JPS58194808A - Compress mastication tablet and manufacture - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] The present invention relates to compressed chewable tablets, such as antacid tablets.

Although the tablets are breakage resistant, they disintegrate quickly into an emulsion with a smooth, creamy, pleasant flavor, without the "graininess" normally associated with antacid tablets. There is no such thing.

Flavor and mouthfeel are very important factors in the formulation of chewable tablets, especially pharmaceutical dosage forms of chewable tablets. Many pharmaceutical preparations and tablet confections are designed as chewable tablets to provide a good flavor or to increase the surface area of the drug and allow for faster action in the gastrointestinal or circulatory system. .

As a result, tablet formulations must be developed to satisfy several basic requirements. Sufficient cohesiveness to form a firm tablet under compression; Sufficient lubricity to prevent binding within the die cavity; Adequate fluidity to provide uniform weight. non-stick under compression, uniform drug release and post-dose release, and can be produced in high-speed equipment.

Additionally, many pharmaceutical ingredients generally have an unpleasant mouthfeel and unpleasant flavor due to their chalky, gritty, bland, astringent properties. Therefore, the practical value of the pharmaceutical ingredient is substantially reduced as the patient's aversion to these may result in the pharmaceutical ingredient not being taken as prescribed.

In an effort to overcome this problem, flavorings have been used in pharmaceuticals, especially in antacids and vitamins, to mask their unpleasant bland and astringent properties and their accompanying chalkiness. is canceling out. Unfortunately, it has been found that flavoring only masks the unpleasant flavor, while the chalkiness, grittiness, blandness and astringency remain.

U.S. Patent No. 3,843,778 (Diamond eL
al) discloses a technique in which antacid particles are coated with a water-insoluble, inert, non-toxic hydrocarbon oil and formulated into suspensions or tablets, which It is said to virtually eliminate bad taste and mouthfeel. Alkylaryl sulfonates, alkyl sulfates or sulfonates, sulfonated amides or amines, sulfated or sulfonated esters may also be used to aid in the attachment of the oil to the electropositive antacid particles. honey chill, dodecyl sulfosuccinate, hydrated aluminum silicate (e.g.
Electronegative materials such as surfactants selected from bentonite and kaolin are used.

U.S. Pat. No. 3,253,988 (Scoct) discloses oils and fats.

That is, the present invention discloses an orally administrable antacid prepared by convexly combining an ester of a higher fatty acid and a trihydric alcohol with an antacid. The antacid can be in the form of a wax-like solid, emulsion or suspension, and is obviously prepared simply by uniformly mixing all the ingredients.

British Patent No. 15332 B □ (Armour-1'
)ial Inc, ) discloses antacid tablets containing oil, antacid, sugar, starch, and water. It is manufactured by a wet granulation process and uses fats and oils that have a melting point above body temperature. Still, the tabletting process must be heated to 105-120 degrees Fahrenheit to avoid sticking to the punch surfaces. This antacid tablet contains antacid ingredients, water,
Sugar and fat are mixed to form a powder mixture, and this mixture is formed into tablets by applying a pressure of 50 to 600) S1 while keeping the tablet machine including the punch at a high temperature. It is said to be manufactured.

This tablet is made by mixing liquid fat and antacid with sugar and water, cooling the resulting mixture below 40'F, then passing this mixture through a mill to form a powder mixture. It can also be produced by forming into tablets.

Generally, tablets are manufactured by direct compression and include the active ingredient,
The composition to be tabletted, including flavors, binders, etc., is fed into the die chamber of a tablet press and directly compressed into tablets. The hardness of the resulting tablet is a linear function of the compression pressure employed. If so-called soft tablets, ie, easily chewable tablets, are desired, a disintegrant such as alginic acid is added to the tablet premix. Alternatively, soft tablets are formed by employing lower compression temperatures.

The result in both cases is virtually the same: very brittle;
You will get softer tablets that are easier to swallow.

