JPS58103301A - Powdery aerosol suspension liquid - Google Patents

Abstract

PURPOSE:To provide the titled liquid storable for a long time without causing the lowering of redispersibility, and useful as a cosmetic and quasi-drug, by dispersing a specific substrate powder composed of silicon dioxide, magnesium oxide and aluminum oxide and fine powder of solid drug in a specific liquefied propellant. CONSTITUTION:The objective powdery aerosol suspension liquid is prepared by dispersing (A) 5-20(wt)% substrate powder having a pH of 6-8 and consisting of 42-64% silicon dioxide, 26-35% magnesium oxide and 1-20% aluminum oxide and (B) 0.2-15% fine powder of solid drug insoluble in the liquefied propellant (e.g. hydrocortisone, predonizolone, etc.) in (C) a liquefied propellant composed of 50-80% freon gas and 10-35% liquefied petroleum gas and/or 10-35% dimethyl ether. The use of the substrate enables the formation of homogeneous suspension easily only by turning the container upside down several times or shaking, even after a long-term storage.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a powder aerosol-turbid liquid for use in cosmetic crystals or quasi-medical products, in which a liquefied propellant and an insoluble liquid powder component are used as a clouding agent. Alternatively, it is conventionally known to suspend and disperse a liquefied propellant using a surfactant, fill it in a pressure container, and perform spraying.

For example, a method of separating solid drug fine powder insoluble in liquefied propellants such as butane and chlorofluorocarbons into the liquefied propellant using lecithin, lanolin, cholesterol, or their derivatives dissolved in esters of higher fatty acids. Kosho 40-
No. 28956). Or, a method in which a liquid nonionic surfactant that is less than IfLB#lO and is soluble in a liquefied propellant such as fluorocarbon gas is added to the liquefied propellant together with a base fine powder←Japanese Patent Publication No. 36-14397 ); or butane;
A finely powdered medical substance made of phosphate ester steel that is soluble in liquefied propellants such as pentane and chlorofluorocarbons, linear or side chain higher alcohols that have 11 to 30 longitudinal atoms and is liquid at room temperature, and natural phosphorus fat. (Japanese Patent Publication No. 42-14804). Alternatively, a method of suspending fine powder and a liquefied propellant such as fluorocarbons or liquefied petroleum gas using a liquid suspending agent made of a cetylated partial ester of a long-chain fatty acid of a polyhydric alcohol (No. 411 Kosho 41-409) ) etc. are known. However, the conventionally known methods described above tend to produce various undesirable results as aerosol products, such as agglomeration and poor redispersibility. That is, as a liquefied propellant, liquefied petroleum gas, dimethyl ether, or both are added to fluorocarbon gas and used. This is the amount of CFC gas used that is said to destroy ozone Mt. It uses a mixture of inexpensive liquefied petroleum scum and dimethyl ether in addition to &:IiI+ fluorocarbon gas. However, when attempting to form a suspension by using liquefied petroleum scum or dimethyl ether as a propellant and coexisting with a conventionally known base powder, the suspended particles settle quickly and have poor floating or redispersibility, resulting in agglomeration. This makes uniform spraying difficult, tends to cause clogging of the pulp and actuator, and has an adverse effect on the efficacy of the drug ingredients.

In particular, when there is a large amount of fine solid chemical powder suspended, clogging of the valve and actuator becomes even more serious. The powder used in the above-mentioned conventional powder aerosol or the conventionally known powder aerosol contains Merck, kaolin, bentonite, and many other natural ingredients. Fine chemical powder,
Auxiliary agents, esters, and a surfactant to prevent agglomeration were coexisting, and CFC gas was used as a propellant. If fluorocarbon gas is used as a propellant, it will cause the problem of ozone layer depletion as mentioned above, and it will also have the disadvantage of being expensive. If dimethyl ether, liquefied petroleum gas, etc. are used,
Agglomeration occurs and redispersibility becomes poor.Addition of a surfactant to improve these problems somewhat improves the above-mentioned drawbacks, but it also causes stickiness and worsens the feeling of use.

