JPS63135310A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having excellent beautifying effects, shelf stability, high safety to skin and improved industrial productivity, by blending a cosmetic with a component of a plant of the genus Sorghum of the family Gramineae. CONSTITUTION:Any of various cosmetics such as cream, lotion, soap, pack, compact powder, skin cosmetic, ointment, etc., is blended with a component of a plant of the genus Sorghum of the family Gramineae having high melanocyte inhibition ratio and excellent inhibitory effects on melanin formation, such as juice obtained by squeezing the plant, an extract obtained by extracting the plant with water and/or a lower alcohol, preferably a substance obtained by decoloring the juice or the extract with active carbon to give a cosmetic having the above-mentioned effects.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to cosmetics that have an excellent whitening effect, are highly storage stable, and are highly safe for the skin.

Darkening, age spots, and freckles on the skin caused by sunburn are generally caused by an increase in active melanocytes due to hormonal abnormalities or stimulation by ultraviolet rays, and due to this influence, melanin, a colored pigment, is released into the skin tissue and increases. arise.

Therefore, we can improve these skin problems.

Various compounds that suppress melanin production are known to have a whitening effect, such as ascorbic acid and its esters, hydroquinone and its derivatives (Japanese Unexamined Patent Application Publication No. 58-15-1982), which inhibit melanin production by reducing melanin precursors, and hydroquinone and its derivatives.
No. 4507 and No. 61-207306.207312,
210007 and 210008), glutathione and cysteine that inhibit the activity of the enzyme tyrosinase, colloidal sulfur that exfoliates dead skin cells and bleaches melanin, and sugar pigments that are components of brown sugar (Special Publication No. 59-48809). These compounds are used in the form of being added to cosmetics such as creams, ointments, and lotions and applied to the skin.

However, when the above-mentioned compounds are used in various cosmetics, ascorbic acid, glutathione, and cysteine have poor storage stability, and colloidal sulfur has weak whitening effects. Additionally, although hydroquinone exhibits an excellent melanin-suppressing effect, it causes side effects such as skin irritation caused by hydroquinone oxidation products and vitiligo-like skin discoloration that occurs because it also suppresses the production of melanin that normally resides in the skin. In addition, sugar pigments are industrially disadvantageous because the yield from sugarcane, which is the raw material, is very low.

Therefore, there has been a demand for the development of a whitening agent that has excellent whitening effects, high storage stability and safety, and is suitable for inclusion in cosmetics.

The present invention was made in view of the above circumstances, and an object of the present invention is to provide a cosmetic that not only has an excellent whitening effect but also has high storage stability and safety for the skin, and has good industrial productivity.

In order to achieve the above object, the present inventors screened various plant ingredients and conducted intensive studies on their skin whitening effects. We have discovered that ingredients from plants of the genus Sorghum of the Poaceae family, which are widely used as cosmetics, exhibit a high rate of inhibiting active melanocytes, and also have high storage stability and safety for the skin when incorporated into cosmetics. In addition, water and/or
The inventors have also discovered that lower alcohol extracts have superior whitening effects, and that these ingredients are treated with activated carbon to provide better color tone and whitening effects, leading to the present invention. It is something that

The present invention will be explained in more detail below.

The plants of the genus Sorghum of the Poaceae family used in the present invention are generally referred to as turghum, and have been widely used as feed for a long time.
gare) and its varieties, Johnson grass (S, h
alepersis) and its variants, Chenigeras (S.
, vigatum) and its varieties, Sorghum (S.
, nitudum) and hybrids produced between these plants of the genus Sorghum. In the present invention, these may be used alone or in combination of two or more.

In the present invention, as a component of a plant of the genus Sorghum of the Poaceae family, even if the juice obtained by pressing the above-mentioned plant body is mixed,
Alternatively, an extract obtained by extracting a plant body with an extraction solvent may be blended.

Here, the method for extracting the plant body can be 1 using a normal method.
For example, the extract can be easily extracted by adding an extraction solvent such as water or lower alcohol to a chipped plant, thoroughly crushing the plant using a mixer, etc., and then filtering to remove the plant pieces. Obtainable.

