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JPS5568290A - Stabilization of urokinase - Google Patents

Stabilization of urokinase

Info

Publication number
JPS5568290A
JPS5568290A JP14204978A JP14204978A JPS5568290A JP S5568290 A JPS5568290 A JP S5568290A JP 14204978 A JP14204978 A JP 14204978A JP 14204978 A JP14204978 A JP 14204978A JP S5568290 A JPS5568290 A JP S5568290A
Authority
JP
Japan
Prior art keywords
urokinase
hydrodextran
added
sulfate
molecular weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14204978A
Other languages
Japanese (ja)
Inventor
Nobuhiko Miwa
Hiroichi Takayanagi
Teruo Sawada
Akira Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP14204978A priority Critical patent/JPS5568290A/en
Publication of JPS5568290A publication Critical patent/JPS5568290A/en
Pending legal-status Critical Current

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  • Enzymes And Modification Thereof (AREA)

Abstract

PURPOSE: Hydrodextran sulfate is added to urokinase to stabilize the activity of urokinase and improve the moldability on medical preparation.
CONSTITUTION: In the extraction, purification, preparation or freeze-drying process for urokinase, a hydrodextran sulfate preferably of 1,500W20,000 molecular weight and 3W20wt% sulfur content, preferably potassium hydrodextran sulfate, is added to a solution or powder of urokinase at a ratio of 0.05W70mg per 1,000 PU. When necessary, further a gelatin of 5,000W60,000 molecular weight and 6W8pH isoelectric point is added thereto at a ratio of 0.01W40mg.
COPYRIGHT: (C)1980,JPO&Japio
JP14204978A 1978-11-16 1978-11-16 Stabilization of urokinase Pending JPS5568290A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14204978A JPS5568290A (en) 1978-11-16 1978-11-16 Stabilization of urokinase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14204978A JPS5568290A (en) 1978-11-16 1978-11-16 Stabilization of urokinase

Publications (1)

Publication Number Publication Date
JPS5568290A true JPS5568290A (en) 1980-05-22

Family

ID=15306208

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14204978A Pending JPS5568290A (en) 1978-11-16 1978-11-16 Stabilization of urokinase

Country Status (1)

Country Link
JP (1) JPS5568290A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0418032A (en) * 1989-09-21 1992-01-22 Mitsui Toatsu Chem Inc Fibrinolytic agent containing tissue plasminogen activator or derivative thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0418032A (en) * 1989-09-21 1992-01-22 Mitsui Toatsu Chem Inc Fibrinolytic agent containing tissue plasminogen activator or derivative thereof

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