JPS61112007A - Solubilized water-based clear cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic in a state of a clear aqueous solution, giving excellent feeling to the skin and having excellent applicability, by solubilizing an oily substance in waster to form a clear homogeneous solution using a specific mono-O-acryl-3-glycerylphosphorylcholine as a solubilizing agent. CONSTITUTION:A solubilized water-based clear cosmetic composed of a solubilizing agent, an oily substance and water is prepared by using at least one kind of mono-O-acryl-3-glycerylphosphorylcholine selected from 1-palmitoyl-3- glycerylphosphorylcholine, 2-palmitoyl-3-glycerylphosphorylcholine, 1-stearoyl-3- glycerylphosphorylcholine and 2-stearoyl-3-glycerylphosphorylcholine. The amount of the oily substance is preferably 0.0001-1wt% of the whole cosmetic composition. EFFECT:Excellent storage stability and good appearance.

Description

Detailed Description of the Invention (!i Field of Industrial Application) The present invention uses a specific mono 0-γsil-8-glycerylphosphorylcholine described below as a nI-enabling agent to transparently and uniformly dissolve an oily substance in water. The present invention relates to a transparent aqueous liquid skin cosmetic that is solubilized in.

In addition, it is a solubilized product that has a mild effect on the skin and gives a good feeling of 13P-h, has excellent usability and storage stability, and has a good appearance (clear 9M bright). This invention relates to a type of water-based transparent cosmetic.

(Prior art) Conventionally, synthetic surfactants have been used as solubilizing agents in the solubilized transparent cosmetics of Roshan Junzu, but synthetic surfactants tend to cause skin irritation. There are 11 points.

On the other hand, lecithins such as rabbit lecithin and soybean lecithin are! 3
Although it is known as a mild natural emulsifier, it has poor solubility in water and ability to solubilize oily substances in water, becomes cloudy when mixed with water, and deteriorates in quality and changes odor during long-term storage. There are drawbacks such as being easy to use. Therefore, lecithins cannot transparently solubilize oily substances in water, but cannot produce a solubilized water-based transparent cosmetic as described below.

(Problems to be Solved by the Invention) As a result of intensive research to develop a phospholipid-based solubilizer that improves the drawbacks of the above-mentioned conventional techniques, the present inventors found that the specific mono-O-acyl-3 described below - Glycerylphosphorylcholine does not irritate the skin, is stable, dissolves transparently in water, solubilizes oily substances transparently in water, has a mild effect on the skin, gives a good feeling, and is easy to use. The present invention has been completed based on the discovery that it is possible to easily produce a solubilized water-based transparent cosmetic with good storage stability and appearance.

The purpose of the present invention is to provide a solubilized water-based product that has a mild effect on the skin, gives a good feeling, is excellent in usability and storage stability, and has a good appearance (clear and transparent). Our goal is to provide transparent cosmetics.

Another object of the present invention is to provide a novel solubilizing agent useful for solubilized aqueous transparent cosmetics.

(Means for Solving the Problems) The above-mentioned object consists of a solubilizer, an oily substance, and water as the main components, and as a solubilizer, 1-palmitoyl-8-glycerylphosphorylcholine, 2-palmitoyl- A solubilized type containing at least one mono-acyl-3-glycerylphosphorylcholine selected from the group consisting of 8-glycerylphosphorylcholine, 1-stearoyl-8-glycerylphosphorylcholine, and 2-stearoyl-3-glycerylphosphorylcholine. Achieved by water-based transparent cosmetics. The specific mono-long chain acyl-8-glycerylphosphorylcholine in the present invention is a known compound, and has the following structural formulas (11 to (4)
).

(1) 1-palmitoyl-8-glycerylphosphorylcholine H2C-00-(CH2)140Hs (212-palmitoyl-3-glycerylphosphorylcholine υ (3I 1-stearoyl-・3-glycerylphosphoryl: 1-phosphorus (4) 2-stearoyl- 8-Glycerylphosphorylcholine The above-mentioned specific mono-O-acyl-3-glycerylphosphorylcholine can be obtained, for example, by treating phosphatidylcholine as a raw material with snake venom phospholipase or pancreatin, an enzyme extracted from pig pancreas, and fractionating it by high performance liquid chromatography. It will be done.

