JPS57167993A - Novel 3-((4-carboxy-3-hydroxyisothiazole-5-yl) thiomethyl)-delta3-cephem derivative - Google Patents
Novel 3-((4-carboxy-3-hydroxyisothiazole-5-yl) thiomethyl)-delta3-cephem derivativeInfo
- Publication number
- JPS57167993A JPS57167993A JP56052409A JP5240981A JPS57167993A JP S57167993 A JPS57167993 A JP S57167993A JP 56052409 A JP56052409 A JP 56052409A JP 5240981 A JP5240981 A JP 5240981A JP S57167993 A JPS57167993 A JP S57167993A
- Authority
- JP
- Japan
- Prior art keywords
- carboxy
- compound shown
- hydroxyisothiazole
- thiomethyl
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound shown by the formulaI(R is H, pyridinecarbonyl, piperazine carbonyl; pyridine ring and piperazine ring may be further replaced by 1W3 groups of lower alkyl, OH, and/or oxo) and its salt.
EXAMPLE: D-7-(α-tert-Butoxycarboxamide)-p-hydroxy-phenylacetamido)-3-[(4-carboxy-3-hydroxyisothiazole-5-yl)thiomethyl]-Δ3-cephem-4-carboxylic acid.
USE: An antibacterial agent. Effective against Gram-positve and Gram-negative bacteria.
PROCESS: A compound shown by the formula II (R1 is amino-protecting group, pyridinecarbonyl, etc.) is reacted with a novel compound shown by the formula III (R2 is H, carboxy-protecting group), and, if necessary, the protecting group is eliminated, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56052409A JPS57167993A (en) | 1981-04-09 | 1981-04-09 | Novel 3-((4-carboxy-3-hydroxyisothiazole-5-yl) thiomethyl)-delta3-cephem derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56052409A JPS57167993A (en) | 1981-04-09 | 1981-04-09 | Novel 3-((4-carboxy-3-hydroxyisothiazole-5-yl) thiomethyl)-delta3-cephem derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57167993A true JPS57167993A (en) | 1982-10-16 |
Family
ID=12913982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56052409A Pending JPS57167993A (en) | 1981-04-09 | 1981-04-09 | Novel 3-((4-carboxy-3-hydroxyisothiazole-5-yl) thiomethyl)-delta3-cephem derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57167993A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6045584A (en) * | 1983-06-03 | 1985-03-12 | イ・セ・イ−フアルマ | Cephalosporin derivative, manufacture and antifungal medicinal composition |
-
1981
- 1981-04-09 JP JP56052409A patent/JPS57167993A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6045584A (en) * | 1983-06-03 | 1985-03-12 | イ・セ・イ−フアルマ | Cephalosporin derivative, manufacture and antifungal medicinal composition |
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