JPS61164143A - Dispensing nozzle in common use as photometric cell for automatic analysis instrument - Google Patents
Dispensing nozzle in common use as photometric cell for automatic analysis instrumentInfo
- Publication number
- JPS61164143A JPS61164143A JP556185A JP556185A JPS61164143A JP S61164143 A JPS61164143 A JP S61164143A JP 556185 A JP556185 A JP 556185A JP 556185 A JP556185 A JP 556185A JP S61164143 A JPS61164143 A JP S61164143A
- Authority
- JP
- Japan
- Prior art keywords
- nozzle
- dispensing nozzle
- dispensing
- cell
- specimen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Optical Measuring Cells (AREA)
Abstract
Description
【発明の詳細な説明】
（イ）産業上の利用分野
本発明は、自動分析装置における測光セル兼用分注ノズ
ルに関し、特に光学セルとして使用できる測光セル兼用
の分注ノズルに関する。DETAILED DESCRIPTION OF THE INVENTION (A) Field of Industrial Application The present invention relates to a dispensing nozzle that also serves as a photometric cell in an automatic analyzer, and more particularly to a dispensing nozzle that also serves as a photometric cell that can be used as an optical cell.
また、本発明は、自動分析装置、特に液体試料、例えば
血漿、血清、尿、その他体液及び分泌液等の検体を自動
的に化学分析する自動分析装置における分注ノズルに関
し、特に検体分注ノズル、殊に光学セルとして使用で終
る検体分注ノズルに関する。The present invention also relates to a dispensing nozzle in an automatic analyzer, particularly an automatic analyzer for automatically chemically analyzing liquid samples such as plasma, serum, urine, other body fluids, secretions, etc., and particularly to a sample dispensing nozzle. In particular, it relates to a sample dispensing nozzle that ends up being used as an optical cell.
、本発明の自動分析装置用の測光セル兼分注ノズルは、
バッチ式、フロ一式、ディスクリート方式等の作動原理
の如何に係らず、広く自動分析装置等の作動原理の如何
に係らず、広く自動分析装置に利用できるものである。, the photometric cell/dispensing nozzle for the automatic analyzer of the present invention is
It can be widely used in automatic analyzers, regardless of the operating principle, such as batch type, flow type, discrete type, etc., regardless of the operating principle of automatic analyzers.
（ロ） 従米扶術
血漿、血清、尿、その他体液及び分泌液等の検体につい
ての分析値は、例えば、診断、治療指針等に使用され、
常に正確度が要求される。しかし、血漿、血清、尿、そ
の他体液及び分泌液等の検体についての吸光度測定は、
疾患時に、体液等に増量又は出現する妨害成分、例えば
、溶血、黄痕、乳び又は異常蛋白質等によって影響され
るために、健常者の血清では正確に測定できても、患者
の血清では正確な測定値が得られないこととなり、常に
一定の正確度で分析することができず、問題であった。(b) Analytical values of samples such as blood plasma, serum, urine, and other body fluids and secretions may be used, for example, for diagnosis, treatment guidelines, etc.
Accuracy is always required. However, absorbance measurements for samples such as plasma, serum, urine, and other body fluids and secretions are
During disease, it is affected by interfering components that increase in amount or appear in body fluids, such as hemolysis, yellow stains, chyle, or abnormal proteins. This was a problem because accurate measurement values could not be obtained, and analysis could not always be performed with a certain degree of accuracy.
そこで、従米では、このような妨害成分の影響を防ぐた
めに、検体毎に、又は各検体の検査項目毎に、検体ブラ
ンクを設けて妨害成分による影響を補正しているが、こ
のように、検体ブランクを設けて分析を行うには、検体
ブランクについても、他の検体と同様な分析手順を踏む
必要があるので、自動分析装置においては、処理個数が
限定されていることもあって、検体ブランクを立てると
、その分だけ検体処理速度が低下し、また、検体処理項
目数を減少させることにもなり、問題であった。Therefore, in order to prevent the influence of such interfering components, Jubei provides sample blanks for each sample or for each test item of each sample to correct the influence of interfering components. In order to perform analysis with a blank, it is necessary to follow the same analysis procedure for the sample blank as for other samples. This was a problem because increasing the number of samples would reduce the sample processing speed and reduce the number of sample processing items.
