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JPS57150692A - 4-hetero ring-substituted-2,6-di-tert-butyl-phenol derivative - Google Patents

4-hetero ring-substituted-2,6-di-tert-butyl-phenol derivative

Info

Publication number
JPS57150692A
JPS57150692A JP56023515A JP2351581A JPS57150692A JP S57150692 A JPS57150692 A JP S57150692A JP 56023515 A JP56023515 A JP 56023515A JP 2351581 A JP2351581 A JP 2351581A JP S57150692 A JPS57150692 A JP S57150692A
Authority
JP
Japan
Prior art keywords
agent
butyl
substituted
hetero ring
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56023515A
Other languages
Japanese (ja)
Other versions
JPH0139434B2 (en
Inventor
Kazuo Kubo
Yasuo Isomura
Shuichi Sakamoto
Hiroshige Honma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP56023515A priority Critical patent/JPS57150692A/en
Priority to US06/347,982 priority patent/US4636516A/en
Priority to CA000396501A priority patent/CA1181751A/en
Priority to CA000396500A priority patent/CA1181074A/en
Priority to AU80616/82A priority patent/AU550035B2/en
Priority to AT82300861T priority patent/ATE17721T1/en
Priority to ES509780A priority patent/ES8302722A1/en
Priority to DE8282300861T priority patent/DE3268733D1/en
Priority to EP85200531A priority patent/EP0164765A1/en
Priority to ES509781A priority patent/ES509781A0/en
Priority to EP82300861A priority patent/EP0059090B1/en
Publication of JPS57150692A publication Critical patent/JPS57150692A/en
Publication of JPH0139434B2 publication Critical patent/JPH0139434B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

NEW MATERIAL:The 4-hetero ring-substituted-2,6-di-t-butyl-phenol derivative of formulaI(one of R1-R4 is group of formula II, and the other three are H, halogen, substituted or unsubstituted lower alkyl, etc.; n is 0-2; dotted line represents a double bond or a single bond) or its salt. EXAMPLE:6-(3,5-Di-t-butyl-4-hydroxyphenyl)-2,3-dihydroimidazo[2,1-b]th iazole. USE:Antiphlogistic agent, antipyretic and analgesic agent, antiarthritic agent, antirheumatic agent, and immunoregulating agent. PROCESS:A compound of formulaIwherein n=0 can be prepared by reacting the 2-amino-thiazole derivative or 2-aminothiazoline derivative of formula III with the haloacetyl dervative of formula IV. The product can be converted to the monoxide compound (n=1) and the dioxide compound (n=2) ty treating with an oxidizing agent (e.g. H2O2).
JP56023515A 1981-02-19 1981-02-19 4-hetero ring-substituted-2,6-di-tert-butyl-phenol derivative Granted JPS57150692A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP56023515A JPS57150692A (en) 1981-02-19 1981-02-19 4-hetero ring-substituted-2,6-di-tert-butyl-phenol derivative
US06/347,982 US4636516A (en) 1981-02-19 1982-02-11 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds
CA000396501A CA1181751A (en) 1981-02-19 1982-02-17 Process of production for 3,5-di-tert-butyl-4- hydroxyphenyl-substituted heterocyclic compounds
CA000396500A CA1181074A (en) 1981-02-19 1982-02-17 Process for producing 3,5-di-tert-butyl-4- hydroxyphenyl-substituted heterocyclic compounds
AU80616/82A AU550035B2 (en) 1981-02-19 1982-02-19 3,5-di-tert-butyl-4-hydroxyphenyl substituted heterocyclic compound
AT82300861T ATE17721T1 (en) 1981-02-19 1982-02-19 3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS.
ES509780A ES8302722A1 (en) 1981-02-19 1982-02-19 4-hetero ring-substituted-2,6-di-tert-butyl-phenol derivative
DE8282300861T DE3268733D1 (en) 1981-02-19 1982-02-19 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds
EP85200531A EP0164765A1 (en) 1981-02-19 1982-02-19 3,5-Di-Tert-Butyl-4-hydroxyphenyl-substituted heterocyclic compounds
ES509781A ES509781A0 (en) 1981-02-19 1982-02-19 A PRODUCTION METHOD OF A SUBSTITUTED 3,5-DI-T-BUTIL-4-HI-DROXIFENIL-HETEROCICLICO COMPOUND.
EP82300861A EP0059090B1 (en) 1981-02-19 1982-02-19 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56023515A JPS57150692A (en) 1981-02-19 1981-02-19 4-hetero ring-substituted-2,6-di-tert-butyl-phenol derivative

Publications (2)

Publication Number Publication Date
JPS57150692A true JPS57150692A (en) 1982-09-17
JPH0139434B2 JPH0139434B2 (en) 1989-08-21

Family

ID=12112578

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56023515A Granted JPS57150692A (en) 1981-02-19 1981-02-19 4-hetero ring-substituted-2,6-di-tert-butyl-phenol derivative

Country Status (3)

Country Link
JP (1) JPS57150692A (en)
CA (2) CA1181751A (en)
ES (2) ES8302722A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868183A (en) * 1986-07-21 1989-09-19 Otsuka Pharmaceutical Factory, Inc. N-pyrazinyl substituted P-aminophenols

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868183A (en) * 1986-07-21 1989-09-19 Otsuka Pharmaceutical Factory, Inc. N-pyrazinyl substituted P-aminophenols
US5059598A (en) * 1986-07-21 1991-10-22 Otsuka Pharmaceutical Factory, Inc. N-heterocyclo-substituted p-aminophenols

Also Published As

Publication number Publication date
ES8304144A1 (en) 1983-02-16
ES509781A0 (en) 1983-02-16
CA1181751A (en) 1985-01-29
CA1181074A (en) 1985-01-15
ES509780A0 (en) 1983-01-16
ES8302722A1 (en) 1983-01-16
JPH0139434B2 (en) 1989-08-21

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