl isethionate is used in the examples and comparative examples of the present invention.

The weak alkali salts of higher fatty acids used in the present invention are acid alkali neutralization of higher fatty acids having 8 to 20 carbon atoms and higher sodium and potassium, triethanolamine derived from animal and vegetable fats and oils such as tallow, lard, fish oil, palm oil, palm oil and palm kernel oil. Although there is a weak alkali salt obtained by the reaction, sodium stearate is used in Examples and Comparative Examples of the present invention.

Antifungal agent in the cosmetic soap composition of the present invention by mixing one or two or more selected from iodopropynylbutylcarbamate, thiabendazole, hexamidine diisethionate use. The antifungal agent used in the present invention has an excellent antifungal effect, and the three antifungal effects were similar to each other. The antifungal agent in the cosmetic soap composition of the present invention is preferably used 0.1 to 5.0% by weight. If the antifungal agent is used less than 0.1% by weight, there is almost no antifungal effect of the soap, when the antifungal agent is used more than 5.0% by weight, the antifungal effect is excellent, but the time-lapse stability of the soap worsens, so the initial color of the soap turns brown.

In the cosmetic soap composition of the present invention, the keratin exfoliation / softener is a higher fatty acid having 8 to 20 carbon atoms or less derived from animal or vegetable fats and oils such as tallow, lard, fish oil, palm oil, palm oil, palm kernel oil, and the like. It can be mixed and used. In the present invention, the keratin exfoliation / softener is preferably contained in the range of 4.0 to 30.0% by weight. If less than 4.0% by weight of keratin exfoliation / softener is used, the exfoliation / softening effect is not sufficiently exhibited. If it is used more than 30.0% by weight, soap is soft, sticky, difficult to mold, extruded and molded to prepare soap. You will not be able to. In Examples and Comparative Examples of the present invention, lauric acid and palm oil fatty acid were used alone or in combination.

In the present invention, the pH adjusting agent is one or two or more of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, gluconic acid, and the like, or one or two or more beta hydroxy acids such as salicylic acid and serine. Can be used mixed. In the present invention, the pH adjuster preferably contains 0.1 to 6.0% by weight. The pH adjuster has a slight pH difference depending on the type of acid used, but when used below 0.1% by weight, the pH of the composition is greater than 7.0, and when used above 6.0% by weight, the pH of the composition is less than 5.5. This results in poor color stability of the composition over time, which is presumed to be a phenomenon in which the cleaning components are hydrolyzed by the excessive use of the pH adjuster.

In addition, the cosmetic soap composition of the present invention can be used as a binder organic salts and inorganic salts, and may also be used in combination with an emulsifier, a flavoring agent, a pigment, a metal ion blocking agent and an antioxidant.

The cosmetic soap composition of the present invention can be prepared according to a general method of manufacturing cosmetic soap. First, in the amalgamator, stir-mix the hypoallergenic cleaning component, the weak alkali salt of higher fatty acid, and other additives, and slowly add the dissolve and dissolve the antifungal agent and the pH adjuster in the keratin exfoliation / softener (if necessary, a small amount of water and emulsifier) May be used), and then passed through a roll mill so that the compositions may be uniformly mixed, and then molded, extruded, cut and shaped to prepare a cosmetic soap composition having a uniform shape.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the technical scope of the present invention is not limited thereto.

Example 1

53.0% by weight of sodium cocoyl isethionate, 7.0% by weight of sodium stearate, 9.2% by weight of purified water, 0.3% by weight of titanium dioxide, and 1.0% by weight of perfume are placed in an amalgamator and slowly mixed and stirred therein. 0.5% by weight of iodopropynylbutylcarbamate and 3.5% by weight of glycolic acid are added by dispersing and dissolving in 20.5% by weight of palm oil fatty acid and 5.0% by weight of lauric acid, and uniformly mixed with a roll mill to form, Extruded, cut and molded to prepare a cosmetic soap composition of a uniform shape.

Example 2-6 and Comparative Example 1-5

Example 2-3 and Comparative Example 1-5 are prepared by the same cosmetic method as in Example 1 according to the ingredients and contents shown in Table 1 below.