It has also been suggested to use oleaginous substances in tablet premixes to obtain tablet softness.

However, it has been found that the addition of oily substances to the tablet premix causes the ingredients to be tableted to stick to the die chamber, significantly reducing the binding effect of the binder present in the mix.

The present invention has excellent hardness and flexibility (flexi-b
The purpose of the present invention is to provide a unique compressed chewable tablet that is easy to chew, rapidly disintegrates, and dissolves during the day, although it is resistant to breakage and crushing. The compressed light tablet of the present invention comprises (a) an edible oil and fat substance, an oil and fat absorbing substance in which the oil and fat substance is absorbed on the surface or inside, one or more tablet binders mixed therewith, and optionally one or more types of tablet binder. a pretreated granular oil composition formed from antioxidants, flavors and/or colorants, Φ) a mixture of active ingredient particles, such as one or more antacid particles, optionally;
a pretreated active ingredient composition formed from an edible oil, a binder, an emulsifier, a flavor and a colorant, wherein the active ingredient particles are coated with these other ingredients; and (C) a binder, optionally a flavor. consisting of a pretreated direct compression tableting aid composition, these compositions (a),
Mix (b) and (C) and form the mixture into compressed chewable tablets.

In a preferred embodiment of the compressed chewable tablet of the present invention, the active ingredient consists of antacid particles, and the pretreated granular fat composition (a) is a fat-absorbing substance, preferably 1. <
Iri, microcrystalline cellulose, fatty substances absorbed in the microcrystalline cellulose, optionally a colorant such as titanium dioxide, optionally butylated hydroxytoluene;
Una antioxidant, if desired, simetiko 7 (simet
A tablet binder, an exfoliant, a tablet sugar and/or dextrose hydrate, and, optionally, one or more flavors.

A preferred pretreated active ingredient composition (1)) comprises particles of antacids such as calcium carbonate, aluminum hydroxide, magnesium hydroxide, preferably particles of a mixture of all these antacids. a binder, preferably carboxymethylcellulose, which helps the adhesion of flavors and emulsifiers to the oil-absorbing particles to provide a smooth mouthfeel; It contains an emulsifier such as polyglycerol esters of fatty acids, an edible oil, preferably a vegetable oil, and a flavor to help the emulsifier spread over the antacid particles.

A preferred pretreated direct compression tableting aid composition (C) contains a tablet binder, preferably tableting sugar and/or dextrose-hydrate, flavor, flavor oil.

In the compression single-pack tablet forming process of the present invention, the edible oil and fat substance that imparts good softness, flexibility, and flavor to the tablet is isolated from other ingredients, that is, the tablet press machine - It is essential that the chamber be in such a condition as not to make it sticky or to negate the binding action of the tablet binder present.

This is achieved by the following method for producing compressed chewable tablets of the present invention. The production method of the present invention involves melting an edible fat substance, mixing this melted fat substance with a coloring agent and an antioxidant, if used, and mixing this mixture with a fat absorption substance to absorb the fat substance. The resulting mixture is dried, hardened, passed through a sieve, and pretreated by mixing with one or more tablet binders and flavors, if used. The step of forming a granular oil composition (a) is to mix the particles of the active ingredient and the binder, mix them together, and, if used, separately mix with one or more emulsifiers, edible oils and flavors; The mixture is mixed in a trench to form a free-flowing powder;
forming a pretreated active ingredient composition (1)) in which the active ingredient particles are coated with a binder, an oil, a flavor and an emulsifier; the steps of mixing these compositions and forming compressed tablets from the resulting mixture.

The hardness of the resulting tablets does not directly correlate with the compression pressure. In fact, tablets obtained according to the method of the invention under medium or high pressure (e.g., using pressures of about 4000 to about 10000 psi) have excellent hardness, flexibility,
Although less brittle, it is still easily chewable and dissolves during the day.

