JPS6075422A - Dentifrice composition - Google Patents

Abstract

PURPOSE:To provide a dentifrice composition having excellent to eliminate foul breath, by adding an N-alkyloylsarcosinate and a chlorhexidine salt to a dentifrice composition containing a silica-based abrasive. CONSTITUTION:A dentifrice composition exhibiting remarkable effect to suppress the foul breath and capable of surely eliminating the foul breath is produced by adding 0.05-0.5(wt)% N-alkyloylsarcosinate (e.g. N-lauroyl, N-myristoyl, etc.) and 1-1,000ppm of a chlorhexidine salt to a dentifrice composition containing 1-40% silica-based abrasive (e.g. precipitated silica, silica xerogel, silica aerogel, etc. having a primary particle diameter of <=500mum and a secondary particle diameter of 1-30mu). If necessary, the dentifrice composition may be incorporated in addition to the above silica-based abrasive, with other abrasive (e.g. dibasic calcium phosphate), silica-based thickener, binder, thickener, and various active components such as vitamins, tartar-preventive, antibacterial agent, preventive for sordes on teeth, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides N-
The present invention relates to a dentifrice composition having an effect of removing bad breath by incorporating an alkyl sarcosinate and a chlorhexidine salt.

Toothbrushing compositions are used to clean and clean the oral cavity and keep the oral cavity hygienic.In this case, the toothbrushing composition has the function of removing bad breath that makes people feel uncomfortable. It is desired that

Conventionally, chlorhexidine salts have been incorporated into dentifrice compositions as an active ingredient for preventing bad breath, but the effect may not be sufficient in some cases.

In this case, in order to improve the effectiveness of preventing bad breath,
Efforts have been made to suppress bad breath by adding large amounts of fragrances or using strong fragrances, but this has not always been effective.

As a result of intensive research into a toothpaste composition with excellent breath odor removal effects, the present inventors unexpectedly discovered that a silica-based abrasive was used as the abrasive, and N-alkyloyl sarcosinate and chlorhexidine salts were used as the abrasive. The present invention was based on the discovery that when used together, the halitosis suppressing effect is significantly exhibited and bad breath can be reliably removed.

The present invention will be explained in more detail below.

The dentifrice composition according to the present invention contains a silica-based abrasive and also contains N-alkyloyl sarcosinate and chlorhexidine salts as active ingredients.

In this case, as the silica-based abrasive, for example, JP-A No. 49
-91994 publication, JP-A-49-94712 publication,
JP-A-50-64198, JP-A-50-6549
Publication No. 7, JP-A-51-928695, JP-A-5
Those described in Japanese Patent Publication No. 1-136841 and Japanese Patent Publication No. 54-4919 are used. More specific examples include Zeodent■, Zeo■, 5lde
Precipitated silica, silica xerodal, silica aerodal, etc. sold under the trademark nt■, which have primary particles of 500 mμ or less and secondary particles of 1 to 30 μm, can be used. In this case, precipitated silica is particularly preferably used, with a 5io2 content of 70% or more, preferably 90% or more, an alkali/alkaline earth metal oxide content of θ to 5%, and metals such as aluminum, magnesium, calcium, etc. relative to SiO□. The amount of bonded oxides is 0 to 10%, preferably 0 to 5%, the attached moisture content (loss on drying) is 1 to 10%, and the average particle size is 0.5%.
~30μ, more preferably 1~15μ, specific surface area per 1g (BET method) 500? ? 1 or less, more preferably 3
00m or less, refractive index 1.44-1.47, liquid absorption 0.6
~1.3CWj; Those having properties of 1 are preferably used. Specifically, Zeo 49 from Huber, Inc.
, zeodent 113, 5yloid AL-1, 63, 74, 404 from W, R, Grace, UK, Neoa from J, Crossfisld k 5ons, UK
yl ETs 5ident from Degussa Germany
3, 20, etc. are mentioned.

In addition, in the present invention, the silica-based abrasive may be used alone or in combination of two or more types, and the amount of the silica-based abrasive is not particularly limited.
% by weight (the same applies hereinafter), preferably 5 to 30%.

