JPWO2021078832A5 - - Google Patents
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- JPWO2021078832A5 JPWO2021078832A5 JP2022523916A JP2022523916A JPWO2021078832A5 JP WO2021078832 A5 JPWO2021078832 A5 JP WO2021078832A5 JP 2022523916 A JP2022523916 A JP 2022523916A JP 2022523916 A JP2022523916 A JP 2022523916A JP WO2021078832 A5 JPWO2021078832 A5 JP WO2021078832A5
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ここで、本開示のいくつかの実施形態を、添付の図面を参照しながら単に非限定的な例として説明する。
本発明は、例えば、以下を提供する。
（項目１）
作動流体と第１の流体交換媒体との間の物質移動、及び同じ作動流体と前記第１の流体交換媒体とは異なる第２の流体交換媒体との間の物質移動のための作動流体処理装置であって、
前記作動流体処理装置は、
前記第１の流体交換媒体を前記作動流体処理装置に入れる集合的な第１の流体交換媒体入口と、
前記第１の流体交換媒体入口から流体的に分離され、前記第２の流体交換媒体を前記作動流体処理装置に入れる集合的な第２の流体交換媒体入口と、
統合された作動流体処理チャンバと、を備え、
前記チャンバは、
作動流体入口と、
作動流体出口と、
前記作動流体入口と前記作動流体出口との間に配置された第１の物質移動導管の第１の導管群であって、
前記第１の導管群は、
前記第１の流体交換媒体を前記第１の導管群に受け入れる入口端部と、
使用済みの第１の流体交換媒体を前記第１の導管群から排出する出口端部と、を有しており、
前記第１の導管群は、前記第１の流体交換媒体が前記第１の導管群を通って流れるときに、前記作動流体を用いて第１の物質の物質移動を実行する、第１の導管群と、
前記作動流体入口と前記作動流体出口との間に配置された第２の物質移動導管の第２の導管群とを含み、
前記第２の導管群は、
前記第２の流体交換媒体を前記第２の導管群に受け入れる入口端部と、
使用済みの第２の流体交換媒体を前記第２の導管群から排出するための出口端部と、を有し、
前記第２の導管群は、前記第２の流体交換媒体が前記第２の導管群を通って流れるときに、前記作動流体を用いて第２の物質の物質移動を実行し、
前記第１の流体交換媒体入口は、前記第１の流体交換媒体を前記第１の導管群の前記第１の物質移動導管のすべてに集合的に運ぶために、前記第１の導管群の前記入口端部に接続され、
前記第２の流体交換媒体入口は、前記第２の流体交換媒体を前記第２の導管群の前記第２の物質移動導管のすべてに集合的に運ぶために、前記第２の導管群の前記入口端部に接続され、
前記第１の導管群及び前記第２の導管群は、前記チャンバ内の前記作動流体入口と前記作動流体出口との間に配置されて、前記作動流体は、前記作動流体入口から前記チャンバに移動し、次に前記チャンバを通過し、次に前記作動流体出口を介して前記チャンバから出るとき、第１の物質移動導管の前記第１の導管群と第２の物質移動導管の前記第２の導管群の周囲を流れ、
前記作動流体の流れの断面が前記チャンバを通じて実質的に一定に保たれるように、前記チャンバの全容積にわたって本質的に均一な導管分布が存在する、
作動流体処理装置。
（項目２）
前記第１の物質移動導管及び前記第２の物質移動導管は、中空の半透膜繊維である、項目１に記載の作動流体処理装置。
（項目３）
前記半透膜繊維を構成する半透膜が、液体不透過性であり、
膜を越える物質移動を増加させるために開口した微小孔が横切る浸透細孔膜、または膜の長期的な膜湿潤を防ぐ非多孔質層を含む拡散膜のいずれかである、項目２に記載の作動流体処理装置。
（項目４）
前記第１の物質移動導管を構成する前記半透膜が浸透細孔膜であり、
前記第２の物質移動導管を構成する前記半透膜が拡散膜である、項目３に記載の作動流体処理装置。
（項目５）
前記使用済みの第１及び第２の流体交換媒体を受け入れるために、前記第１及び第２の導管群の前記出口端部に接続された単一の共有流体交換媒体出口をさらに備える、項目１～４のいずれか一項に記載の作動流体処理装置。
（項目６）
前記使用済みの第１の流体交換媒体を受け入れる前記第１の導管群の前記出口端部に接続された第１の流体交換媒体出口と、前記使用済みの第２の流体交換媒体を受け入れる前記第２の導管群の前記出口端部に接続された第２の流体交換媒体出口と、をさらに備え、
前記第２の流体交換媒体出口は前記第１の流体交換媒体出口から流体的に分離される、項目１～４のいずれか一項に記載の作動流体処理装置。
（項目７）
前記作動流体が、前記装置を通って移動するとき、前記第１の導管群及び前記第２の導管群を通って順次流れる、項目１～６のいずれか一項に記載の作動流体処理装置。
（項目８）
動作中、前記作動流体の第１の部分は前記第１の導管群を通って流れ、並行して、前記第１の部分とは異なる、前記作動流体の第２の部分は前記第２の導管群を通って流れる、項目１～６のいずれか一項に記載の作動流体処理装置。
（項目９）
前記第１の導管群及び前記第２の導管群は、作動流体の流量を形成する、インターリーブされた第１及び第２の物質移動導管を連携して構成する、項目１～６のいずれか一項に記載の作動流体処理装置。
（項目１０）
前記第１の導管群及び前記第２の導管群は、一方が他方に積み重ねられる、項目１～９のいずれか一項に記載の作動流体処理装置。
（項目１１）
前記第１の導管群及び前記第２の導管群のそれぞれが、中空の半透膜繊維の束を構成する、項目１～１０のいずれか一項に記載の作動流体処理装置。
（項目１２）
前記各繊維束は、１つ以上の層状繊維マットの集合体である、項目１１に記載の作動流体処理装置。
（項目１３）
前記第１の導管群及び前記第２の導管群は、１つ以上の直方体の積み重ねられた繊維マットを形成する、項目１２に記載の作動流体処理装置。
（項目１４）
前記第１の導管群が第１の流体交換媒体の流れ方向を規定し、前記第２の導管群が第２の流体交換媒体の流れ方向を規定し、
前記第１の流れ方向及び前記第２の流れ方向が互いに対して９０°の角度で設定される、項目１３に記載の作動流体処理装置。
（項目１５）
前記装置が円筒状の巻き付け型繊維マット装置である、項目１２に記載の作動流体処理装置。
（項目１６）
各繊維束は、リング形状またはリングの一部の形状の断面を有し、前記繊維束は、共通の中心縦軸の周りに入れ子にされる、項目１５に記載の作動流体処理装置。
（項目１７）
各繊維束内の前記繊維が開ループ形状を有する、項目１１に記載の作動流体処理装置。
（項目１８）
すべての前記繊維束の前記繊維は、前記作動流体処理装置の共通の中心縦軸の周りにループ状にされる、項目１７に記載の作動流体処理装置。
（項目１９）
前記統合された作動流体処理チャンバが、前記作動流体と前記熱交換流体との間の熱交換のための熱交換導管の第３の導管群をさらに含む、項目１～１８のいずれか一項に記載の作動流体処理装置。
（項目２０）
前記装置は、前記作動流体として血液を処理するように適合され、
前記第１の導管群は、前記血液を酸素化するように適合され、前記第２の導管群は、一酸化窒素を血液に送達するように適合される、項目１～１９のいずれか一項に記載の作動流体処理装置。
（項目２１）
前記装置は、前記作動流体として血液を処理するように適合され、
前記第１の導管群は、前記血液を酸素化するように適合され、前記第２の導管群は、麻酔薬を血液に送達するように適合される、項目１～１９のいずれか一項に記載の作動流体処理装置。
（項目２２）
項目２０または２１に記載の作動流体処理装置を使用して、心肺バイパス手術中に患者を治療する方法。
