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JPS5728067A - 2,4 1h,3h -quinazolinedione derivative - Google Patents

2,4 1h,3h -quinazolinedione derivative

Info

Publication number
JPS5728067A
JPS5728067A JP10239680A JP10239680A JPS5728067A JP S5728067 A JPS5728067 A JP S5728067A JP 10239680 A JP10239680 A JP 10239680A JP 10239680 A JP10239680 A JP 10239680A JP S5728067 A JPS5728067 A JP S5728067A
Authority
JP
Japan
Prior art keywords
alkyl
quinazolinedione
formula
expressed
alkoxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10239680A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Akiko Sugimoto
Masao Eguchi
Fujinori Sasaki
Katsuhiko Goto
Soyao Moriguchi
Hisashi Ebisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP10239680A priority Critical patent/JPS5728067A/en
Priority to CA000377591A priority patent/CA1161036A/en
Priority to US06/263,898 priority patent/US4405623A/en
Priority to EP19810103838 priority patent/EP0040793B1/en
Priority to DE8181103838T priority patent/DE3172006D1/en
Publication of JPS5728067A publication Critical patent/JPS5728067A/en
Pending legal-status Critical Current

Links

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 2,4,(1H,3H)-quinazolinedione derivative expressed by formula I (R1 and R3 are alkyl; R2 is alkoxycarbonyl; R1, R2 and R3 are linked to the 5,6- and 7-positions or the 6-,7- and 8-positions of the quinazoline nucleus; R4 is H, halogen, alkyl or alkoxyl; R5 and R6 are H, halogen, alkyl, alkoxyl, CF3, nitro or dialkylamino; however, R4 and R5 form a methylenedioxy).
EXAMPLE: 6-Ethoxycarbonyl-5,7-dimethyl-3-( p-methoxyphenyl )-2,4(1H,3H)-quinazolinedione.
USE: A vasodilator, ameliorant of the blood flow, hypotensive agent and antiarteriosclerotic agent.
PROCESS: A compound expressed by formula II is reacted with an isocyanate expressed by formula III, and the reaction product is then condensed through ring closure.
COPYRIGHT: (C)1982,JPO&Japio
JP10239680A 1980-05-15 1980-07-28 2,4 1h,3h -quinazolinedione derivative Pending JPS5728067A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP10239680A JPS5728067A (en) 1980-07-28 1980-07-28 2,4 1h,3h -quinazolinedione derivative
CA000377591A CA1161036A (en) 1980-05-15 1981-05-14 Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
US06/263,898 US4405623A (en) 1980-05-15 1981-05-15 Quinazolinde-dione compounds, process for production thereof and pharmaceutical use thereof
EP19810103838 EP0040793B1 (en) 1980-05-22 1981-05-19 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
DE8181103838T DE3172006D1 (en) 1980-05-22 1981-05-19 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10239680A JPS5728067A (en) 1980-07-28 1980-07-28 2,4 1h,3h -quinazolinedione derivative

Publications (1)

Publication Number Publication Date
JPS5728067A true JPS5728067A (en) 1982-02-15

Family

ID=14326281

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10239680A Pending JPS5728067A (en) 1980-05-15 1980-07-28 2,4 1h,3h -quinazolinedione derivative

Country Status (1)

Country Link
JP (1) JPS5728067A (en)

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