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JPS56108798A - Purification of erythropoietin - Google Patents

Purification of erythropoietin

Info

Publication number
JPS56108798A
JPS56108798A JP1168580A JP1168580A JPS56108798A JP S56108798 A JPS56108798 A JP S56108798A JP 1168580 A JP1168580 A JP 1168580A JP 1168580 A JP1168580 A JP 1168580A JP S56108798 A JPS56108798 A JP S56108798A
Authority
JP
Japan
Prior art keywords
erythropoietin
antibody
immobilized
animal
containing solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1168580A
Other languages
Japanese (ja)
Inventor
Tadayasu Ogushi
Masaaki Yamada
Eiichi Hasegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP1168580A priority Critical patent/JPS56108798A/en
Publication of JPS56108798A publication Critical patent/JPS56108798A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: To separate and purify erythropoietin which is an essential factor for the differentiation of erythrocyte cell, easily and in high purity, by the selective adsorption of an erythropoietin-containing solution with immobilized erythropoietin antibody, followed by the eluation of the adsorbed compound.
CONSTITUTION: An erythropoietin-containing solution (e.g. urine, plasma, etc.) is brought into contact with an immobilized erythropoietin antibody to effect the selective adsorption of erythropoietin taking advantage of the cross-reactivity of other kinds of erythropoietin. The adsorbed erythropoietin is isolated by elution. The immobilized erythropoietin anitbody can be prepared by carrying an erythropoietin antibody to a proper immobilization carrier, and making insoluble in water. The erythropoietin antibody is obtained, e.g. by administering erythropoietin as an immunogen to a proper animal, immunizing the animal by inoculation, and separating and purifying from the antiserum of the animal.
COPYRIGHT: (C)1981,JPO&Japio
JP1168580A 1980-02-01 1980-02-01 Purification of erythropoietin Pending JPS56108798A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1168580A JPS56108798A (en) 1980-02-01 1980-02-01 Purification of erythropoietin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1168580A JPS56108798A (en) 1980-02-01 1980-02-01 Purification of erythropoietin

Publications (1)

Publication Number Publication Date
JPS56108798A true JPS56108798A (en) 1981-08-28

Family

ID=11784862

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1168580A Pending JPS56108798A (en) 1980-02-01 1980-02-01 Purification of erythropoietin

Country Status (1)

Country Link
JP (1) JPS56108798A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8193415B2 (en) 1999-10-26 2012-06-05 Stichting Dienst Landbouwkundig Onderzock Plant expressing mammalian β1,4-galactosyltransferase and β1,3-glucuronyltransferase
US8309795B2 (en) 2001-01-19 2012-11-13 Phyton Holdings, Llc Method for secretory production of glycoprotein having human-type sugar chain using plant cell
US8492613B2 (en) 2002-03-19 2013-07-23 Stichting Dienst Landbouwkundig Onderzoek GNTIII expression in plants
US8853370B2 (en) 1998-12-09 2014-10-07 Phyton Holdings, Llc Plant-produced glycoprotein comprising human-type sugar chain
US8927810B2 (en) 2002-03-19 2015-01-06 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
US9745594B2 (en) 2007-04-17 2017-08-29 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of a zebrafish glycosyltransferase

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8853370B2 (en) 1998-12-09 2014-10-07 Phyton Holdings, Llc Plant-produced glycoprotein comprising human-type sugar chain
US8193415B2 (en) 1999-10-26 2012-06-05 Stichting Dienst Landbouwkundig Onderzock Plant expressing mammalian β1,4-galactosyltransferase and β1,3-glucuronyltransferase
US8907163B2 (en) 1999-10-26 2014-12-09 Stichting Dienst Landbouwkundig Onderzoek Transgenic plants expressing galactosyltransferase and sialyl transferase
US8309795B2 (en) 2001-01-19 2012-11-13 Phyton Holdings, Llc Method for secretory production of glycoprotein having human-type sugar chain using plant cell
US8735656B2 (en) 2001-01-19 2014-05-27 Phyton Holdings, Llc Method of expressing galactosyltransferase and inhibiting xylosyltransferase or fucosyltransferase in a transgenic plant cell for secretory production of glycoproteins having human-type sugar chains
US9574218B2 (en) 2001-01-19 2017-02-21 Phyton Holdings, Llc Method of co-expressing galactosyltransferase and a glycoprotein in a transgenic plant cell and sialylating the glycoprotein for production of glycoprotein having human-type sugar chain
US8492613B2 (en) 2002-03-19 2013-07-23 Stichting Dienst Landbouwkundig Onderzoek GNTIII expression in plants
US8927810B2 (en) 2002-03-19 2015-01-06 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
US9255277B2 (en) 2002-03-19 2016-02-09 Stichting Dienst Landbouwkundig Onderzoek GNTIII expression in plants
US9745594B2 (en) 2007-04-17 2017-08-29 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of a zebrafish glycosyltransferase

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