（項目２３）
患者の血液と流体交換媒体との間の物質及びエネルギー移動のための体外血液処理装置であって、前記体外血液処理装置は実質的に一定の断面を有する内部血流空洞を規定するハウジングを備え、前記血流空洞は血流がそれを通じて実質的に内部血流空洞の全容積にわたるように構成されており、
前記ハウジングは、
第１のガス交換媒体を介して前記患者の血液を酸素化するように構成された第１の物質移動アセンブリであって、酸素を前記患者の血液に移動するガス移動導管のアレイを備え、前記第１のガス交換媒体のための第１のガス回路を形成する、前記第１の物質移動アセンブリと、
前記熱エネルギー移動媒体を用いて血液を加熱または冷却するように構成され、熱エネルギー移動媒体を運ぶ熱移動導管のアレイを備える、熱交換アセンブリと、
流体交換媒体と前記患者の血液との間の物質移動を提供するように構成された１つ以上の追加の物質移動アセンブリであって、１つ以上の物質を前記患者の血液からまたは前記患者の血液に物質移動するための物質移動導管のアレイをそれぞれが備える、前記１つ以上の追加の物質移動アセンブリと、を収容し、
追加の物質移動アセンブリのそれぞれが、前記第１のガス回路とは異なる、独立した特定の流体交換媒体のための別個の流体回路を形成し、
前記内部血流空洞を流れる血液は、前記第１の物質移動アセンブリ、前記熱交換アセンブリ、及び前記１つ以上の追加の物質移動アセンブリの、すべての前記導管の周りを実質的に均一に流れるように、前記１つ以上の追加の物質移動アセンブリの前記アレイが前記内部血流空洞内の同じ場所に位置しており、
前記第１の物質移動アセンブリ、前記熱交換アセンブリ、及び前記１つ以上の追加の物質移動アセンブリの前記アレイは、連続的な血流経路が前記内部血流空洞を通って画定され、それに沿って血液が流れて前記アセンブリのすべてによって処理されるように前記内部血流空洞内で互いに対して配置され、
前記連続的な血流経路は、一端に血液入口面を、反対端に血液出口面を、全体としての血流方向において有しており、
前記血液入口面から前記血流経路に沿い前記血液出口面に至る前記全体としての血流方向は実質的に直線を辿る、前記装置。
（項目２４）
各アセンブリは、それぞれ、個々のアセンブリへの、及び個々のアセンブリからのそれぞれの流体交換媒体の導入及び除去のための、前記ハウジングに接続された個々の入口及び個々の出口を含む、項目２３に記載の装置。
（項目２５）
前記追加の物質移動アセンブリの少なくとも１つは、特定のガスを前記患者の血液に移動するように構成された前記流体移動アセンブリからなる群から選択され、
前記特定のガスは、揮発性麻酔薬（例えばイソフルランまたはセボフルラン）、一酸化窒素（ＮＯ）、及び不活性ガスとの混合物中の一酸化窒素からなる群から選択される、項目２３または２４に記載の装置。
（項目２６）
前記追加の物質移動アセンブリの少なくとも１つは、特定の液体を前記患者の血液に移動するように構成された流体移動アセンブリからなる群から選択され、
前記特定の液体は、薬剤、緩衝液及び酸または塩基の形態のｐＨ制御剤からなる群から選択される、項目２３～２５のいずれか一項に記載の装置。
（項目２７）
前記追加の物質移動アセンブリのうちの少なくとも１つは、血液電解質、血漿、抗体もしくはエンドトキシンなどの、前記血液中を循環する血液化合物もしくは成分を前記血液から除去するように構成される、かつ／または前記他の物質移動アセンブリのうちの少なくとも１つは血液濾過及び血液透析用に構成される、項目２３～２６のいずれか一項に記載の装置。
（項目２８）
前記追加の物質移動アセンブリのうちの少なくとも１つが、前記患者の血液中のガスのガス分圧を測定するように構成される、項目２３～２７のいずれか一項に記載の装置。
（項目２９）
前記物質移動導管及び前記ガス移動導管が中空繊維であり、
前記物質移動導管及び前記ガス移動導管が微小孔構造を有する、項目２３～２８のいずれか一項に記載の装置。
（項目３０）
各アセンブリの入口は、前記それぞれの流体交換媒体を前記アセンブリの前記導管に分配するための分配ヘッダを有する、項目２４～２９のいずれか一項に記載の装置。
（項目３１）
前記中空繊維が、互いに間隔を置いて配置され、ポッティング材料の層によって互いに固定された開放端部を有する、項目２９に記載の装置。
（項目３２）
前記ポッティング材料の層が前記アセンブリの入口プレート及び出口プレートを構成する、項目３１に記載の装置。
（項目３３）
各アセンブリ入口は、前記それぞれの流体交換媒体を前記アセンブリの前記導管に分配するための分配ヘッダを有し、
前記入口プレートは、前記分配ヘッダの底部に配置される、項目３２に記載の装置。
（項目３４）
前記中空繊維が繊維マットの形態で提供される、項目２９に記載の装置。
（項目３５）
２つの異なるアセンブリの前記導管が互いに９０°の角度で設定され、積み重ねられる、項目２３～３４のいずれか一項に記載の装置。
（項目３６）
２つのアセンブリが、前記装置の１つのチャンバ内で対になり、１方のアセンブリの前記導管が他方のアセンブリの前記導管と前記血流の方向で交互になる、項目２３～３５のいずれか一項に記載の装置。
（項目３７）
前記アセンブリが同心円状のリングとして配置される、項目３４に記載の装置。
（項目３８）
前記アセンブリがループ状に配置され、互いに積み重ねられる、項目３４に記載の装置。
（項目３９）
前記ハウジングに取り付けられた単一の血液入口と単一の血液出口とをさらに備え、前記入口は、患者の血液を前記装置の前記内部血流空洞に導入し、血液が各アレイを前記流体交換媒体の前記流れ方向に実質的に垂直な方向に通過することができる、項目２３～３８のいずれか一項に記載の装置。
（項目４０）
前記アセンブリの前記アレイを無視すれば、前記内部血流空洞に内部仕切りまたは狭窄部がない、項目２３～３９のいずれか一項に記載の装置。
（項目４１）
前記第１の物質移動アセンブリが、
ｉ）酸素に富むガス交換媒体を前記第１の物質移動アセンブリに入れるために前記ハウジング内に配置されたガス入口と、
ｉｉ）酸素に乏しいガス交換媒体を前記第１の物質移動アセンブリから排出するために前記ハウジング内に配置されたガス出口と、をさらに備え、
追加の物質移動アセンブリのそれぞれが、
ｉ）ガス入口とは異なる専用の別個の流体入口であって、流体交換媒体を前記物質移動アセンブリに入れるために前記ハウジング内に配置された、前記専用の別個の流体入口と、ｉｉ）ガス出口とは異なる専用の別個の流体出口であって、流体交換媒体を前記物質移動アセンブリから排出するために前記ハウジング内に配置された、前記専用の別個の流体出口と、をさらに備える、項目２３～４０のいずれか一項に記載の装置。
Some embodiments of the present disclosure will now be described, by way of non-limiting example only, with reference to the accompanying drawings.
The present invention provides, for example, the following.
(Item 1)
A working fluid treatment apparatus for mass transfer between a working fluid and a first fluid exchange medium and between the same working fluid and a second fluid exchange medium different from said first fluid exchange medium and
The working fluid processing device includes:
a collective first fluid exchange medium inlet for admitting the first fluid exchange medium into the working fluid treatment device;
collective second fluid exchange medium inlets fluidly separated from the first fluid exchange medium inlets for admitting the second fluid exchange medium into the working fluid processing device;
an integrated working fluid processing chamber;
The chamber is
a working fluid inlet;
a working fluid outlet;
a first group of first mass transfer conduits positioned between the working fluid inlet and the working fluid outlet, comprising:
The first group of conduits,
an inlet end for receiving the first fluid exchange medium into the first group of conduits;
an outlet end for discharging spent first fluid exchange medium from the first group of conduits;
said first group of conduits performing mass transfer of a first substance with said working fluid when said first fluid exchange medium flows through said first group of conduits; flock and
a second group of second mass transfer conduits positioned between the working fluid inlet and the working fluid outlet;
The second group of conduits,
an inlet end for receiving the second fluid exchange medium into the second group of conduits;
an outlet end for discharging spent second fluid exchange medium from the second group of conduits;
the second group of conduits performs mass transfer of a second substance with the working fluid when the second fluid exchange medium flows through the second group of conduits;
The first fluid exchange medium inlets are configured in the first group of conduits for collectively conveying the first fluid exchange medium to all of the first mass transfer conduits of the first group of conduits. connected to the inlet end,
Said second fluid exchange medium inlet is adapted to said second mass transfer conduit of said second group of conduits for collectively conveying said second fluid exchange medium to all of said second mass transfer conduits of said second group of conduits. connected to the inlet end,
The first group of conduits and the second group of conduits are positioned in the chamber between the working fluid inlet and the working fluid outlet, such that the working fluid travels from the working fluid inlet to the chamber. and then through said chamber and then exiting said chamber via said working fluid outlet, said first group of first mass transfer conduits and said second group of second mass transfer conduits flows around the ducts,
there is an essentially uniform distribution of conduits over the entire volume of the chamber such that the working fluid flow cross-section remains substantially constant throughout the chamber;
Working fluid processing device.
(Item 2)
2. The working fluid treatment device of item 1, wherein the first mass transfer conduit and the second mass transfer conduit are hollow semipermeable membrane fibers.
(Item 3)
The semipermeable membrane constituting the semipermeable membrane fiber is impermeable to liquid,
Item 2, wherein the membrane is either an osmotic pore membrane traversed by open micropores to increase mass transfer across the membrane, or a diffusion membrane comprising a non-porous layer that prevents long-term membrane wetting of the membrane. Working fluid processing device.
(Item 4)
the semipermeable membrane constituting the first mass transfer conduit is an osmotic pore membrane;
4. The working fluid treatment device of item 3, wherein the semi-permeable membrane constituting the second mass transfer conduit is a diffusion membrane.