In other words, as N-alkyloyl sarcosinate, N-
Sodium, potassium or ethanolamine salts of lauroyl, N-myristoyl or N-/4-lumitoyldercosine are used.

In this case, the amount of N-alkyloyldercosinate is preferably 0.05 to 0.5% of the total composition,
More preferably, it is 0.1 to 0.5%. N-7fiv
If the blending amount of chiroyl sarcosinate is less than 0.05%, the blending effect may not be sufficiently achieved.

Further, as the chlorhexidine salts used in the present invention, chlorhexinone hydrochloride, chlorhexidine gluconate, etc. can be used. The amount of chlorhexinone salts is 1 to 11,000 pp, especially 10 to 11,000 pp of the entire composition.
It is preferable to set it as 100 ppm.

In the present invention, in addition to the silica-based abrasive, if necessary, abrasives such as dibasic calcium phosphate dihydrate and anhydride, dibasic calcium phosphate, tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, calcium sulfate, calcium oxide, etc. Titanium, alumina, hydrated alumina, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, tertiary magnesium phosphate, magnesium carbonate (5) One or more of magnesium, bentonite, norconium silicate, synthetic resin, etc. In cases where two or more types of abrasives can be blended, the amount of these abrasives to be blended is selected as appropriate; however, in the case of producing transparent toothpaste, the amount used should be 10% or less based on the weight of the silica-based abrasive. It is preferable that

Furthermore, in the present invention, a silica-based thickener may be added in addition to the silica-based abrasive.
0-8 ■t Tokusil, a large-forming ultrafine powdered silica that can be oxidized and sold under the trademark Aerosil■
■* Finely powdered dulling properties sold under the trademarks of Vitasil■ and N1psil■ with secondary particles of several micrometers or less may be blended.

The toothpaste composition according to the present invention is a toothpaste, Jun! It is used as R toothpaste, powdered toothpaste, etc., and as the component of the toothpaste composition, any commonly used appropriate component can be used.

For example, as a binder, cellulose derivatives such as caradanan, caloxymethylcellulose sodium, methylcellulose, hydroxyethylcellulose, carboxy(6)methylhydroxyethylcellulose sodium, alkali metal alginates such as sodium alginate, alginate propylene glycol ester, and xanthan are used as binders. Gums such as mu, tora ga kant, mu, karaya, arabic, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinyl pyrrolidone, inorganic binders such as heatum, laponite, etc. One or more of these may be blended (the blending amount is usually 0.5 to 5 inches).

Furthermore, one or more of sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene dalycol, polyethylene glycol, polypropylene glycol, xylit, malnut, lafutit, etc. may be blended as a thickening agent ( Blend amount usually 10-7
5%). In addition, water-soluble salts of higher alkyl sulfates whose alkyl group has 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate, and water-soluble higher fatty acids such as sodium hydrogenated coconut oil fatty acid monodaliseride monosulfate. Monoglyceride monosulfate, alkylaryl sulfonate such as sodium dodecylbenzenesulfonate, higher alkyl sulfonate, higher fatty acid ester of 1t2-dihydroxypropane sulfonate, fatty acid group such as sucrose mono- and dilaurate. Number of carbons is 12
~18 sucrose fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene (10, 20, 40゜60.80,100 mol) Hydrogenated castor oil, polymers of ethylene oxide and propylene oxide, polyethylene oxide such as polyoxyethylene polyoxyzolopylene monolauryl ester, fatty acids, fatty alcohols, polyhydric alcohols, and polypropylene oxide P One or more surfactants (compounding amount usually 0 to 7%, preferably 0.5 to 5%) such as nonionic surfactants such as condensation products with betaine type and amphoteric surfactants such as amino acid type. Can be mixed.

The dentifrice composition of the present invention further contains saccharin sodium, stevioside, neohesperidyl dihydride chalcone, glycyrrhizin, perillartin, thaumatin, asparatylphenylalanine methyl ester, p-
Sweeteners such as methoxycinnamic aldehyde, sucrose, lactose, fructose, sodium saccharin (0-1%, preferably 0.01-0.5%), p-hydroxymethylbenzoic acid, p-hydroxyethylbenzoic acid , p-hydroxyethylbenzoic acid, p
- Can contain preservatives such as hydroxybutyl benzoic acid, sodium benzoate, and lower fatty acid monoglycerides, whitening agents such as gelatin, hecton, arginine hydrochloride, albumin, casein, and titanium dioxide, silicone, pigments, and other ingredients. For example, in the case of toothpaste, it can be manufactured by mixing the above-mentioned desired ingredients with an appropriate amount of water.

