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JPS5579322A - Antitumor agent comprising dc-11 - Google Patents

Antitumor agent comprising dc-11

Info

Publication number
JPS5579322A
JPS5579322A JP15302778A JP15302778A JPS5579322A JP S5579322 A JPS5579322 A JP S5579322A JP 15302778 A JP15302778 A JP 15302778A JP 15302778 A JP15302778 A JP 15302778A JP S5579322 A JPS5579322 A JP S5579322A
Authority
JP
Japan
Prior art keywords
adsorbed
acetone
water
antitumor agent
antitumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15302778A
Other languages
Japanese (ja)
Inventor
Fusao Tomita
Tatsuya Tamaoki
Nobuo Nakamura
Shuji Okubo
Kimikatsu Shirahata
Seiji Kasai
Tetsuo Oka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP15302778A priority Critical patent/JPS5579322A/en
Publication of JPS5579322A publication Critical patent/JPS5579322A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

NEW MATERIAL:Antibiotic DC-11. Melting point: 225W228°C (decomposition). Elementary analysis: H, 6.9%; C, 59%; N, 2.0%. Specific rotatory power: [α]D20= -0.52° (C=2.0, acetone). Solubility: solbule in methanol, ethanol, etc.; slightly soluble in benzene and water; insoluble in ethyl ether, petroleum ether, etc.
USE: Antitumor agnets and antibacterials.
PROCESS: Strains of Micromonospora sp-KY11091 (FERM-P No.4458) are cultured at 25W40°C and pH4W10 in a liquid medium, and the objective substance is adsorbed on a nonionic porous resin, desorbed, and dissolved in water, and adsorbed on active carbon. The substance is then eluted with an organic solvent, e.g. acetone, and purified to give DC-11. The dose as an antitumor agent is preferably 0.1W 0.5mg/kg(man)/day.
COPYRIGHT: (C)1980,JPO&Japio
JP15302778A 1978-12-13 1978-12-13 Antitumor agent comprising dc-11 Pending JPS5579322A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15302778A JPS5579322A (en) 1978-12-13 1978-12-13 Antitumor agent comprising dc-11

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15302778A JPS5579322A (en) 1978-12-13 1978-12-13 Antitumor agent comprising dc-11

Publications (1)

Publication Number Publication Date
JPS5579322A true JPS5579322A (en) 1980-06-14

Family

ID=15553356

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15302778A Pending JPS5579322A (en) 1978-12-13 1978-12-13 Antitumor agent comprising dc-11

Country Status (1)

Country Link
JP (1) JPS5579322A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548536B2 (en) 1998-08-31 2003-04-15 Kyowa Hakko Kogyo Co., Ltd. Agent for inducing apoptosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548536B2 (en) 1998-08-31 2003-04-15 Kyowa Hakko Kogyo Co., Ltd. Agent for inducing apoptosis

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