(Item 5)
Item 1, further comprising a single shared fluid exchange medium outlet connected to said outlet ends of said first and second groups of conduits for receiving said spent first and second fluid exchange medium. 5. The working fluid processing device according to any one of -4.
(Item 6)
a first fluid exchange medium outlet connected to the outlet end of the first group of conduits for receiving the spent first fluid exchange medium; and a first fluid exchange medium outlet for receiving the spent second fluid exchange medium. a second fluid exchange medium outlet connected to the outlet ends of two conduit groups;
5. The working fluid treatment apparatus of any one of items 1-4, wherein the second fluid exchange medium outlet is fluidly separated from the first fluid exchange medium outlet.
(Item 7)
7. A working fluid treatment device according to any one of the preceding items, wherein the working fluid flows through the first group of conduits and the second group of conduits sequentially as it moves through the device.
(Item 8)
In operation, a first portion of said working fluid flows through said first group of conduits and, concurrently, a second portion of said working fluid, different from said first portion, flows through said second conduit. A working fluid treatment device according to any one of items 1 to 6, flowing through the group.
(Item 9)
7. Any one of items 1-6, wherein the first group of conduits and the second group of conduits collectively form interleaved first and second mass transfer conduits that define a working fluid flow rate. A working fluid processing device according to claim 1.
(Item 10)
10. A working fluid treatment apparatus according to any one of items 1 to 9, wherein the first group of conduits and the second group of conduits are stacked one on top of the other.
(Item 11)
11. The working fluid treatment device according to any one of items 1 to 10, wherein each of the first group of conduits and the second group of conduits constitutes a bundle of hollow semipermeable membrane fibers.
(Item 12)
12. A working fluid treatment device according to item 11, wherein each fiber bundle is an assembly of one or more layered fiber mats.
(Item 13)
13. The working fluid treatment device of item 12, wherein the first group of conduits and the second group of conduits form one or more cuboid stacked fiber mats.
(Item 14)
said first set of conduits defining a flow direction of a first fluid exchange medium and said second set of conduits defining a flow direction of a second fluid exchange medium;
14. The working fluid treatment device of item 13, wherein said first flow direction and said second flow direction are set at an angle of 90[deg.] to each other.
(Item 15)
13. A working fluid treatment device according to item 12, wherein said device is a cylindrical wound fiber mat device.
(Item 16)
16. A working fluid treatment device according to item 15, wherein each fiber bundle has a cross-section in the shape of a ring or part of a ring, said fiber bundles being nested about a common central longitudinal axis.
(Item 17)
12. A working fluid treatment device according to item 11, wherein the fibers within each fiber bundle have an open loop shape.
(Item 18)
18. The working fluid treatment device of item 17, wherein the fibers of all the fiber bundles are looped around a common central longitudinal axis of the working fluid treatment device.
(Item 19)
19. Any one of clauses 1-18, wherein the integrated working fluid treatment chamber further comprises a third group of heat exchange conduits for heat exchange between the working fluid and the heat exchange fluid. A working fluid treatment device as described.
(Item 20)
the device is adapted to treat blood as the working fluid;
20. Any one of items 1-19, wherein the first group of conduits is adapted to oxygenate the blood and the second group of conduits is adapted to deliver nitric oxide to the blood. The working fluid processing device according to .
(Item 21)
the device is adapted to treat blood as the working fluid;
20. The method of any one of items 1-19, wherein the first group of conduits is adapted to oxygenate the blood and the second group of conduits is adapted to deliver an anesthetic to the blood. A working fluid treatment device as described.
(Item 22)
22. A method of treating a patient during cardiopulmonary bypass surgery using the working fluid treatment device of item 20 or 21.
(Item 23)
An extracorporeal blood treatment device for material and energy transfer between a patient's blood and a fluid exchange medium, said extracorporeal blood treatment device comprising a housing defining an internal blood flow cavity having a substantially constant cross section. , said blood flow cavity is configured such that blood flow therethrough spans substantially the entire volume of the internal blood flow cavity;
The housing is
a first mass transfer assembly configured to oxygenate the patient's blood via a first gas exchange medium, comprising an array of gas transfer conduits for transferring oxygen to the patient's blood; said first mass transfer assembly forming a first gas circuit for a first gas exchange medium;
a heat exchange assembly configured to heat or cool blood with the thermal energy transfer medium and comprising an array of heat transfer conduits carrying the thermal energy transfer medium;
one or more additional mass transfer assemblies configured to provide mass transfer between a fluid exchange medium and the patient's blood, wherein one or more substances are transferred from or to the patient's blood; said one or more additional mass transfer assemblies each comprising an array of mass transfer conduits for mass transfer to the blood;
each additional mass transfer assembly forming a separate fluid circuit for an independent and specific fluid exchange medium different from said first gas circuit;
Blood flowing through the internal blood flow cavity is caused to flow substantially uniformly around all of the conduits of the first mass transfer assembly, the heat exchange assembly, and the one or more additional mass transfer assemblies. and said array of said one or more additional mass transfer assemblies are co-located within said internal blood flow cavity;
The array of the first mass transfer assembly, the heat exchange assembly, and the one or more additional mass transfer assemblies has a continuous blood flow path defined through the internal blood flow cavity along which positioned relative to each other within the internal blood flow cavity such that blood flows and is processed by all of the assemblies;
said continuous blood flow path having a blood inlet surface at one end and a blood outlet surface at an opposite end in the general blood flow direction;
The apparatus, wherein the overall blood flow direction along the blood flow path from the blood inlet surface to the blood outlet surface follows a substantially straight line.
(Item 24)
to item 23, each assembly including a respective inlet and a respective outlet connected to said housing for the introduction and removal of respective fluid exchange media to and from the respective assembly; Apparatus as described.
(Item 25)
at least one of said additional mass transfer assemblies is selected from the group consisting of said fluid transfer assemblies configured to transfer a specific gas to said patient's blood;
25. Item 23 or 24, wherein said particular gas is selected from the group consisting of volatile anesthetics (e.g. isoflurane or sevoflurane), nitric oxide (NO), and nitric oxide in mixtures with inert gases. device.
