KE3168A - Spirohydantoins - Google Patents

Spirohydantoins

Info

Publication number: KE3168A
Authority: KE; Kenya
Prior art keywords: spirohydantoins
Prior art date: 1977-05-23

Application number

KE3168A

Other languages

English (en)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-05-23

Filing date

1981-10-15

Publication date

1981-11-06

1981-10-15 Application filed by Pfizer filed Critical Pfizer

1981-11-06 Publication of KE3168A publication Critical patent/KE3168A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

KE3168A 1977-05-23 1981-10-15 Spirohydantoins KE3168A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/799,586 US4130714A (en)	1977-05-23	1977-05-23	Hydantoin therapeutic agents

Publications (1)

Publication Number	Publication Date
KE3168A true KE3168A (en)	1981-11-06

Family

ID=25176274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KE3168A KE3168A (en)	1977-05-23	1981-10-15	Spirohydantoins

Country Status (37)

Country	Link
US (1)	US4130714A (xx)
JP (1)	JPS6035350B2 (xx)
AR (1)	AR219531A1 (xx)
AT (1)	AT357170B (xx)
AU (1)	AU499518B1 (xx)
BE (1)	BE867248A (xx)
CA (1)	CA1088073A (xx)
CH (1)	CH631455A5 (xx)
CS (1)	CS200550B2 (xx)
DD (1)	DD137107A5 (xx)
DE (2)	DE2858042C2 (xx)
DK (1)	DK147941C (xx)
EG (1)	EG13691A (xx)
ES (1)	ES470070A1 (xx)
FI (1)	FI62838C (xx)
FR (1)	FR2392024A1 (xx)
GB (1)	GB1572688A (xx)
GR (1)	GR68694B (xx)
HK (1)	HK53981A (xx)
HU (1)	HU177718B (xx)
IE (1)	IE47273B1 (xx)
IL (1)	IL54754A (xx)
IN (1)	IN147854B (xx)
IT (1)	IT1096306B (xx)
KE (1)	KE3168A (xx)
LU (1)	LU79685A1 (xx)
MY (1)	MY8200156A (xx)
NL (1)	NL7804158A (xx)
NO (1)	NO150206C (xx)
NZ (1)	NZ187334A (xx)
PH (1)	PH13828A (xx)
PL (1)	PL110460B1 (xx)
PT (1)	PT68071B (xx)
SE (1)	SE437375B (xx)
SU (1)	SU873885A3 (xx)
YU (1)	YU40829B (xx)
ZA (1)	ZA782919B (xx)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1088945A (en) *	1976-10-18	1980-11-04	Pfizer Limited	Hydantoin derivatives as therapeutic agents
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4210667A (en) *	1979-04-19	1980-07-01	Pfizer Inc.	Pharmaceutical preparations containing coumarin carboxylic acid derivatives
AU532110B2 (en) *	1979-11-13	1983-09-15	Ici Ltd.	Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
US4248882A (en) *	1980-02-12	1981-02-03	Pfizer Inc.	Treating diabetes-associated complications with hydantoin amines
US4286098A (en) *	1980-03-28	1981-08-25	Pfizer Inc.	Process for the preparation of chiral hydantoins
JPS5745185A (en) *	1980-07-21	1982-03-13	Eisai Co Ltd	Hydantoin derivative and its preparation
US4419521A (en) *	1981-11-12	1983-12-06	Pfizer Inc.	6-Halo-4-chromanamines useful as intermediates to make chiral hydantoins
JPS58124788A (ja) *	1982-01-20	1983-07-25	Eisai Co Ltd	光学活性ヒダントイン誘導体，その製造方法ならびにそれを含有する治療用薬剤
US4464385A (en) *	1982-04-15	1984-08-07	Alcon Laboratories, Inc.	Treatment of diabetic complications with hydantoins
US4436745A (en)	1982-04-15	1984-03-13	Alcon Laboratories, Inc.	Method of inhibiting aldose reductase activity
US4540700A (en) *	1982-04-15	1985-09-10	Alcon Laboratories, Inc.	Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4438272A (en)	1982-04-15	1984-03-20	Alcon Laboratories, Inc.	Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
US4431828A (en) *	1982-11-10	1984-02-14	Pfizer Inc.	Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil
US4528387A (en) *	1982-11-10	1985-07-09	Pfizer Inc.	Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid
US4556670A (en) *	1982-12-06	1985-12-03	Pfizer Inc.	Spiro-3-hetero-azolones for treatment of diabetic complications
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
US5153211A (en) *	1983-09-14	1992-10-06	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4537892A (en) *	1983-09-14	1985-08-27	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
DE3561198D1 (en) *	1984-03-23	1988-01-28	Pfizer	Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
US4717725A (en) *	1984-04-11	1988-01-05	Alcon Laboratories, Inc.	Ophthalmic wound healing with aldose reductase inhibitors
US4600717A (en) *	1984-04-11	1986-07-15	Alcon Laboratories, Inc.	Aldose reductase inhibitors useful in ophthalmic wound healing
JPH06772B2 (ja) *	1984-07-09	1994-01-05	鐘淵化学工業株式会社	３―（４―フルオロフエノキシ）プロピオニトリルを用いる６―フルオロ―４―クロマノンの製造法