The compressed chewable tablet of the present invention can be used as an antacid, a vitamin, a laxative,
Contains anti-flatulent, aspirin, acetaminophen, anorectic, etc., has a non-chalky, non-gritty, pleasant flavor and turns into an emulsion or colloidal suspension when exposed to saliva during the day, thus , exhibiting liquid-like trends. Yet, since the tablets of the present invention rapidly disintegrate into a hot solution, the inclusion of an oil-based system also provides an advantageous portable vehicle for flavored beverages to enhance flavor. Examples of such vehicles include tableted coffee whiteners and flavoring agents, bouillon soups, cream soups, and the like.

Depending on its respective properties, the active ingredient is generally present in the final product in an amount of about 90 to 999% (by weight), preferably about 92 to 97%, based on the pretreated active ingredient composition. of tablets, preferably about 10-50%, preferably about 1
Contain 5 to 30%.

As mentioned above, in a preferred embodiment, the active ingredient is an antacid material, about 10-50%, based on the final tablet.
Preferably it will be present at about 15-30%. Examples of suitable antacids include aluminum carbonate, aluminum hydroxide (strained aluminum hydroxide-hexitol stabilized polymer, aluminum hydroxide-magnesium hydroxide simultaneous drying gel, aluminum hydroxide-magnesium trisilicate). Dry 1 Mulberry Genope aluminum hydroxide-sucrose powder hydrate), aluminum phosphate, aluminum hydroxy carbonate, sodium dihydroxy aluminum carbonate, aluminum magnesium glycinate, dihydroxy aluminum aminoacetate, dihydroxy aluminum amino acetic acid, bismuth aluminate, bismuth carbonate, Basic bismuth carbonate, bismuth subgallate, bismuth nitrite, calcium carbonate, calcium phosphate, hydrated magnesium aluminate activated sulfate, magnesium aluminate, magnesium aluminate silicate, magnesium carbonate, magnesium glycinate, magnesium hydroxide, Included are FDA-accepted relatively water-insoluble antacids such as magnesium oxide and magnesium trisilicate.

Preferred antacids are aluminum hydroxide, calcium carbonate, magnesium carbonate and mixtures thereof and magnesium hydroxide.

The fats and oils used may be of substantially water-insoluble, inert, non-toxic hydrocarbon fats and fats and derivatives thereof of UJ, vegetable or mineral origin, and are of vegetable or mineral origin, as permitted by F1) A.
Any commercially available fat or oil having a melting point that meets the desired factor of 11, such as a melting point in the range of 0 to 110'F, need not be limited to one with a melting point of 1000F to 110F. The fat may be about 2-45% based on the desired properties of the final product.
, preferably in the range of about 10-25%. Examples of suitable fats and oils include hydrogenated tallow, hydrogenated vegetable oil, almond oil, coconut oil, corn oil, cottonseed oil, refined linseed oil, and Stream! W noiseline, liquid uJ paraffin, olein, olive oil, palm oil, peanut oil, peach oil, sesame oil,
Examples include dog bean oil and safflower oil.

Preferred oils include corn oil, light liquid petrolatum, liquid paraffin, oleic, olive oil, peanut oil and soybean oil.

The fat-absorbing substances (i.e., fat-absorbing and/or adsorbing substances) include microcrystalline cellulose, corn starch, tapioca, dextrin, sucrose, sorbitol, xylitol, mannitol, etc., with microcrystalline cellulose being preferred. . The fat-absorbing material is about 25 to 75%, preferably about 40 to 75%, based on the pretreated fat composition.
present in an amount of 60%, weight ratio to oil substance, approximately 0.
625=1 to about 1.875:1, preferably about 1=1
~ about 1.5:1 is used. The fat-absorbing material comprises about 10-30%, preferably about 10-20% in the final tablet formulation.
be present in an amount of

The fat-absorbing substance is preferably in finely ground form;
The preferred average particle size is 90±20 microns.

