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JPS5681568A - Pyridazinone derivative - Google Patents

Pyridazinone derivative

Info

Publication number
JPS5681568A
JPS5681568A JP15899679A JP15899679A JPS5681568A JP S5681568 A JPS5681568 A JP S5681568A JP 15899679 A JP15899679 A JP 15899679A JP 15899679 A JP15899679 A JP 15899679A JP S5681568 A JPS5681568 A JP S5681568A
Authority
JP
Japan
Prior art keywords
formula
solvent
compound
lower alkyl
ulcer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15899679A
Other languages
Japanese (ja)
Other versions
JPS6242900B2 (en
Inventor
Toshihiro Yamada
Yoichi Nobuhara
Hiroshi Shimamura
Kazuo Yoshihara
Masahiko Oki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MORISHITA SEIYAKU KK
Morishita Pharmaceuticals Co Ltd
Original Assignee
MORISHITA SEIYAKU KK
Morishita Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MORISHITA SEIYAKU KK, Morishita Pharmaceuticals Co Ltd filed Critical MORISHITA SEIYAKU KK
Priority to JP15899679A priority Critical patent/JPS5681568A/en
Priority to ZA00807209A priority patent/ZA807209B/en
Priority to EP19800304409 priority patent/EP0030835B1/en
Priority to ES498263A priority patent/ES8201553A1/en
Priority to DE8080304409T priority patent/DE3063196D1/en
Priority to AT80304409T priority patent/ATE3288T1/en
Publication of JPS5681568A publication Critical patent/JPS5681568A/en
Publication of JPS6242900B2 publication Critical patent/JPS6242900B2/ja
Granted legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A pyridazinone derivative of formula I (R1 is lower alkyl; Z is S or methylene; X is S or NH; m is 1W3; n is 0W2).
EXAMPLE: N-Cyano-S-methyl-N'-[ 3-(3-oxo-6-phenyl-2-pyridazinyl)propyl ]isothiourea.
USE: Remedy and preventive for peptic ulcer, e.g. hyperacidity, gastric ulcer, duodenal ulcer, etc. Long duration, low toxicity, and low tendency of causing the drug- resistant state.
PROCESS: A compound of formula I wherein X is S is prepared e.g. by reacting an amine derivative of formula II with a compound of formula III (R2 is lower alkyl) in a solvent such a ethanol, acetonitrile, etc. or in the absence of solvent.
COPYRIGHT: (C)1981,JPO&Japio
JP15899679A 1979-12-05 1979-12-05 Pyridazinone derivative Granted JPS5681568A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP15899679A JPS5681568A (en) 1979-12-05 1979-12-05 Pyridazinone derivative
ZA00807209A ZA807209B (en) 1979-12-05 1980-11-19 Derivatives of 2-substituted-6-phenyl-3(2h)-pyridazinone
EP19800304409 EP0030835B1 (en) 1979-12-05 1980-12-05 Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
ES498263A ES8201553A1 (en) 1979-12-05 1980-12-05 Procedure for the preparation of derivatives of 6-fenil-3 (2H) -piridacinona 2-substitute. (Machine-translation by Google Translate, not legally binding)
DE8080304409T DE3063196D1 (en) 1979-12-05 1980-12-05 Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
AT80304409T ATE3288T1 (en) 1979-12-05 1980-12-05 2-SUBSTITUTED-6-PHENYL-3(2H)-PYRIDAZINONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15899679A JPS5681568A (en) 1979-12-05 1979-12-05 Pyridazinone derivative

Publications (2)

Publication Number Publication Date
JPS5681568A true JPS5681568A (en) 1981-07-03
JPS6242900B2 JPS6242900B2 (en) 1987-09-10

Family

ID=15683939

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15899679A Granted JPS5681568A (en) 1979-12-05 1979-12-05 Pyridazinone derivative

Country Status (2)

Country Link
JP (1) JPS5681568A (en)
ZA (1) ZA807209B (en)

Also Published As

Publication number Publication date
ZA807209B (en) 1981-11-25
JPS6242900B2 (en) 1987-09-10

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