(Item 26)
at least one of said additional mass transfer assemblies is selected from the group consisting of fluid transfer assemblies configured to transfer a specific liquid to said patient's blood;
26. Apparatus according to any one of items 23 to 25, wherein said specific liquid is selected from the group consisting of drugs, buffers and pH control agents in acid or base form.
(Item 27)
at least one of said additional mass transfer assemblies is configured to remove from said blood circulating blood compounds or components, such as blood electrolytes, plasma, antibodies or endotoxins, and/or 27. Apparatus according to any one of items 23-26, wherein at least one of said other mass transfer assemblies is configured for hemofiltration and hemodialysis.
(Item 28)
28. The apparatus of any one of items 23-27, wherein at least one of said additional mass transfer assemblies is configured to measure the gas partial pressure of a gas in said patient's blood.
(Item 29)
wherein said mass transfer conduit and said gas transfer conduit are hollow fibers;
29. Apparatus according to any one of items 23-28, wherein said mass transfer conduit and said gas transfer conduit have a microporous structure.
(Item 30)
30. Apparatus according to any one of items 24 to 29, wherein the inlet of each assembly has a distribution header for distributing said respective fluid exchange medium to said conduits of said assembly.
(Item 31)
30. The apparatus of item 29, wherein the hollow fibers have open ends spaced from each other and secured to each other by a layer of potting material.
(Item 32)
32. Apparatus according to item 31, wherein the layers of potting material constitute inlet and outlet plates of the assembly.
(Item 33)
each assembly inlet having a distribution header for distributing said respective fluid exchange medium to said conduits of said assembly;
33. Apparatus according to item 32, wherein the inlet plate is located at the bottom of the distribution header.
(Item 34)
30. Apparatus according to item 29, wherein the hollow fibers are provided in the form of a fiber mat.
(Item 35)
35. Apparatus according to any one of items 23-34, wherein said conduits of two different assemblies are set at an angle of 90° to each other and stacked.
(Item 36)
36. Any one of items 23-35, wherein two assemblies are paired within one chamber of the device, the conduits of one assembly alternating in the direction of blood flow with the conduits of the other assembly. 3. Apparatus according to paragraph.
(Item 37)
35. Apparatus according to item 34, wherein the assemblies are arranged as concentric rings.
(Item 38)
35. Apparatus according to item 34, wherein the assemblies are arranged in a loop and stacked on top of each other.
(Item 39)
Further comprising a single blood inlet and a single blood outlet attached to the housing, the inlet introducing a patient's blood into the internal blood flow cavity of the device, the blood flowing through each array through the fluid exchange. 39. Apparatus according to any one of items 23 to 38, capable of passing in a direction substantially perpendicular to said flow direction of the medium.
(Item 40)
40. The apparatus of any one of items 23-39, wherein disregarding said array of said assemblies, said internal blood flow cavity is free of internal partitions or constrictions.
(Item 41)
the first mass transfer assembly comprising:
i) a gas inlet positioned within said housing for admitting an oxygen-enriched gas exchange medium into said first mass transfer assembly;
ii) a gas outlet disposed within said housing for discharging oxygen-poor gas exchange medium from said first mass transfer assembly;
each of the additional mass transfer assemblies,
i) a dedicated and separate fluid inlet different from the gas inlet, the dedicated and separate fluid inlet positioned within the housing for admitting a fluid exchange medium into the mass transfer assembly; and ii) a gas outlet. a dedicated separate fluid outlet different from the said dedicated separate fluid outlet disposed within said housing for discharging fluid exchange medium from said mass transfer assembly, items 23- 41. Apparatus according to any one of Clauses 40.
Claims (41)
前記作動流体処理装置は、
前記第１の流体交換媒体を前記作動流体処理装置に入れる集合的な第１の流体交換媒体入口と、
前記第１の流体交換媒体入口から流体的に分離され、前記第２の流体交換媒体を前記作動流体処理装置に入れる集合的な第２の流体交換媒体入口と、
統合された作動流体処理チャンバと、を備え、
前記チャンバは、
作動流体入口と、
作動流体出口と、
前記作動流体入口と前記作動流体出口との間に配置された第１の物質移動導管の第１の導管群であって、
前記第１の導管群は、
前記第１の流体交換媒体を前記第１の導管群に受け入れる入口端部と、
使用済みの第１の流体交換媒体を前記第１の導管群から排出する出口端部と、を有しており、
前記第１の導管群は、前記第１の流体交換媒体が前記第１の導管群を通って流れるときに、前記作動流体を用いて第１の物質の物質移動を実行する、第１の導管群と、
前記作動流体入口と前記作動流体出口との間に配置された第２の物質移動導管の第２の導管群とを含み、
前記第２の導管群は、
前記第２の流体交換媒体を前記第２の導管群に受け入れる入口端部と、
使用済みの第２の流体交換媒体を前記第２の導管群から排出するための出口端部と、を有し、
前記第２の導管群は、前記第２の流体交換媒体が前記第２の導管群を通って流れるときに、前記作動流体を用いて第２の物質の物質移動を実行し、
前記第１の流体交換媒体入口は、前記第１の流体交換媒体を前記第１の導管群の前記第１の物質移動導管のすべてに集合的に運ぶために、前記第１の導管群の前記入口端部に接続され、
前記第２の流体交換媒体入口は、前記第２の流体交換媒体を前記第２の導管群の前記第２の物質移動導管のすべてに集合的に運ぶために、前記第２の導管群の前記入口端部に接続され、
前記第１の導管群及び前記第２の導管群は、前記チャンバ内の前記作動流体入口と前記作動流体出口との間に配置されて、前記作動流体は、前記作動流体入口から前記チャンバに移動し、次に前記チャンバを通過し、次に前記作動流体出口を介して前記チャンバから出るとき、第１の物質移動導管の前記第１の導管群と第２の物質移動導管の前記第２の導管群の周囲を流れ、
前記作動流体の流れの断面が前記チャンバを通じて実質的に一定に保たれるように、前記チャンバの全容積にわたって本質的に均一な導管分布が存在する、
作動流体処理装置。 A working fluid treatment apparatus for mass transfer between a working fluid and a first fluid exchange medium and between the same working fluid and a second fluid exchange medium different from said first fluid exchange medium and