As mentioned above, the pretreated fat composition and the pretreated tableting aid composition include a tablet binder.

Examples include textulose hydrate (e.g.
/ CI-S (Cerelose) 204.3)
, DE 'H3B ~45 corn white two 7' solid,
Examples include sugars, sugar alcohols and mixtures thereof, such as milk t'f, mannitol, sorbitol, xylitol, sucrose, invert sugar and mixtures thereof; tablet sugar, dextrose hydrate and mixtures thereof; preferable. The total amount of binder present is about 20-60%, preferably about 30-40%, based on the final tablet.
range from about 10 to about 5 for the pretreated oil and fat composition.
0%, preferably 1 to 30%, and about 20 to 30% binder. The pretreated tableting aid composition has a content of about 90-99.
It contains 9% binder, preferably about 97-99.5%.

The edible oil in the pretreated active ingredient composition is an emulsifier that helps spread the active ingredient particles and is about 1-4%;
Preferably, it is present in an amount ranging from about 1.5% to 2.5%. The edible oil includes any of the edible oils listed above with respect to the fat and oil substances.

Any emulsifier or surfactant with an HLB value of 8 or higher that is acceptable for foods by the FDA can be used in the pretreated active ingredient composition, and in forming the antacid tablets of the present invention. Based on final tablet formulation, approximately 005-2
．． It is used in an amount of 5%, preferably about 0.1-1.0%.

In nuclear pretreated active ingredient compositions, about 1-4%, preferably about 15-25% is used.

Examples of emulsifiers or surfactants used to aid in the release of antacids include alkylaryl sulfonates, alkyl sulfates, sulfonated amides or amines, sulfated or sulfonated esters or ethers, alkyl sulfonic acids. salts, such as dodecyl sulfosuccinate, hydrated aluminum silicates (e.g. micronized bentonite or kaolin), Cab-0-5il (Cab-0-5il), etc.
Corporation.

Trademark Q for silica pigments sold by Boston Mass.
ls.

(Philadelphia Quartz Co, P
triglycerol monostearate, triglycerol monoshortening, octaglycerol monooleate, octaglycerol monostearate, etc.
Decacrycerol Decaoleate, 5pan (iQ
, 1'wcen 60 and 80.

Preferred are polyoxyethylene sorbicone fatty acid esters such as stearate, oleate, palmitate, etc., such as 1'ween 60 and 80, and octaglycerol monooleate, triglycerol monostearate and triglycerol monoshortening.

Lubricants present in the pretreated active ingredient composition include cellulose gums, such as carboxymethylcellulose gum,
Xanthan gum, locust bean gum, alginic acid or mixtures thereof are included, pretreated active ingredient composition width is about 1-5%, based on the final tablet about 2.5-5%
3.5%, preferably 1 (J O, 75-1.5%).

The essential ingredients present in the preferred antacid tablets of the invention to mask chalkiness, grittiness, blandness and astringency are natural or synthetic oily types or other flavors, such as cocoa, chocolate, etc. , especially mint chocolate, butter, milk, cream, vanilla butterfat, eggs, egg whites and peppermint oil,
Wing 9'' Lean Oil, Spearmint Oil Natoka included, Chocolate Ma or Vanilla preferred.

Approximately 0.05-1% of these flavors based on the tablet;
Preferably, when used in an amount of about 0.5-0.8%, the flavor, along with fats and oils, minimizes harshness and
Provides a synergistic effect that improves organization and area.

The fat substance in the flavor described in No. 111 may be used as the fat substance in the pretreated fat substance composition, and further,
Flavor may be present in each of the three pre-treated compositions, with the majority of the flavor being present in the pre-treated tableting aid composition.