このような妨害成分の影響を回避するために、追加試薬
を加える方法も提案されたが、妨害成分の総ての影響が
回避できるものではなく、たとえば、乳び度に天外な変
動をきたし、測定の正確さが期待できず問題であった。In order to avoid the effects of such interfering components, a method of adding additional reagents has been proposed, but it is not possible to avoid all the effects of interfering components; This was a problem because the measurement accuracy could not be expected.
また、検体ブランク以外にも、試薬の変質による試薬ブ
ランクを時折測定する必要があるが、この場合も同様で
あり、問題であった。In addition to sample blanks, it is sometimes necessary to measure reagent blanks due to deterioration of reagents, but this is also the same problem.
（ニ） 目 的
本発明は、たとえば、従来の自動化学分析装置における
検体ブランク及び試薬ブランクの測定に係る問題点を解
消するものであり、反応ラインをブランク測定に使用し
ないで済む新規な分注ノズル、特に、自動化学分析用の
新規な分注ノズルを提供するにある。(D) Purpose The present invention solves the problems associated with the measurement of sample blanks and reagent blanks in conventional automatic chemical analyzers, for example, and provides a novel dispensing method that eliminates the need to use the reaction line for blank measurements. The present invention provides a nozzle, particularly a novel dispensing nozzle for automated chemical analysis.
（ニ） 楕 成
本発明は、分注ノズルを光学セル兼用とするために、分
注ノズル部１こ光学セル部を形成するものである。(D) Oval formation In the present invention, the dispensing nozzle section 1 is formed as an optical cell section in order to make the dispensing nozzle also serve as an optical cell.
すなわち、本発明は、ノズル壁の少くとも一部の対向ｒ
る壁部が光学的に透明な窓部材で形成されていることを
特徴とする自動分析装置用の測光セル兼用分注ノズルで
ある。That is, the present invention provides at least a portion of the nozzle wall facing r.
This is a dispensing nozzle that also serves as a photometric cell for an automatic analyzer, characterized in that the wall portion thereof is formed of an optically transparent window member.
本発明のノズルは、光学セルとして使用で鰺る部分を有
し、分注ノズルとして液体の吸引及び吐出ができれば如
何なる形式及び形状に形成することができる。したがっ
て、このノズルのセル部は、従来公知の種々の測光セル
の形状に倣って、例えば、角形セル状、試験管セル状、
ミクロセル状、７０−セル状等、種々の形状に形成する
ことかで島、その対向する壁部は、必ずしも平板状に形
成されるものでなく、湾曲形状に形成してもよい。The nozzle of the present invention has a part that can be used as an optical cell, and can be formed in any form and shape as long as it can suck and discharge liquid as a dispensing nozzle. Therefore, the cell portion of this nozzle can be shaped like a rectangular cell, a test tube cell, etc., following the shapes of various conventionally known photometric cells.
The island and its opposing walls are not necessarily formed in a flat plate shape, but may be formed in a curved shape.
本発明のノズル部の少くとも一部の対向する壁部は、セ
ル部を形成するように、すなわち、吸光度測定を可能と
するように、光学的に透明な材料、例えば、適当な窓部
材で形成されるので、測光セルの光透過部の材質と同様
にガラス、石英及びプラスチック等が使用される。At least some of the opposing walls of the nozzle part of the invention are made of an optically transparent material, for example a suitable window member, so as to form a cell part, i.e. to allow absorbance measurements. Therefore, glass, quartz, plastic, or the like is used, similar to the material of the light transmitting part of the photometric cell.
以Ｆ、添イ・１図面を参照して、本発明の実施の態様の
−を説明するが、本発明の技術的範囲は、この説明によ
り限定されるものではない。Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings, but the technical scope of the present invention is not limited by this description.
（ホ） 実施例
第１図は、本発明の分注ノズルの一実施例におけるセル
部の部分的断面図であり、第２図は本発明の別の実施例
の分注ノズルについての使用態様の一部破断した概略の
説明図である。(E) Embodiment FIG. 1 is a partial cross-sectional view of a cell portion in one embodiment of the dispensing nozzle of the present invention, and FIG. 2 is a usage mode of the dispensing nozzle of another embodiment of the present invention. FIG. 2 is a partially cutaway schematic explanatory diagram.