The working fluid processing device includes:
a collective first fluid exchange medium inlet for admitting the first fluid exchange medium into the working fluid treatment device;
collective second fluid exchange medium inlets fluidly separated from the first fluid exchange medium inlets for admitting the second fluid exchange medium into the working fluid processing device;
an integrated working fluid processing chamber;
The chamber is
a working fluid inlet;
a working fluid outlet;
a first group of first mass transfer conduits positioned between the working fluid inlet and the working fluid outlet, comprising:
The first group of conduits,
an inlet end for receiving the first fluid exchange medium into the first group of conduits;
an outlet end for discharging spent first fluid exchange medium from the first group of conduits;
said first group of conduits performing mass transfer of a first substance with said working fluid when said first fluid exchange medium flows through said first group of conduits; flock and
a second group of second mass transfer conduits positioned between the working fluid inlet and the working fluid outlet;
The second group of conduits,
an inlet end for receiving the second fluid exchange medium into the second group of conduits;
an outlet end for discharging spent second fluid exchange medium from the second group of conduits;
the second group of conduits performs mass transfer of a second substance with the working fluid when the second fluid exchange medium flows through the second group of conduits;
The first fluid exchange medium inlets are configured in the first group of conduits for collectively conveying the first fluid exchange medium to all of the first mass transfer conduits of the first group of conduits. connected to the inlet end,
Said second fluid exchange medium inlet is adapted to said second mass transfer conduit of said second group of conduits for collectively conveying said second fluid exchange medium to all of said second mass transfer conduits of said second group of conduits. connected to the inlet end,
The first group of conduits and the second group of conduits are positioned in the chamber between the working fluid inlet and the working fluid outlet, such that the working fluid travels from the working fluid inlet to the chamber. and then through said chamber and then exiting said chamber via said working fluid outlet, said first group of first mass transfer conduits and said second group of second mass transfer conduits flows around the ducts,
there is an essentially uniform distribution of conduits over the entire volume of the chamber such that the working fluid flow cross-section remains substantially constant throughout the chamber;
Working fluid processing device.
膜を越える物質移動を増加させるために開口した微小孔が横切る浸透細孔膜、または膜の長期的な膜湿潤を防ぐ非多孔質層を含む拡散膜のいずれかである、請求項２に記載の作動流体処理装置。 The semipermeable membrane constituting the semipermeable membrane fiber is impermeable to liquid,
3. The method of claim 2, which is either an osmotic pore membrane traversed by open micropores to increase mass transfer across the membrane, or a diffusion membrane comprising a non-porous layer that prevents long-term membrane wetting of the membrane. working fluid treatment device.
前記第２の物質移動導管を構成する前記半透膜が拡散膜である、請求項３に記載の作動流体処理装置。 the semipermeable membrane constituting the first mass transfer conduit is an osmotic pore membrane;
4. The working fluid treatment device of claim 3, wherein said semi-permeable membrane comprising said second mass transfer conduit is a diffusion membrane.
前記第２の流体交換媒体出口は前記第１の流体交換媒体出口から流体的に分離される、請求項１～４のいずれか一項に記載の作動流体処理装置。 a first fluid exchange medium outlet connected to the outlet end of the first group of conduits for receiving the spent first fluid exchange medium; and a first fluid exchange medium outlet for receiving the spent second fluid exchange medium. a second fluid exchange medium outlet connected to the outlet ends of two conduit groups;
A working fluid treatment apparatus according to any preceding claim, wherein the second fluid exchange medium outlet is fluidly separated from the first fluid exchange medium outlet.
前記第１の流れ方向及び前記第２の流れ方向が互いに対して９０°の角度で設定される、請求項１３に記載の作動流体処理装置。 said first set of conduits defining a flow direction of a first fluid exchange medium and said second set of conduits defining a flow direction of a second fluid exchange medium;
14. The working fluid treatment apparatus of claim 13, wherein said first flow direction and said second flow direction are set at an angle of 90[deg.] to each other.
前記第１の導管群は、前記血液を酸素化するように適合され、前記第２の導管群は、一酸化窒素を血液に送達するように適合される、請求項１～１９のいずれか一項に記載の作動流体処理装置。 the device is adapted to treat blood as the working fluid;
20. The first group of conduits is adapted to oxygenate the blood and the second group of conduits is adapted to deliver nitric oxide to the blood. A working fluid processing device according to claim 1.
前記第１の導管群は、前記血液を酸素化するように適合され、前記第２の導管群は、麻酔薬を血液に送達するように適合される、請求項１～１９のいずれか一項に記載の作動流体処理装置。 the device is adapted to treat blood as the working fluid;
20. Any one of claims 1-19, wherein the first group of conduits is adapted to oxygenate the blood and the second group of conduits is adapted to deliver an anesthetic to the blood. The working fluid processing device according to .
