JPS5377057A - 1,2-benxisoxazole derivatives - Google Patents
1,2-benxisoxazole derivativesInfo
- Publication number
- JPS5377057A JPS5377057A JP15175976A JP15175976A JPS5377057A JP S5377057 A JPS5377057 A JP S5377057A JP 15175976 A JP15175976 A JP 15175976A JP 15175976 A JP15175976 A JP 15175976A JP S5377057 A JPS5377057 A JP S5377057A
- Authority
- JP
- Japan
- Prior art keywords
- derivatives
- benxisoxazole
- benzisoxazole
- sulfamoylmethyl
- 4methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: 1,2-Benzisoxazole derivatives I [X is H, halogen, etc.; R1,2 are H, alkyl, OH (R1 and R2 are not OH at the same time); or the -N(R2)R1 is 4methyl-1-piperazinyl; n is 1 - 3], e.g. 3-sulfamoylmethyl-1,2-benzisoxazole.
COPYRIGHT: (C)1978,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15175976A JPS6033114B2 (en) | 1976-12-16 | 1976-12-16 | 1,2-benzisoxazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15175976A JPS6033114B2 (en) | 1976-12-16 | 1976-12-16 | 1,2-benzisoxazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5377057A true JPS5377057A (en) | 1978-07-08 |
JPS6033114B2 JPS6033114B2 (en) | 1985-08-01 |
Family
ID=15525664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15175976A Expired JPS6033114B2 (en) | 1976-12-16 | 1976-12-16 | 1,2-benzisoxazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6033114B2 (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0094833A2 (en) * | 1982-05-18 | 1983-11-23 | Dainippon Pharmaceutical Co., Ltd. | Novel 1,2-benzisoxazole derivatives |
US4420485A (en) * | 1982-09-29 | 1983-12-13 | Hoechst-Roussel Pharmaceuticals Inc. | 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] |
WO2002070495A1 (en) * | 2001-03-02 | 2002-09-12 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 1,2-benzisoxazole-3-acetic acid |
WO2003020708A1 (en) * | 2001-08-30 | 2003-03-13 | Teva Pharmaceutical Industries Ltd. | Zonisamide intermediate and synthesis |
WO2004063173A1 (en) * | 2003-01-10 | 2004-07-29 | Dipharma S.P.A. | A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid and the intermediates thereof |
JP2004244410A (en) * | 2003-01-22 | 2004-09-02 | Dainippon Pharmaceut Co Ltd | Method for producing zonisamide crystal containing no 1, 2-dichloroethane, and high purity crystal of zonisamide |
EP1472236A1 (en) * | 2002-02-22 | 2004-11-03 | Teva Pharmaceutical Industries Ltd. | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide |
US6841683B2 (en) | 2001-08-30 | 2005-01-11 | Teva Pharmaceutical Industries Ltd. | Sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms |
US6900333B2 (en) | 2003-01-13 | 2005-05-31 | Dainippon Pharmaceutical Co., Ltd. | Process for the preparation of 1, 2-dichlorethane free crystals of zonisamide |
US7081539B2 (en) | 2004-03-25 | 2006-07-25 | Dainippon Sumitomo Pharma Co., Ltd. | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide |
WO2007032441A1 (en) * | 2005-09-16 | 2007-03-22 | Dainippon Sumitomo Pharma Co., Ltd. | Method for sulfonating 1,2-benzisoxazole-3-acetic acid |
US7268234B2 (en) | 2005-09-16 | 2007-09-11 | Dainippon Sumitomo Pharma Co., Ltd. | Method for sulfonation of 1,2-benzisoxazole-3-acetic acid |
US7375233B2 (en) | 2005-12-16 | 2008-05-20 | Apotex Pharmachem Inc. | Process for the preparation of zonisamide and the intermediates thereof |
JP2017530958A (en) * | 2014-09-12 | 2017-10-19 | 蘇州旺山旺水生物医薬有限公司 | Aminosulfonyl compounds, methods for their production, and uses |
