JPS62270700A - Detergent - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed Description of the Invention] 3. Detailed Description of the Invention [Field of Industrial Application] The present invention provides a cleaning agent, more specifically, a cleaning agent that prevents skin from becoming tight and dry due to cleaning, and prevents the occurrence of rough skin. Concerning highly effective cleaning products.

[Prior Art 1] One of the major purposes of cleansers such as facial cleansers is to sufficiently remove dirt and not cause skin irritation.

However, it prevents the skin from becoming tight and dry due to washing,
Although the development of a medicinal agent effective in preventing the occurrence of rough skin has been long awaited, no drug has been found to date.

° Conventionally, various raw materials extracted from natural products, such as proteins, polysaccharides, extracted extracts, natural polymers, etc., have been incorporated into cleaning products because of their distinctive effects. However, the effects have not yet been sufficient to meet expectations.

[Problems to be Solved by the Invention] ``In view of the current situation, the present inventors have developed a method for preventing rough skin and sagging skin that is highly effective in preventing skin tightening and scratching caused by washing and preventing skin roughness. As a result of intensive research into whether there is a way to prevent loss of luster and increase the effect of preventing aging, the present invention was completed by discovering that this objective could be achieved by blending Iridaceae plants or their extracts. reached.

[Means for Solving the Problems] That is, the present invention includes one or more selected from the group consisting of Iridaceae plants, Iridaceae plant extracts, and Iridaceae plant extracts. We provide a special cleaning agent.

Hereinafter, the configuration of the present invention will be explained in detail.

The Iridaceae plants that can be used in the present invention include one or more species of the Iridus genus, such as white iris, purple iris, iris iris, and screw iris. Shiboria iris, purple iris, and Shiboria iris generally use roots, but screw iris uses seeds as well as roots.

Iridaceae plants may be blended into the cleaning agent as a powder, or as an extract extracted with an appropriate solvent.

In the extraction method, whole plants or rhizomes of Iridaceae plants can be heated under reflux in a suitable solvent such as water, lower alcohols such as methanol or ethanol, or hydrous lower alcohols, and then filtered. Generally, this extract is concentrated and used.

After distilling off the solvent, the extract obtained by this method can be roughly dissolved in a solvent such as 1,3-butylene glycol, or the obtained liquid can be appropriately concentrated to form a concentrate. It can also be used for inventions. Alternatively, an extract obtained by fractionating the extract obtained by the above-described method using adsorption chromatography such as silica gel chromatography can also be used.

When the iris family plant is blended as a powder, the blending amount is 00001 to 10% by weight, preferably 0.05 to 5% by weight, and more preferably 0.0001 to 10% by weight, preferably 0.05 to 5% by weight, based on the total amount of the cleaning agent.
01-1% by weight.

If it is less than 0.001% by weight, no significant effect can be expected even if it is blended. If it exceeds 10%, it is unfavorable in the manufacturing process of the product. When the Iridaceae plant is blended as an extract or as a fractionated extract, the amount of dry residue is 0.0001 to 1% by weight, preferably 0.005 to 0.00% by weight of the total amount of the cleaning agent. 5% by weight, preferably 0.01 to 0.1% by weight. 0.001
If it is less than % by weight, the effect of the present invention will not be exhibited even if it is blended.

In addition to the above-mentioned essential ingredients, the cleaning agent of the present invention may optionally contain various ingredients commonly used in cosmetics, pharmaceuticals, etc., i.e., aqueous ingredients, to the extent that the effects of the present invention are not impaired.
Powder components, oils, surfactants, humectants, thickeners, preservatives, antioxidants, fragrances, colorants, ultraviolet absorbers, drugs, etc. can be blended. Among the drugs, when Samurai is blended with L-ascorbic acid or other esters, a remarkable effect is exhibited.The formulation of the cleaning agent of the present invention may be arbitrary; for example, it may be a solubilized type such as a lotion, Any dosage form may be used, including emulsion systems such as milky lotions and creams, ointments, powder dispersion systems, water-oil two-layer systems, and water-oil three-layer systems.

Further, the use of the cleansing agent of the present invention is arbitrary, and it can be used not only for general skin but also for hair products.

[Example] Next, the present invention will be roughly explained in detail using test examples and examples. Test Examples 1 and 2 are general in vitro screening methods and animal screening methods for drugs that prevent and smooth skin roughness.

Note that the present invention is not limited to these. The blending amount is in weight%.

Test Example 1 Effect on promoting skin cell proliferation Human skin tissue was cut into small pieces, attached to the bottom of a cell culture dish, and cultured in Eagle'MEM culture solution (containing 10% tallow serum) for one week. The entire surface is filled with fibroblasts. This fibroblast is 0.25
% trypsin solution to make single cells, then make a cell suspension of 10,000 cells/J, add 0.1+nt of this solution per Petri dish, and Eag.
] e'MEM culture solution and dried residual liquid of Iris family plant extract (final concentration 0,005%) were further added to CO2-
After culturing in an incubator for two weeks, the cells were fixed and stained, and then cell colonies were counted. The case in which the dried residue of the Iridaceae plant extract was not added was used as a control. The results are shown in Figure 1. Colony formation rate was calculated using the following formula.

