JPS5839614A - Composition for oral cavity application - Google Patents

Abstract

PURPOSE:To provide a composition for oral cavity application, exhibiting high antibacterial activity against Fusobacterium nucleatum and useful for preventing oral odor and periodontosis, by using extract of sage and/or rosemarry in combination with lauric acid monoglyceride. CONSTITUTION:A composition for oral cavity application is obtained by adding (A) sage and/or rosemarry extract and (B) lauric acid monoglyceride to a composition for oral cavity application such as dentrifrice e.g. toothpaste, moistened tooth powder, tooth powder, etc., mouth wash, oral paste, troche, chewing gum, gargle tablet, etc. The amount of the component (A) is preferably 0.0005-5wt%, especially 0.005-2wt% of the whole composition, and that of the component (B) is preferably 0.001-10wt%, especially 0.01-3wt% of the whole composition in terms of 100% purity. The above components exhibit synergistic excellent antibacterial effect against Fusobacterium nucleatum which is a pathogenic bacterium of oral odor and periodontosis, at a small amount, and give the objective oral cavity composition having high safety.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides an oral composition that exhibits good antibacterial activity against Fusibacterium nucleatum by using a sage extract and/or a rosemary extract in combination with lauric acid monoglyceride. Regarding.

There are various types of bacteria in the oral cavity, and 7 of them include Fus-ba*t@
r1wwm mw@l*atmns) is indole,
Since it produces hydrogen sulfide, mercaptan, etc.)
7zoI Cacterium eucleitum is attracting attention as one of the causative bacteria of bad breath and periodontal disease. Therefore, inhibiting the growth of 7zo/Blue Cacterium nucleatum is effective in preventing bad breath and periodontal disease.
Although antibacterial properties have been recognized in No. 31034, the antibacterial activity against Fusibacterium nucleatum is not high as shown in the experimental examples described below.

In view of the above circumstances, the present inventors conducted intensive research on active ingredients that have a high antibacterial effect against Fusibacterium nucleatum, screened various plants as a natural product additive, and developed sage extract. , rosemary extracts were selected, and as a result of using them alone or in combination with lauric acid monoglyceride, they exhibited a synergistic and specific antibacterial effect against 7zonoelectrium nucleatum even in small doses. Therefore, blending extracts of sage and rosemary and lauric acid monoglyceride into oral compositions can prevent bad breath.
The present invention was made based on the discovery that this method is effective in preventing 1-period disease.

The present invention will be explained in detail below.

The present invention relates to toothpaste, moisturized toothpaste, powdered toothpaste, and wash 40
The present invention is a composition containing sage extract and/or rosemary extract and lauric acid monoglyceride in oral compositions such as tablets, oral tablets, troches, chewing gums, and gargling tablets.

In this case, the raw materials used to obtain the extract of sage and rosemary include powder of 0, sage and rosemary; the residue of extracting oil from these by steam distillation and other essential oil extraction residue; or sage, Lower alcohols such as rosemary, ethyl ether, ethylene chloride, dioxane, acetone, ethanol or methanol,
When extracted with polar solvents such as ethyl acetate, propylene glycol, glycerin, and water, the resulting oleoresin and its extraction residue; Those selected from oleoresins obtained by extraction with nonpolar solvents such as carbon, chloroform, dichloromethane, 1,2-dichloroethane, toluene, and benzene, and the extraction residue thereof are used. When obtaining extracts of sage and rosemary from these raw materials, one or more of these raw materials may be mixed with a polar solvent and/or a non-polar solvent (the solvents listed above are used). The extract (extract liquid or extract from which the solvent has been distilled off) is collected. In the present invention, this extract can be used as part 11, but it is also possible to use a steam distillation residue obtained by steam distilling this extract, or a steam distillation residue obtained by subjecting this extract to activated carbon, diatomaceous earth, or acid clay. treated with an adsorbent of
Furthermore, the residue obtained by steam distillation after treating the extract with an adsorbent can also be suitably used as an extract of sage or rosemary.

Note that a known method can be used as the extraction method, for example, a method such as digesting dry powder of sage or rosemary in a solvent can be used. In this case, the solvent is preferably an organic solvent, and an organic solvent extract obtained by extracting sage or rosemary with an organic solvent is more effective.

In addition, in the present invention, even if one kind obtained by the above method is used as the extract of sage and rosemary, two
You may use more than one species in combination.

Further, the amount of the extract of sage and rosemary added to the oral composition is preferably 0.0001 SIG (weight %, same hereinafter) to 5-1, especially o, oos to 2-2.

The purity of the lauric acid monoglyceride used in the present invention is not particularly limited, and commercially available products can be used. For example, R-220 manufactured by Matsumoto Yushi Co., Ltd. and Toyo Ionin D901 manufactured by Takemoto Yushi Co., Ltd. can be used. The amount of lauric acid monoglyceride added to the oral composition is preferably 0.001 to 1 O-1, particularly 0.01 to 3, in terms of 10011i purity.

