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JPS5663977A - Secoprostaglandin i2 derivative and its preparation - Google Patents

Secoprostaglandin i2 derivative and its preparation

Info

Publication number
JPS5663977A
JPS5663977A JP13938479A JP13938479A JPS5663977A JP S5663977 A JPS5663977 A JP S5663977A JP 13938479 A JP13938479 A JP 13938479A JP 13938479 A JP13938479 A JP 13938479A JP S5663977 A JPS5663977 A JP S5663977A
Authority
JP
Japan
Prior art keywords
formula
secoprostaglandin
derivative
kinds
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13938479A
Other languages
Japanese (ja)
Inventor
Seiji Kurozumi
Takeshi Yu
Takeo Oba
Toshio Tanaka
Kenzo Watanabe
Kiyoshi Sakauchi
Noriaki Okamura
Yoshiaki Okamiya
Tatsuyuki Naritomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP13938479A priority Critical patent/JPS5663977A/en
Publication of JPS5663977A publication Critical patent/JPS5663977A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

NEW MATERIAL:A secoprostaglandin I2 derivative of formula I (R is H, 1W6C alkyl, etc.; Z is H or protecting group).
EXAMPLE: dl-11,12-Seco-PG I2 methyl ester.
USE: Pharmaceuticals having possibilities to suppress lipid metabolism, inflammation, and some kinds of cancer when applied to cardiac vessel, kidney, digestive tracts, etc.
PROCESS: The compound of formula I is prepared by the dehydrohalogenation of a compound of formula II (X is Br or I) with a base (e.g. Na2CO3). The amount of the base is 1W100 times equivalent to the raw material. Two or more kinds of bases may be used at the same time. The reaction temperature is -20W+150°C, and the reaction completes usually within 10min.W100hr.
COPYRIGHT: (C)1981,JPO&Japio
JP13938479A 1979-10-30 1979-10-30 Secoprostaglandin i2 derivative and its preparation Pending JPS5663977A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13938479A JPS5663977A (en) 1979-10-30 1979-10-30 Secoprostaglandin i2 derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13938479A JPS5663977A (en) 1979-10-30 1979-10-30 Secoprostaglandin i2 derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5663977A true JPS5663977A (en) 1981-05-30

Family

ID=15244050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13938479A Pending JPS5663977A (en) 1979-10-30 1979-10-30 Secoprostaglandin i2 derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5663977A (en)

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