JPS6151570A - Production of slide for chemical analysis - Google Patents
Production of slide for chemical analysisInfo
- Publication number
- JPS6151570A JPS6151570A JP17307084A JP17307084A JPS6151570A JP S6151570 A JPS6151570 A JP S6151570A JP 17307084 A JP17307084 A JP 17307084A JP 17307084 A JP17307084 A JP 17307084A JP S6151570 A JPS6151570 A JP S6151570A
- Authority
- JP
- Japan
- Prior art keywords
- mount
- chemical analysis
- base material
- slide
- plastic sheet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
Description
【発明の詳細な説明】
産業上の利用分野
この発明は液体試料を化学的に分析測定する化学分析ス
ライドの製造方法に関するものである。DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application This invention relates to a method for manufacturing a chemical analysis slide for chemically analyzing and measuring a liquid sample.
一般に、血液、血清等の液体試料について。 Generally for liquid samples such as blood and serum.
当該液体試料における特定の成分の含有の有無あるいは
その含有量等を知るべき場合に反応試薬による化学分析
が行われる。液体試料の化学分析法としては、乾式法と
湿式法とがあるが。Chemical analysis using a reaction reagent is performed when it is necessary to know whether or not a particular component is contained in the liquid sample, or its content. There are two methods for chemical analysis of liquid samples: dry methods and wet methods.
このうち乾式法は、化学分析スライドを用い。Among these, the dry method uses chemical analysis slides.
該スライドに分析すべき液体試料を滴下して供給し、こ
れを反応用恒温槽内に置いて液体試料と試薬とを反応せ
しめ、その反応の進行状態または結果を1例えば反応に
よる色の濃度変化を光学式濃度測定器により測定する手
段、その他の手段により測定検出する方法であり、液体
試料を実際上固体として取り扱うことができる点で非常
に便利である。A liquid sample to be analyzed is dripped onto the slide, placed in a thermostatic chamber for reaction, and the liquid sample reacts with the reagent. This is a method of measurement and detection using an optical concentration meter or other means, and is very convenient in that a liquid sample can actually be treated as a solid.
ところが、従来化学分析スライド用マウントの如き形状
の製品を連続して得るには、ロール状に巻いた長尺基材
を使用して行っていたが。However, conventionally, in order to continuously obtain products shaped like slide mounts for chemical analysis, a long base material wound into a roll was used.
これにより得たマウント及びマウントカバーはその基材
が元をリールから引出され、最終的に裁断されるまでの
区間が長く、走行中に基材の伸びや蛇行が生ずる結果、
マウント側の基材の走行初期に行われる絞込み部の成形
位置と、マウントカバー側の基材に予め穿孔されている
分注用透孔との中心が狂ったり、双方の基材のを癖のた
めに平面性が得られず1巻癖の度合により濃度測定手段
との密着性にバラツキを生ずるなど高精度、良品質の化
学分析スライドを生産することが困難であった。The mount and mount cover obtained by this method have a long section from when the base material is pulled out from the reel until it is finally cut, and as a result, the base material may stretch or meander during running.
The molding position of the narrowing part performed at the beginning of the travel of the base material on the mount side may be misaligned with the dispensing hole pre-drilled in the base material on the mount cover side, or the shape of both base materials may be distorted. Therefore, it is difficult to produce chemical analysis slides with high precision and good quality because flatness cannot be obtained and the degree of curling causes variations in adhesion to the concentration measuring means.
〔発明の目的)
この発明はマウント及びマウントカバーの基材の伸びや
蛇行及び基材の@ 12fによって生ずるトラブルをな
りシ、高精度、良品質の化学分析スライドを効率的に製
造できるようにした化学分析スライドの型造方法を提供
することを目的としている。[Object of the invention] This invention eliminates troubles caused by elongation and meandering of the base material of the mount and mount cover, and @12f of the base material, and makes it possible to efficiently manufacture chemical analysis slides with high precision and good quality. The purpose is to provide a method for molding chemical analysis slides.
この発明はプラスチックシートの基材から長方形のマウ
ント用エレメントを打ち抜いて、マウント上面に1又は
2以上の凹状の絞込み部を形成して該絞込み部に化学分
析フィルムを充填し、前記マウント上面にマウントカバ
ーを供給して、接着した後、非絞込み部に沿って化学分
析スライドに相当する大きさに裁断するように構成した
ものである。This invention punches out a rectangular mounting element from a plastic sheet base material, forms one or more concave narrowed parts on the upper surface of the mount, fills the narrowed parts with a chemical analysis film, and mounts the element on the upper surface of the mount. After the cover is supplied and adhered, it is cut along the non-squeezed portion into a size corresponding to a chemical analysis slide.