本例の分注ノズル１は、ノズル壁２にセル部３が形成さ
れている。本例においては、ノズル壁部材４はステンレ
ス製であり、セル部３の窓部材５は〃フス製である。／
グル１内は、洗浄が容易なように、段部を形成せずに、
全体的に滑らかに形成されている。In the dispensing nozzle 1 of this example, a cell portion 3 is formed in a nozzle wall 2. In this example, the nozzle wall member 4 is made of stainless steel, and the window member 5 of the cell portion 3 is made of floss. /
The inside of the glue 1 has no stepped portion for easy cleaning.
The overall shape is smooth.
筒状の窓部材５には、両端に筒状差込み部材７が形成さ
れており、また、筒状のノズル壁部材４には、一端に、
該差込み部７と嵌合する差込み用の穴６が形成されてい
る。The cylindrical window member 5 has a cylindrical insertion member 7 formed at both ends, and the cylindrical nozzle wall member 4 has a cylindrical insert member 7 formed at one end.
An insertion hole 6 that fits into the insertion portion 7 is formed.
したがって、本例の分注ノズルのセル部は、ステンレス
製のノズル壁部材４の差込み用の穴６に、窓部材５の差
込み部７を差込み接着剤で固定して形成される。Therefore, the cell portion of the dispensing nozzle of this example is formed by fixing the insertion portion 7 of the window member 5 into the insertion hole 6 of the nozzle wall member 4 made of stainless steel with an insertion adhesive.
第２図には、分注ノズル１の分注操作時の行路８の両側
に測光装置を内蔵するボックス９及び１０が設けられて
いる。□一方のボックス９１こは、光源１１、反射板１
２、光照射用レンズ１３が設けられでおり、光源１１を
発する光束（一点鎖線で示されている。）は反射板１２
で反射され、光照射用レンズ１３から分注ノズル１から
のセル部３に照射される。他方のボックス１０には、分
注ノズル１のセル部３を透過した光を受光するレンズ１
５、レンズ１５を通った光の光路１４に配置される反射
板１６、反射板１６に対応して配置される回折格子１７
及び回折格子１７で回折された光の強度を測光する受光
素子１日が配置されてしする。In FIG. 2, boxes 9 and 10 containing photometric devices are provided on both sides of the path 8 of the dispensing nozzle 1 during the dispensing operation. □One box 91 has a light source 11 and a reflector 1
2. A light irradiation lens 13 is provided, and the light beam (indicated by a dashed line) emitted from the light source 11 is reflected by a reflection plate 12.
The light is reflected from the light irradiation lens 13 and irradiated from the dispensing nozzle 1 onto the cell section 3 . The other box 10 includes a lens 1 that receives the light that has passed through the cell section 3 of the dispensing nozzle 1.
5. A reflecting plate 16 placed in the optical path 14 of the light passing through the lens 15, and a diffraction grating 17 placed corresponding to the reflecting plate 16.
A light receiving element for measuring the intensity of light diffracted by the diffraction grating 17 is also arranged.
このように測光装置は、ボックス９及び１０内に、分注
ノズル１の分注作動時の移動路を挟んで配置されるので
、分注のためにノズル１内に吸引保持された液体の吸光
度を測定することが容易であり、本例の分注ノズルを検
体分注ノズルとして使用すれば、検体分注時に検体ブラ
ンク、または溶血度、乳び度、黄痕指数等の血清情報を
測定することができる。したがって、検体ブランク、又
は溶血度、乳び度及び黄痕指数等の測定を分析ラインを
使用しないで測定することがで終るので、検体ブランク
等の測定をしても、自動化学分析装置の検体処理速度を
低下させることはない。In this way, the photometer is placed in the boxes 9 and 10 across the path of movement of the dispensing nozzle 1 during dispensing operation, so that it measures the absorbance of the liquid sucked and held in the nozzle 1 for dispensing. If the dispensing nozzle of this example is used as a sample dispensing nozzle, it is possible to measure a sample blank or serum information such as hemolysis degree, chyle index, yellow stain index, etc. when dispensing a sample. be able to. Therefore, it is possible to measure the sample blank or the degree of hemolysis, chylosity, yellow stain index, etc. without using an analysis line, so even if the sample blank is measured, the sample of the automatic chemical analyzer will not be able to handle the measurement. It does not reduce processing speed.