WO2022009863A1 (en) | 2020-07-07 | 2022-01-13 | 大日本住友製薬株式会社 | Benzisoxazole derivative |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3434269B1 (en) | 2016-03-25 | 2020-12-23 | Teikoku Seiyaku Co., Ltd. | Transdermal absorption-type patch preparation comprising zonisamide |
-
1976
- 1976-12-16 JP JP15175976A patent/JPS6033114B2/en not_active Expired
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0094833A3 (en) * | 1982-05-18 | 1985-05-29 | Dainippon Pharmaceutical Co., Ltd. | Novel 1,2-benzisoxazole derivatives |
EP0094833A2 (en) * | 1982-05-18 | 1983-11-23 | Dainippon Pharmaceutical Co., Ltd. | Novel 1,2-benzisoxazole derivatives |
US4420485A (en) * | 1982-09-29 | 1983-12-13 | Hoechst-Roussel Pharmaceuticals Inc. | 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] |
WO2002070495A1 (en) * | 2001-03-02 | 2002-09-12 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 1,2-benzisoxazole-3-acetic acid |
US6677458B2 (en) | 2001-03-02 | 2004-01-13 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 1,2-benzisoxazole-3-acetic acid |
WO2003020708A1 (en) * | 2001-08-30 | 2003-03-13 | Teva Pharmaceutical Industries Ltd. | Zonisamide intermediate and synthesis |
US6841683B2 (en) | 2001-08-30 | 2005-01-11 | Teva Pharmaceutical Industries Ltd. | Sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms |
EP1472236A4 (en) * | 2002-02-22 | 2006-04-19 | Teva Pharma | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide |
EP1472236A1 (en) * | 2002-02-22 | 2004-11-03 | Teva Pharmaceutical Industries Ltd. | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide |
US6936720B2 (en) | 2002-02-22 | 2005-08-30 | Teva Pharmaceutical Industries Ltd. | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide |
WO2004063173A1 (en) * | 2003-01-10 | 2004-07-29 | Dipharma S.P.A. | A process for the preparation of benzo[d]isoxazol-3-yl-methanesulfonic acid and the intermediates thereof |
US7291742B2 (en) | 2003-01-10 | 2007-11-06 | Dipharma S.P.A. | Process for the preparation of benzo [d] isoxazol-3-yl-methanesulfonic acid and the intermediates thereof |
US6900333B2 (en) | 2003-01-13 | 2005-05-31 | Dainippon Pharmaceutical Co., Ltd. | Process for the preparation of 1, 2-dichlorethane free crystals of zonisamide |
JP2004244410A (en) * | 2003-01-22 | 2004-09-02 | Dainippon Pharmaceut Co Ltd | Method for producing zonisamide crystal containing no 1, 2-dichloroethane, and high purity crystal of zonisamide |
US7081539B2 (en) | 2004-03-25 | 2006-07-25 | Dainippon Sumitomo Pharma Co., Ltd. | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide |
US7262304B2 (en) | 2004-03-25 | 2007-08-28 | Dainippon Sumitomo Pharma Co., Ltd. | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide |
WO2007032441A1 (en) * | 2005-09-16 | 2007-03-22 | Dainippon Sumitomo Pharma Co., Ltd. | Method for sulfonating 1,2-benzisoxazole-3-acetic acid |
US7268234B2 (en) | 2005-09-16 | 2007-09-11 | Dainippon Sumitomo Pharma Co., Ltd. | Method for sulfonation of 1,2-benzisoxazole-3-acetic acid |
US7375233B2 (en) | 2005-12-16 | 2008-05-20 | Apotex Pharmachem Inc. | Process for the preparation of zonisamide and the intermediates thereof |
JP2017530958A (en) * | 2014-09-12 | 2017-10-19 | 蘇州旺山旺水生物医薬有限公司 | Aminosulfonyl compounds, methods for their production, and uses |
WO2022009863A1 (en) | 2020-07-07 | 2022-01-13 | 大日本住友製薬株式会社 | Benzisoxazole derivative |
US11535599B2 (en) | 2020-07-07 | 2022-12-27 | Sumitomo Pharma Co., Ltd. | Benzisoxazole derivative |
KR20230035592A (en) | 2020-07-07 | 2023-03-14 | 스미토모 파마 가부시키가이샤 | Benzoisoxazole derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6033114B2 (en) | 1985-08-01 |
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