JPS60214721A - Cosmetic composition for preventing liver-spot - Google Patents

Abstract

PURPOSE:The titled composition, containing an extract of peony root bark (root bark of Paeonia moutan), peony root (root of Paeoniae lactiflora), geranium herb, Arctii Fructus (fruit of Arctium lappa L.), etc. as an active constituent, and having very high inhibitory effect on liver-spots and improved safety. CONSTITUTION:A cosmetic composition containing 10-100mg extract of at least one of peony root bark (dried root bark of Paeonia moutan), peony root (dried or steam seasoned Paeoniae lactiflora), geranium herb (dried whole herb of Geranium thunbergii Sieb. et Zucc.), Arctii Fructus (dried ripe fruit of Arctium lappa L.), Coicis Semen (dried ripe seed of Coix lacryma-jobi L. after removing seed coat thereof), seseli (dried root of Seseli libanotis), scutellaria (dried root of Scutellaria baicalensis), horse chestnut (fruit of Aesculus turbinate Blume of the family Hippocastanaceae), pueraria (dried root of Pueraria lobata), licorice (dried root part of leguminous, perennial herb of Glycyrrhiza glabra var. glandulifera) and pear fruit with water or a water-soluble alcohol therein. The above- mentioned extract has improved ability to inhibit activity of tyrosinase, prevents pigmentation of melanin dyestuff and inhibits effectively occurrence of liver- spots.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a stain-preventing cosmetic composition, the purpose of which is to use it as a lotion or auxiliary skin cosmetic to have an extremely high stain-suppressing effect, and to contain essential ingredients that are conventionally available in orally administered drugs or foods. An object of the present invention is to provide an extremely safe stain-preventing cosmetic composition containing ingredients whose safety has been confirmed as such.

Stain-preventing cosmetics such as sunscreen creams contain medicinal ingredients that inhibit tyrosinase activity, such as Plancenter.

Plan Center refers to placenta extract, which is difficult to obtain in Japan, and because it is obtained from placenta as a raw material, its supply is limited and it is extremely expensive.

The medicinal effect of Plan Center is primarily to inhibit the activity of tyrosinase, an enzyme that decomposes tyrosine, and by inhibiting tyrosinase activity, it prevents the deposition of melanin pigment on the skin, thereby suppressing the appearance of age spots. It is believed that.

In light of the above circumstances, the inventors have made this invention as a result of intensive research into a stain-preventing cosmetic composition that is easily available from Plan Center and contains highly safe ingredients with excellent tyrosinase activity inhibition ability. reached.

That is, the present invention provides a stain-preventing cosmetic composition containing as an essential ingredient an extract of at least one of peonies, peonies, Kennoshoko, burdock, yokuinin, burdock, scutellariae, horse chestnut, cuckoo, licorice, and pear fruits. This is related.

The button skin (Bodanpi) used in this invention refers to the button skin (Paeoniaceae Paenoi) used in this invention.
amoutan 51m5) is dried root bark.

The peony used in this invention is the dried or steam-dried root of the peony (Paeonia 1actiflora), which is a perennial plant of the Paeoniaceae family, and has traditionally been used as an analgesic in Chinese medicine. say.

Gennoshoko used in this invention is also known as “
It is a perennial herb of the Phyllantaceae family that is so famous as an anti-diarrheal agent that it is called ``the current evidence'', and the whole plant is used by drying it.

The burdock used in this invention is a member of the Asteraceae family (Comp) whose root is commonly used as a vegetable.

5itae) perennial Fruct (＾rctii Fruct)
It refers to the dried mature fruit of the Japanese plant.

Yokuinin used in this invention is a member of the Poaceae family (Graminaceae).
inae) Coix lacryma-
jobi L.

var, ma-yuen 5 tapf) is the dried mature seed from which the seed coat has been removed.

Bofuu used in this invention is a member of the Apiaceae family (IJmbe).
Ledebourie (Ledebourie)
lla 5eseloides W,) etc.

The scutellariae used in this invention is a member of the Lamiaceae family (Labiaceae).
tae) Scutllaria bai
Calensis Georgi).

The horse chestnut (Aesculu) used in this invention
s Gurbinata Balune) is a fruit of the family Chestaceae, and usually refers to the extract of this fruit.

Candela (licorice) used in this invention is a member of the Fabaceae family (Leg).
uminosae) is the dried perennial roots of the plant.

Example A stain prevention lotion with the following composition was prepared.

Glycerin 5.0 (χ) Polyethylene glycol 0.2 Surfactant 2.0 Oleyl alcohol 0.1 Ethanol 15.0 Fragrance 0.1 Extract (8) to (K)' 0.05 Coloring agent Appropriate amount of purified water Balance total 100m1 Test Example 1 Using the stain-preventing lotions (A) to (L) obtained in the above examples and the stain-preventing lotion prepared in the same manner as in the examples and containing Plancenter as a comparative example, women of makeup age were treated. A total of 120 people (18 to 45 years old) were observed to see if their age spots had been reduced.

The results are shown in Table 1.

1 Table 1 1 Effect l No effect 1 1 Example Al 8 1 2 1 -m-□-← 1 Example 1 9 11 1 -1--← 1 Example cl 7 l 3 l I Example DI s l 2 l + 1 Example El 6 1 4 l To 1 Example Fl 6 1 4 1 +-Masu□-----□□Published---□---□H1 Example cl 7 1 3 l @-1-----H 1 Example H1515l I Example II 7 1 3 1 1 Example Jl 6 1 4 1 1 Example Kl 6 1 4 1 To---m- I Comparative example 16141 Yes' Example 21J has an average value of 62.5χ, and some of the ingredients exhibit an effect of 70% or more, indicating that it has an effect superior to that of the comparative example.

Test Example 2 The tyrosinase inhibitory activity of the compounded ingredients was determined by quantifying dopachrome (Shimano Civil Code).

L-tyrosine (1 mg/1 ml) 0.5
ml, tyrosinase 1 mg-4000V/ml)
0.5ml, phosphate buffer (PH6,8,0,1M)2
2.0 ml of each component was added as a 0.1 χ aqueous solution, and relatively, 2 ml each of hydroquinone 0.01 χ and 0°001 χ and placenta were added.

The results are summarized in Table 2.

Table 2 1 1 Tyrosinase activity 1 1 1 Inhibition rate (%) 1 1 Hydroquinone 0.01χ I 100 11 Hydroquinone 0.001 1 test example C1701 1//D l 601 1 E l 80 1 + l F l 80 l I G l 60 I I Hl 50 1 1 I l 80 1 1 J l 401 1 K l 40 1 It is clear from the above results Thus, it can be seen that the stain-preventing cosmetic composition according to the present invention has excellent effects.

Claims (1)

[Claims] (1) At least one of the following: button skin, peony, gennoshoko, burdock, yokuinin, burdock, scutellariae, horse chestnut, cuckoo, licorice, and pear fruit.
A stain-preventing cosmetic composition containing a seed extract as an essential ingredient.