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JPS5775983A - Novel derivative of 5,6,7,-tetrahydro-2,6-naphthyridine and its preparation - Google Patents

Novel derivative of 5,6,7,-tetrahydro-2,6-naphthyridine and its preparation

Info

Publication number
JPS5775983A
JPS5775983A JP55150719A JP15071980A JPS5775983A JP S5775983 A JPS5775983 A JP S5775983A JP 55150719 A JP55150719 A JP 55150719A JP 15071980 A JP15071980 A JP 15071980A JP S5775983 A JPS5775983 A JP S5775983A
Authority
JP
Japan
Prior art keywords
naphthyridine
tetrahydro
compound
formula
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55150719A
Other languages
Japanese (ja)
Inventor
Hiroshi Yamanaka
Hiroshi Miyazaki
Akira Shiozawa
Yuichiro Ichikawa
Michio Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP55150719A priority Critical patent/JPS5775983A/en
Priority to SE8106359A priority patent/SE8106359L/en
Priority to FR8120262A priority patent/FR2492825A1/en
Priority to ES507200A priority patent/ES507200A0/en
Priority to IT8124760A priority patent/IT8124760A0/en
Priority to DE19813143016 priority patent/DE3143016A1/en
Priority to GB8132554A priority patent/GB2087390B/en
Publication of JPS5775983A publication Critical patent/JPS5775983A/en
Priority to ES516935A priority patent/ES8402589A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The compound of formulaI[A is 2W4C alkylene; Y is di(lower alkyl)amino, piperidino, or group of formula II (B is H, halogen, lower alkyl, lower akoxy, or halogen-substituted lower alkyl)], and its non-toxic salt.
EXAMPLE: 5,6,7,8-Tetrahydro-6-)3-diethylaminopropyl)-1,6-naphthyridine.
USE: Antidinic. It has high selectivity to the dizziness caused by the peripheral labyrinth disorder.
PROCESS: The compound of formulaIis prepared either by condensing the sec-amine derivative of formula H-Y to the compound of formula III obtained by the reaction of 5,6,7,8-tetrahydro-1,6-naphthyridine with the compound of formula X1-A-X2 (X1 and X2 are halogen) or by condensing 5,6,7,8-tetrahydro-1,6-naphthyridine to the compound of formula X-A-Y.
COPYRIGHT: (C)1982,JPO&Japio
JP55150719A 1980-10-29 1980-10-29 Novel derivative of 5,6,7,-tetrahydro-2,6-naphthyridine and its preparation Pending JPS5775983A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP55150719A JPS5775983A (en) 1980-10-29 1980-10-29 Novel derivative of 5,6,7,-tetrahydro-2,6-naphthyridine and its preparation
SE8106359A SE8106359L (en) 1980-10-29 1981-10-28 5,6,7,8-TETRAHYDRO-1,6-NAPTYRIDE INGREDIENTS AND SETS TO PREPARE THEM
FR8120262A FR2492825A1 (en) 1980-10-29 1981-10-28 6-Substd. tetra:hydro-1,6-naphthyridine derivs. - useful as anti-vertigo agents and muscle relaxants
ES507200A ES507200A0 (en) 1980-10-29 1981-10-29 PROCEDURE FOR THE MANUFACTURE OF DERIVATIVES OF 5,6,7.8-TETRAHIDRO-1,6-NAFTIRIDINA.
IT8124760A IT8124760A0 (en) 1980-10-29 1981-10-29 DERIVATIVES OF 5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE AND PROCEDURE FOR THEIR PREPARATION.
DE19813143016 DE3143016A1 (en) 1980-10-29 1981-10-29 5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
GB8132554A GB2087390B (en) 1980-10-29 1981-10-29 5,6,7,8-tetrahydro-1,6-naphthyridine derivatives and their preparation
ES516935A ES8402589A1 (en) 1980-10-29 1982-10-15 5,6,7,8-Tetrahydro-1,6 naphthyridine derivatives and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55150719A JPS5775983A (en) 1980-10-29 1980-10-29 Novel derivative of 5,6,7,-tetrahydro-2,6-naphthyridine and its preparation

Publications (1)

Publication Number Publication Date
JPS5775983A true JPS5775983A (en) 1982-05-12

Family

ID=15502904

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55150719A Pending JPS5775983A (en) 1980-10-29 1980-10-29 Novel derivative of 5,6,7,-tetrahydro-2,6-naphthyridine and its preparation

Country Status (4)

Country Link
JP (1) JPS5775983A (en)
ES (1) ES507200A0 (en)
FR (1) FR2492825A1 (en)
SE (1) SE8106359L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000388A1 (en) * 1997-06-30 1999-01-07 Nippon Kayaku Kabushiki Kaisha Novel naphthyridine derivatives or salts thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255089A (en) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd Antiviral agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3555034A (en) * 1968-06-18 1971-01-12 American Home Prod Certain 5,6,7,8-tetrahydro-1,6-naphthyridin-2-ol esters
JPS5553291A (en) * 1978-10-17 1980-04-18 Nippon Kayaku Co Ltd Naphthylidine derivative and its preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000388A1 (en) * 1997-06-30 1999-01-07 Nippon Kayaku Kabushiki Kaisha Novel naphthyridine derivatives or salts thereof
US6294547B1 (en) 1997-06-30 2001-09-25 Nippon Kayaku Kabushiki Kaisha Naphthyridine deratives or salts thereof

Also Published As

Publication number Publication date
SE8106359L (en) 1982-04-30
ES8303406A1 (en) 1983-02-01
FR2492825A1 (en) 1982-04-30
ES507200A0 (en) 1983-02-01

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