The specific mono-O-acyl-3-glycerylphosphorylcholine is safe for the human body, and its skin irritation was determined according to the Draize method described below.
Animal skin 11i1 Sou score and 7 irritation score for human skin are both 0 (zero). We have confirmed that.

(Draize, J.H., As5ociation
of Food and ])rugofficia
ls of the tJnited 5tates,
”Appraisal of the 3afety o
f Chemicals in Foods, Dru
gsand Cosmetics”, 46 (1
959).

Texas
fHeath, Au5tin,) In the present invention, the specific mono-0-acyl-8-glycerylphosphorylcholine is used singly or in combination as a solubilizing agent.

The usage amount (compounding amount) is from 0.001 to 0.001 based on the total amount Nu (weight of the composition*) of the prescription ingredients in the cosmetic.
The ratio is 5%, preferably 0.01 to 1%. o,
When the amount is less than ooi% by weight, the solubilization of the oily substance tends to be poor, and when it is more than 5% by weight, the solubility in the system decreases and it tends to be easily washed out.

The oily substances used in the present invention refer to oily substances in a broad sense, including oil-soluble fragrances extracted from natural animals and plants, synthetic oil-soluble fragrances, and oil-soluble vitamins (e.g., vitamin D, vitamin E, Toribun F, vitamin group vitamins, pyridoxine caprilate, pyridoxine cybalmitate, Q-α-tocopherol acetate, nicotine ad/
-α-tocopherol, ascorbyl civalmitate,
vitamin derivatives such as ascorbyl heptivalmitate and ascorbyl monostearate), oil-soluble hormones (
For example, estradiol, ethinylestradiol, estrone, diethylstilbestrol, etc.), oil-soluble pigments (for example, Sudan-m, tetrabromefluorescein, dibromefluorescein, fluorescein, quinizarin green 88, etc.), oil-soluble ultraviolet absorbers ( For example, oxybenzone, methyl 2,5-diisopropyl cinnamate, etc.), animal and vegetable oils (for example, avocado oil, olive oil, almond oil, palm oil, etc.), higher aliphatic hydrocarbons (for example, liquid paraffin, squalane, etc.), Higher fatty acids (for example, isostearic acid, oleic acid, etc.),
Higher alcohols (e.g., isostearyl alcohol, octyldodecanol, etc.), ester oils (e.g.,
isopropyl myristate, octyldodecyl myristate, etc.). These oily substances may be used singly or in combination. The blending amount is 0.0001 to 1'I based on the total amount of prescription ingredients (A H < i).
% M, preferably 0.001-0.8% by weight. If the amount is less than 0.0001z%, the unique characteristic effects of the oily substance will be diminished, and if the amount is larger than %, the solubilization tends to be poor.

The amount of water in the present invention is 60 to 99.9%, preferably 60 to 96% based on the total weight of the prescription ingredients.
Heavy fit 9≦.

Although the solubilized aqueous clearing agent of the present invention does not require the addition of alcohol, the addition of an appropriate amount of alcohol can provide a refreshing feeling and improve the drying speed. The amount of alcohol blended is at most 80% by weight, preferably 6 to 20% by weight.

Moreover, the solubilized aqueous transparent cosmetic of the present invention is 2 It! j
In the case of m-Condige Nichining i-Silin etc., known required pigments are further added and blended. The amount of pigment added is at most 10
m10. %, preferably 0.5 to 5% by weight. Examples of pigments include kaolin, mica, sericite, talc, yellow iron oxide, and red iron oxide.

In addition, the solubilized aqueous transparent cosmetic of the present invention may further contain known preservatives, nutritional supplements, water-soluble pigments, ultraviolet absorbers, astringents, etc. as necessary. Known additive components may also be blended.

Examples of the solubilized water-based transparent cosmetics of the present invention include skin conditioning lotion, wiping lotion, softening lotion, acne treatment lotion, aftershave lotion, two-layer conditioner daily lotion, cleansing lotion, etc. It is useful as

Examples will be described below.

The part shown in the examples means the heavy part. The characteristics (appearance, feel during use, etc.) of the transparent cosmetics shown in Examples were examined by eight specialized inspectors. The appearance was judged visually, and the tactile effects of the sample compositions were examined, such as the feel when applied to the skin (light feeling, sticky feeling), the finish after application, etc.

