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JPS5756421A - Preparation of prolonged release type complex - Google Patents

Preparation of prolonged release type complex

Info

Publication number
JPS5756421A
JPS5756421A JP13267080A JP13267080A JPS5756421A JP S5756421 A JPS5756421 A JP S5756421A JP 13267080 A JP13267080 A JP 13267080A JP 13267080 A JP13267080 A JP 13267080A JP S5756421 A JPS5756421 A JP S5756421A
Authority
JP
Japan
Prior art keywords
prolonged release
release type
type complex
protein
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13267080A
Other languages
Japanese (ja)
Other versions
JPS6041048B2 (en
Inventor
Isao Kaetsu
Masaharu Asano
Masaru Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Agency
Original Assignee
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON GENSHIRYOKU KENKYUSHO, Japan Atomic Energy Research Institute filed Critical NIPPON GENSHIRYOKU KENKYUSHO
Priority to JP13267080A priority Critical patent/JPS6041048B2/en
Publication of JPS5756421A publication Critical patent/JPS5756421A/en
Publication of JPS6041048B2 publication Critical patent/JPS6041048B2/en
Expired legal-status Critical Current

Links

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To obtain a prolonged release type complex having a very long duration of drug effect, by mixing a physiologically active substance with a protein, a hydrophilic vinyl polymerizable monomer and a body fluid and/or isotonic solution, and irradiating the mixture solution with ionizing radiation.
CONSTITUTION: A physiologically active substance is mixed with a protein, a body fluid and/or isotonic solution, and the resultnant solution is then freeze-dried and further impregnated with a hydrophilic vinyl polymerizable monome and then irradiated with ionizing radiation and polymerized to give a prolonged release type complex. Alternatively, the physilogically active substance is mixed with the protein, hydrophilic vinyl polymerizable monomer and the body fluid and/or isotonic solution, and irradiated with light or ionizing radiation to give the aimed prolonged release type complex. Hydroxyethyl methacrylate, etc. may be cited as the monomer, and the resultant complex exhibits no foreign body reaction to the living body tissue, assimilated therewith well and can be digested slowly.
COPYRIGHT: (C)1982,JPO&Japio
JP13267080A 1980-09-24 1980-09-24 Method for producing sustained release complex Expired JPS6041048B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13267080A JPS6041048B2 (en) 1980-09-24 1980-09-24 Method for producing sustained release complex

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13267080A JPS6041048B2 (en) 1980-09-24 1980-09-24 Method for producing sustained release complex

Publications (2)

Publication Number Publication Date
JPS5756421A true JPS5756421A (en) 1982-04-05
JPS6041048B2 JPS6041048B2 (en) 1985-09-13

Family

ID=15086746

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13267080A Expired JPS6041048B2 (en) 1980-09-24 1980-09-24 Method for producing sustained release complex

Country Status (1)

Country Link
JP (1) JPS6041048B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61243015A (en) * 1985-04-18 1986-10-29 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Depot medicine containing cell proliferation inhibitor
JP2008001764A (en) * 2006-06-21 2008-01-10 Gunma Univ Method for producing particulate molding comprising protein and particulate molding comprising protein and obtained by the method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61243015A (en) * 1985-04-18 1986-10-29 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Depot medicine containing cell proliferation inhibitor
JP2008001764A (en) * 2006-06-21 2008-01-10 Gunma Univ Method for producing particulate molding comprising protein and particulate molding comprising protein and obtained by the method

Also Published As

Publication number Publication date
JPS6041048B2 (en) 1985-09-13

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