(9) When preparing a transparent toothpaste composition, a silica-based abrasive is used as the abrasive, and the vehicle mixed with this is adjusted to have substantially the same refractive index as the silica-based abrasive. A silica-based abrasive and this transparent vehicle are mixed together.

Furthermore, in the present invention, allantoins such as allantoin chlorhydroxyaluminum, enzymes such as ibusilone aminocabroic acid, tranexamic acid, dextranase, amylase, grotease, mutanase, lysozyme, fosterase, lytic enzyme, and lytic enzyme, monofluorinated Alkali metal monofluorophosphates such as sodium phosphate and potassium monofluorophosphate, fluorides such as sodium fluoride, ammonium fluoride, and stannous fluoride, dihydrocholesterol, glycyrrhetinic salts, glycyrrhetinic acid, glycerophosphate, EHD
One type of active ingredient such as P% copper chlorophyllin sodium, hinokitiol, calopegtide, azulene, chamomile, etc., water-soluble inorganic phosphoric acid compound, bi(10) cumin, tartar inhibitor, antibacterial agent, plaque inhibitor, etc. Or two or more kinds can be blended.

According to the present invention, when chlorhexidine salts are blended alone in a dentifrice composition, the effect of preventing bad breath may not be sufficient, but when a silica-based abrasive is used as an abrasive and N-alkyloyl sarcosinate is used, By incorporating chlorhexidine and chlorhexidine salts, bad breath could be reliably removed.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

A dentifrice composition having the following formulation was prepared, and the durability of the halitosis preventive effect was evaluated by a panel of 10 people with strong halitosis, a panel with normal halitosis, and a panel with weak halitosis using an in 5 ' evaluation method. The results are shown in Table 1.

Flat I A 2 A 3 Precipitated silica 2o 2o 3 (Zeodent 113■) Dicalcium phosphate dihydrate --45 Igneous silica 3 3 - 70 Tisolbit 45 45 20 96% glycerin 20 20 10 Cullin sodium 0.1 0.1 0.1 Titanium oxide 0.05 0.05 - Fragrance 111 Chlorhexinone hydrochloride 1100pp 1100pp
Note that the "in altu" evaluation method is as follows.

Evaluation method Anti-slip with a small amount of water, add methionine to this discharged liquid,
Methyl mercagutan (CH) is produced by keeping it warm under anaerobic conditions.
3SH)'t is determined by chromatography.

This operation was performed before and after tooth brushing to evaluate the halitosis suppressing effect.

As is clear from the results of the halitosis suppression rate table, the use of a silica-based abrasive as the abrasive and the combined use of sodium N-lauroyldercosine and chlorhexidine hydrochloride (13) resulted in a good halitosis suppression rate. It is found that a gentle toothpaste can be obtained.

Examples are shown below.