Example 1 (skin conditioning lotion) 111 prescription ■ 1-palmitoyl-8-glycerylphosphorylcholine 0.2 parts ■ Fragrance (
Lavender oil) 0.05 parts ■ Methyl paraoxybenzoate o, tlP ■ Purified water
99.65 parts (2) Production method Mix and dissolve the above component (2) into a portion of component (2), and dissolve a fraction of component (2) therein. Next, a mixed and dissolved solution of component (2) was added to the remainder of component (2) and mixed uniformly to obtain a skin conditioning lotion of the present invention.

This skin lotion had a transparent appearance. This skin lotion is easy to apply and has a smooth finish after application, and
It had a good moist feeling.

Comparative Example 1 A comparative skin lotion was prepared in the same manner as in Example 1, except that 1-palmitoyl-8-glycerylphosphorylcholine was not used and 99.85 parts of water was used. As a result, the appearance of the obtained skin conditioning lotion was extremely cloudy, perfume particles were suspended, the finish after application was not smooth, and it was not possible to impart a moisturizing and confusing feeling to the skin.

Comparative Example 2 A comparative skin lotion was prepared in the same manner as in Example 1, except that phosphatidylcholine was used instead of 1-palmitoyl-8-glycerylphosphorylcholine. As a result, the appearance of the obtained skin conditioning lotion was cloudy, the finish after application was not smooth and sticky, and it was not possible to give a moist feeling to the skin.

Comparative Example 8 A comparative skin lotion was prepared in the same manner as in Example 1, except that egg yolk lecithin was used in place of 1-palmitoyl-8-glycerylphosphorylcholine. As a result, the appearance of the skin conditioning lotion obtained was cloudy, the finish after application was not smooth, and it was unable to give a moist feeling to the skin. Furthermore, after being left at room temperature for 6 months, the product changed odor and produced a strange odor.

Example 2 (wipe-off lotion) A wiping lotion was prepared with a formulation based on the WS4 table.

Table 2 shows the characteristics of each of the obtained wiping lotions.

Table 2 As is clear from the results, mono-O-acyl-3
-The amount of glycerylphosphorylcholine is 0.001~
A clear wipe-off lotion with a good feel at 5 weight percent (preferably 0.01 to 1 weight 96) was obtained.

Example 3 (Softening Lotion) Table 8 A softening lotion was manufactured by JJ Co., Ltd. using the following formulation.

Table 4 shows the properties of the obtained softening lotion. As is clear from this result, the amount of oily substance blended is o, o o
ot ~ iii% (preferably 0.01 ~ o, aN
i%), a transparent softening lotion with a good feel was obtained.

Table 8 Collection 4! i Example 4 (Acne Treatment Lotion) (1) Prescription ■ Ethanol 20 parts ■ Estradiol 0.001 part ■ 2-stearoyl-8-glycerylphosphorylcholine
o, part i■ 1.3-butylene glycol
6.0 copies ■ Blue No. 1 0.000
1 part ■ Purified water 74.9 parts (21 Preparation method Mix and dissolve component ■ in component The treatment lotion was NM%i.This acne treatment lotion had a pale blue, transparent appearance.When used, this acne treatment lotion blended well into the skin, had a smooth finish, and had a nice refreshing feel. In addition, it had a good moisturizing effect.

Example 5 (Aftershave Lotion) [1+Formulation ■ Ethanol 80 parts ■ Fragrance (clary sage oil) 0.05 m ■ Isopropylmethylphenol 0.01 part ■ Vitamin A O, 05 parts ■ 2-stearoyl-8-glycerylphosphorylcholine
0.15 parts ■ Polyethylene glycol 200
2. Q section ■ Purified water 67
．． 59 parts [21 Manufacturing method Ingredients ■ to ■ were mixed and dissolved in the above component (■), and a mixture of ingredients (■, ■, and ■) mixed and dissolved in component (■) was added thereto to prepare the aftershave lotion lin of the present invention. . When this T-lift shave lotion was shipped after shaving, the finish was smooth, had a refreshing and refreshing feel, and was also good in suppressing itching and irritation.

