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JPS5668680A - Novel piperidine derivative and hypotensive agent containing the same - Google Patents

Novel piperidine derivative and hypotensive agent containing the same

Info

Publication number
JPS5668680A
JPS5668680A JP14284979A JP14284979A JPS5668680A JP S5668680 A JPS5668680 A JP S5668680A JP 14284979 A JP14284979 A JP 14284979A JP 14284979 A JP14284979 A JP 14284979A JP S5668680 A JPS5668680 A JP S5668680A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound
hypotensive agent
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14284979A
Other languages
Japanese (ja)
Inventor
Yoshihiro Nakamizo
Hiroyuki Obase
Kazuhiro Kubo
Yutaka Kasuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP14284979A priority Critical patent/JPS5668680A/en
Publication of JPS5668680A publication Critical patent/JPS5668680A/en
Pending legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I [Ar is naphthyl, phenyl, etc.; Q is CO, CH2, CH(OR1) (R1 is H, alkyl, etc.); R is H, alkyl or cycloalkyl; Z is group of formula II (R2 is H, alkyl or alkoxycarbonyl, etc.) or formula III (R3 is alkyl)] and an acid addition salt thereof.
EXAMPLE: 1-[ 2-Oxo-2-( 3, 4-dimethoxyphenyl )-1-ethyl ]-4-( 2-keto-1-benzimidazolinyl )-piperidine.
USE: A hypotensive agent.
PROCESS: The compound of formula I in which Q is CO is obtained by the reaction shown in the reaction scheme (X is a releasing group, e.g. halogen, OSO2CH3, etc.), and the resultant compound is reduced and acylated or alkylated to afford the compound of formula I in which Q is CH(OR1).
COPYRIGHT: (C)1981,JPO&Japio
JP14284979A 1979-11-06 1979-11-06 Novel piperidine derivative and hypotensive agent containing the same Pending JPS5668680A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14284979A JPS5668680A (en) 1979-11-06 1979-11-06 Novel piperidine derivative and hypotensive agent containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14284979A JPS5668680A (en) 1979-11-06 1979-11-06 Novel piperidine derivative and hypotensive agent containing the same

Publications (1)

Publication Number Publication Date
JPS5668680A true JPS5668680A (en) 1981-06-09

Family

ID=15325039

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14284979A Pending JPS5668680A (en) 1979-11-06 1979-11-06 Novel piperidine derivative and hypotensive agent containing the same

Country Status (1)

Country Link
JP (1) JPS5668680A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4867283A (en) * 1971-12-18 1973-09-13
JPS4941381A (en) * 1972-04-12 1974-04-18
JPS4995980A (en) * 1973-01-04 1974-09-11
JPS54160371A (en) * 1978-06-02 1979-12-19 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and hypotensive agents comprising it
JPS5517385A (en) * 1978-07-20 1980-02-06 Science Union & Cie Benzimidazolinone derivative and medical composition containing it
JPS5585585A (en) * 1978-12-25 1980-06-27 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and hypotensor containing the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4867283A (en) * 1971-12-18 1973-09-13
JPS4941381A (en) * 1972-04-12 1974-04-18
JPS4995980A (en) * 1973-01-04 1974-09-11
JPS54160371A (en) * 1978-06-02 1979-12-19 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and hypotensive agents comprising it
JPS5517385A (en) * 1978-07-20 1980-02-06 Science Union & Cie Benzimidazolinone derivative and medical composition containing it
JPS5585585A (en) * 1978-12-25 1980-06-27 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and hypotensor containing the same

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