As other ingredients of the present invention, appropriate ingredients are used depending on the type of oral composition. For example, in the case of toothpaste, second phosphorus group A, sium, dihydrate and anhydrous. , calcium carbonate, calcium birophosphate, calcium sulfate, insoluble sodium metaphosphate, amorphous silica, -crystalline-
Abrasives such as crystalline silica, aluminosilicate, aluminum hydroxide, aluminum oxide, and resin (compounding amount is usually 2
0-6091), binders (0,3
~51G), /lyethylene glycol, sorbitol,
Thickening agents such as glycerin and propylene glycol (10~
7on), sodium lacryl sulfate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium N-lauroyl dercosinate, K-acyl glutanate, lauryl jetanolamide, Foaming agents such as saccharated fatty acid esters (θ~51
i), and peppermint, spare oil, and t.
-Menthol, Cal? Fragrances such as fragrance materials such as N, oilnol, and anethole, sweeteners such as saccharinna 1 licum, stevioside, neohesberidyl dihydrochalcone, glycyrrhizin, irilartin, p-methoxycinnat, quaaldehyde, and thaumatin, preservatives, etc. The ingredients are mixed with water and prepared according to conventional methods. 9. In mouthwash, mouthwash, mouthwash, and other mouthwashes, ingredients are appropriately blended according to the properties of the product.

In addition, in the present invention, in addition to sage, rosemary extract, noglyceride such as lauric acid, lysozyme chloride, textlanase, lytic enzyme, mutanase, chlorhexidine or its salt, sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride , alkylglycine, alkyldiaminoethylglycine salt, allantoin, 8-di-tukagulonic acid, tranexamic acid, azulene and vitamins! , sodium fluorophosphate,
Active ingredients such as sodium fluoride, tritin fluoride, a water-soluble mono- or di-phosphate quaternary ammonium compound, and sodium chloride can also be blended.

Therefore, the oral composition according to the present invention has the effect that sage extract and/or rosemary extract and lauric acid monodaliseride are used together, so that the fins act synergistically with each other. It exhibits an excellent anti-1 effect against C. nucleatum and is therefore effective in preventing bad breath and periodontal disease caused by this bacterium.

In addition, the oral composition of the present invention contains a highly safe plant extract as an active ingredient, and is highly effective even at a relatively low concentration, so the amount can be reduced. Therefore, it is highly safe to use.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

Dry sage powder 100. Add 300 d of methanol to OP, reflux for 1 hour on a water bath at 70 to 80 C with a cooling tube attached, and then separate the methanol fraction by furnace, add fresh methanol to the residue, repeat the same reflux twice, and Three extraction operations were performed.

The methanol extract was concentrated under reduced pressure to obtain 27.4jF of green color.

Further, 15011j of methanol was added to 30Jl+ of dried rosemary powder, and the mixture was refluxed for 1 hour on a water bath at 70 to 80°C with a cooling tube attached. The following procedure was carried out in the same manner as in the case of sage, and 7.3P of a dark greenish brown solid was obtained.

Other solvents were operated in the same manner as above to obtain various extracts of sage, rho:f-friichi.

Table vJ1 shows the extraction results.

Table 1 Next, a medium containing 0.004% of lauri, phosphoric acid monoglyceride (50% purity), 0.00% of each extract of sage and rosemary was added. ) 5-containing medium, laflic acid monoglyceride (so-purity) 0.0 O4- and each extract of sage and rosemary 0.05- to a medium containing pre-cultured Fusopacterium nucleatum 1436 in an amount of 1/Zoo In addition, under anaerobic conditions (80% N2, 10% H2, 101
6CO,) and incubated for 2 days at 37°C. Then, the speciesity of bacterial growth was determined by absorbance at 550 nvm. The results are shown in Table 2.

The medium used was Todd-Haitt medium (manufactured by IFCO) containing 0.05-cysteine.

Tuna 2 table 550 n- absorbance 21st! As a result, by using extracts of sage, rosemilli, and laflic acid monoglyceride in combination, they act synergistically on Fusi/4acterium nucleatum, resulting in excellent fighting power against Fusi/4acterium nucleatum. It is found that

Examples are shown below.

