JPS5955827A - Plaster for adhesive salve preparation - Google Patents

Abstract

PURPOSE:To provide the titled plaster capable of keeping the drug stably without causing decomposition, by adding nutmeg (extract) and clove (extract) to a plaster composed of a rubber-based adhesive substance. CONSTITUTION:A plaster composed of natural rubber, a synthetic rubber or their mixture, which may contain a tackifier, an agent for regulating the adhesive and holding power, a filler, etc., is compounded with nutmeg (extract) and clove (extract) at a weight ratio of 1:30-30:1. The amount of the additive is 0.05- 20wt%, preferably 0.2-5wt% (or 0.01-10wt%, preferably 0.1-5wt% for extract). When a drug applicable to the skin is compounded with the plaster, an adhesive drug preparation having stable drug content against aging can be obtained. The composition is especially effective when the drug is a compound containing phenolic OH group or an amino compound.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a publication for viscous patch preparations by Kienori Jii and a viscous patch preparation published by this organization from January to March. Jouf Shishikuni Kimitsu is an improvement of a paste made of a rubber-based adhesive substance used for adhesive patch preparations, and a sticky patch made by blending a drug into the improved rods. Regarding formulations.

Conventionally, drugs administered to the integument have been intended to locally act on the integument and its underlying tissues, such as bactericides, disinfectants, and skin irritants. However, in recent years, attempts have been made to administer drugs that have systemic effects through the skin, and various drugs have been proposed or attempted to be administered through the skin.

Dermal administration of drugs is carried out, for example, in the form of an adhesive patch, in which the drug is mixed into a plaster made of an adhesive substance.
If a preparation made of a rubber-based adhesive material is stored for a long period of time, the therapeutic effect of preparation B tends to be significantly reduced due to decomposition and volatilization of the drug.

By the way, volatilization and photodecomposition of drugs can be prevented by sealing them with aluminum laminate packaging and shielding them from light. The decomposition of the drug still progressed even with amine thread compound 1 tl-1 and aluminum laminate flexure.
Many items become unusable after being stored for 2-3 hours. Therefore, it is desired to develop a plaster or a rubber-based adhesive patch made of a rubber-based adhesive material in which the drug does not undergo decomposition even if the drug is added thereto.

Under these circumstances, Kien and his colleagues have conducted various studies, and have found that at least one kind selected from Nikuzuku and Nikuzuku extract, as well as cloves, stem cloves, mother cloves, and these It has been found that if at least one selected from the extracts of the following is blended, even if the drug is blended into the bite, the drug will not turn on and will remain stably present.

Kimi-ensu] was completed based on this new knowledge, and contains at least one kind selected from Nikuzuku and Nikuzuku extract, cloves, and a plaster made of a rubber-based sticky substance.
The present invention relates to a patch preparation for dead cats that contains at least one selected from the group consisting of cylindrical needles, mother needles, and extracts thereof, and an adhesive patch preparation that further contains a drug in the cylinder.

The rubber thread used in the present invention is a diene-based polymer compound that has been conventionally used as an adhesive for rubber thread adhesive patch preparations, specifically natural rubber, synthetic rubber, Examples include mixtures of these. Examples of synthetic rubber include styrene-in-plane-styrene foam-lock copolymerized rubber, styrene-1-diene rubber, polybutene rubber,
Examples include polyimbrene rubber, glutyl rubber, and silicone rubber. In the plaster made of rubber adhesive substance,
Furthermore, as a third component, terpene thread resin, tackifier such as petroleum resin, 5A@) 3 paraffin, animal and vegetable oils (e.g. Ori-1 oil, soybean oil, beef tallow, tonne fat), polypden, lower isoprene, wax. Adhesion and holding power such as 1. %I additives, fillers such as titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate, water and emulsifiers (e.g., nrubitan monooleate, sodium lauryl sulfonate), emulsifiers (
Examples include magnesium stearate and aluminum stearate.

The clove character used in “Ki-enri” is Eugenia car.
It is made by drying (air-drying) the buds of yo-phyl Iata, the stem cloves are dried flower feces of the above plant, and the mother cloves are dried unripe fruits of the same plant. Also, Nikuzuku is Myristica fragrans
This is Jin Jin. These are usually powders (preferably 1d10
0 mesh or less).

In addition, these extracts include, for example, organic solvents (e.g., methanol, ethanol, impropatol,
Examples include acetone, n-hexane, toluene) and a mixed solvent of any of the above solvents and water.

The amount of cloves (axis cloves, mother cloves) and daylily is about 0.05 to 20% by weight, preferably about 0.2 to 5% by weight, based on the entire plaster made of rubber adhesive substance. When these are added in the form of extracts, 0. (Approximately 11-10% by weight, preferably approximately 0, 5, 5, 5, 5, 5, 6, 5, 6, 5, 6, 7, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 12, 10, 12, 12, 12, 12, 10, 11, 11, 10, 10 each, respectively, FIGS. 1,500, 200, 2000, and about 10% by weight).

