JPS61234867A - Material for living body - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to biomaterials, particularly biomaterials useful as artificial bones and artificial tooth roots.

Conventionally, materials for artificial bones and artificial tooth roots include metal materials such as silver and tantalum, alloy materials such as fupartochromium alloy, titanium alloy, and stainless steel, polymer materials such as polymethyl methacrylate and high-density polyethylene, alumina ceramics, and synthetic apatite. Ceramic materials such as these have been used. However, although metals and alloy materials have excellent strength, they have poor affinity with living tissues, and when used in the human body for a long period of time, metal ions may be released and harm living tissues. Although the material is stable in the living body, it has low strength and does not chemically bond with bones, so it can only be used in very limited areas, and there is a risk that monomers left unresolved during manufacturing may elute and damage living tissue. was there. Furthermore, although alumina ceramics, which are ceramic materials, have excellent strength, they do not chemically bond with bone, and synthetic apatite, on the other hand, strongly bonds with bone, but has a problem of low strength.

The present invention was made in view of the above-mentioned problems, and aims to provide a biological material that has excellent biocompatibility, forms a direct chemical bond with bone, and has high strength.

The biological material of the present invention is characterized in that it contains ceramic fibers or whiskers in a fired body of Pt0B CaO-based glass.

The Prom-(!ao glass used in the present invention preferably contains at least 1 to 30% by weight of P and O.
, (!ao 25-55%, PlogJjJtm total composition 25-80%.

The reason why the composition range of the PjOlCaO glass is limited as described above is as follows.

If the P, O, content is less than 1%, it will be difficult to chemically bond with bones in the body, and if it is more than 30%, the chemical durability will be poor, and at the same time it will dissolve easily in body fluids, and at the same time will have strong devitrification.
Vitrification becomes difficult.

If CaO is less than 25%, the strength of the molded product will be low, and if it is more than 55%, devitrification will be strong and vitrification will be difficult.

If the total amount of P, O, and CaO is less than 25%, the bonding force with bone will be weak, and if it is more than 80%, chemical durability will deteriorate and devitrification will occur, making vitrification difficult. .

The ceramic fibers contained in the fired Plog-(!ao glass) increase the strength of the fired glass.
SiO(7) fibers, glass fibers, and carbon fibers are suitable, and these are used in the form of long fibers or short fibers. The short fibers are obtained by cutting long fibers into pieces. The whisker is a fibrous single crystal, and any of commonly obtained metal carbides, borides, nitrides, and oxynitrides can be used.

The method for producing the biological material of the present invention will be described below.

The method of incorporating ceramic fibers into the fired body of Pros CaO glass in the present invention includes two methods: using long ceramic fibers in an array, and mixing short ceramic fibers cut into small pieces. It varies depending on.

When ceramic fibers are used in an array, a plurality of long ceramic fibers are arranged in the axial direction in a hollow cylinder under tension, and in the cylinder is a PO06-CaO system pulverized to a size of 28o mesh or less. Particles of glass granulated to about 100 particles using a spray dryer, for example, are introduced, or P,O@-CaO-based glass powder is mixed with organic substances such as α-terpineol and butyl carpitol acetate to form a slurry, and the mixture is press-fitted. Next, by applying a press or a rubber press to preform and firing this, a biomaterial in which the ceramic fibers are oriented in the axial direction in a fired body of P,0@-CaO glass can be obtained. The attached drawing is a partially cutaway perspective view of a cylindrical biomaterial 10 obtained by the above method, in which ceramic fibers 12 are arranged in the axial direction and are included in the fired body of glass 11. ing.

In addition, when chopped ceramic fibers are mixed and used, chopped ceramic fibers and ploll-CaO
The glass powder is thoroughly mixed in advance, and then organic agents such as paraffin, wax, and polyvinyl alcohol are mixed, and then preformed into the desired shape using a press 1 and a press. By doing so, P, Q@ -Ca
1. In the fired body of O-based glass. It is possible to obtain a biological material in which the butty ceramic fibers are uniformly dispersed.

The present invention will be explained in more detail below using more specific examples.

Example 1 In wt% ptos 10%, (iao 35%, S10
．． Glass raw materials prepared to have a concentration of 45% Mg and 10% Mg were melted at 1450°C for 4 hours, poured between water-cooled rollers to obtain ribbon-shaped glass, and then ground to 280 mesh or less using an alumina ball mill. . Using a spray dryer, the obtained glass powder is heated to 80~
The granules were granulated to a size of 100p, and the granules were fused with 20 diameter Al-0° fibers in an axial direction of about 1! It was placed in a press container with an outer diameter of 15 mm and a length of 60 mm in which 50 pieces were arranged at nm intervals, and subjected to a 2000 kg/61i water pressure press, a so-called rubber press, to obtain a 10φ x 50 mm preform. After that, the Al, O, and fibers protruding from the outside of this molded body were cut and fired at 1100°C for 4 hours, and the glass crystallized and apatite and olastonite crystals precipitated. Al,
A biomaterial was obtained in which Qs7° fibers were arranged in the axial direction and contained therein. While the bending strength of the crystallized glass alone without alumina fibers was 2000 k-, the bending strength of the biological material obtained by the above method was significantly increased to 5000 k-.

Example 2 80% by weight of glass powder having the same composition as Example 1, pulverized to 280 mesh or less, and a glass powder with a diameter of 10. - length 200) Z
r017 Mix 20% by weight of Yiber thoroughly, add a small amount of wax, stir while heating to 200°C, blend the wax into the powder, put it into a press mold, shape it into a prismatic shape, and then After that, a rubber press was applied at 2000 k- to produce a prismatic preform of 10 x 10 x 50 mm.

The obtained molded body was placed in an electric furnace and heated at 600°C for 1 hour to burn off the wax, and then fired at 1000°C for 4 hours. As a result, apatite and olastonite precipitated in the crystallized glass. A biological material in which Zr0t fibers were uniformly dispersed was obtained, and its bending strength was 460.
It was OK.

Example 3 Pros 20%, OaO 40%, Sin, in weight %
30%, Mg02%, B, 0.3%, Nan04%, K
Raw materials mixed to 801% are heated to 145% in an electric furnace.
After melting at 0°C for 4 hours, it was poured on a water-cooled roller to obtain a ribbon-shaped glass, and then processed in an Al, C% ball mill at 28
0me.

It was crushed to a fine powder. 75% of the obtained powdered glass and silicon oxynitride whiskers with a thickness of about 5 mm and a length of 200 to 300 pieces were thoroughly mixed, a small amount of paraffin was added, and the mixture was mixed again at 120°C, followed by pre-pressure pressing and rubber pressing. diameter 10m
A cylinder with a length of 50 mm is preformed and heated in an electric furnace.
After baking for 00'' CI hours and removing paraffin, 1
It was baked at 200°C for 4 hours. As a result, a fired body was obtained in which oxynitride whiskers were uniformly dispersed in crystallized glass in which apatite, olastonite, and tricalcium phosphate were precipitated, and the bending strength of the body was measured to be 7000.
A significant increase in strength was observed as kd.

The artificial bone prepared from the fired bodies of Examples 1 to 3 of the present invention was inserted into the defective part of the sheep's main shrine, and after the ZoJ period had passed, it was removed together with the bone to check the adhesion state with the bone and the compatibility with the living body. An investigation of the effect on the artificial bone's performance and peripheral performance revealed that it was strongly bonded to the bone and did not cause any harm to the mucus surrounding the artificial bone, and no cracks or other damage was observed.

[Brief explanation of the drawing]

FIG. 1 is a partially cutaway perspective view of a biological material in which ceramic fibers are arranged and contained in a fired body of qtas. (10) Biomaterial (11) Glass sintered body (12)
Ceramic fiber procedural amendment May 6, 1986

Claims (5)

[Claims] (1) A biological material comprising ceramic fibers or whiskers in a fired body of P_2O_5-CaO glass. (2) P_2O_5-CaO glass contains at least 1 to 30% of P_2O_5 and 25 to 55% of CaO by weight.
%, P_2O_5 and CaO in a total composition of 25 to 80%. (3) Ceramic fibers include Al_2O_3 and SiO_2
, ZrO_2, SiC, glass fiber, and carbon fiber. (4) The biological material according to claim 1, wherein the ceramic fibers are ceramic long fibers or short ceramic fibers. (5) Whiskers are metal carbides, borides, nitrides,
The biological material according to claim 1, which is selected from oxynitrides.