次に、この発明を添付図面に示す一実施例にもとづいて
説明する。Next, the present invention will be described based on an embodiment shown in the accompanying drawings.
1はマウント用基材、2は該基材1上に定めたマウント
打抜きVI域Aを1又は2以上(図示の例では5個の領
J!3i)を含むように打抜きしたマウント用エレメン
トである。該マウント用エレメント2にはその打抜きと
同時に長さ方向の両端に位置決め用の透孔3.3′と、
マウント打抜き領域Aの中心に測光用透孔4が形成され
る。1 is a mounting base material, and 2 is a mounting element that is punched out so as to include one or more (in the illustrated example, five regions J!3i) of the mount punching area A defined on the base material 1. be. The mounting element 2 has through holes 3.3' for positioning at both lengthwise ends at the same time as the punching.
A photometric through hole 4 is formed at the center of the mount punching area A.
マウント用エレメント2は第2図に示すようニ走行ライ
ン10の初期位置に設置したマガジン11より適宜の1
7シヤ一機構I2により走行ライン10に順次一定のタ
イミングにより供給されるようになっている。該走行ラ
イン1゜には一定のストロークで前後動し、その前進時
にライン上に突出して供給されたマウント用エレメント
2を係留して送り、後進時にライン下に没するように作
動する爪体13を備えた1股送機措14が設けられてい
る。As shown in FIG.
The seven-shear mechanism I2 sequentially supplies the fuel to the travel line 10 at a constant timing. There is a claw body 13 on the running line 1° that moves back and forth with a constant stroke, mooring and sending the supplied mounting element 2 protruding onto the line when moving forward, and sinking below the line when moving backward. A one-way feed mechanism 14 is provided.
搬送fjufM 14により走行ライン10上を間歇的
に順送りされるマウント用エレメント2は位置決メ用m
TL3. 3 ’ ニヒン14 a、 14 bカ挿
通された状態で進行し、その第1ステーシヨンにおいて
、プレス成形機15が作動して前述の如く定められたマ
ウント打抜き領域への上面中央部(測光用透孔4が中心
になるよう)に凹状の絞込み部5が成形される。この成
形は前述の如くマウント用エレメント2に予め測光用透
孔4を穿孔しないときは圧空成形、真空成形機を用いて
行うことも可能であり、この場合は成形後、絞込み部5
の中心にzlす光用透孔4を穿孔する手段を(j’;I
えることとなる。The mounting element 2, which is intermittently sequentially fed on the traveling line 10 by the conveyor fjufM 14, is a positioning element 2.
TL3. At the first station, the press molding machine 15 is operated to form the central part of the upper surface (through-hole for photometry) into the mount punching area determined as described above. A concave narrowed portion 5 is formed so that the concave portion 4 is centered. As mentioned above, if the photometric through-hole 4 is not drilled in the mounting element 2 in advance, it is also possible to perform this molding using a pressure forming or vacuum forming machine.
(j'; I
It will be possible to do so.
絞込み部5が成形されたマウント用エレメント2は位置
決めされた状態で、1般送機構14の送り作動により第
2ステーシヨンに至り、該絞込み部5内に化学分析フィ
ルム6がその供給機構16により充填される。化学分析
フィルム4は第3図に示すように透明支持体6aの上面
に試薬N6bを形成し、該試’JJFieb上に展開層
6cを積層してなる。該展開層6Cはこれに滴下した液
体試料を面方向に拡散して試薬層6bに反応させるため
のものである。The mounting element 2 with the narrowed part 5 formed therein reaches the second station by the feeding operation of the first general feeding mechanism 14 in a positioned state, and the chemical analysis film 6 is filled into the narrowed part 5 by the feeding mechanism 16. be done. As shown in FIG. 3, the chemical analysis film 4 is formed by forming a reagent N6b on the upper surface of a transparent support 6a, and laminating a developing layer 6c on top of the reagent N6b. The spreading layer 6C is for spreading the liquid sample dropped thereon in the surface direction and causing it to react with the reagent layer 6b.