（へ）効 果
本発明は、自動化学分析装置の分注ノズルを測光セル」
に用のものとするために、分注ノズルにセル部を設けた
ので、検体ブランク、又は溶血度、乳び度及び黄痘指数
といった血清情報が、検体分注時に測定することがでか
、分析ラインに負担を掛けることがない。したがって、
例えば、検体ブランクを検体毎又は検査項目毎に測定し
ても、分析ラインの検体処理速度を低下することがなく
、また、検体処理項目を減少することもない。(f) Effect The present invention provides a dispensing nozzle for an automatic chemical analyzer as a photometric cell.
In order to make it suitable for use, a cell part is provided in the dispensing nozzle, so serum information such as a sample blank or hemolysis level, chyle index, and jaundice index can be measured at the time of sample dispensing. There is no burden on the analysis line. therefore,
For example, even if a sample blank is measured for each sample or each test item, the sample processing speed of the analysis line will not be reduced, and the number of sample processing items will not be reduced.
本発明の分注／ズルによると、検体分注時に溶血時、乳
び度及び黄痕指数等の血清情報が測定できるので、血清
をその侭測定することとなり、試薬等の影響のない正確
な血清情報をえることができる。According to the dispensing/cheating method of the present invention, serum information such as hemolysis, chylosity, and yellow stain index can be measured when dispensing a sample, so the serum can be measured as it is, making it possible to accurately measure blood serum without the influence of reagents, etc. Serum information can be obtained.
また、本発明の分注ノズルによると、検体ブランクに同
様の操作を行う必要がないので、余分な試薬を消費しな
いで済み、分析コストが低減される。Further, according to the dispensing nozzle of the present invention, there is no need to perform the same operation on a sample blank, so there is no need to consume extra reagents, and analysis costs are reduced.
本発明は、分注ノズルを測光セル兼用とした点で画期的
なものであり、しかも、従来の自動化学分析分析装置に
比して優れた点が多いので、他に及ぼす影響が大島い。The present invention is revolutionary in that the dispensing nozzle can also be used as a photometric cell, and it has many advantages over conventional automatic chemical analysis analyzers, so it has less impact on other devices. .
第１図は、本発明の分注ノズルの一実施例におけるセル
部の部分的断面図であり、＃５２図は、本発明の別の実
施例の分注ノズルについての使用態様の一部破断した概
略の説明図である。
図中の符号については、１は分注７ズル、３はセル部、
４はノズル壁部材、５は窓部材、６は差込み用の穴、７
は筒状差込み部材、８は分注／ズルの通路、９及び１０
はボックス、１１は光源、１２及び１６は反射板、１３
及び１５はレンズ、１４は光路、１７は回折格子、１８
は受光素子である。
代 理 人FIG. 1 is a partial cross-sectional view of the cell part in one embodiment of the dispensing nozzle of the present invention, and FIG. FIG. Regarding the symbols in the figure, 1 is the dispensing 7 z, 3 is the cell part,
4 is a nozzle wall member, 5 is a window member, 6 is a hole for insertion, 7
is a cylindrical insert member, 8 is a dispensing/zure passage, 9 and 10
is a box, 11 is a light source, 12 and 16 are reflectors, 13
and 15 is a lens, 14 is an optical path, 17 is a diffraction grating, and 18
is a light receiving element. Agent
Claims (1)
な窓部材で形成されていることを特徴とする自動分析装
置用の測光セル兼用分注ノズル。1. A dispensing nozzle that also serves as a photometric cell for an automatic analyzer, characterized in that at least part of the opposing nozzle wall is formed of an optically transparent window member.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP556185A JPS61164143A (en) | 1985-01-16 | 1985-01-16 | Dispensing nozzle in common use as photometric cell for automatic analysis instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP556185A JPS61164143A (en) | 1985-01-16 | 1985-01-16 | Dispensing nozzle in common use as photometric cell for automatic analysis instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61164143A true JPS61164143A (en) | 1986-07-24 |
Family
ID=11614613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP556185A Pending JPS61164143A (en) | 1985-01-16 | 1985-01-16 | Dispensing nozzle in common use as photometric cell for automatic analysis instrument |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61164143A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02150553U (en) * | 1989-05-23 | 1990-12-26 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57108638A (en) * | 1980-12-26 | 1982-07-06 | Olympus Optical Co Ltd | Method of chemical analysis |
-
1985
- 1985-01-16 JP JP556185A patent/JPS61164143A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57108638A (en) * | 1980-12-26 | 1982-07-06 | Olympus Optical Co Ltd | Method of chemical analysis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02150553U (en) * | 1989-05-23 | 1990-12-26 |
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