Colony formation rate = ヱ × 100% T = Z Yame:
As shown in Figure 1, the number of implanted cells per colony petri dish in which the Iridaceae plant extract residue was added showed a remarkable effect compared to the control.

ゝProduction method: 10K roots of iris plants such as white iris
4Q% ethanol 801 was added to the pieces, which were thoroughly washed with water and cut into pieces of about 5 mm, and immersed at 50°C for 2 days. The extract was filtered, the filtrate was stirred at 40'C for 5 hours,
The precipitate that has separated out is removed by filtration. This filtrate is distilled under reduced pressure and concentrated.

Test Example 2 Effect on rabbit auricular blood vessels After a rabbit is anesthetized with urethane, the central side of the posterior auricular artery is ligated from the convex side of the auricle, and a cannula is inserted through a rough incision on the distal side. After cutting the auricle between the proximal ligation site and the cannula insertion site, the auricle was immediately kept at 37°C.
Perfuse with e' (II) to wash away blood in the auricle. The auricle was placed on a funnel, connected to a tube connected to an infusion bottle, and maintained at 37 °C at a pressure of approximately 30-40 cm. Tyrode (perfuse at night. During perfusion and at night, collect using a fraction collector. Collection interval is 6 minutes, collection volume is 5 to 8 mL in principle, but change as necessary. When the volume becomes constant, inject the test substance such as physiological saline or 50% ethanol (prepared overnight, etc.) into the rubber tube connected to the cannula, and then measure the volume of perfusion fluid.The injection volume should be 0.1 mL. .

Judgment indicates the degree of action of the test substance based on the difference in the amount of perfusion fluid before and after drug injection. The rate of change in the amount of perfusion fluid was calculated using the following formula, and the effect of the sample on blood vessels was measured.

+: Relaxation of blood vessels - Constriction of blood vessels Table-1 From the results shown in Table-1, it is considered that the iris extract exhibits a relaxing effect on rabbit auricular blood vessels.

Since this drug is thought to dilate blood vessels and promote blood circulation in human skin and improve rough skin, we next conducted a test on humans.

10 roots of iris family plants such as white iris
Kg was thoroughly washed with water, cut into pieces of about 5 mm, added with 80% of 40% ethanol, and immersed at 500C for 2 days.

The extract is filtered, the filtrate is stirred at 40'C for 5 hours, and the precipitate that has separated out is removed by filtration. This filtrate was distilled under reduced pressure and condensed. Add 1,3-butylene glycol to the concentrate, stir for 1 hour, let stand for 3 days, and filter to obtain 20 kg of extract.

Test Example 3 Practical Use Test In the cream formulated in Example 1, the iris extract was changed to 0% by weight and 2% by weight, and a test was conducted on skin roughness prevention and rough skin improvement effects using a human body panel. . That is, a replica of the skin surface morphology of a healthy female person (face) is taken using a replica method using myristic resin and observed using a microscope (17x magnification).

Using 20 people (skin roughness panel) who were judged to have a skin roughness rating of 1.2 based on the condition of skin markings and peeling of the stratum corneum based on the criteria shown in Table 2, the test sample obtained in Example 1 was applied to both left and right half of their faces. Apply a cream that does not contain iris extract and a cream that does not contain white iris extract, and leave it outdoors for 1 hour. The same cream was applied twice a day to both the left and right sides of the skin for two weeks. Two weeks later, a replica was taken again and the condition of the skin was observed and evaluated according to the criteria in Table 2.

Table 2 (blank space below) Table 3 The results show that facial areas treated with a cleansing agent containing extract of white iris are more effective in preventing and improving skin roughness than facial areas treated with other cleansing agents. was recognized.

Example 1 Cream A.

Setanol 0.5 Vaseline 2.0 Squalane
7.0 Self-emulsifying glycerin monostearate 2.5 Polyoxyethylene (hereinafter referred to as POE: 20 mol) sorbitan monostearate 1.5 Jojoba oil 5. OB.

Propylene glycol 5.0 Glycerin 5.0 White iris extract *2. ○Montmorillonite
5. ○Potassium hydroxide
0.3 Sodium hyaluronate 0,
05 Water / Residue *Wash the roots of the white iris thoroughly with water, add 120 parts of 70% ethanol to 20 parts of powder, stir occasionally for 10 days at room temperature, extract, filter and extract about 100 parts. Obtain the extract.

-Production method 1 Heat A (oil phase) and B (water phase) to 70°C,
Completely dissolve. Add A to the mixture and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain cream.

Example 2 Scalp Treatment A, Liquid Paraffin 15.0 Vaseline 2.0 Cetanol
2.0 stearic acid
2.5 Glycerin monostearate 1.0 POE (6) Sorbitan monostearate 1.0 Fragrance 0.5 Antioxidant Appropriate amount of preservative
Appropriate amount B, glycerin 2.
0 Purple iris extract* 0.02 Polyethylene tallycol 1500 5.0 Powerful iris extract
1.0 soluble collagen
0.1 Purified water Remainder *Wash the purple iris root thoroughly with water, powder it, add 10 L of water to 5 kg, heat under reflux for 10 hours, filter, leave the obtained filtrate for 3 days, filter, and remove the filtrate. Add water to make the total amount 1
(It was set as l.