[Example 1] Precipitated silica 30% 70 Thisorbite 50 Sodium lauryl sulfate 1.8 Fatty acid zoethanolamide 0.5 Sodium saccharin 0.1 Fragrance 1 Chlorhexidine gluconate 0.003 N-Lauroylsarcosine sodium 0 .1 Purified ice Total remaining 100 cm C14) [Example 2] Precipitated silica 28 cm 95 tiglycerin 3° 70 thisorbitol 2° Sodium α-olefin sulfonate 1.7 Fatty acid zoethanolamide 0.5 Sodium saccharin 0. 1 Fragrance 1 Chlorhexinone gluconate 0.005N-sodium lauroyl sarcosinate 0.2 Purified ice Remaining total 100 Chi C1 et al.) [Example 3] Precipitated silica 25 Igneous silica 2 95% glycerin 31 70 Tisolbit 31 Polyethylene glycol 400 4 Cal? Oxymethyl 0.5 Sodium cellulose chlorine/neutralizing agent 0.510.2 Sodium lauryl sulfate 1 Sucrose fatty acid ester 1 Fatty acid diethanolamai P 0.5 Sodium saccharin 0.1 Kabetsu 1.1 Chlorhexidine gluconic acid m 0.01 N-lauroyldercosine sodium 0.1 Purified water Remaining amount 100% [Example 4] Precipitated silica 20 Igneous silica 2,5 95 Tiglycerin 39 70% sorbitol 31 Caldexymethyl 0.4 Sodium cellulose Carrageenan 0.6 Sodium lauryl sulfate 1.5 Fatty acid diethanolamide 0.5 Satucalin sodium 0.1 Flavor 1 Chlorhexidine hydrochloride o, ooi N-lauroyl sarcosine 0.5 Sodium purified water Remainder (17) (16) [Implemented] Example 5] Precipitated silica 28 95 tiglycerin 25 70 thisorbitol 30 propylene glycol 3 cal? Xymethyl 0.3 Cellulose sodium carrageenan 0.4 Xanthan gum 0.3 Sodium lauryl sulfate 1.7 Fatty acid diethanolamide 1 Satucharin sodium 0.1 Flavor 1 Chlorhexinone hydrochloride 0.003 Purified ice Residue (18) [Example 6 ] Precipitated silica 18% Igneous silica 3 95% glycerin 20 70 Thisorbit 39 Polyethylene glycol 400 3 Carbopol/neutralizing agent 0.5/0.2 Sodium lauryl sulfate 1.7 Fatty acid noethanolamide 0.8 Satucalin Sodium o, i Flavor 1.1 Chlorhexidine hydrochloride o, oos Purified water Balance 100% (1o1 [Example 7] Precipitated silica 20% 95 Tiglycerin 19 70 Thisorbit 41 Polyethylene glycol 5 00 Carboxymethyl 05 Cellulose sodium carrageenan 0 .6 Sodium lauryl sulfate 1 Sucrose fatty acid ester 1 Fatty acid diethanolamide 1 Satucalin sodium 0.1 Fragrance 1.1 Chlorhexidine hydrochloride 0.01 N-2 uroyl sarcosine 0.05 Sodium purified water Remaining total 100 units [implemented] Example 8] Precipitated silica 1 o Igneous silica 4 95 tiglycerin 5° propylene glycol 3 Xanthan gum 0.3 Sodium α-olefin sulfonate 1.5 fatty acid diethanolamide 1 Sodium saccharin 0.1 Flavor 1 Chlorhexidine glucon [i 0.03 (21) (20) [Example 9] Precipitated silica 15 Igneous silica 3 95 Tiglycerin 45 Propylene glycol 3 Cal-xymethyl 1.1 Cellulose sodium fatty acid jetanolamide 0.5 Satucalin Sodium 0.1 Flavoring 1 Chlorhexidine hydrochloride 0.05 Purified ice residue (22) [Example 10] Precipitated silica 35q6 95% glycerin 25 70 Thisorbit 25 Polyethylene dalicol 400 5 Caldexymethyl 03 Cellulose sodium carrageenan 0.8 Fatty acid Zoethanolamide 05 Satucharin sodium 01 Flavor 1.1 Chlorhexidine glucon [i 0.5 Purified ice All of the toothpastes of Examples 1 to 10 have enhanced halitosis preventive effects and have good sustainability.

Applicant: Lion Corporation Deputy Attorney Takashi Shima

Claims (1)

[Scope of Claims] 1. A dentifrice composition comprising a dentifrice composition containing a silica-based abrasive and an N-alkyloyldercosine salt and a hydroxychlorhexidine salt. 2. The dentifrice composition according to claim 1, wherein the amount of N-alkyloyl sarcosinate is 0.05 to 0.5% by weight of the total weight. 3. The amount of chlorhexidine salts is 1 to 11 of the total.
The dentifrice composition according to claim 1 or 2, which has a content of 0.000 pp. 4. The dentifrice composition according to any one of claims 1 to 3, wherein the chlorhexidine salt is chlorhexidine hydrochloride or chlorhexidine dalconate.