US4680306A (en) *	1984-07-20	1987-07-14	Pfizer Inc.	Sprio-imidazolones for treatment of diabetes complications
WO1986001107A1 (en) *	1984-08-14	1986-02-27	Pfizer Inc.	Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making
DE3565105D1 (en) *	1984-08-20	1988-10-27	Pfizer	Process for the production as asymmetric hydantoins
US4620019A (en) *	1984-08-23	1986-10-28	Pfizer Inc.	S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil
US4609663A (en) *	1984-09-11	1986-09-02	Alcon Laboratories, Inc.	Aldose reductase inhibitors useful in glaucoma therapy
US4551542A (en) *	1984-09-26	1985-11-05	Pfizer Inc.	Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
US4966911A (en) *	1984-11-20	1990-10-30	Washington Research Foundation	Immunoregulatory agents
US5340829A (en) *	1984-11-20	1994-08-23	Washington Research Foundation	Immunoregulatory agents
JPS61200991A (ja) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
WO1986007353A1 (en)	1985-06-14	1986-12-18	Pfizer Inc.	Intermediate in the production of an asymmetric hydantoin
JPS627654U (xx) *	1985-06-26	1987-01-17
US4853410A (en) *	1986-01-17	1989-08-01	Pfizer Inc.	Hydroxyacetic acid derivatives for the treatment of diabetic complications
JPS6357588A (ja) *	1986-08-28	1988-03-12	Sanwa Kagaku Kenkyusho Co Ltd	ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPH01503460A (ja) *	1987-03-20	1989-11-22	アルコン　ラボラトリーズ、インコーポレイテツド	糖尿病における、インシュリン感受性を増強させるためのアルドース還元酵素阻害剤の使用
US4841079A (en) *	1987-08-07	1989-06-20	Pfizer, Inc.	Process for the production of asymmetric hydantoins
US4952694A (en) *	1988-07-27	1990-08-28	Pfizer Inc.	Novel resolution process for racemic spiro-hydantoins
US5006657A (en) *	1988-07-27	1991-04-09	Pfizer Inc.	Intermediates in a resolution process for racemic spiro hydantoins
AU617541B2 (en) *	1988-10-20	1991-11-28	Wyeth	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
JPH05508386A (ja) *	1989-02-10	1993-11-25	ワシントン　リサーチ　ファンデション	免疫調整剤
US4980357A (en) *	1990-03-01	1990-12-25	Pfizer Inc.	Azolidinedione derivatives
US5039672A (en) *	1990-04-05	1991-08-13	Pfizer Inc.	Heterocyclic compounds as aldose reductase inhibitors
US5236945A (en) *	1990-06-11	1993-08-17	Pfizer Inc.	1H-indazole-3-acetic acids as aldose reductase inhibitors
US5206367A (en) *	1992-02-18	1993-04-27	Pfizer Inc.	Preparation of optically active spiro-hydantoins
KR950703539A (ko) *	1992-09-28	1995-09-20	알렌 제이. 스피겔	당뇨병 합병증 치료용 치환된 피리미딘(substituted pyrimidines for control or diabetic complications)
US5521208A (en) *	1993-07-29	1996-05-28	Alcon Laboratories, Inc.	Compositions and methods for the treatment of the metabolically impaired and for improved compliance
CN100378118C (zh) *	1997-04-15	2008-04-02	Csir公司	具有食欲抑制剂活性的药物组合物
GB2355657B (en) *	1999-10-27	2004-07-28	Phytopharm Plc	Inhibitors Of Gastric Acid Secretion
GB2363985B (en)	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
AU2002215160A1 (en)	2000-11-30	2002-06-11	Pfizer Products Inc.	Combination of gaba agonists and aldose reductase inhibitors
US20110092566A1 (en) *	2004-11-19	2011-04-21	Srivastava Satish K	Treatment of cancer with aldose reductase inhibitors
US8158667B2 (en)	2006-08-21	2012-04-17	Kador Peter F	Topical treatment of cataracts in dogs
EP2368560A1 (en)	2007-03-12	2011-09-28	Zadec ApS	An anti-diabetic extract of rooibos
EP2848252A3 (en)	2007-03-23	2015-06-17	The Board of Regents of the University of Texas System	Aldose reductase inhibitors for use in treating uveitis
US20090270490A1 (en) *	2008-04-24	2009-10-29	The Board Of Regents Of The University Of Texas System	Methods involving aldose reductase inhibition
AU2011348074B2 (en)	2010-12-23	2016-04-28	The Board Of Regents Of The University Of Texas System	Methods for treating COPD
UA118035C2 (uk) *	2013-10-07	2018-11-12	Сінгента Партісіпейшнс Аг	Гербіцидні сполуки
WO2019165195A1 (en)	2018-02-22	2019-08-29	Srivastava Satish	Combination therapy for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2683718A (en) *	1952-01-11	1954-07-13	Searle & Co	Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione
DE1135915B (de) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
CA1088945A (en) *	1976-10-18	1980-11-04	Pfizer Limited	Hydantoin derivatives as therapeutic agents

