JPS61271210A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic, containing an extract component prepared by extracting the root of Salvia miltiorrhiza Bunge, etc. as an active constituent, having improved skin beautifying effect and beautifying and whitening effect and humectant effect and capable of producing effect, e.g. tension, gloss, smoothness, etc. of the skin by using in cream, toilet water, etc. CONSTITUTION:A cosmetic containing an extract component prepared by extracting the dried root of Salvia miltorrhiza Bunge or Salvia przewalskii Maxim. var. mandarinorum Stib. as an active constituent. The Salvia miltiorrhiza Bunge or Salvia przewalskii Maxim. var. mandarinorum Stib. is a perennial plant belonging to the genus Labiatae. The extract thereof is obtained by cutting the dried root of the Salvia miltiorrhiza Bunge or Salvia przewalskii Maxim. var. mandarinorum Stib. to fragements having <=2cm thickness or powder with a cutter, and extracting the resultant fragments or powder with an organic solvent, e.g. ethyl acetate or acetone, and/or water. In using as a cosmetic, a water-soluble high polymer, e.g. polypeptide or casein, is preferably further incorporated with the above-mentioned active constituent, because the percutaneous absorption is increased. The amount of the active constituent to be incorporated is preferably 0.1-5wt%.

Description

[Detailed Description of the Invention] "Object of the Invention" The present invention is characterized by containing an extract obtained from the root of Danshen as an active ingredient, which has excellent skin beautifying effects, whitening effects, moisturizing effects, etc. It is related to cosmetics.

BACKGROUND ART Since ancient times, many basic cosmetics have been proposed for the purpose of conditioning, beautifying, and whitening the skin, and each has achieved certain effects.

From the viewpoint of wound healing and cell activation, the present inventor has conducted extensive research into natural active ingredients, and as a result has found that the extract obtained from the root of Danshen has beneficial effects on the skin, such as skin beautification, whitening, and moisturizing. The present invention was completed by discovering the effects of hair growth and hair growth.

That is, the present invention relates to a cosmetic material containing as an active ingredient an extracted component obtained by extracting from the root of Danshen.

"Structure of the Invention" Danshen applied to the present invention is a perennial plant 3alvia m1ltiorrhiza belonging to the Lamiaceae family.
Bunge or 5alvia przewal
skii Maxim var, mandarinor
um 5tib, and the present invention uses an extract (hereinafter abbreviated as Danjin extract) extracted mainly from the dried roots of the above plants using an organic solvent and/or water. Incidentally, the above-mentioned Danshen has already been used for other purposes. That is, it is taken as a herbal medicine for the purpose of vasodilation and cardiac inotropy.

For the production of the above-mentioned Tanjin extract, known methods can be used. For example, first, the dried root of Tanjin is cut into small pieces with a thickness of 2 cm or less using a cutter, or coarsely ground into powder, and then the dried root of Danjin , butanol, propatool,
After extraction by immersion in an extraction solvent obtained by using an organic solvent such as ethanol or methanol and water, either alone or by mixing two or more of them, the extraction solvent is removed from the resulting extract and the active ingredients are separated and collected. I can do it. The extract thus obtained is generally a pale yellowish brown to reddish brown semisolid or powder, and has almost no odor. or,
The above-mentioned extract can be used after being further purified by techniques such as column chromatography, droplet countercurrent partition chromatography, activated carbon or activated clay treatment, if necessary.

Moreover, a cosmetic containing a water-soluble polymer substance in addition to the Dansin extract has a particularly favorable skin conditioning effect. This is probably because the water-soluble polymeric substance acts as a vehicle on the skin, effectively transferring the active ingredient Astragalus extract to the stratum corneum and increasing transdermal absorption. Such water-soluble polymer substances include those with molecules of 12,000 or more, such as polypeptides, water-soluble collagen, mucopolysaccharides, hyaluronic acid, gums, casein, dextrin, gelatin, pectin, etc. One or more of these may be used.

Next, the cosmetics provided by the present invention include creams, milky lotions, lotions, lip balms, lip colors, under make-up, hair nourishing products, and many others. Although it is arbitrarily selected depending on the properties of the cosmetic, it is usually approximately 0.0% of the total weight.
The amount is 1 to 10% by weight, preferably 0.1 to 5% by weight. In addition, the amount of the water-soluble polymer substance blended is approximately 0 based on the total weight.
．． 001 to 1% by weight.

Next, the method of compounding is to use Tanjin extract as it is or with water.
It can be dissolved in alcohol, polyhydric alcohol, etc. and incorporated into cosmetics in the same manner as conventional medicinal ingredients.

In addition to the above-mentioned Danjin extract and water-soluble polymer substances, the cosmetics according to the present invention also contain additives commonly used in cosmetics, such as oils and fats, surfactants, antioxidants, fragrances, pigments, alcohols, Polyhydric alcohols, preservatives, sunscreen agents, water, humectants, etc. can be added.