Example 6 (double-layer conditioner lotion) (1
) Prescription ■ Ethyl alcohol 10 parts ■ Fragrance (hyacinth abunli, -)) 0.1 part ■ Zinc sulfate 0.8 units 15 ■ Zinc white 1.0 part ■ Red iron 0.01 part ■
Tarri
1.0 part ■ Sodium carbonate 0.2 part [Phase] Purified water
87.19 parts (2: Production method) Mix ingredients ■, ■, and ■ with a part of the above-mentioned component 0. Then, add a mixture of ingredients ■ to ■ that have been thoroughly mixed in advance to this aqueous solution, Disperse the mixture uniformly while stirring.Next, gradually add a solution of component (■) to the remainder of component (0) while stirring, and then uniformly mix the solution of component (■) into component (■). The two-layer conditioner lotion of the present invention was made from sea bream.

As a result of examining the uniform miscibility of this two-layer conditioning lawn 1 during shaking, it was found that the powder layer and water layer, which had been separated, were mixed together by shaking the required number of times four times, and the powder was added to the water. A suspension was produced in which the bodies were uniformly dispersed. From these results, it was found that this two-layered conditioned gel can easily be shaken to form a uniformly suspended two-layered conditioned gel and can be maintained stably for an appropriate period of time, making it extremely usable. I admitted that it was easy. After being allowed to stand still for 1 hour, it had a beautiful appearance that was clearly separated into two layers: a transparent hot-colored water layer and a pale red powder layer.

This two-layer conditioner daily lotion had no sticky feeling when used, had a good feel and a refreshing feeling, and had a good finish after application.

Patent originator Kanebo Co., Ltd. 3> , , 1 procedural amendment ifC
Method) % Formula % 1. Indication of the case Patent Application No. 288470 of 1988 2. Name of the invention Solubilized water-based transparent cosmetics 3. Relationship with the case Patent applicant Residence F9T Sumida-ku, Tokyo Tokuta 5-chome 17-4 Name
(095) Kanebo Co., Ltd. - Representative Susumu Okamoto 1. ′,:Pa′1,,+,,,
,.

Contact information: Kinbo Co., Ltd. Patent Department, 1-5-90 Tomobuchi-cho, Bejima-ku, Osaka 534 Tel: (06) 921-1251 4. Date of amendment order - \ Su〆mei! MJ4! Contents of the amendment (1) of the ``Planning Rules for Inventions'' in I, Ming Lu, from the bottom line of page 6 to the 4th line of page 7, the test ``[Draize, J,) +As5ociat
ion of Food and Drug -----
−・・−・Omitted−・・−・−・Texas, 5tat
e I) parts of Health, Au
5tin], ``Literature: Draize, U.S. Government Food and Drug Association, ``Safety Evaluation of Chemical Substances Used in Food, Drugs, and Cosmetics, p. 46-59 [J, aDraize, As5ociat.
ion of Food and Drug 0ffic
ials of the United 5tates
.

“Appraisal of the 5afet)'
ofchemicalsinFood,Drug
s and Cosmetics”, P, 46-5
9 (1959)] J.

Procedural Amendment (Voluntary) September 1985 Today, Director General of the Patent Office Mr. Uga Michibe 1, Indication of Case 1932
Patent Application No. 288470, filed in 1999, 2, Name of the invention: Solubilized water-based transparent cosmetics 8, Person making the correction and relationship with the five cases Patent applicant address: 5-17-4 Sumida, Sumida-ku, Tokyo 584
Kanebo Co., Ltd. Patent Department, 1-5-90 Tomobuchi-cho, Bejima-ku, Osaka Tel: (06) 921-1251 4. Number of inventions increased by amendment None 5゜Subject of amendment 6. Contents of amendment (1) Details ``, written at the bottom of the second line of page 6, will be corrected to ``.

Claims (3)

[Claims] (1) The main constituent components are a solubilizer, an oily substance, and water, and the solubilizers include 1-palmitoyl-3-glycerylphosphorylcholine, 2-palmitoyl-3-glycerylphosphorylcholine, and 1-stearoyl-8-glyceryl. A solubilized water-based transparent cosmetic containing at least one mono-O-acyl-3-glycerylphosphorylcholine selected from the group consisting of phosphorylcholine and 2-stearoyl-3-glycerylphosphorylcholine. (2) Claim 1, wherein at least one of the mono-O-acyl-3-glycerylphosphorylcholines is blended in an amount of 0.001 to 5% by weight based on the total weight of the prescription ingredients. A solubilized water-based transparent cosmetic. (3) The solubilized water-based transparent cosmetic according to claim (1), wherein the oily substance is blended in an amount of 0.0001 to 1% by weight based on the total weight of the prescription ingredients.