In the present invention, when blending this extract into cosmetics,
The extract may be blended as it is, or it may be blended after it has been a-condensed or the solvent has been completely distilled off to dryness.

In this case, there are no restrictions on the extraction solvent; for example, water, lower alcohols, ether, acetone, petroleum ether, etc. can be used, especially water and lower alcohols.

It is preferable to use a polar solvent such as a hydrous lower alcohol. Here, methanol, ethanol, impropatol, etc. can be used as the lower alcohol, and a mixed solvent of two or more of these may be used.

In addition, the water-containing lower alcohol has a weight ratio of these lower alcohols and water of 50:50 to 95:5, especially 60:4.
A mixture in a ratio of 0 to 90:10 is preferred.

The amount of extraction solvent is not particularly limited, but it is preferably about 0.5 to 10 times the weight of the raw plant.

Furthermore, it is more preferable to subject the above-mentioned squeezed juice or extract to activated carbon treatment or other decolorization treatment using activated clay, etc., in terms of the whitening effect and the color tone of the extract. In this case, the amount of decolorizing agent such as activated carbon added is 0.000 to the raw plant body.
It is preferable that the sag be about 1 to 1 percent.

The cosmetics of the present invention can be applied to various cosmetics, such as creams such as emollient cream, vanishing cream, and foundation cream, lotions such as emollient lotion, foundation lotion, and astringent lotion, soaps, packs, Examples include compact powders, other skin cosmetics, and ointments.

In addition, the cosmetics of the present invention are water-based type, alcohol type,
It can be prepared in the following forms: W/○ emulsion type, O/W emulsion type, multilayer emulsion type having a dispersion mode of W10/W, powder type, stick type, spray type, paste type, etc.

Furthermore, as the ingredients of the cosmetic composition of the present invention, in addition to the above-mentioned ingredients of the gramineous sorghum plant, known ingredients depending on the type of cosmetic composition to be prepared may be blended. For example, distilled water, deionized water, ethanol, isopropyl alcohol, glycerin, polypropylene glycol, polyethylene glycol.

Polyhydric alcohols such as sorbitol and polyvinyl alcohol, animal oils and fats, vegetable oils and fats, mineral oils, hydrogenated oils, waxes such as carnauba wax and beeswax, higher hydrocarbons such as liquid paraffin and paraffin wax, fatty acids such as stearic acid, Surfactants such as emulsifiers, anionic surfactants, cationic surfactants, nonionic surfactants, 2 amphoteric surfactants, gum tragacanth, xanthan gum, sodium alginate, methylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, carboxyvinyl polymers, etc. Water-soluble polymer compounds, talc, kaolin, calcium carbonate, calcium hydrogen phosphate,
Starch and other non-toxic carriers are selectively used depending on the type of cosmetic.

Perfumes, flavors, pigments, sweeteners, and preservatives may also be added if necessary. Plus, vitamins.

Active ingredients such as hormones, antihistamines, astringents, enzymes, allantoin, hinokitiol, β-cholestanol, ultraviolet absorbers, and bactericides may also be incorporated into cosmetics.

As explained above, the cosmetic of the present invention exhibits a high melanocyte suppression rate and has an excellent whitening effect by incorporating ingredients from a plant of the genus Sorghum, which has an excellent suppressive effect on melanin production. In addition, it has high storage stability and safety to the skin, and has good industrial productivity.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment Example 1] Syrup vulgare
var saccaratum) was crushed, extracted with 1 liter of water, and filtered to collect the water extract.Then, water was distilled off under reduced pressure and dried to obtain amino acids. 92.07 g of brown powder with odor was obtained (yield:
3.41% 9 Invention product 1) based on fresh stems. Note that the water extraction was performed at room temperature for 2 hours with stirring.

