JPS58118506A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:The titled composition, containing diethanolamide of a fatty acid consisting of diethanolamide of myristic acid as a principal component, having no bitterness, and useful as a component in toothpaste, local liniment, etc. having particularly improved aftertaste and juice effect. CONSTITUTION:A composition for the oral cavity containing diethanolamide of a fatty acid containing 50% or more diethanolamide of myristic acid and more preferably an anionic surfactant to improve the juice effect at (1:50)-(5:1), preferably (1:20)-(3:1), weight ratio between the diethanolamide of the fatty acid and the anionic surfactant. Sodium lauryl sulfate, etc. is used as the anionic surfactant, and the amont of the diethanolamide of the fatty acid in the total composition is 0.01-10%, preferably 0.1-5%.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention achieves
This invention relates to an oral composition with improved bitterness, aftertaste, juice effect, etc.

Conventionally, it has been known that lauric acid jetanolamide is blended into oral compositions, but when lauric acid jetanolamide is blended into oral compositions, it imparts a bitter taste and particularly worsens the aftertaste. Therefore, there is a problem in blending a large amount of lauric acid jetanolamide. In addition, it has been known that the juice effect can be improved by using lauric acid jetanolamide in combination with an anionic activator, but as mentioned above, lauric acid jetanolamide has a strong bitter taste, so in practice Even if more than % is added, there is a limit to the degree of taste improvement.

In view of the above circumstances, the present inventors conducted various studies on oral compositions with good taste, and found that the number of constituent fatty acid carbon atoms is 1.
By using fatty acid jetanolamide, whose main component is myristic acid jetanolamide, it is possible to eliminate bitterness, especially the bad aftertaste, and when not used in combination with an anionic activator. It was discovered that the juice effect could be further improved, and this led to the present invention.

The present invention will be explained in detail below.

The oral composition according to the present invention has a constituent fatty acid carbon number of 14.
This is a blend of fatty acid jetanolamide whose main component is myristic acid jetanolamide.
It contains at least 0 tchi (weight -1 or less), preferably at least 70 tchi. In this case, the fatty acid jetanolamide may contain lauric acid jetanolamide and/or rumitic acid jetanolamide.

The amount of fatty acid jetanolamide containing myristic acid jetanolamide as the main component is the total oral composition + 7
) 0.01 to 10%, especially 0.1 to 5%. Fatty acid jetanolamide containing myristic acid jetanolamide of 501 or more, especially 70 or more, does not give a bitter taste and does not leave a bad aftertaste, so it can be blended with 0.51 or more, and in this way, it can be blended in large amounts. However, there will be no problem.

In the present invention, fatty acid jetanolamide containing myristic acid jetanolamide as a main component can also be used in combination with other active agents. In this case, by using a substance containing myristic acid jetanolamide as a main component together with an anionic activator, the poor juice effect of the anionic activator can be improved more than when using lauric acid jetanolamide. I can do it. In addition, when using fatty acid jetanolamide whose main component is myristic acid jetanolamide and an anion activator together, the ratio of the combination is 1:50 to 1:50 by weight from the viewpoint of improving the juice effect.
5:l#, particularly preferably 1:20 to 3:1.

Water-soluble higher alkyl sulfate esters with an alkyl group having 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate, are used as anionic activators in combination with fatty acid jetanolamide, whose main component is myristic acid jetanolamide. The number of carbon atoms in the fatty acid group is 10 to 18.
Water-soluble salt of higher fatty acid monoglypeptide sulfonate, radium α-olefin sulfonate, higher fatty acid sodium monoglyceride monosulfate, sodium-N-methyl-N-anolumitoyl tauride, radium-N-lauroyl dercosinate, sodium- N-
Examples include rheumatoid acid β-alanine, radium-N-long chain acylamino acid, and the like. If necessary, fatty acid groups such as stearyl monoglypeptide, sucrose mono- and dilaurate have a carbon number of 12 to 18. Average degree of esterification: 1.
2 to 1.8, sugar fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester.

Maltitol fatty acid ester, ethylene glycol approx. 6
Sorbitan monostearate condensate with 0 mol added,
Nonionic activators such as polymers of standing tyrene oxide and propylene oxide and derivatives such as polyoxyethylene polyoxypropylene monolauryl ester, etc.
A surfactant or a combination of two or more surfactants may be used (compounding amount usually 0 to 7%).