1977
- 1977-05-23 US US05/799,586 patent/US4130714A/en not_active Expired - Lifetime
1978
- 1978-03-30 SE SE7803626A patent/SE437375B/sv not_active IP Right Cessation
- 1978-04-15 IN IN272/DEL/78A patent/IN147854B/en unknown
- 1978-04-19 NL NL7804158A patent/NL7804158A/xx active Search and Examination
- 1978-04-19 PH PH21026A patent/PH13828A/en unknown
- 1978-05-11 CS CS783021A patent/CS200550B2/cs unknown
- 1978-05-13 JP JP53057064A patent/JPS6035350B2/ja not_active Expired
- 1978-05-16 PL PL1978206826A patent/PL110460B1/pl unknown
- 1978-05-16 YU YU1169/78A patent/YU40829B/xx unknown
- 1978-05-17 SU SU782616255A patent/SU873885A3/ru active
- 1978-05-17 HU HU78PI625A patent/HU177718B/hu not_active IP Right Cessation
- 1978-05-18 DD DD78205450A patent/DD137107A5/xx unknown
- 1978-05-18 GB GB20352/78A patent/GB1572688A/en not_active Expired
- 1978-05-18 AR AR272227A patent/AR219531A1/es active
- 1978-05-19 CA CA303,740A patent/CA1088073A/en not_active Expired
- 1978-05-19 DE DE2858042A patent/DE2858042C2/de not_active Expired
- 1978-05-19 BE BE187841A patent/BE867248A/xx not_active IP Right Cessation
- 1978-05-19 AT AT365378A patent/AT357170B/de not_active IP Right Cessation
- 1978-05-19 DE DE2821966A patent/DE2821966C2/de not_active Expired
- 1978-05-20 GR GR56282A patent/GR68694B/el unknown
- 1978-05-20 EG EG320/78A patent/EG13691A/xx active
- 1978-05-22 IT IT23672/78A patent/IT1096306B/it active
- 1978-05-22 LU LU79685A patent/LU79685A1/xx unknown
- 1978-05-22 IE IE1015/78A patent/IE47273B1/en not_active IP Right Cessation
- 1978-05-22 CH CH552778A patent/CH631455A5/fr not_active IP Right Cessation
- 1978-05-22 IL IL54754A patent/IL54754A/xx not_active IP Right Cessation
- 1978-05-22 FI FI781613A patent/FI62838C/fi not_active IP Right Cessation
- 1978-05-22 NO NO781769A patent/NO150206C/no unknown
- 1978-05-22 ZA ZA00782919A patent/ZA782919B/xx unknown
- 1978-05-22 ES ES470070A patent/ES470070A1/es not_active Expired
- 1978-05-22 DK DK226778A patent/DK147941C/da not_active IP Right Cessation
- 1978-05-22 PT PT68071A patent/PT68071B/pt unknown
- 1978-05-22 NZ NZ187334A patent/NZ187334A/en unknown
- 1978-05-22 FR FR7815032A patent/FR2392024A1/fr active Granted
- 1978-05-22 AU AU36328/78A patent/AU499518B1/en not_active Expired
1981
- 1981-10-15 KE KE3168A patent/KE3168A/xx unknown
- 1981-11-05 HK HK539/81A patent/HK53981A/xx unknown
1982
- 1982-12-30 MY MY156/82A patent/MY8200156A/xx unknown