Yet, the antacid tablets of the present invention are free from other lacerations'--acceptable substances;
For example, sugars, sugar alcohols, hydrogenated starch hydrolysates (
Lycasin), synthetic 1F flavoring agents (e.g. sorbitol, xylitol, saccharin salts, free acid of saccharin, zyclamate, free zyclamic acid, dihydrochalcones, L-7 sparathy-L-phenylalanine methyl ester, isomatti 1-- flavoring agents and coloring agents, including other flavours, disintegrants such as starch, other binders, lubricants (e.g. calcium stearate, stearic acid, stearic acid). Magnesium (05-3%)), antioxidants (e.g. butylated hydroxytoluene), anti-bloating agents (e.g.
simethicone) and the like.

Additionally, the antacid tablets may be sealed in a sealant, such as gum arabic or starch, to prevent breakage. Additionally, the tablets 1 may be spray coated or otherwise coated with chocolate or other standard confectionery coatings to prevent breakage during shipping and handling and to further reduce the chalkiness of the tablets. Additionally, a confectionery glaze may be applied to the coating to prevent premature melting during handling.

In formulating the antacid tablets of the present invention, the antacid material preferably has a primary particle size of 100 microns or less, preferably 50 microns or less, and stirring is essential during antacid tablet manufacture. The antacids, fats, flavors, and other ingredients are vigorously mixed at each step until completely evenly distributed.

Next, a preferred chewable tablet formulation of the present invention will be shown.

■. Pretreated fat and oil composition components Dispersed composition % Tablet basis % Oil and fat material (1,r, hydrogenated vegetable oil) 30-50 10-20 Oil-absorbing material (preferably microcrystalline cellulose) 20-50 3510-15 Tablet binder (preferably tablet sugar and dextrose hydrate) 20-307.5-15 Flavor 0.1-0.4 0.05-0.15
Colorant 0.05-0.4 0.1-0
．． 3 Antioxidant 0.05-0.1 0.0
1 to 0.03■, Pretreated Active Ingredient Composition Ingredients Composition Based % Tablet Based % Active Ingredient (Preferably Antacid CaCO35o~6o 1o~15A I (0
11) 3 15~25 3~6Mg(Of-I)
2) 15-25 3-6 Lubricant (preferably carboxymethyl cellulose) 1.5-4 05-1.5 Emulsifier (preferably polyglycerol ester of fatty acid) 1-3 0.25-()
, 75 Edible oil (preferably hydrogenated vegetable oil) 1-3 0.25-0.
75 Flavor 0.2-0.5 0.0
5 to 0.15■, pretreated tableting aid composition component Composition based % Tablet based % Tablet size α7!1llI (good for tablets and dextrose hydrate) 95 to 99.9 30-4° Flavor 1.5-5 0.1-1 Next, the present invention will be explained in more detail with reference to Examples.

Example 1 An antacid pretreatment is then prepared from 03 premixes.

Premix ■ Pre-treatment component of oil and fat composition Part by weight based on tablet Hydrogenated vegetable oil (Santina l'rNT)] 6.2
25 Microcrystalline cellulose (Avicel p) (102,
Particle size 907L) 12.27 Titanium dioxide (colorant) 003 Simethicone LV
A (antiflatulent) ■7'-1-su) O-:Z,
-Hydrate (Cantab) 10 people Evanilla flavor 01 Butylated hydroxytoluene (antioxidant) 0.01 According to this recipe, titanium dioxide, 5 antina 1NT (
Heat the oil, simethicone, and butylated hydroxytoluene to 140° F. with stirring. Mixture Hobart (
Hobart) Transfer to a mixer and add the microcrystalline cellulose while stirring. When mixed, the microcrystalline cellulose absorbs its weight of fat and oil, and the mixture assumes the appearance of an oily powder. Transfer this mixture to a tray and let it harden. Fully cured, dry and weeping.

Pass through 16 screens and transfer to Hobart mixer. Add dextrose-hydrate and vanilla flavor;
Mix the mixture for 3 minutes.