In addition, the blending ratio Fil of cloves (axis cloves, mother cloves) and Nikudzuku is 30 to 30:1, and the same blending ratio may be used when these are used as extracts.

The paste of Kienori J can be formulated into an adhesive patch preparation by incorporating a drug that can be applied to the outer skin.

Face to face, Ki-ni [:! The adhesive patch preparation using the plaster of the present invention has the effect that the drug blended therein is kept stable without being decomposed. There are no particular restrictions on drugs as long as they can be formulated into a transdermal patch and administered; for example, drugs that can be absorbed transdermally (however, they may be absorbed transdermally with the aid of a transdermal absorption aid, etc.). Examples include topical drugs and systemic drugs), drugs for treating skin diseases, drugs that irritate the skin, and drugs for treating indefinite complaints. In particular, the content of phenolic hydroxyl group-containing compounds and amine thread compounds is significantly reduced in pastes made of conventional rubber-based adhesive substances, so the paste of the present invention is particularly useful when formulating such drugs. Compounds containing phenolic hydroxyl groups, such as salicylic acid derivatives (monoglycol salicylate, methyl salicylate, etc.)
, vitamin E and its derivatives, cabzaicin, etc., and examples of amine compounds include ethanolamine thread antihistamines such as diphenhydramine.
Ethylenediamine thread antihistamines such as chlorpheniramine even 4! Of course, lidocaine is also available. Other active ingredients include tungsten, such as t-menthol, t
1-& cold skin stinging drugs such as el-enfer, thymol, d-borneol, non-steroid itoconates such as indomethacin, cyclofenac sodium, fungicides such as acrinol, tocanthus extract, nonylic acid hanylylamide Warm-sensing skin irritating drugs such as , kabuda, inn, shokiyo extract, canthari gingi, and cantharidin;

In addition, in preparing the dry stone pillar patch preparation of the present invention, it is possible to first add all the drug to the substance "rubber thread stickiness" and then add cloves (axis cloves, mother cloves) and nikuzuku. Needless to say, ll/″1.

Further, the adhesive patch preparation of the present invention is usually used by being spread on a support such as cloth or glass film.

The Mizumoto EIJ will be described in more detail below with reference to Examples and Experimental Examples, but the Mizumoto EIJ is not limited thereto.

In addition, in the following description, ``Miyako'' means ``1-juryubu''.

Example 1 42 parts of inbrene rubber were masticated in a kneader at 180 DEG C. for 20 minutes, and after cooling to 120 DEG C., 5 parts of a dried clove ethanol extract and 5 parts of a dried clove ethanol extract were added and kneaded for 10 minutes.

Further, while continuing kneading, 33 parts of natural rosin was added and kneaded for 15 minutes, and after cooling at 80° (L), 2 parts of liquid paraffin and 8 parts of beeswax were added and kneaded for 25 minutes. Obtain a plaster.

Example 2 Methyl salicylate 4 was further added to the paste obtained in Example 1.
．． 1 part, 0.88 part of diphenhydramine and 0.02 part of captuicin, and 5 parts of 1f'41#. The material obtained by kneading was spread on cloth to a thickness of 02 #s to obtain an adhesive patch (q preparation).

Example 8 5 parts of 50 to 100 mesh of daylily powder and 50 to 100 mesh in place of daylily extract and clove extract in the formulation of Example 1
Using 5 parts of 100 mesh pieces, an adhesive patch preparation was obtained in the same manner as in Examples 1 and 2.

Comparative Examples 1 to 3 The formulation of Example 1 above except for clove extract and day owl extract (Comparative Example 1), the form from which clove extract was removed (comparative example 2), and the form from which only day owl extract was removed (comparative example 3). ), and in the same manner as in Examples 1 and 2, respective adhesive patch XJ preparations were obtained.

Example The residual rate (%) of each drug when each of the preparations obtained in the above Examples and Comparative Examples was sealed and packaged in an aluminum-polyester laminate envelope and stored at 40°C for 3 months. ) are shown in Table 1.

Table 1 Residual rate of each drug) Patent applicant: Nitto Electric Industry Co., Ltd.

Claims (2)

[Claims] (1) Adhesive made of a paste made of a rubber-based adhesive substance, mixed with at least one selected from Niku-zuku and Niku-zuku extract, and at least one selected from clove, stem clove, mother clove, and extracts of these. Adhesive patch preparation Kawagypsum. (2) The clove extract, the clove extract, the mother clove extract, and the stem clove extract are extracted from an organic solvent or a mixed solvent of 41 organic solvent and water! r#*'r'uf range <1) The plaster described in item 1).