"Production Example" Production Example-1 Cut 5000 pieces of dried root of Danjin into pieces with a thickness of 2 cm or less using a cutting machine, add 21 parts of methanol to this, and cut 1 piece of dried root at room temperature.
Mix, stir, extract and filter for an hour. This operation was repeated twice, and the filtrate was collected and concentrated to dryness under reduced pressure to obtain 20 g of tanjin extract as a light brown semi-solid. (Yield 4%) Production Example-2 After cutting 200G of dried roots of Danjin using a cutting machine,
Grind into powder using a grinder. Add 1 g of 50% water-containing methanol to the mixture, stir and extract at room temperature for 1 hour, and filter. Repeat this operation twice and collect the filtrate to give approximately 0.3
Concentrate under reduced pressure until N. Add 0.31 liters of water to this and stir to make a uniform dispersion, then add 3 ml of n-butanol each time.
Extraction was performed three times using 001111, and the extracts were collected and concentrated to dryness under reduced pressure to obtain Tanjin Extract 56q as a light brown semi-solid. (Yield 28%) Production Example 3 Danjin root 500Q is sliced into flakes with a thickness of about 5 mm, 2 g of hot water at about 60° C. is added thereto, mixed with stirring for 30 minutes, extracted, and filtered. This operation was repeated twice, and the filtrate was collected and freeze-dried to obtain 205 g of tanjin extract in the form of a light brown semi-solid. (Yield: 41%) "Effects of the Invention" Next, in order to confirm the skin conditioning effect of Danjin extract used in the present invention, a wound healing test was conducted using rats, and the results are shown in Table 2. . The test method is as follows.

Samples> Oil-in-water creams that do not contain Danjin extract (Comparative Example-1) and those that contain 1.0% (Example-1)
), one containing 3.0% (Example-2), and the above three types were prepared as shown in Table-1 below.

As experimental animals for the wound healing test, 40 SD rats from 5 groups were preliminarily bred for 7 days after purchase and were divided into groups 1 to 4, with 10 rats each. First, the hair on the backs of the rats in each group was removed using electric clippers, and the rats were cleaned with absorbent cotton impregnated with a water-ethanol 3 nia disinfectant solution. Then a circular chisel (
φ111IIR) to create four symmetrical skin defects along the midline. Next, group 1 was made into an untreated group, group (■) was applied with the cream of Comparative Example-1 after the observation was completed once a day, and groups (■ and IV) were similarly treated with the cream of Example-1 and Example-2, respectively. Cream was applied. All specimens were applied once a day at 0.00% per injured area. It was defined as IQ. Also, a
Measurement of #J wound area and visual observation were performed once a day. In addition, the wound area (un) of each group is the average value of 10 animals (
(rounded to the second decimal place), and the cure rate was determined by the following formula.

Healing rate - (wound area on day 0 - wound area on day 11) 0
Day-to-day wound area x 100 (%) (blank below) As mentioned above, cosmetics containing Danjin extract have an excellent wound healing effect, and the wound recovers quickly. The skin condition of the eyes) was also compared to the untreated group and comparative example-1.
It was more beautiful than the rest.

Next, the cosmetics applied to the present invention were subjected to sensory evaluation after continuous use for 20 days in a clinical test, and the results are shown in Table 3. At this time, the emollient cream of late Example 3 was used as the product of the present invention, and the emollient cream of Example 3 from which Danjin extract was removed was used as a control product.

The test method is as follows.

Clinical test: A panel of 20 mixed male and female subjects applied the control product to the inside of the left upper arm and the invention product to the inside of the right upper arm twice a day in the same manner as in normal use, and applied this for 20 days. After continuing,
The four sensory evaluation items of skin firmness, gloss, smoothness, and freshness were evaluated using the following criteria, and the average value of the 20 participants was used as the evaluation score.

Very few words and very few words
Always now
Niitomo Table-3 The values are above the sensory evaluation points, and the cosmetics applied to the present invention exert favorable effects on skin firmness, luster, smoothness, freshness, etc. when used continuously on the skin. be.

Further, regarding the hair-restoring effect of Example 5, the hair-restoring effect was confirmed in clinical tests, although the number of cases was small.

"Example" Next, an example of the present invention will be shown. Examples 1 and 2 are as shown in Table 1 above. Hereinafter, the blending amounts are in parts by weight.

Danjin Extract of I Preparation Example-1 0.5C Fragrance
Mix and heat an appropriate amount of the above Formulation A to 80'C. To this is added the above formulation B mixed and heated to 80'C in the same way, homogeneously emulsified with a homomixer, added with the above C and cooled to obtain a product.

Mix and heat Formulation B above to 70'C. To this is added the above formulation A mixed and heated to 70'C in the same manner, uniformly emulsified with a homomixer, and cooled to obtain a product.

The above formulation A was dissolved by stirring, and the above formulation B was added thereto and mixed to obtain a transparent liquid hair nourishing agent.

"! Fee
The above formulations A and B are dissolved by heating, and A is added to B to solubilize it to obtain a product.

Claims (1)

[Scope of Claims] 1) A cosmetic product containing as an active ingredient an extracted ingredient obtained by extracting from the root of Danshen. 2) The cosmetic according to claim 1, which contains a water-soluble polymer substance.