Premix 1 pack Flavor-improving antacid pre-treatment ingredient Tablet standard weight loss CaCO
313 AI(OH)3 5Mg(O
H) 24 Carboxymethylcellulose 0.75 Emulsifier (polyglycerol ester of fatty acids/l/) (Santone 8-1-0
) 0.5 vegetable oil (Durk
ex 500) 0.5 people Evanilla flavor 0.1 According to this recipe, Ca CO3, AI (011)3,
Tri-blend Mg(01-()2 and carboxymethylcellulose. In a separate container, 5anto
Mix ne F3-1-Q (emulsifier), vegetable oil oyohi vanilla flavor and slowly add the mixture to the antacid/CMC mixture. Continue mixing until a uniform free-flowing powder is obtained. For salivation stimulation, each antacid particle is coated with oil, flavor, and emulsifier 11.

Premix If Pre-treatment component of direct compression tabletting aid Tablet standard wheel - parts Dextrose hydrate 23 Sugar for tablets
125 people Evanilla flavor
04 Peppermint oil 0.
1. Tri-blend the dextrose-hydrate and tablet terms in a Hobart mixer, add the vanilla flavor and peppermint oil to this and mix for 5 minutes.

In a mixer, premixes I, III and liver were further mixed with 0.5% carboxymethylcellulose gum.
Tri-blend for 5 minutes. The resulting composition is then tabletted using a conventional tablet press.

The chewing tablet of the present invention produced in this way is soft and
It has flexibility. This antacid tablet will not break if dropped from 2.5 meters onto a hard floor, whereas conventional chewable tablets will shatter on the hard floor when dropped from such a height. Furthermore, the obtained one tablet of the antacid chew of the present invention has a durometer reading of
As shown by 1 and the "tablet hardness reading", the conventional chewing method 1@tablet is also soft and easy to chew.

Durometer reading (average of 10 samples per product unit γ) Test force required for penetration (bond)
Rolaids 35.5T
ll m s 42.
2Pepto Bismol 38
．． 2Fl 1ntstones Vi tamins
27.9 Antacid tablets of Example 1 1o,
0 tablet cutting hardness reading sample Force required to crush tablets by radial compression Rolaids 5.71 (Average of 5 times) Tums 6.52 (Average of 5 times) Antacid bar 1j chewing tablet of Example 1 2.97 ( Furthermore, the antacid tablets obtained above are non-chalky,
It has a pleasant flavor without any harshness, and was also found to exhibit a liquid-like behavior, with the emulsion turning into a colloidal suspension when exposed to saliva in [-1].

Example 2 Low calorie antacid chew tablets are prepared as in Example 1 except half of the dextrose-hydrate is replaced with immaltitol (Palatinit).

Example 3 Vitamin tablets with a final weight of 1 g are manufactured in the same manner as in Example 1, except that Premix (1) (active ingredient premix) is used in the following formulation.

Premix ■ Ingredients 250 #lfI (100% US R1) A) Vitamin C75tHf/ Niacinamide 22 my Pyridoxine Hydrochloride 2.9 ll1g Riboflavin 2 mW Thiamin.
Mononitrate 1.3 yq Vitamin A 60001U
Iron (elecLrolytic) 2
0 tl? Example 4 Aspirin chewable tablets with a final weight of 37 are prepared as in Example 1 except that Premix II (active ingredient premix) consists of salicylic acid. This chewing lI
The tablets contain approximately 750 ytr(1→)-lytic acid per dose.

Example 5 Analgesic chewing tablets are produced in the same manner as in Example 4, except that the active ingredient is acetic acid/aminophen.