In addition, 810 mg of activated carbon was added to the water extract obtained by the above method.
(0.03% by weight based on raw stems) and stirred at room temperature for 30 minutes, filtered to remove activated carbon, and the filtrate was evaporated under reduced pressure at 50°C to dryness. .23 g was obtained (yield: 3.30% based on fresh stems 1 product of the present invention 2).

Furthermore, 3 was extracted with water and treated with activated carbon as above.
After adding 0.0ml of ethanol and stirring at room temperature for 2 hours, the filtrate was obtained by filtration, and the ethanol was distilled off under reduced pressure to dryness to obtain 5.5g of light brown mucilage (yield: 0.21%2) of the product of the present invention3).

Additionally, 30-g of ethanol was added to 5 g of the aqueous extract of the syrup Turgum (invention product 1), stirred at room temperature for 2 hours, filtered to obtain a filtrate, and the ethanol was distilled off under reduced pressure to dryness. Then, 575 μ of yellow powder was obtained (yield: 0.42% based on fresh stems (inventive product 4), which was dissolved in 50% ethanol, and activated carbon was added to 6 μ (1 μg per inventive product 4). %) and stirred at room temperature for 30 minutes, the activated carbon was removed by filtration, and the filtrate was dried under reduced pressure at 50°C to obtain 440 cm of milky white powder (
Yield: 0.32% based on fresh stems2) Product of the present invention5).

On the other hand, 50% aqueous ethanol IN was added to 100 g of dried Tsuruga gum chips, and the mixture was extracted at 50° C. for 2 hours. After the extraction, the plant pieces were removed by filtration, and the resulting extract was distilled off under reduced pressure to obtain 4.5 g of a reddish-brown slimy extract (yield: 2.44% based on the raw stem).

Invention product 6).

In addition, ethanol IQ was added to 100 g of Tsuruga gum chips and treated in the same manner as above to obtain a reddish-purple slimy extract 2.1.
1 (yield: 1.20% based on fresh stems) 2 Inventive product 7
).

Next, the whitening effect of the above extract was investigated by the following method.

- J Evaluation A fixed amount of a 10% ethanol solution of the sample (above extract) was applied every day for 7 days to the depilated area of a C57 black mouse whose dorsal region was depilated, and during that period, it was irradiated with 172 MED of UV-B ultraviolet rays every day.

This operation was performed on 10 C57 black mice.
After the irradiation, a total of 20 samples were collected from each mouse, two on the left and right of the hair removal area on the back, the number of dopa-positive melanocytes per 1 mA was measured, and the inhibition rate (%) of active melanocytes compared to the control was determined. As a control, water was used for Invention Products 1 and 2, and ethanol was used for Invention Products 3 to 7.

The results are shown in Table 1. In addition, Table 1 shows the
10% solution of sugar dye described in No. 8809 (comparative amount 1
), the results for a commercially available 10% ascorbic acid phosphate solution (comparative amount 2), and a commercially available 10% hydroquinone solution (comparative amount 3) are shown. went.

From the results in Table 1, it is clear that the products of the present invention have a high active melanocyte suppression rate and are excellent in whitening effects.In particular, among the products of the present invention, water extracts of plants are treated with activated carbon and further extracted with alcohol. It was confirmed that the extract showed the highest melanocyte inhibition rate.

The present invention will be specifically described below with reference to Examples, but the present invention is not limited to the Examples below.

[Example 1] Skin lotion glycerin monostearate 1% by weight isopropyl palmitate 3 Lanolin 1 Glycerin 5 Paraoxybenzoic acid methyl ester 0.1 Extract of a sorghum plant belonging to the Poaceae family (Product of the present invention 3) 1 Fragrance 1 Color
micro needle
100.0% by weight [Example 2] Skin cream Glycerin monostearate 10% by weight Lanolin 2 Glycerin 15 Paraoxybenzoic acid methyl ester 0.1 Extract of a plant of the genus Sorghum (Poaceae) (product of the present invention 5) 0.5 Fragrance
Trace amount [Example 3] Packing agent

Claims (1)

[Claims] 1. A cosmetic product characterized by containing ingredients of a plant belonging to the genus Sorghum of the Poaceae family.