JPS6440491A - Production of high-purity sialic acid - Google Patents
Production of high-purity sialic acidInfo
- Publication number
- JPS6440491A JPS6440491A JP62195465A JP19546587A JPS6440491A JP S6440491 A JPS6440491 A JP S6440491A JP 62195465 A JP62195465 A JP 62195465A JP 19546587 A JP19546587 A JP 19546587A JP S6440491 A JPS6440491 A JP S6440491A
- Authority
- JP
- Japan
- Prior art keywords
- sialic acid
- substance
- electrodialysis
- milky
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title abstract 7
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title abstract 7
- 239000000126 substance Substances 0.000 abstract 6
- 238000000909 electrodialysis Methods 0.000 abstract 3
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005341 cation exchange Methods 0.000 abstract 1
- 238000011033 desalting Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE:To obtain the titled sialic acid useful as a synthetic raw material for sugar chain of glycoprotein, etc., in high efficiency at a low cost, by hydrolyzing a milky substance containing sialic acid and desalting and purifying the hydrolyzed liquid by electrodialysis. CONSTITUTION:Sialic acid is isolated from a milky substance containing sialic acid by hydrolysis. The hydrolyzed liquid containing sialic acid is desalted by electrodialysis and then purified again by electrodialysis to obtain the objective sialic acid. The pH of the milky substance is preferably lowered before hydrolysis by the addition of an acid to the substance in an amount of 0.01-1.0N or by passing the substance through a cation exchange polymer and the substance is hydrolyzed preferably by heating at 80-100 deg.C for 15-120min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19546587A JPH07103139B2 (en) | 1987-08-05 | 1987-08-05 | Method for preparing high-purity sialic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19546587A JPH07103139B2 (en) | 1987-08-05 | 1987-08-05 | Method for preparing high-purity sialic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6440491A true JPS6440491A (en) | 1989-02-10 |
| JPH07103139B2 JPH07103139B2 (en) | 1995-11-08 |
Family
ID=16341530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19546587A Expired - Fee Related JPH07103139B2 (en) | 1987-08-05 | 1987-08-05 | Method for preparing high-purity sialic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH07103139B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02237992A (en) * | 1989-03-10 | 1990-09-20 | Snow Brand Milk Prod Co Ltd | Production of sialic acids-containing lactose |
| CN114507262A (en) * | 2022-03-01 | 2022-05-17 | 德元堂(上海)健康科技发展有限公司 | Hydrolysis process of polysialic acid |
| CN114539333A (en) * | 2022-03-01 | 2022-05-27 | 德元堂(上海)健康科技发展有限公司 | Cyclic production process of sialic acid |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024043776A1 (en) * | 2022-08-22 | 2024-02-29 | Chee Boon Moh | A formulated and synthesised edible bird's nest and milk based nutritional product and methods for preparation thereof |
| KR20240053422A (en) * | 2022-10-17 | 2024-04-24 | 주식회사 엘지화학 | Manufacturing method of hydroxyalkanoic acid and lactic acid |
-
1987
- 1987-08-05 JP JP19546587A patent/JPH07103139B2/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02237992A (en) * | 1989-03-10 | 1990-09-20 | Snow Brand Milk Prod Co Ltd | Production of sialic acids-containing lactose |
| CN114507262A (en) * | 2022-03-01 | 2022-05-17 | 德元堂(上海)健康科技发展有限公司 | Hydrolysis process of polysialic acid |
| CN114539333A (en) * | 2022-03-01 | 2022-05-27 | 德元堂(上海)健康科技发展有限公司 | Cyclic production process of sialic acid |
| CN114507262B (en) * | 2022-03-01 | 2023-12-19 | 德元堂(上海)健康科技发展有限公司 | Hydrolysis process of polysialic acid |
| CN114539333B (en) * | 2022-03-01 | 2023-12-22 | 德元堂(上海)健康科技发展有限公司 | Cyclic production process of sialic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07103139B2 (en) | 1995-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |