JPS62298509A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic effective in improving moisture-retaining function of skin (chap-ameliorating, horny tissue improving and moisture- retaining effect), having excellent skin-beautifying effect and chap-amelioration effect at lip and low irritation to skin, by compounding lecithin and mucin to a cosmetic. CONSTITUTION:Lecithin and mucin are added to a cosmetic at a weight ratio of preferably 1:(1-10). The lecithin is a glycerophospholipid separated from yolk or soybean and its main component is phosphatidylcholine, however, an industrial grade lecithin usually contains small amounts of phosphatidyl ethanolamine, phosphatidyl inositol, etc. Mucin is a viscous substance separated from gastric juice or saliva of mammal, especially cattle or pig and is stably available on an industrial scale. The amount of lecithin in the skin cosmetic is usually 0.05-10wt% based on the whole cosmetic and that of mucin is 0.2-10wt%. The cosmetic can be used in the form of lotion, milky lotion, cream, lip cream, pack, etc.

Description

Detailed Description of the Invention 8. Detailed Description of the Invention (Field of the Invention) The present invention provides a skin moisture retaining function (improving effect on rough skin, improving keratin) obtained by blending lecithin and mucin. The present invention relates to a skin cosmetic that improves skin care (e.g., admixture retention effect) and exhibits beautifying effects.

(Prior art) In order to maintain healthy and beautiful skin, hydrophilic skin moisturizers and oily skin softeners that provide appropriate moisture and oil to the skin have traditionally been blended into skin cosmetics. There is.

Skin moisturizers include glycerin, propylene glycol,
Polyethylene glycol, pyrrolidone carboxylate, etc. are used, but these may absorb water from the stratum corneum, the outermost layer of the skin, causing moisture loss in the skin, and they may also cause large amounts of water to be lost. However, skin cosmetics containing such substances have not always been satisfactory, as they give an uncomfortable feeling such as stickiness.

In addition, liquid puffin, vaseline, olive oil, squalane, furulin, synthetic ester oil, etc. are used as skin softeners, but these are also included in skin cosmetics to the extent that they sufficiently prevent water evaporation from the epidermis. TokiK had drawbacks such as being a cause of inhibiting the normal metabolism of the skin.

(Disclosure of the Invention) In view of the above-mentioned drawbacks of skin moisturizers and emollients, the present inventors have developed a method that maintains the skin in a healthy state and continuously improves the moisture retention function of the skin. As a result of intensive research with the aim of providing skin cosmetics, we have found that a skin cosmetic containing specific mucin and lecithin described below exhibits an effect that meets the purpose, and also provides moisturizing (moist) properties to the skin. The present invention was completed based on the discovery that it has a beautifying effect by imparting softness, elasticity, and luster to the skin.

(Objective of the Invention) The object of the present invention is to provide moisture retention function of the skin (improving effect on rough skin,
Our goal is to provide skin cosmetics with excellent keratin-improving effect, moisturizing effect) and skin-beautifying effect (sensory test).

(Structure of the Invention) The present invention is a skin cosmetic containing lecithin and mucin.

(Detailed Description of the Invention) Lecithin used in the present invention is a known substance, and is industrially a glycerophospholipid mainly obtained from egg yolks and soybeans. Its main component is phosphatidylcholine, but industrial grade products usually contain small amounts of 7-osphatidylethanolamine, phosphatidylinositol, lysolecithin, etc. The lecithin mentioned above is soybean lecithin.

It is a general term for egg yolk lecithin, hydrogenated lecithin, lysolecithin, etc., and also includes phosphatidylethanolamine, phosphatidylinositol, and ft-sphatidylcholine.

The amount of lecithin used in the present invention is 0.05 to 10% by weight (hereinafter abbreviated as wt%), preferably 0.1 to 5% by weight, based on the total amount of the skin cosmetic.

The mucin used in the present invention is a known substance, and generally refers to a highly viscous sticky substance produced by animal epithelial cells, mucous membranes, salivary glands, etc., but it is not industrially stable. Available are viscous substances obtained from the stomach or saliva of mammals (especially cows, pigs).

The manufacturing method may be based on, for example, the description in US Pat. No. 2,805,714. Examples thereof are described in the Experimental Examples below.

(5i! Experimental example) (1) Remove the stomach from a pig immediately after slaughter and remove its contents.

(2) After separating the gastric fundus lining from the obtained stomach and further removing the non-stomach fundus, gastric mucosa 8.44 is obtained.

(3) The gastric mucosa obtained in Glass Fining Tank K (2) containing 10 times the amount of Q, 5 wt% hydrochloric acid solution is placed into the gastric mucosa, and the mixture is stirred and crushed for a short time at room temperature.

(4) Since a solution part and a precipitate part are generated, filtering is necessary.
A clearer filtrate C811> is obtained.

(5) Add sodium carbonate to the filtrate obtained in (4) to adjust the PR to 4.6, then add the same amount of ethanol as this aqueous solution and leave it at 4°C overnight.

(6) Wash the obtained precipitate with water several times.

(7) Add acidic sodium carbonate water and adjust P]I to 7.0.

(8) Dry the aqueous solution by spray drying 65. F
(pig gastric mucin) In addition, cow saliva 41 was collected and used in the above experimental example (5).
) After applying the same treatment as above, the cow saliva mucin 61.
I got 0.9+.

The characteristic values and analysis values of each mucin obtained above are
Record in the table.

Table 1 In the present invention, the amount of mucin blended is preferably in the range of 0.2 to 1Qwt% based on the total amount of the skin cosmetic. If the blending amount is less than 0.2 Wt%, the effect will not be sufficiently achieved, while if it exceeds IQwt%, no improvement in the effect commensurate with the increase can be expected.

In addition, the blending ratio (weight ratio) of the lecithin and mucin is:
It is preferable that lecithin:mucin=1:1-10.

It is presumed that the lecithin and mucin incorporated in the skin cosmetic of the present invention form a unique gel matrix, thereby forming a highly moisturizing film on the skin surface.

The skin cosmetics of the present invention include, for example, lotions, milky lotions,
It can be applied to creams, lip balms, packs, etc.

In addition to the above, the skin cosmetics of the present invention may contain pigments, fragrances, preservatives, surfactants, preservatives, pigments, antioxidants, etc. as appropriate within the scope of achieving the purpose of the present invention. Can be done.

(Example) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples.

The moisturizing effect test method, rough skin improvement effect test method, keratin improvement effect test method, sensory test (beautifying skin effect test method), and lip balm practical test are as follows.

(1) Rough skin improvement effect test method 11! The effects of continuous application for 4 weeks were investigated on 20 middle-aged and elderly subjects with pK rough skin. Approximately 1 I of the sample was applied to the test site of the left lower leg of the subject once a day, and the condition of the skin before and after the test was judged according to the following criteria. No sample was applied to the right lower leg, which served as a control.

Judgment criteria for skin dryness -: Normal ±: Slight dryness, no flaking +: Slight dryness, flaking ++: Dryness, flaking Moderate softness +++: Dryness, flaking Significantly Compare the judgment results of the test site and control site before and after the test. , if the skin dryness has improved by two or more levels (e.g. +→-1)
++→±) is valid, one level improvement is slightly valid,
If there was no change, it was considered invalid. The test results are shown as the number of subjects who found the drug to be effective or somewhat effective.

(2) Effect test method for improving keratin (increasing anti-peeling properties of keratinocytes) Scotch tape (Tiban mending tape) was adhered to the skin of the test area before and after the above-mentioned rough skin improvement measurement test, and this was peeled off. The condition of the corneocytes attached to the tape was examined in detail using a scanning electron microscope, and the anti-desalination property of skin corneocytes was analyzed according to the following criteria to determine the corneum improving effect.

Judgment criteria for keratin improving effect (increased anti-desquamation property of keratinocytes) Evaluation score: 1 No scale observed 2 Small scale scattered 8 Small to medium scale noticeable 4 Large scale noticeable evaluation is the evaluation score of the test area after 4 weeks of continuous application. A difference of 2 points or more from that of the control site was considered valid, a difference of 1 point was considered somewhat effective, and a difference of 0 points was considered invalid.

