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JPS5765190A - Preparation of (-)-alpha-hydroxymethylbutyric acid - Google Patents

Preparation of (-)-alpha-hydroxymethylbutyric acid

Info

Publication number
JPS5765190A
JPS5765190A JP14025880A JP14025880A JPS5765190A JP S5765190 A JPS5765190 A JP S5765190A JP 14025880 A JP14025880 A JP 14025880A JP 14025880 A JP14025880 A JP 14025880A JP S5765190 A JPS5765190 A JP S5765190A
Authority
JP
Japan
Prior art keywords
acid
microorganisms
alpha
preparation
hydroxymethylbutyric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14025880A
Other languages
Japanese (ja)
Other versions
JPS5953839B2 (en
Inventor
Shigeki Hamaguchi
Masahiro Ogura
Junzo Hasegawa
Hajime Kawarada
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP14025880A priority Critical patent/JPS5953839B2/en
Publication of JPS5765190A publication Critical patent/JPS5765190A/en
Publication of JPS5953839B2 publication Critical patent/JPS5953839B2/en
Expired legal-status Critical Current

Links

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare (-)-α-hydroxymethylbutyric acid by treating (-)-α-methyl- butyric acid with microorganisms belonging to Candida genus.
CONSTITUTION: (-)-α-Methylbutyric acid is microorganisms belonging to Candida genus, e.g. Candida rugosa IFO0750 strain, in a medium containing (-)-α-methylbutyric acid at 4.0W9.5pH. As an alternative method, (-)-α-hydroxymethyllbutyric acid is prepared by culturing the above microorganisms in a nutrient medium at 4.0W9.5pH, adding (±)-α-methylbutyric acid to the cultivation liquid or the suspension of microorganisms obtained from the liquid, and reacting under aerobic conditions keeping the pH at 6.0W9.0.
COPYRIGHT: (C)1982,JPO&Japio
JP14025880A 1980-10-06 1980-10-06 Method for producing (−)-α-hydroxymethylbutyric acid Expired JPS5953839B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14025880A JPS5953839B2 (en) 1980-10-06 1980-10-06 Method for producing (−)-α-hydroxymethylbutyric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14025880A JPS5953839B2 (en) 1980-10-06 1980-10-06 Method for producing (−)-α-hydroxymethylbutyric acid

Publications (2)

Publication Number Publication Date
JPS5765190A true JPS5765190A (en) 1982-04-20
JPS5953839B2 JPS5953839B2 (en) 1984-12-27

Family

ID=15264594

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14025880A Expired JPS5953839B2 (en) 1980-10-06 1980-10-06 Method for producing (−)-α-hydroxymethylbutyric acid

Country Status (1)

Country Link
JP (1) JPS5953839B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0144832A2 (en) * 1983-12-06 1985-06-19 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Process for the preparation of optically active alpha-substituted 3-hydroxypropionic-acid derivatives
JP2006503053A (en) * 2002-09-19 2006-01-26 ノバルティス アクチエンゲゼルシャフト Intermediate production method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0144832A2 (en) * 1983-12-06 1985-06-19 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Process for the preparation of optically active alpha-substituted 3-hydroxypropionic-acid derivatives
JP2006503053A (en) * 2002-09-19 2006-01-26 ノバルティス アクチエンゲゼルシャフト Intermediate production method

Also Published As

Publication number Publication date
JPS5953839B2 (en) 1984-12-27

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