The oral composition according to the present invention includes toothpaste, ? pI toothpaste,
It is used as a dentifrice such as a liquid toothpaste, a mouthwash, a topical coating agent, etc. As other components of these oral compositions, appropriate components are used depending on the substance, purpose of use, etc.

For example, when brushing teeth, calcium hydrogen phosphate
One or two types of dihydrates and anhydrides, calcium carbonate, calcium pitetraphosphate, insoluble sodium metaphosphate, silica, aluminosilicate, alumina, aluminum hydroxide, tertiary magnesium phosphate, magnesium carbonate, synthetic resins, etc. The above-mentioned abrasives are usually mixed in a total of 10 to 9,096, particularly 30 to 60, of the total amount. In addition, in the case of toothpaste, the binder is caradanan, cellulose derivatives such as cal-oxymethyl-7-sodium, and alkali metal alginates such as sodium alginate.

One or more of gums such as xanthan gum, synthetic binders such as polyvinyl alcohol, inorganic binders such as pea gum, etc. may be blended (amount usually 0.3 to 5%).
. In addition, Solpi is used as a thickening agent.

, glycol, ethylene glycol, glopylene glycol, 1,3-butylene glycol, polyethylene glycol, xylitol, multi, t.

One or more types of rough chits and the like may be blended (compounding amount usually 10 to 70%).

In addition, the oral composition of the present invention may optionally contain essential oils such as K. mint and spearmint, t-menthol, Cal. Perfume materials such as Anethole, Eugenol, Anethole, etc. may be added alone or in combination to the extent of about 0.1 to 5% of the total amount. Also,

Cullin sodium, stevioside, neohesberidyl dihydrochalcone, glycyrrhizin, perillartin, p
- Sweeteners such as methoxycinnamic aldehyde, p-
Hydroxymethylbensy.

Preservatives such as Quacid, p-hydroxybutylpencil, Quacid, and other ingredients may be blended.

Furthermore, the oral composition of the present invention contains enzymes such as dextranase, amylase, proteinase, mutanase, lysozyme, and Lytecendim, sodium monofluorophos 7A-F, and bodium monofluorophore as active ingredients. Alkali metal monofluorotetraphosphates such as phosphates, sodium fluorides, fluorine compounds such as fluoride 1fs, stannous compounds such as tin pyruphosphate, chlorhexidine salts, epsilon amii7 caproic acid, tranexamic acid, dihydrocarbons, etc. Cholesterol, glycyrrhizin salts,
One or more starches such as glyceptalophos heptaate, sodium chloride, and a water-soluble inorganic phosphoric acid compound may be blended.

As mentioned above, the oral composition according to the present invention has improved bitterness and bad aftertaste, and has a good overall taste by incorporating fatty acid jetanolamide, which is a main component of jetanolamide myristate. In addition, when used in combination with an anionic activator, the poor juice effect of anionic activators is significantly improved.

Experimental examples and examples are shown below.

[Experimental Example 1] Mouthwashes with the following formulation were prepared, and their bitterness and interest were sensory evaluated by five experts.

The results are shown in Table 1.

Mouthwash prescription ethanol 10 * Glycerin 5 Sorbitol 5 Sodium saccharin 0.1 Fragrance 1,0 Sorbitan monooleate 0.1 Fatty acid diethanolamide 0-5.0 Water
100 left, On Note that the evaluation criteria (absolute evaluation) are as follows.

O: Almost no bitterness felt.

Δ: A fist with a slight bitterness, but no real humor. X: Bitter taste.

[Experiment example 2] Prepare toothpaste with the following formulation, and check its foaming and bitterness.

The aftertaste and juice effect were compared and evaluated sensually by 10 experts/mothers using the following toothpaste from which fatty acid jetanolamide was removed as a standard.

The results are shown in Table 2.

Toothpaste prescription calcium hydrogen phosphate (dihydrate) 45. OS Sorbyy) (7011) 25.0 Carrageenan 1.0 Sodium lauryl sulfate
1.5 fatty acid diethanolamide
1.0 Satsukalinna Fium o,
iFragrance 1.
0 Purified water Remaining 100, 〇- Table 2 Rating 5: Very good compared to standard toothpaste 4: Good 3: Fair 2: Bad 1: Very poor [Experimental Example 3] A toothpaste with the following formulation was prepared. , specializing in its taste, especially its bitterness/
Sensory evaluation was performed using five panelists. All results are shown in Table 3.

