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JPS5692239A - Preparation of 5-oxohexyl compound - Google Patents

Preparation of 5-oxohexyl compound

Info

Publication number
JPS5692239A
JPS5692239A JP16939279A JP16939279A JPS5692239A JP S5692239 A JPS5692239 A JP S5692239A JP 16939279 A JP16939279 A JP 16939279A JP 16939279 A JP16939279 A JP 16939279A JP S5692239 A JPS5692239 A JP S5692239A
Authority
JP
Japan
Prior art keywords
oxohexyl
compound
acid
formula
hexynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16939279A
Other languages
Japanese (ja)
Inventor
Toshiyuki Takashima
Eiko Taima
Sei Kondo
Kazuo Endo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP16939279A priority Critical patent/JPS5692239A/en
Publication of JPS5692239A publication Critical patent/JPS5692239A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare a 5-oxohexyl compound useful as an intermediate of a vasodilator and an agent for improving erythrocyte deformability, easily, in high yield, by hydrating an acetylene derivative such as 5-hexynyl alcohol in the presence of an acid.
CONSTITUTION: A 5-oxohexyl compound of formula II (R' is OH, halogen or acyloxy) (e.g. 5-oxohexyl chloride, 5-oxohexyl acetate, etc.) is prepared by hydrating an acetylene derivative of formula I (R is OH or halogen) (e.g. 5-hexynyl bromide, 5-hexynyl chloride etc.) in the presence of an acid (e.g. hydrochloric acid, hydrobromic acid, etc.). The compound of formula I is prepared easily from tetrahydropyran-2-methanol or from tetramethylene bromide and a monoacetylide.
COPYRIGHT: (C)1981,JPO&Japio
JP16939279A 1979-12-27 1979-12-27 Preparation of 5-oxohexyl compound Pending JPS5692239A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16939279A JPS5692239A (en) 1979-12-27 1979-12-27 Preparation of 5-oxohexyl compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16939279A JPS5692239A (en) 1979-12-27 1979-12-27 Preparation of 5-oxohexyl compound

Publications (1)

Publication Number Publication Date
JPS5692239A true JPS5692239A (en) 1981-07-25

Family

ID=15885742

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16939279A Pending JPS5692239A (en) 1979-12-27 1979-12-27 Preparation of 5-oxohexyl compound

Country Status (1)

Country Link
JP (1) JPS5692239A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
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WO2015125572A1 (en) * 2014-02-19 2015-08-27 富士フイルム株式会社 Thiopyranose compound and method for producing same
US9884882B2 (en) 2014-02-18 2018-02-06 Fujifilm Corporation Method for producing thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate
US9896471B2 (en) 2012-03-28 2018-02-20 Fujifilm Corporation Salt of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine
US10059734B2 (en) 2014-10-31 2018-08-28 Fujifilm Corporation Thionucleoside derivative or salt thereof, and pharmaceutical composition
US10093645B2 (en) 2012-08-13 2018-10-09 Fujifilm Corporation Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same
US11141421B2 (en) 2018-01-29 2021-10-12 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
US11369625B2 (en) 2016-08-31 2022-06-28 Fujifilm Corporation Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9896471B2 (en) 2012-03-28 2018-02-20 Fujifilm Corporation Salt of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine
US10093645B2 (en) 2012-08-13 2018-10-09 Fujifilm Corporation Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same
US10570112B2 (en) 2012-08-13 2020-02-25 Fujifilm Corporation Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same
US9884882B2 (en) 2014-02-18 2018-02-06 Fujifilm Corporation Method for producing thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate
WO2015125572A1 (en) * 2014-02-19 2015-08-27 富士フイルム株式会社 Thiopyranose compound and method for producing same
US9815812B2 (en) 2014-02-19 2017-11-14 Fujifilm Corporation Thiopyranose compound and method for producing same
US10059734B2 (en) 2014-10-31 2018-08-28 Fujifilm Corporation Thionucleoside derivative or salt thereof, and pharmaceutical composition
US10385089B2 (en) 2014-10-31 2019-08-20 Fujifilm Corporation Thionucleoside derivative or salt thereof, and pharmaceutical composition
US11369625B2 (en) 2016-08-31 2022-06-28 Fujifilm Corporation Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit
US11141421B2 (en) 2018-01-29 2021-10-12 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer

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