前述の如く、絞込み部5内に化学分析フィルム6を充填
した後、第3ステーシヨンに至ったマウント用エレメン
ト2は該ステーションにおいて、その上面にマウントカ
バー用エレメント7がその収容マガジン17より適宜供
給手段を用いて重ねられる。該マウントカバー用エレメ
ント7は前記マウント用エレメント2と同様の平面性基
材(図示せず)から同形同大に打抜いたもので、マウン
ト用エレメント2の絞込み部5の中心に対応する位置に
予め試料分注用透孔7aが穿孔されているとともに、そ
の両6ii1には位置決め用の通孔7b、7b’が穿孔
され、マウント用エレメント2上に正しく重ねられる。As mentioned above, after the chemical analysis film 6 is filled into the narrowing part 5, the mounting element 2 reaches the third station, where the mounting cover element 7 is placed on the upper surface of the mounting element 2 and is appropriately supplied from the storage magazine 17. can be stacked using The mount cover element 7 is punched out in the same shape and size from the same planar base material (not shown) as the mount element 2, and is located at a position corresponding to the center of the narrowed part 5 of the mount element 2. A sample dispensing hole 7a is drilled in advance in the sample dispensing hole 7a, and positioning holes 7b and 7b' are drilled in both of the holes 6ii1, so that the mounting element 2 is properly stacked.
マウント用エレメント2上にマウントカバー用エレメン
ト7を重ねた後、第4ステーシヨンに設置した溶接機1
8が作動して両者が接着される。なお1両ニレメンI−
2,7の接着は溶接以外の手段例えば接着剤接着による
ことも可能である。Welding machine 1 installed at the fourth station after overlapping mount cover element 7 on mount element 2
8 is activated and the two are bonded together. In addition, 1 car Niremen I-
2 and 7 may be bonded by means other than welding, such as adhesive bonding.
両エレメント2.7は接着後、第5ステーシヨンにおい
て、裁断機19の作動により前記マウント打抜き領域A
に沿って裁断され、化学分析スライドとして次工程に搬
送される。After bonding, both elements 2.7 are cut out in the mount punching area A by the operation of the cutting machine 19 at the fifth station.
The slides are cut along the lines and transported to the next process as chemical analysis slides.
なお、上記製造工程において、前記走行ライン上で化学
分析フィルムの塗布工程も同時に組込むことも可能であ
る。この場合、マウント用エレメント即らマウント基材
として透明性の良好な素材を用いるときは、化学分析フ
ィルム6の透明支持体6aを兼用させ、測光用の透孔を
設けない分析スライドを製造することもできるものであ
る。また、マウント及びマウントカバー基材は必要に応
じて表面にシボ加工を施したものを用い、上面のキズ、
汚れなどを目立たなくして、その商品価値を向上させる
とともに。In addition, in the above-mentioned manufacturing process, it is also possible to simultaneously incorporate a chemical analysis film coating process on the above-mentioned traveling line. In this case, when a material with good transparency is used as the mounting element, that is, the mounting base material, the transparent support 6a of the chemical analysis film 6 can also be used, and an analysis slide without through holes for photometry can be manufactured. It is also possible. In addition, the mount and mount cover base material are made with textured surfaces as necessary, so that scratches on the top surface and
It makes dirt less noticeable and improves the product value.
鉛筆等により必要な情報を直接書込み可能にすることも
可能である。It is also possible to directly write necessary information with a pencil or the like.
このように、この発明はマウント上面に1又は2以上の
凹状の絞込み部を形成して該絞込み部に化学分析フィル
ムを充填し、前記マウント上面にマウントカバーを供給
して、接着した後。As described above, the present invention forms one or more concave narrowed portions on the upper surface of the mount, fills the narrowed portions with a chemical analysis film, and supplies and adheres the mount cover to the upper surface of the mount.
非絞込み部に沿って化学分析スライドに相当する大きさ
に裁断する化学分析スライドの製造方法において、絞込
み部を形成するマウントを。In a method of manufacturing a chemical analysis slide that is cut along the non-restricted area into a size corresponding to the chemical analysis slide, the mount that forms the recessed area.
