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JPS6425780A - 1-methylcarbapenem derivative - Google Patents

1-methylcarbapenem derivative

Info

Publication number
JPS6425780A
JPS6425780A JP63104617A JP10461788A JPS6425780A JP S6425780 A JPS6425780 A JP S6425780A JP 63104617 A JP63104617 A JP 63104617A JP 10461788 A JP10461788 A JP 10461788A JP S6425780 A JPS6425780 A JP S6425780A
Authority
JP
Japan
Prior art keywords
formula
compound
methylcarbapenem derivative
produced
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63104617A
Other languages
Japanese (ja)
Inventor
Masao Sugimura
Teruo Tanaka
Tomoyuki Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP63104617A priority Critical patent/JPS6425780A/en
Publication of JPS6425780A publication Critical patent/JPS6425780A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The 1-methylcarbapenem derivative of formula 1 [R<1> and R<2> are H, halogen, nitro, alkyl, allyl, alkoxycarbonyl, cyano, alkoxy, alkylsulfonyl or R<1> and R<2> together form -CH=CH-CH=CH-, -(CH2)3- or -(CH2)4-; R<3> is H or carboxyl-protecting group; R<4> is H or OH-protecting group; n is 0, 1 or 2]. EXAMPLE:(1R, 5R,6S)-[(R)-1-t-butyldimethylsilyloxyethyl]-1-methyl-2-phenylthio-1- carbadethiapen-2-em-3-carboxylic acid 4-nitrobenzyl ester. USE:A synthetic intermediate for (1R)-1-methylcarbapenem derivative having excellent antibacterial activity. PREPARATION:The compound of formula I, i.e. the compound of formula 1a or formula 1b (m is 1 or 2) can be produced from the compound of formula 2 produced by the reaction of the compound of formula 3 with the compound of formula 4.
JP63104617A 1987-04-28 1988-04-27 1-methylcarbapenem derivative Pending JPS6425780A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63104617A JPS6425780A (en) 1987-04-28 1988-04-27 1-methylcarbapenem derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10322487 1987-04-28
JP63104617A JPS6425780A (en) 1987-04-28 1988-04-27 1-methylcarbapenem derivative

Publications (1)

Publication Number Publication Date
JPS6425780A true JPS6425780A (en) 1989-01-27

Family

ID=26443871

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63104617A Pending JPS6425780A (en) 1987-04-28 1988-04-27 1-methylcarbapenem derivative

Country Status (1)

Country Link
JP (1) JPS6425780A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0188816A1 (en) * 1984-12-27 1986-07-30 Sumitomo Pharmaceuticals Company, Limited Novel beta-lactams and their production
EP0202048A1 (en) * 1985-04-27 1986-11-20 Sankyo Company Limited Carbapenem derivatives, their preparation, and pharmaceutical compositions containing them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0188816A1 (en) * 1984-12-27 1986-07-30 Sumitomo Pharmaceuticals Company, Limited Novel beta-lactams and their production
EP0202048A1 (en) * 1985-04-27 1986-11-20 Sankyo Company Limited Carbapenem derivatives, their preparation, and pharmaceutical compositions containing them

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