-Manufacturing method- A scalp treatment was obtained according to Example 1.

Example 3 Emulsion A, squalane 5.0 oleyl oleate 3.0 petrolatum 2.0 sorbitan sesquioleate 0.8 POE (20) oleyl ether 1.2 octyl paradimethylaminobenzoate 4.0 fragrance 0.3 preservative agent
Appropriate amount B, 1,3-butylene glycol 5, Q Shiboria iris extract *
0.5 Ethanol 3.0 Ruboxyvinyl Polymer-0.2 Potassium Hydroxide 0.1 Sodium Hexametaphosphate 0.05 Seishui
, Residue *Wash the roots of Shiboria iris thoroughly with water,
50 tons of 1.3-butylene gelicol was added to 10 kg of the pieces cut into pieces of about 5 mm, and the mixture was immersed at 500C for 2 days. This was filtered, the filtrate was stirred at room temperature for 5 hours, and the precipitate deposited was removed by filtration. 1,3-butylene glycol was added to the filtrate to make a total volume of 1 t5 cl.

-Manufacturing method- A milky lotion was obtained in accordance with Example 1.

Example 4 Foundation A, Setanol 3.5 Deodorized lanolin 4.0 Jojoba oil
5.0 Vaseline
2. ○Squalane 6.0
Stearic acid monoglycerol ester 2.5 POE (60) Hydrogenated castor oil 1.5 POE (
20) Cef) Lt E-te) It 1.0 Preservative
Appropriate amount of fragrance
0.3B, propylene glycol
10.0 Shiboria iris extract *2.0 Glyceryl paradimethylaminobenzoate 0.1 Mixed powder 12. O Trisodium edetate 0.2 Purified water
Residue *Rinse the roots of Shiboria iris thoroughly with water, approx.
Ethanol 501 was added to 10 kg of pieces cut into pieces of mm, and the mixture was immersed at 50'C for 2 days. This was filtered, and the filtrate was stirred at room temperature for 5 hours, and the precipitate deposited was removed by filtration. Ethanol was distilled off from the filtrate, and 1,3-butylene glycol was added to the residue to give a total volume of 501 ml.

Ichifihoichi A foundation was obtained according to Example 1.

Example 5 Lotion A, ethanol 5.0POE
(15) Oleyl ether 2.02-ethylhexyl-P-dimethylaminobenzoate, 0.18 fragrance
0.05B, 1.3-butylene glycol 10.0 Purple iris extract *
1.0 Glycerin 5.0 Ascorbic acid 0.4 Purified water
Residue *Wash the purple iris root thoroughly with water, add 101 g of water to 5 kg of powder, and add 101 g of water.
The filtrate was heated under reflux for a period of time, filtered, and the resulting filtrate was allowed to stand for 3 days, filtered, and water was added to the filtrate. , closed.

-Production method- The alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.

Example 6 Ointment Purple iris extraction (r1j* 5.0 Stearyl alcohol 18.0 Japanese iris
20. ○POE (10) Monooleate 0.25 Glycerin monostearate 0.25 Vaseline 40.0 Purified water
Residue *Wash the purple eye and squirrel roots thoroughly with water and cut them into approximately 5 mm pieces.Add 50 parts of ethanol to 10 kg, and make 500
It was soaked in C for 2 days. This was filtered, the filtrate was stirred at room temperature for 5 hours, and the deposited precipitate was removed by filtration. Ethanol was added to the filtrate to make the total volume 50M.

Keep the purified water at 70°C (aqueous phase) and keep the other ingredients at 70°C.
Mix and dissolve (oil phase). The oil phase was added to the water phase, uniformly emulsified using a homomixer, and then cooled to obtain an ointment.

[Effects of the Invention] The cleansing agent of the present invention has the effect of preventing and improving skin roughness, preventing skin sagging, loss of luster, etc., and preventing aging by incorporating ingredients from Iridaceae plants or their extracts. It has the advantage of significantly increasing efficacy without side effects.

Claims (5)

[Claims] (1) One or two selected from the group consisting of Iridaceae plants, Iridaceae plant extracts, and Iridaceae plant extracts.
A cleaning agent characterized by containing at least one species. (2) The cleaning agent according to claim 1, wherein the plant belonging to the Iridaceae family is Iris genus White iris, Purple iris, Shiboria iris, or Screw iris. (3) Total of 0.00 as dried Iridaceae plants
The cleaning agent according to claim 1 or 2, which contains 1% to 10% (wt%). (4) The cleaning agent according to claim 1 or 2, which contains a total of 0.0001% to 1% (wt%) of an extract of a plant belonging to the iris family as a dry residue. (5) The cleaning agent according to claim 1 or 2, which contains a total of 0.0001% to 1% (wt%) of an extract of a plant belonging to the iris family as a dry residue.