Toothpaste prescription Calcium hydrogen phosphate (dihydrate) 42.0% silicic anhydride 2.0 sorbitol (70
16) 15.0 Glycerin
10.0 Calgoxymethylcellulose 1.0 Sodium lauryl sulfate 1.5 Fatty acid zoethanolamide 0.5-2,0 Sodium Calin
0.1 fragrance
1.0 Purified Ice Remaining 100.0% Table 3 The evaluation criteria (absolute evaluation) are as follows.

○: Almost no bitterness △: Somewhat bitterness ×: Strong bitterness From the results in Tables 1 to 3, the main component is myristic acid jetanolamide, which has a fatty acid carbon number of 14 as fatty acid jetanolamide. It has been found that by using a composition containing the following, it is possible to eliminate bitterness even when the amount of the composition is increased, and to obtain an oral composition that can improve the aftertaste and juice effect, and also has good foaming.

[Example 1] Su/calcium hydrogen oxide (dihydrate) 45.01
Silicic anhydride 2.0 Cal? Xymethyl 7Lworth 05 Carrageenan
0.5 Sorbi, ) (70%) 25.
0 Sodium lauryl sulfate 1.5 myst Δ test diethanolamide (C14=971) 1.
0. Sodium quince 0.1 Sodium monofluorophosphate 0.76 Flavor
1.2001 [Example 2] Calcium hydrogen phosphate (dihydrate) 32.0%
Calcium hydrogen phosphate (anhydrous salt) 10.0
Storium alginate 0.5 carrageenan 0.5v ruby, ) (70
%) 15.0 Glycerin
15.0 Sodium lauryl sulfate
1.5 ml of food diethanolamide (C14=80%
) 1.5 Saccharin Sodium
0.1 dextranase 0.2 scent
Fee 1.0 [
Example 3 Calcium hydrogen phosphate (dihydrate) 45.0%
Calgoxymethyl cellulose 1.0 solbi,)
(70ch) 30.0 Sodium lauryl sulfate 1.5 Myristic diethanolamide (C14=07%) 1.2 Sodium quince 0.1 Allanto ink p-hydroxyaluminum 0.3 Flavor
1.0 Purified ice remainder [Example 4] Calcium hydrogen phosphate (dihydrate) 44.0%
Silicic anhydride 1.0 Propylene glycol 3.0 Sorbit (70 t)
20.0 Glycerin 8.0 Sodium lauryl sulfate 1.5 Myristic diethanolamide (C14=90) O,S Sodium saccharin 0. IC-aminocaproic acid 0.03 fragrance
1.0 purified ice
Remaining 100.0% [Example 5] Aluminum hydroxide 43.0% niic anhydride
2.5 Cal? oxymethylcellulose 0.6 carayenan 0
4 Sorpi, ) (70%) 28.0 Propylene glycol 2.0 Lithium lauryl sulfate 1.5 Myristi ΔShun diethanolamide (C14=601) 0.5 Sodium quince 01 Chlorhexidine
0.1 fragrance
1.0 [Example 6] Aluminum fluoride 42.0% anhydrous silicon”
2.0 Carboxymethyl cellulose 1.1 Glycerin 25
．． 0 Sodium lauryl sulfate 1.5 Myristic diethanolamide (C14 = 90%) 1.0 Sodium saccharin 0.1 Tranexamic acid 0.05 Flavor
1.0 [Example 7] Precipitated silica 30.0% Calppol 940 0.6 Caldexymethylcellulose 0.4 Sorbit (70 t) 4
00 Glycerin 20.0 Sodium lauryl sulfate 1.8 ml diethanol 7 md CCta = 8 s) 1.2 Su, Karin 0.17 Stannous fluoride
0.41 Sodium phosphate dibasic 0
．． 1 fragrance 1
．． 0 purified ice Remaining 100, O- [Example 8] Precipitated silica 25.0 tcal xymethyl cellulose 0.6 carrageenan
0.5 Sorpi, ) (70 嗟)
50.0 Glycerin 10.0 Sodium lauryl sulfate 1.8 Myristic diethanolamide (C14=90%) 0.8 Saccharin 0. II Liethylene glycol + 400 3.0 fragrance
1.0 purified ice 100.0 ice left

Claims (1)

[Scope of Claims] 1. An oral composition comprising a fatty acid jetanolamide containing myristic acid jetanolamide as a main component. 2. The oral composition according to claim 1, wherein the fatty acid jetanolamide contains 50 weight or more of myristic acid jetanolamide. 3. The oral composition according to claim 1 or 2, further comprising an anionic activator. 4. The oral composition according to any one of claims 1 to 3, further comprising a nonionic active agent different from the fatty acid jetanolamide.