前記ハウジングは、
第１のガス交換媒体を介して前記患者の血液を酸素化するように構成された第１の物質移動アセンブリであって、酸素を前記患者の血液に移動するガス移動導管のアレイを備え、前記第１のガス交換媒体のための第１のガス回路を形成する、前記第１の物質移動アセンブリと、
前記熱エネルギー移動媒体を用いて血液を加熱または冷却するように構成され、熱エネルギー移動媒体を運ぶ熱移動導管のアレイを備える、熱交換アセンブリと、
流体交換媒体と前記患者の血液との間の物質移動を提供するように構成された１つ以上の追加の物質移動アセンブリであって、１つ以上の物質を前記患者の血液からまたは前記患者の血液に物質移動するための物質移動導管のアレイをそれぞれが備える、前記１つ以上の追加の物質移動アセンブリと、を収容し、
追加の物質移動アセンブリのそれぞれが、前記第１のガス回路とは異なる、独立した特定の流体交換媒体のための別個の流体回路を形成し、
前記内部血流空洞を流れる血液は、前記第１の物質移動アセンブリ、前記熱交換アセンブリ、及び前記１つ以上の追加の物質移動アセンブリの、すべての前記導管の周りを実質的に均一に流れるように、前記１つ以上の追加の物質移動アセンブリの前記アレイが前記内部血流空洞内の同じ場所に位置しており、
前記第１の物質移動アセンブリ、前記熱交換アセンブリ、及び前記１つ以上の追加の物質移動アセンブリの前記アレイは、連続的な血流経路が前記内部血流空洞を通って画定され、それに沿って血液が流れて前記アセンブリのすべてによって処理されるように前記内部血流空洞内で互いに対して配置され、
前記連続的な血流経路は、一端に血液入口面を、反対端に血液出口面を、全体としての血流方向において有しており、
前記血液入口面から前記血流経路に沿い前記血液出口面に至る前記全体としての血流方向は実質的に直線を辿る、前記装置。 An extracorporeal blood treatment device for material and energy transfer between a patient's blood and a fluid exchange medium, said extracorporeal blood treatment device comprising a housing defining an internal blood flow cavity having a substantially constant cross section. , said blood flow cavity is configured such that blood flow therethrough spans substantially the entire volume of the internal blood flow cavity;
The housing is
a first mass transfer assembly configured to oxygenate the patient's blood via a first gas exchange medium, comprising an array of gas transfer conduits for transferring oxygen to the patient's blood; said first mass transfer assembly forming a first gas circuit for a first gas exchange medium;
a heat exchange assembly configured to heat or cool blood with the thermal energy transfer medium and comprising an array of heat transfer conduits carrying the thermal energy transfer medium;
one or more additional mass transfer assemblies configured to provide mass transfer between a fluid exchange medium and the patient's blood, wherein one or more substances are transferred from or to the patient's blood; said one or more additional mass transfer assemblies each comprising an array of mass transfer conduits for mass transfer to the blood;
each additional mass transfer assembly forming a separate fluid circuit for an independent and specific fluid exchange medium different from said first gas circuit;
Blood flowing through the internal blood flow cavity is caused to flow substantially uniformly around all of the conduits of the first mass transfer assembly, the heat exchange assembly, and the one or more additional mass transfer assemblies. and said array of said one or more additional mass transfer assemblies are co-located within said internal blood flow cavity;
The array of the first mass transfer assembly, the heat exchange assembly, and the one or more additional mass transfer assemblies has a continuous blood flow path defined through the internal blood flow cavity along which positioned relative to each other within the internal blood flow cavity such that blood flows and is processed by all of the assemblies;
said continuous blood flow path having a blood inlet surface at one end and a blood outlet surface at an opposite end in the general blood flow direction;
The apparatus, wherein the overall blood flow direction along the blood flow path from the blood inlet surface to the blood outlet surface follows a substantially straight line.
前記特定のガスは、揮発性麻酔薬（例えばイソフルランまたはセボフルラン）、一酸化窒素（ＮＯ）、及び不活性ガスとの混合物中の一酸化窒素からなる群から選択される、請求項２３または２４に記載の装置。 at least one of said additional mass transfer assemblies is selected from the group consisting of said fluid transfer assemblies configured to transfer a specific gas to said patient's blood;
25. The method of claim 23 or 24, wherein said specific gas is selected from the group consisting of volatile anesthetics (e.g. isoflurane or sevoflurane), nitric oxide (NO), and nitric oxide in mixtures with inert gases. Apparatus as described.
前記特定の液体は、薬剤、緩衝液及び酸または塩基の形態のｐＨ制御剤からなる群から選択される、請求項２３～２５のいずれか一項に記載の装置。 at least one of said additional mass transfer assemblies is selected from the group consisting of fluid transfer assemblies configured to transfer a specific liquid to said patient's blood;
A device according to any one of claims 23 to 25, wherein said specific liquid is selected from the group consisting of drugs, buffers and pH control agents in acid or base form.
前記物質移動導管及び前記ガス移動導管が微小孔構造を有する、請求項２３～２８のいずれか一項に記載の装置。 wherein said mass transfer conduit and said gas transfer conduit are hollow fibers;
A device according to any one of claims 23 to 28, wherein said mass transfer conduit and said gas transfer conduit have a microporous structure.
前記入口プレートは、前記分配ヘッダの底部に配置される、請求項３２に記載の装置。 each assembly inlet having a distribution header for distributing said respective fluid exchange medium to said conduits of said assembly;
