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JPWO2021055744A5 - - Google Patents

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Publication number
JPWO2021055744A5
JPWO2021055744A5 JP2022517374A JP2022517374A JPWO2021055744A5 JP WO2021055744 A5 JPWO2021055744 A5 JP WO2021055744A5 JP 2022517374 A JP2022517374 A JP 2022517374A JP 2022517374 A JP2022517374 A JP 2022517374A JP WO2021055744 A5 JPWO2021055744 A5 JP WO2021055744A5
Authority
JP
Japan
Prior art keywords
difluoromethyl
thiadiazol
amino
sulfonyl
indazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022517374A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022548690A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/051486 external-priority patent/WO2021055744A1/en
Publication of JP2022548690A publication Critical patent/JP2022548690A/ja
Publication of JPWO2021055744A5 publication Critical patent/JPWO2021055744A5/ja
Pending legal-status Critical Current

Links

JP2022517374A 2019-09-20 2020-09-18 Parg阻害剤としての4-置換インドールおよびインダゾールスルホンアミド誘導体 Pending JP2022548690A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962903438P 2019-09-20 2019-09-20
US62/903,438 2019-09-20
PCT/US2020/051486 WO2021055744A1 (en) 2019-09-20 2020-09-18 4-substituted indole and indazole sulfonamido derivatives as parg inhibitors

Publications (2)

Publication Number Publication Date
JP2022548690A JP2022548690A (ja) 2022-11-21
JPWO2021055744A5 true JPWO2021055744A5 (zh) 2023-09-20

Family

ID=72744866

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022517374A Pending JP2022548690A (ja) 2019-09-20 2020-09-18 Parg阻害剤としての4-置換インドールおよびインダゾールスルホンアミド誘導体

Country Status (12)

Country Link
US (1) US20220389003A1 (zh)
EP (1) EP4031249A1 (zh)
JP (1) JP2022548690A (zh)
KR (1) KR20220066922A (zh)
CN (1) CN114555593A (zh)
AU (1) AU2020348489A1 (zh)
BR (1) BR112022004624A2 (zh)
CA (1) CA3147493A1 (zh)
IL (1) IL291436A (zh)
MX (1) MX2022003276A (zh)
TW (1) TW202120501A (zh)
WO (1) WO2021055744A1 (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41179A (fr) 2014-12-19 2017-10-24 Cancer Research Tech Ltd Composés inhibiteurs de parg
WO2023057389A1 (en) 2021-10-04 2023-04-13 Forx Therapeutics Ag Parg inhibitory compounds
EP4413000A1 (en) 2021-10-04 2024-08-14 FoRx Therapeutics AG N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer
US20230265057A1 (en) * 2022-02-14 2023-08-24 Arase Therapeutics Inc. Inhibitors of parg
WO2023165571A1 (zh) 2022-03-04 2023-09-07 上海璎黎药业有限公司 一种含五元杂芳环结构化合物、其药物组合物及应用
WO2023175184A1 (en) 2022-03-17 2023-09-21 Forx Therapeutics Ag 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer
WO2023175185A1 (en) 2022-03-17 2023-09-21 Forx Therapeutics Ag 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer
MX2024011545A (es) * 2022-03-23 2024-09-26 Ideaya Biosciences Inc Compuestos de indazol sustituidos con piperazina como inhibidores de parg.
CN117157299B (zh) * 2022-04-28 2024-05-28 北京丹擎医药科技有限公司 三环杂环衍生物及其组合物和应用
WO2023224998A1 (en) * 2022-05-17 2023-11-23 858 Therapeutics, Inc. Inhibitors of parg
US11939335B2 (en) 2022-05-17 2024-03-26 858 Therapeutics, Inc. Substituted imidazo[1,2-a]quinazolines and imidazo [1,2-a]pyrido[4,3-e]pyrimidines as inhibitors of PARG
WO2024017306A1 (zh) * 2022-07-19 2024-01-25 苏州信诺维医药科技股份有限公司 含硫杂芳环化合物、其药物组合物及其用途
EP4311829A1 (en) 2022-07-28 2024-01-31 Nodus Oncology Limited Substituted bicyclic heteroaryl sulfonamide derivatives for the treatment of cancer
WO2024074497A1 (en) 2022-10-03 2024-04-11 Forx Therapeutics Ag Parg inhibitory compound
KR20240051861A (ko) * 2022-10-13 2024-04-22 한미약품 주식회사 Yap-tead 상호작용 억제를 위한 신규한 헤테로비시클릭 화합물 및 이를 포함하는 약학적 조성물
WO2024148280A1 (en) 2023-01-06 2024-07-11 Ideaya Biosciences, Inc. Treatment of er+ breast cancer comprising homologous recombination deficiency using parc inhibitor
WO2024173234A1 (en) * 2023-02-13 2024-08-22 Arase Therapeutics Inc. Inhibitors of parg
WO2024173453A1 (en) * 2023-02-14 2024-08-22 Ideaya Biosciences, Inc. Heteroaryl-substituted imidazopyridine compounds
WO2024173514A1 (en) * 2023-02-14 2024-08-22 Ideaya Biosciences, Inc. Amide and ester-substituted imidazopyridine compounds
WO2024173530A1 (en) * 2023-02-14 2024-08-22 Ideaya Biosciences, Inc. Heteroaryl-substituted pyrazolo/imidazo pyridine compounds
WO2024173524A1 (en) * 2023-02-14 2024-08-22 Ideaya Biosciences, Inc. Heteroaryl-substituted benzimidazole compounds
WO2024209035A1 (en) 2023-04-05 2024-10-10 Forx Therapeutics Ag Parg inhibitory compounds
WO2024211506A1 (en) 2023-04-05 2024-10-10 Ideaya Biosciences, Inc. Combination therapy comprising a parg inhibitor and a topoisomerase inhibitor for treating cancer
WO2024222842A1 (en) * 2023-04-27 2024-10-31 Danatlas Pharmaceuticals Co., Ltd. Tricyclic heterocyclic derivatives, compositions and uses thereof
CN118459452B (zh) * 2024-07-10 2024-10-25 苏州国匡医药科技有限公司 一种多聚adp核糖水解酶抑制剂及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US6184225B1 (en) 1996-02-13 2001-02-06 Zeneca Limited Quinazoline derivatives as VEGF inhibitors
CA2244897C (en) 1996-03-05 2006-04-11 Zeneca Limited 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
PL205557B1 (pl) 1999-02-10 2010-05-31 Astrazeneca Ab Pochodne indolu
NZ522074A (en) 2000-05-31 2004-06-25 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
IL153325A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
KR20030014425A (ko) 2000-07-07 2003-02-17 앤지오젠 파마슈티칼스 리미티드 혈관 손상제인 콜치놀 유도체
MA41179A (fr) * 2014-12-19 2017-10-24 Cancer Research Tech Ltd Composés inhibiteurs de parg
PT3870575T (pt) * 2018-10-25 2023-05-12 Viiv Healthcare Uk No 5 Ltd Inibidores da replicação do vírus da imunodeficiência humana

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