Special ff113 Applicant Nabisco Bragg Incorporated Patent Attorney Aoyama Aoyama and 2 others 5-0 Driftwood Lane, Norwalk, Connecticut, U.S.A. Inventor Donald A.M. Matsukai Pleasantville, New York, U.S.A.・Deerfield Lane 135 No. 49-

Claims (1)

[Scope of Claims] (]) (a) An edible oil or fat substance, an oil or fat absorption substance on which the oil or fat substance has been absorbed, and one or more tablet binders mixed therewith, and optionally one or more tablet binders. A pretreated granular fat composition consisting of an antioxidant, a flavor and/or a colorant, 0)) a particle mixture of active ingredients, and optionally an edible oil, a binder, an emulsifier, a flavor and a colorant; pretreated active ingredient compositions in which the ingredient particles are coated with these other ingredients;
and (C) a mixture of pretreated direct compression tabletting aids consisting of a binder and, optionally, a flavor, characterized by good hardness and flexibility and easy chewability. 1 compressed chewable tablet. (2) The tablet of item (1) above, wherein the active ingredient is an antacid substance. (3) The tablet according to item (1) or item (2) above, wherein the antacid substance is calcium carbonate, magnesium chloride, magnesium hydroxide, aluminum hydroxide, or a mixture thereof. (4) The tablet according to any one of items (1) to (3) above, wherein the fat-absorbing substance is microcrystalline cellulose, corn starch, tapioca, dextrin, sucrose, sorbitol, xylitol, or mannitol. (5) The tablet according to any one of items (1) to (4) above, wherein the fat substance is animal, vegetable, or mineral oil. (6) The oil and fat substance is hydrogenated tallow, hydrogenated vegetable oil, almond oil, coconut oil, corn oil, cottonseed oil, refined linseed oil, light liquid petrolatum, liquid uJ paraffin, olein, olive oil, palm oil, peanut oil, peach oil , sesame oil, soybean oil, or safflower oil. (7) a heavy weight ratio of the oil and fat substance to the oil and fat absorbing substance;
Said No. (
A tablet according to any one of items 1) to (6). (8) Items (1) to (7) above, wherein the tablet binder is sugar for tablets, dextrose-suhydrate, or a mixture thereof.
) any one tablet. (9) the active ingredient comprises one or more antacids;
1. The treated granular oil and fat composition (a) contains microcrystalline cellulose as the oil-absorbing substance, hydrogenated vegetable oil absorbed in the microcrystalline cellulose as the oil and fat substance, optionally a coloring agent, optionally an antioxidant, optionally, antiflatulent, tablet binder consisting of raw sugar and/or dextrose-hydrate, optionally one or more flavors, wherein said pretreated active ingredient composition (1)) contains calcium carbonate, aluminum hydroxide and / One or more antacid particles made of magnesium hydroxide or a mixture of all of these, carboxymethyl cellulose which is an indulator that helps the adhesion of flavors and emulsifiers to fat-absorbing particles to give a smooth mouthfeel. decrease in surface tension at
A direct compression tableting aid consisting of a polyglycerol ester, an emulsifier that helps stimulate saliva secretion, vegetable oil, an edible oil that helps the emulsifier spread over the antacid particles, and flavoring. Composition (c)
For tablets 1: The tablet according to item (1) above, which contains a tablet binding agent made from calcium and/or dextrose, a hydrate, a flavor oil, and a flavor oil. (10) Melt the fat substance for α, mix with coloring agent and/or antioxidant, if desired, mix the obtained mixture with an oil-absorbing substance, absorb the oil-fat substance, and make oily obtaining a powder which, after drying, hardening and passing through a sieve, is mixed with one or more tablet binders and, optionally, flavors to form a pretreated fat composition (a); The active ingredient particles are mixed with the active ingredient particles and the binder, and, if used, one or more emulsifiers, edible oils and flavors, and the mixture is mixed to form a free-flowing powder to form the active ingredient particles. Pretreated active ingredient composition 0) coated with binders, oils, flavors and emulsifiers
), and one or more tablet binders are mixed with one or more flavors to form a pretreated direct compression tableting aid composition (C), and these compositions are mixed; A method for producing compressed chewable tablets that are easy to chew and have good hardness and flexibility, the method comprising forming compressed tablets from the obtained mixture. (11) The method according to item (10) above, wherein the active ingredient comprises one or more antacids.