[Example 1] Toothpaste Dicalcium Phosphate/Dihydric 50 Tiglycerin
20 Cal xymethyl cellulose 1
．． 0 Sodium lauryl sulfate 1.0
Fragrance 1.0 Sezo methanol extract 0.05 Lauric acid monoglyceride 0.2 Sa
Karin o
, i Sodium fluoride 0.1 Allantoin 0.1 [Example 2] Toothpaste Dicalcicum phosphate dihydrate 50 -
Sorpi, To
10 grams
10 Sodium lauryl sulfate 2.0 Calgaxymethylcellulose 1.0 Flavor 1.0 Sage 80 Thiethanol extract 0.1 Lauric acid monoglyceride 01 Sodium monofluorophosphate 0.3 Eta
Nol
2.0, saccharin 0.1
0.1100.0- [Example 3] Toothpaste calcium carbonate s〇-Guri
Serine 20 Karanan 0.5 Caloxymethyl cellulose 1.0 Lauryl diethanolamide 1. Ossi, sugar monolaurate 2.0 Flavoring ・0.
8” Sage Petroleum Ether Extract 0.
1 Lauric acid monoglyceride 0.3
Satucalin 0.1 Chlorhexidine hydrochloride 0.00
5 Dextranase 0.01 as 0.1100.
0 Chi [Example 4] Toothpaste dicalcium phosphate dihydrate 50
Chiguri Serin
20 cal is oxymethyl cellulose
2.0 Sozocum lauryl sulfate 2.0 Fragrance 1.0
Water extract of sage 0.1 Lacrylic acid monoglyceride 0.15 Chlorhexicine gluconate 0.01 Saccharin, 0.1
% Glycyrrhizic acid 0.2
Bentonite 0.5 100.091 [Example 5] Toothpaste Silicic anhydride 3o Tiglycerin
3゜solvi, g
2゜Radium lauryl sulfate 2
．． 0 Calgaxymethyl cellulose 1.0 Fragrance 1.0 Saccharin 0.1 Acetone extraction of 0-Zumary 11no
, l Lafric acid monoglyceride 0
．． 2 Tranequinic acid 0.1100.
0 [Example 6] Oxyethylene monostearate (Example 6) 2.011 Sorbitan monooleate 2.0 11
Cetyl alcohol 2.0 odor Petyl alcohol 3.0 Glopylene glycol, 15.0 Cal xymethyl cellulose 5.0 Gelatin 1.0 Saccharin
0.2 seiso methanol extract
0.1 Lauric acid monoglypeptide
0.1 lysozyme chloride
5,000 units/P chlorhexicine hydrochloride
0. OI% fragrance
0.3100.01 [Example 7] For oral cavities/arm staglycerin monolaflate 3.0% oleyl alcohol 5.0? Liethylene glycol 15. .

White petrolatum 3. ON-Pal Den Toil Gluta tX Ryo Mononatrichum 0.5 and Droxyethyl Cellulose 5.0 16
Sage ethylene chloride extract 0.05
Lacrylic acid monoglyceride 0.2 Tocopherol acetate 0.1 Chlorhexidine hydrochloride 0.01 Saccharin 0.2 Fragrance
Fee 0.31
00.0 bags [Example 8] Mouthwash ethanol 20.0
11 Satukarin 0.0
5 Flavors 1.
0 Sodium monofluorophosphate 9m 0.1
Chlor gluconate to medium cysine 0.0
1 laurylzoethanolamide 0.3
7) n-~Yasan-methano + (1:1) extract
0.1 Lauric acid monoglyceride
0,1 glycyrrhizinate
0.1 allantoin
0.1 water
Remaining 100.0g6 [Example 9] Liquid toothpaste glycerin
35, oIIbN-Cocoyl Glutami Naryo Sennonatrichum 1.5 Karadanan 1
．． 5 Kagulingushi, Ga-2.0 Flavor 0.9
Ethanol 1.0 Sodium monofluorophosphate 050-
30-Ethanol extract of Zumaryi o, os Lauric acid monodaliseride 0.1 Chlorhexidine hydrochloride 0.01 Water
100.0 remaining
[Example 10] Lozenge arabic pum 6.
0% Glucose 72.0 Gelatin 3.0 Flavor 0.2
Dextranase 0.11
Chlorhexidine gluconate 0.01
Sage ethanol extract 0.1 Lauric acid monoglyceride 0.2 Celery/tanol extract o, i Water
10.0 remaining
．． 0 96 [Example 11] Chewing base 40.01
1 Calcium carbonate 2.0
Starch syrup 15.0 Powdered sugar 40.0
Fragrance 0.5
Dextranase 0.10
- n-hexane extract of Sumari 0.1 Lacrylic acid monoglyceride 0,15100.016 [Example 12] Gargling agent Sodium bicarbonate 54 Sodium diphosphate 10 T.

l Liethylene glycol 3.0 fragrance
Materials 2.0 Oleic acid 0.1 Sodium monofluorophosphate 0.1 Chlorhexidine hydrochloride 0.05 Ethanol extract of sage 0.050 Ethanol extract of Sumary 0.05 Lauric acid monoglyceride
O11 Allantoin
0.1 phosphoric acid
17.0100.0% [Example 13] Toothpaste powder calcium diphosphate dihydrate 50.0
Calcicum dicarbonate 30.0glycerin 10. Oa-olefin sulfur *-) 1.0 fragrance
Fee 1.0 sa Tsuka
Phosphorus 0.1
Sodium monofluorophosphate 0.10
- Methanol extract of Zumari 0.1 Lauric acid monoglyceride 0.3 Dextran
0.5 Applicant Lion Co., Ltd. Agent Patent Attorney Takashi Kojima, WJ Patent Attorney Hanyo Takahata

Claims (1)

[Claims] A composition for the knees, characterized in that it is made by using a combination of sage extract and/or rosemary extract and lauric acid monoglyceride.