The judgment results are expressed as the number of subjects who found the test to be effective or somewhat effective.

(3) Moisturizing effect test method Before and after the start and end of the rough skin improvement effect test, the skin conductance value (unit: micromho) of the test site of each subject was measured using an impedance meter (1, B, manufactured by S Company, IB
8-854).

It is generally accepted that the higher the skin conductance value, the lower the [9C resistance of the skin and the higher the stratum corneum water content of the skin.

[1 effect is the stratum corneum moisture increase rate (%) calculated by the following formula.
) was evaluated.

Wo: Conductance value of the sample application site before the start of the test W: 〃 〃At the end! The test results were shown as the average value of the rate of increase in stratum corneum moisture for 20 subjects.

(4) Sensory test (skin beautification effect test) Female subjects (85 and up) who complain of rough skin, fine wrinkles, dry skin, etc.
The sample was applied to 20 people (55 years old) twice a day (morning and evening) for 8 consecutive months, and the effects were evaluated after 8 months.

The test results showed that the skin was moisturized, the skin was smooth, and the skin was smooth.
It is shown by the number of people who answered that their skin became taut.

(5) Lip balm practical test Twenty female subjects complaining of chapped lips conducted a practical test once a day for one month, and answered the following questionnaire.

Effect on chapped lips The test will be based on whether the chapped lips have improved (healed) compared to before the test.

・Effect on lip gloss The test will be based on whether or not your lips are glossier than before the test.

Examples 1 to 2, Comparative Examples 1 to 4 [Two-layered skin low scene] Pig stomach mucin and cow saliva mucin obtained in the experimental example as shown in the composition below, and the lecithin described in Table 2 were Mix according to each skin condition (1) Composition (2) 141i! Method After each of the components (4) and (6) is uniformly dissolved, the components (4) and (4) are mixed and stirred for a while, and then poured into a container.

When using, shake and disperse the contents uniformly.

(3) Characteristics The results of various tests conducted on each two-layer skin low scene are listed in the right column of Table 2.

As shown in Table 2, the skin low sheen of the present invention of Examples 1 and 2 was found to have superior properties in various tests compared to the skin low sheen of comparative examples 1 to 4 that contained only mucin. Ta. Furthermore, in Comparative Example 4, in which soybean protein other than lecithin according to the present invention was blended, the desired effect could not be obtained.

As in Examples 1 and 2, the combination of mucin and lecithin, which is a phospholipid, clearly showed a remarkable effect on the elastic properties.

. Examples 8 to 6, Comparative Examples 5 to 6 [Skin cream] In the same manner as in Example 1, each skin cream was prepared with the following composition and various tests were conducted. Preparation method Component (4) and component ω) were each heated and dissolved at 80°C, mixed, and cooled to 80°C with stirring to prepare each skin cream.

(3) Properties As shown in Table 2, the skin creams of Examples 8 to 6, which are skin cosmetics of the present invention, have a rough skin improving effect and a keratin improving effect compared to the skin creams of Comparative Examples 6 to 6. It has excellent moisturizing properties, and it has excellent moisture retention properties, and it has excellent sensory test Examples 7 to 8. Comparative Examples 7 to 8 [Lip balm] (1) HA composition (IF! Manufacturing method (A) component and ω) component were heated and dissolved at 80°C, mixed, stirred and cooled to SaC to form each lip balm. The cream was made in R.

(3) Properties As shown in Table 8, it was found that the combined use of mucin and water-soluble polysaccharide caused these components to act on the mucous membranes of the lips, improving roughness and imparting shine.

(Effects of the Invention) As described above, the present invention improves the moisture retention function of the skin (
rough skin improvement effect, keratin improvement effect, moisturizing effect) and skin beautification effect (
It is clear that the present invention provides a skin care additive that is excellent in improving effects on chapped lips (sensory test) and has low skin irritation.

Claims (1)

[Claims] A skin cosmetic containing lecithin and mucin.