予め、プラスチックシートの基材から長方形のエレメン
トを打ら抜いておくことを特徴としているから、従来の
如く長区間基材を走行させて諸工程を行わせるときのよ
うな伸びや蛇行の問題及び基材のS癖によって生ずるカ
ールの問題がなく、高精度、良品質の化学分析スライド
を効率的に製造できるという優れた効果を奏するもので
ある。Since rectangular elements are punched out in advance from the plastic sheet base material, problems such as elongation and meandering that occur when the base material is run over long distances to perform various processes, as in the past, are avoided. This method has the excellent effect of efficiently producing chemical analysis slides with high precision and good quality without the problem of curling caused by the S-curve of the base material.
図はこの発明を実施する装置の一例を示すもので、第1
図はマウント基材及びそれより打抜いたマウント用エレ
メントの斜視図、第2図は製造工程の略示的正面図、第
3図はマウント用エレメントの絞込み部に化学分析フィ
ルムを供給する過程の斜視図、第4図はマウント用エレ
メントにマウントカバー用エレメントを重ねる状態の斜
視図である。
t−マウント基材 2・−マウント用エレメント5−一
絞込み部 6−化学分析フィルム7−マウントカバ
ー用エレメント
特 許 出願人 小西六写真工業株式会社第1図
第2図The figure shows an example of an apparatus for carrying out this invention.
The figure is a perspective view of the mounting base material and the mounting element punched from it, Figure 2 is a schematic front view of the manufacturing process, and Figure 3 is the process of supplying the chemical analysis film to the narrowing part of the mounting element. A perspective view, FIG. 4 is a perspective view of a state in which a mount cover element is overlapped with a mount element. T-Mount base material 2.-Mount element 5-1 Narrowing section 6-Chemical analysis film 7-Mount cover element Patent Applicant Konishiroku Photo Industry Co., Ltd. Figure 1 Figure 2
Claims (1)
て該絞込み部に化学分析フィルムを充填し、前記マウン
ト上面にマウントカバーを供給して、接着した後、非絞
込み部に沿って化学分析スライドに相当する大きさに裁
断する化学分析スライドの製造方法において、絞込み部
を形成するマウントを、予め、プラスチックシートの基
材から形成単位のエレメントに打ち抜いておくことを特
徴とする化学分析スライドの製造方法。One or more concave constrictions are formed on the top surface of the mount, the concave portions are filled with a chemical analysis film, a mount cover is supplied to the top surface of the mount, and after bonding, chemical analysis is performed along the non-constricted portions. A method for manufacturing a chemical analysis slide in which the slide is cut into a size corresponding to the slide, characterized in that a mount forming a constriction part is punched out in advance from a base material of a plastic sheet into a forming unit element. Production method.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17307084A JPS6151570A (en) | 1984-08-20 | 1984-08-20 | Production of slide for chemical analysis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17307084A JPS6151570A (en) | 1984-08-20 | 1984-08-20 | Production of slide for chemical analysis |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6151570A true JPS6151570A (en) | 1986-03-14 |
Family
ID=15953646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17307084A Pending JPS6151570A (en) | 1984-08-20 | 1984-08-20 | Production of slide for chemical analysis |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6151570A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63172944A (en) * | 1987-01-13 | 1988-07-16 | Fuji Photo Film Co Ltd | Production of slide for chemical analysis |
US5904891A (en) * | 1994-10-17 | 1999-05-18 | Fuji Photo Film Co., Ltd. | Disk producing method for photo film cassette |
US6136261A (en) * | 1995-03-20 | 2000-10-24 | Fuji Photo Film Co., Ltd. | Disk producing method and apparatus |
US6417408B2 (en) | 1996-12-06 | 2002-07-09 | Nippon Shokubai Co., Ltd. | Production process for (poly)alkylene glycol monoalkyl ether |
-
1984
- 1984-08-20 JP JP17307084A patent/JPS6151570A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63172944A (en) * | 1987-01-13 | 1988-07-16 | Fuji Photo Film Co Ltd | Production of slide for chemical analysis |
US5904891A (en) * | 1994-10-17 | 1999-05-18 | Fuji Photo Film Co., Ltd. | Disk producing method for photo film cassette |
US6136261A (en) * | 1995-03-20 | 2000-10-24 | Fuji Photo Film Co., Ltd. | Disk producing method and apparatus |
US6358035B1 (en) | 1995-03-20 | 2002-03-19 | Fuji Photo Film Co., Ltd. | Disk producing apparatus |
US6417408B2 (en) | 1996-12-06 | 2002-07-09 | Nippon Shokubai Co., Ltd. | Production process for (poly)alkylene glycol monoalkyl ether |
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