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JPS57167941A - Purification of clinofibrate - Google Patents

Purification of clinofibrate

Info

Publication number
JPS57167941A
JPS57167941A JP5405781A JP5405781A JPS57167941A JP S57167941 A JPS57167941 A JP S57167941A JP 5405781 A JP5405781 A JP 5405781A JP 5405781 A JP5405781 A JP 5405781A JP S57167941 A JPS57167941 A JP S57167941A
Authority
JP
Japan
Prior art keywords
clinofibrate
acid
ammonium salt
precipitated
ammonia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5405781A
Other languages
Japanese (ja)
Other versions
JPS6213936B2 (en
Inventor
Noritaka Hanma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP5405781A priority Critical patent/JPS57167941A/en
Publication of JPS57167941A publication Critical patent/JPS57167941A/en
Publication of JPS6213936B2 publication Critical patent/JPS6213936B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: To prepare high purity clinofibrate, in high yield, by reacting crude clinofibrate with ammonia in acetone or methyl ethyl ketone, separating the precipitated clinofibrate ammonium salt, and treating with an acid.
CONSTITUTION: Crude clinofibrate of formula[2,2'-(4,4'-cyclohexylidenediphenoxy)-2,2'-dimethyl-dibutyric acid]is made to react with ammonia in acetone or methyl ethyl ketone, and the precipitated clinofibrate ammonium salt, is separated and treated with an acid to obtain the objective clinofibrate. The loss of clinofibrate is small because the separation of the clinofibrate ammonium salt from the ammonium salt of the by-produced carboxylic acids (e.g. 2,3-dimethylacrylic acid, 2-methylacrylic acid, etc.) can be carried out almost perfectly.
COPYRIGHT: (C)1982,JPO&Japio
JP5405781A 1981-04-09 1981-04-09 Purification of clinofibrate Granted JPS57167941A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5405781A JPS57167941A (en) 1981-04-09 1981-04-09 Purification of clinofibrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5405781A JPS57167941A (en) 1981-04-09 1981-04-09 Purification of clinofibrate

Publications (2)

Publication Number Publication Date
JPS57167941A true JPS57167941A (en) 1982-10-16
JPS6213936B2 JPS6213936B2 (en) 1987-03-30

Family

ID=12959979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5405781A Granted JPS57167941A (en) 1981-04-09 1981-04-09 Purification of clinofibrate

Country Status (1)

Country Link
JP (1) JPS57167941A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102816060A (en) * 2012-09-14 2012-12-12 瑞阳制药有限公司 Preparation method of high-purity clinofibrate

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH022320U (en) * 1988-06-13 1990-01-09

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102816060A (en) * 2012-09-14 2012-12-12 瑞阳制药有限公司 Preparation method of high-purity clinofibrate

Also Published As

Publication number Publication date
JPS6213936B2 (en) 1987-03-30

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