33. The apparatus of Claim 32, wherein the inlet plate is located at the bottom of the distribution header.
ｉ）酸素に富むガス交換媒体を前記第１の物質移動アセンブリに入れるために前記ハウジング内に配置されたガス入口と、
ｉｉ）酸素に乏しいガス交換媒体を前記第１の物質移動アセンブリから排出するために前記ハウジング内に配置されたガス出口と、をさらに備え、
追加の物質移動アセンブリのそれぞれが、
ｉ）ガス入口とは異なる専用の別個の流体入口であって、流体交換媒体を前記物質移動アセンブリに入れるために前記ハウジング内に配置された、前記専用の別個の流体入口と、ｉｉ）ガス出口とは異なる専用の別個の流体出口であって、流体交換媒体を前記物質移動アセンブリから排出するために前記ハウジング内に配置された、前記専用の別個の流体出口と、をさらに備える、請求項２３～４０のいずれか一項に記載の装置。
the first mass transfer assembly comprising:
i) a gas inlet positioned within said housing for admitting an oxygen-enriched gas exchange medium into said first mass transfer assembly;
ii) a gas outlet disposed within said housing for discharging oxygen-poor gas exchange medium from said first mass transfer assembly;
each of the additional mass transfer assemblies,
i) a dedicated and separate fluid inlet different from the gas inlet, the dedicated and separate fluid inlet positioned within the housing for admitting a fluid exchange medium into the mass transfer assembly; and ii) a gas outlet. and a dedicated separate fluid outlet different from the said dedicated separate fluid outlet disposed within said housing for discharging fluid exchange medium from said mass transfer assembly. 40. Apparatus according to any one of claims 1-40.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023135230A JP2023153306A (en) | 2019-10-25 | 2023-08-23 | Working fluid treatment device for mass transfer between working fluid and two fluid exchange media |
| JP2024135010A JP2024149768A (en) | 2019-10-25 | 2024-08-13 | Working fluid treatment device for mass transfer between a working fluid and two fluid exchange media - Patents.com |
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|---|---|---|---|
| US201962926210P | 2019-10-25 | 2019-10-25 | |
| US62/926,210 | 2019-10-25 | ||
| PCT/EP2020/079692 WO2021078832A1 (en) | 2019-10-25 | 2020-10-22 | A working fluid treatment device for mass transfer between a working fluid and two fluid exchange media |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| JP2023135230A Division JP2023153306A (en) | 2019-10-25 | 2023-08-23 | Working fluid treatment device for mass transfer between working fluid and two fluid exchange media |
| JP2024135010A Division JP2024149768A (en) | 2019-10-25 | 2024-08-13 | Working fluid treatment device for mass transfer between a working fluid and two fluid exchange media - Patents.com |
Publications (2)
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| JP2022553380A JP2022553380A (en) | 2022-12-22 |
| JPWO2021078832A5 true JPWO2021078832A5 (en) | 2023-08-31 |
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| JP2022523916A Pending JP2022553380A (en) | 2019-10-25 | 2020-10-22 | Working fluid processing device for mass transfer between a working fluid and two fluid exchange media |
| JP2023135230A Pending JP2023153306A (en) | 2019-10-25 | 2023-08-23 | Working fluid treatment device for mass transfer between working fluid and two fluid exchange media |
| JP2024135010A Pending JP2024149768A (en) | 2019-10-25 | 2024-08-13 | Working fluid treatment device for mass transfer between a working fluid and two fluid exchange media - Patents.com |
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| JP2023135230A Pending JP2023153306A (en) | 2019-10-25 | 2023-08-23 | Working fluid treatment device for mass transfer between working fluid and two fluid exchange media |
| JP2024135010A Pending JP2024149768A (en) | 2019-10-25 | 2024-08-13 | Working fluid treatment device for mass transfer between a working fluid and two fluid exchange media - Patents.com |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210121620A1 (en) |
| EP (1) | EP4048339A1 (en) |
| JP (3) | JP2022553380A (en) |
| KR (1) | KR20220121780A (en) |
| CN (1) | CN114867504A (en) |
| AU (1) | AU2020370717A1 (en) |
| CA (2) | CA3235847A1 (en) |
| WO (1) | WO2021078832A1 (en) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4151088A (en) * | 1978-01-23 | 1979-04-24 | Baxter Travenol Laboratories, Inc. | Membrane diffusion device with integral heat exchanger and reservoir |
| DE3733542A1 (en) | 1986-10-13 | 1988-07-14 | Akzo Gmbh | Mass transfer appliance |
| US5236665A (en) | 1988-10-20 | 1993-08-17 | Baxter International Inc. | Hollow fiber treatment apparatus and membrane oxygenator |
| US5120501A (en) | 1988-10-20 | 1992-06-09 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
| US5162101A (en) * | 1989-01-13 | 1992-11-10 | Minntech Corporation | Oxygenator wedge configuration |
| US5312589A (en) * | 1993-03-04 | 1994-05-17 | Electromedics, Inc. | Gas transfer apparatus |
| JP4258908B2 (en) | 1999-09-14 | 2009-04-30 | 株式会社ジェイ・エム・エス | Oxygenator |
| DE102005031582A1 (en) | 2005-07-06 | 2007-01-11 | Maquet Cardiopulmonary Ag | Device for treating blood in an extracorporeal blood circulation |
| DE102009008601A1 (en) * | 2009-02-12 | 2010-08-19 | Novalung Gmbh | Device for the treatment of a biological fluid |
| US20150246169A1 (en) * | 2011-10-14 | 2015-09-03 | Cytopherx, Inc. | Cartridge and method for increasing myocardial function |
| US10401876B1 (en) * | 2011-11-16 | 2019-09-03 | Zane Coleman | Fluid collection component comprising a film with fluid channels |
| EP2777801B1 (en) | 2013-03-15 | 2019-08-28 | Maquet Cardiopulmonary AG | Device for eliminating CO2 from patient blood |
| US9408960B2 (en) * | 2013-12-19 | 2016-08-09 | Medtronic, Inc. | Partial radial heat exchanger and oxygenator |
| CN111032106B (en) | 2017-08-15 | 2023-02-10 | 马里兰大学巴尔的摩 | Dual chamber gas exchanger for respiratory support |
| US10688238B2 (en) * | 2017-09-29 | 2020-06-23 | General Electric Company | Anesthesia system for cardiopulmonary bypass machine |
| CN111818951B (en) | 2018-03-02 | 2024-01-02 | 频谱医疗有限公司 | Oxygenation system |
-
2020
- 2020-10-22 CN CN202080089650.1A patent/CN114867504A/en active Pending
- 2020-10-22 EP EP20797428.8A patent/EP4048339A1/en active Pending
- 2020-10-22 KR KR1020227016746A patent/KR20220121780A/en unknown
- 2020-10-22 CA CA3235847A patent/CA3235847A1/en active Pending
- 2020-10-22 WO PCT/EP2020/079692 patent/WO2021078832A1/en unknown
- 2020-10-22 CA CA3158571A patent/CA3158571A1/en active Pending
- 2020-10-22 US US17/077,752 patent/US20210121620A1/en active Pending
- 2020-10-22 JP JP2022523916A patent/JP2022553380A/en active Pending
- 2020-10-22 AU AU2020370717A patent/AU2020370717A1/en active Pending
-
2023
- 2023-08-23 JP JP2023135230A patent/JP2023153306A/en active Pending
-
2024
- 2024-08-13 JP JP2024135010A patent/JP2024149768A/en active Pending
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