The present invention was achieved as a result of repeated research in order to improve the above-mentioned drawbacks.
By using a base powder with a pH of 6 to 8 consisting of 26 to 35 wt% of magnesium oxide and 9 to 2 wt% of aluminum oxide, it is possible to use only 70' gas and not fluorocarbon gas and liquefied petroleum gas. Or, even if dimethyl ether or both are used as a propellant, agglomeration may occur.
It does not deteriorate redispersibility (it is stable and does not undergo deterioration even during long-term storage, and there is no change in its effectiveness even if the target active ingredient, auxiliary agents, etc. are added to the above composition). From these effects, the present invention is particularly effective when used in powdered aerosol products for cosmetics and other products. Used in a range of 20 wt%.The above base powder has a particle size of 1
00μ or less, preferably 5 to 35μ, and the amount is 20ft% or less, preferably 2 to 8wt% based on the total amount of the dosage form. As the solid drug powder for forming a dosage form insoluble in liquefied petroleum gas such as liquefied petroleum gas, dimethyl ether, etc., completely different substances are used depending on the purpose of its formation; examples include hydrocotisone, These include prednisolone, dexamethasone, iron oxide, fradiomycin sulfate, and those that have the astringent effect of aluminum salts.
, 2-15 Wt% is used, and the particle size of 4 is usually 100μ or less, preferably 5-35μ. Further, as the fluorocarbon gas, dichlorodifluoromethane, dichlorotetrafluoroethane, or trichloromonofluoromethane can be used by mixing with evaporated petroleum scum or dimethyl ether. This mixing ratio is Froncas 50 ~ sow
t%, 10 to 35 wt% of aggravated petroleum scum, or 10 to 35 wt% of dimethyl ether, or both. This propellant, base powder, and fine drug powder are filled into an aerosol container and mixed by shaking well. The suspension obtained in this way does not cause sedimentation, flotation, or poor redispersion of flocculation even if left for a long period of time, and does not cause pulp clogging or actuator clogging, etc. even after being left for a long period of time. It was also possible to easily form a uniform suspension by simply inverting the aerosol container several times. Further, no corrosion of the aerosol container occurred.

In the examples below, the redispersion state refers to the state of dispersion of the powder observed after it was left at 45°C for 6 months. ◎ Uniformly dispersed △ Slight tendency to agglomerate Thing X Partially forms a strong agglomerate XX Indicates a strongly agglomerated substance.

In addition, valve clogging refers to pulp &: those that do not become sticky after being injected for 6 months at 45°C, fi [B, 5% condition, and do not produce stickiness, and those that are clogged. was defined as an “occurrence”.

Corrosion property was defined as ``no'' if there was no corrosion observed with the naked eye after storage at 45°C for 6 months, and ``1'' if corrosion occurred, including a small amount.

In addition, 1 to 3.7 to 9.12 to 14.17 to 19.
22-24 are external medicines, 4-6.1O111°15.16
．． 20.21.25-34 are antiperspirants, 35.36 are body powders. Among the conventional products, numbers 1 to 1 are body powders,
5 to 8 are antiperspirants. The classification of powder bases A to E is based on the following proportions.

i ro ha ni silicon dioxide 54 60 60 64 4
f5 magnesium oxide 26 30 35 35
35 aluminum oxide 20 10 5 1
20 The numerical values used in the above formulations and practical examples indicate Wt.

Claims (1)

[Claims] Silicon dioxide 42~64wt%, magnesium oxide 26~
5-20 wt% base powder tube of pH 6-B consisting of 35 ft% and 20 wt% of aluminum oxide, and 5-20 wt% of fluorocarbon gas and 10-35 w of electrified petroleum gas.
A liquefied propellant consisting of 10% to 10% to 10% to 10% to 16% by weight of methyl ether and 10% to 100% by weight of ethyl ether, and t) A liquefied propellant insoluble in the liquefied propellant.
%, the powder aerosol suspension is characterized by suspending and dispersing the above-mentioned liquefied microscopic wheel and the above-mentioned base powder in the above-mentioned liquefied propellant.