Experiment method

The cosmetic soap compositions of Example 1-6 and Comparative Example 1-5 prepared as described above were measured for the exfoliation / swallowing effect, antifungal effect, workability, time stability and pH according to the following experimental method.

1) keratin exfoliation / softening effect

In the present invention, keratin exfoliation / softening effect was put into a hilltop chamber with 0.4 ml of 10% dihydroxyacetone solution for 15 adults and attached to the upper inner part of the arm for 1 hour, and then removed and colored. After 6 hours, the dihydroxyacetone solution is repeatedly treated to increase the degree. After 24 hours, the dihydroxy acetone solution is measured before and after the color difference meter. The color change is measured by ΔE value every day while applying a sample of 8% aqueous solution, and when the degree of discoloration becomes the same as the initial skin, it is regarded as the exfoliation / softening effect. The keratin exfoliation / softening effect means that the lower the numerical value, the better the effect. The ΔE value calculates the L, a, and b values measured by the color difference meter by the following equation.

ΔE = `` (△ L) + (Δa) + (Δb) } Where n = 1/2

2) antifungal effect

Antifungal effect was determined by diluting each sample by concentration and inoculating each athlete's foot fungus by diluting solid plate culture medium. The minimum growth inhibitory concentration (M.I.C) of each bacterium was measured. The smaller the value, the better the antifungal effect. As a result of measuring the minimum growth inhibitory concentration of the bacteria against the antifungal agent itself that can be used in the present invention was shown as follows. The minimum growth inhibitory concentration of the bacteria for each antifungal agent is similar to each other, and its antifungal effect is very good.

The workability is evaluated based on the following criteria when the soap is stuck to the machine in the molding, extrusion and mold state when the soap is manufactured by the manufacturing process of the general fatty acid cosmetic soap.

4) Stability over time

Each sample is stored for 3 months in a room temperature and 40 ° C humidity chamber, and the raw material change of the sample is visually compared with the stored sample at a weekly interval.

5) pH measurement

In pH measurement, 1% aqueous solution of the sample was measured with a pH ion meter. In addition, the pH change results according to the content of glycolic acid and citric acid for Example 1 were as follows.

The test results are shown in Table 2 below.

As can be seen from the experimental results of Table 2, the minimum growth inhibitory concentration of the bacteria in the antifungal effect is slightly different depending on the amount of the antifungal agent used, considering the soap use concentration and the minimum bactericidal concentration of the bacteria, the experiment As a result, the antifungal agent of the present invention should be used at least 0.1% by weight, and should not exceed 5% by weight because of poor stability over time. A clinical trial of the cosmetic soap composition of Example 1 for 20 athletes' athletes showed a cure rate of about 75%.

The exfoliation / softening effect is excellent as the content of higher fatty acid increases, and should not exceed 30% by weight in consideration of workability. In addition, the pH of each cosmetic soap adjuster shows a pH difference depending on the content of the cleaning agent and the pH adjuster, but considering the stability in the present invention, the content of the pH adjuster for adjusting similar to the skin pH is 0.1 to 6.0 The weight percentages were found to be appropriate.

Claims (5)

0.1 to 5.0% by weight of one or two or more antifungal agents selected from iodopropynylbutylcarbamate and thiabendazole and hexaamidinediisethionate, and 4.0 to 30.0% by weight of keratin exfoliation / softener And 0.1 to 6.0% by weight of a pH adjuster. The cosmetic soap composition according to claim 1, wherein the cosmetic soap cleaning agent is a hypoallergenic cleaning component alone or a mixture of the hypoallergenic cleaning component and a weak alkali salt of a higher fatty acid. The cosmetic soap composition according to claim 1, wherein the exfoliating / softening agent is a C8-20 higher fatty acid derived from animal or vegetable fats and oils such as tallow, lard, fish oil, palm oil, palm oil, palm kernel oil. The cosmetic soap composition of claim 1 wherein the pH adjuster is alpha hydroxy acids and / or beta hydroxy acids. The cosmetic soap composition according to claim 1 or 4, wherein the liquidity of the composition is pH 5.5 to less than pH 7.0.