Also Published As

Publication number	Publication date
PT68071A (en)	1978-06-01
CS200550B2 (en)	1980-09-15
FI62838B (fi)	1982-11-30
AU499518B1 (en)	1979-04-26
FR2392024B1 (xx)	1981-07-24
NO781769L (no)	1978-11-24
HK53981A (en)	1981-11-13
FI781613A (fi)	1978-11-24
IE781015L (en)	1978-11-23
FI62838C (fi)	1983-03-10
EG13691A (en)	1982-12-31
IN147854B (xx)	1980-07-19
CA1088073A (en)	1980-10-21
BE867248A (fr)	1978-11-20
IT7823672A0 (it)	1978-05-22
NO150206B (no)	1984-05-28
IT1096306B (it)	1985-08-26
US4130714A (en)	1978-12-19
LU79685A1 (fr)	1979-12-06
YU116978A (en)	1983-02-28
IL54754A0 (en)	1978-07-31
PL206826A1 (pl)	1979-04-23
DE2821966C2 (de)	1983-06-01
JPS6035350B2 (ja)	1985-08-14
AT357170B (de)	1980-06-25
DK226778A (da)	1978-11-24
DD137107A5 (de)	1979-08-15
DK147941B (da)	1985-01-14
DK147941C (da)	1985-08-26
HU177718B (en)	1981-12-28
CH631455A5 (fr)	1982-08-13
IE47273B1 (en)	1984-02-08
DE2858042C2 (de)	1983-11-24
PT68071B (en)	1979-10-26
NZ187334A (en)	1984-04-27
GB1572688A (en)	1980-07-30
ZA782919B (en)	1979-06-27
DE2821966A1 (de)	1978-11-30
ATA365378A (de)	1979-11-15
FR2392024A1 (fr)	1978-12-22
JPS53144575A (en)	1978-12-15
SU873885A3 (ru)	1981-10-15
ES470070A1 (es)	1979-01-01
NL7804158A (nl)	1978-11-27
PL110460B1 (en)	1980-07-31
GR68694B (xx)	1982-02-01
YU40829B (en)	1986-06-30
NO150206C (no)	1984-09-05
SE7803626L (sv)	1978-11-24
MY8200156A (en)	1982-12-31
SE437375B (sv)	1985-02-25
IL54754A (en)	1982-04-30
AR219531A1 (es)	1980-08-29
PH13828A (en)	1980-10-07

Publication	Publication Date	Title
MY8200156A (en)	1982-12-31	Spirohydantoins
CS343178A2 (en)	1988-06-15	Plynova turbina
AU4201478A (en)	1979-06-07	Step-stools
CS7801289A2 (en)	1984-02-13	Zpusob deleni smesi nukleovych kyselin
AU515984B2 (en)	1981-05-14	4-substituted-pyrazoles
AU3526278A (en)	1979-10-25	L-sucrose
AU3728978A (en)	1980-01-03	Sulfamoyl-aryl-ketones
AU4022878A (en)	1980-04-03	Thiopropionamides
AU3828478A (en)	1980-01-31	Benzodiazepine-diones
AU4286678A (en)	1979-07-05	4a-aryl-octahydro-1h-2-pyrindines
CS541878A1 (en)	1985-05-15	Zpusob vyroby tricyklickych derivatu pyrimidinu
AU3785078A (en)	1980-01-10	Piperidino-propanols
AU3918778A (en)	1980-02-28	Beta-substituted-diketones
AU3939078A (en)	1980-03-06	2-chlorosulfinylazetidin-4-ones
AU3939978A (en)	1980-03-06	2-guanidinomethyl-indoline
AU4255778A (en)	1979-06-21	3-di-n-propyl-acetoxy-benzodiazepin-2-ones
AU4026278A (en)	1980-04-03	Thienobenzazepines
AU4216378A (en)	1979-06-14	Antibiotic-a-40104
BG28612A1 (en)	1980-06-16	Auto- train
AU3774978A (en)	1980-01-10	Butyl-p-benzoylbenzoates
AU4225778A (en)	1979-06-21	Imino-bridged benzocycloheptapyridines
AU3845478A (en)	1980-01-31	Isoquinoline-diones
GB1540961A (en)	1979-02-21	Clockradio-recorder
AU520181B2 (en)	1982-01-21	Lkylthiophenoxypropanolamines
AU3374278A (en)	1979-09-06	Flag-wave