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JPS57192359A - Optical resolution of 3-benzoyl-2-methylindole derivative - Google Patents

Optical resolution of 3-benzoyl-2-methylindole derivative

Info

Publication number
JPS57192359A
JPS57192359A JP6405781A JP6405781A JPS57192359A JP S57192359 A JPS57192359 A JP S57192359A JP 6405781 A JP6405781 A JP 6405781A JP 6405781 A JP6405781 A JP 6405781A JP S57192359 A JPS57192359 A JP S57192359A
Authority
JP
Japan
Prior art keywords
benzoyl
formula
derivative
optical
methylindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6405781A
Other languages
Japanese (ja)
Inventor
Takeo Oba
Takeshi Yu
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Atsuo Hasato
Seiji Kurozumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP6405781A priority Critical patent/JPS57192359A/en
Publication of JPS57192359A publication Critical patent/JPS57192359A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound having optical activity easily, by reacting a (±)-3-benzoyl-2-methylindole derivative with an optical active lactol to give an acetal derivative, subjecting it to optical resolution by a simple means, eliminating lactol from it.
CONSTITUTION: A (±)-3-benzoyl-2-methylindole derivative shown by the formula III (n is 1 or 2) is reacted with optical active lactol shown by the formulaIor formula II in the presence of an acid agent by dehydration method, to give an acetal derivative shown by the formula IV or formula V. A steroisomer of the acetal derivative is separated by chromatography, etc., the acetal bond is severed in the presence of acid agent, to give an optical active 3-benzoyl-2-methylindole derivative shown by the formula VI (* is asymmetric carbon atom) in high optical yield.
COPYRIGHT: (C)1982,JPO&Japio
JP6405781A 1981-04-30 1981-04-30 Optical resolution of 3-benzoyl-2-methylindole derivative Pending JPS57192359A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6405781A JPS57192359A (en) 1981-04-30 1981-04-30 Optical resolution of 3-benzoyl-2-methylindole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6405781A JPS57192359A (en) 1981-04-30 1981-04-30 Optical resolution of 3-benzoyl-2-methylindole derivative

Publications (1)

Publication Number Publication Date
JPS57192359A true JPS57192359A (en) 1982-11-26

Family

ID=13247077

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6405781A Pending JPS57192359A (en) 1981-04-30 1981-04-30 Optical resolution of 3-benzoyl-2-methylindole derivative

Country Status (1)

Country Link
JP (1) JPS57192359A (en)

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