[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

JPS5566523A - Preparation of aromatic acetic acid - Google Patents

Preparation of aromatic acetic acid

Info

Publication number
JPS5566523A
JPS5566523A JP13936478A JP13936478A JPS5566523A JP S5566523 A JPS5566523 A JP S5566523A JP 13936478 A JP13936478 A JP 13936478A JP 13936478 A JP13936478 A JP 13936478A JP S5566523 A JPS5566523 A JP S5566523A
Authority
JP
Japan
Prior art keywords
formula
acetic acid
alkanethiol
aromatic
trihalomethane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13936478A
Other languages
Japanese (ja)
Other versions
JPS5935370B2 (en
Inventor
Sei Kondo
Tamotsu Fujimoto
Minoru Suda
Daiei Tsunemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP13936478A priority Critical patent/JPS5935370B2/en
Priority to US06/093,818 priority patent/US4268442A/en
Priority to DE7979104475T priority patent/DE2962737D1/en
Priority to AT724679A priority patent/AT370075B/en
Priority to EP79104475A priority patent/EP0011279B1/en
Priority to CA339,768A priority patent/CA1133916A/en
Publication of JPS5566523A publication Critical patent/JPS5566523A/en
Publication of JPS5935370B2 publication Critical patent/JPS5935370B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

PURPOSE: To obtain the title compound useful as an antipyretic, antiphlogistic, etc., in high yield, from an aromatic aldehyde in one step, by using a highly nucleophilic alkanethiol and trihalomethane in the presence of a base and a specific polar mixed solvent.
CONSTITUTION: An a romatic acetic acid of formula I is obtained by reacting an easily available aromatic aldehyde of formula II (Ar is aromatic radical) with an alkanethiol of formula III (R is alkyl) and a trihalomethane of formula IV in the presence of a base in a mixture of water and an aprotic polar solvent (e.g. dimethyl sulfoxide, etc.). By using the highly nucleophilic alkanethiol and the polar mixed solvent which can be easily substituted at the nucleus, the mercapto anion reacts easily to the nucleus of the α-thio-substituted aromatic acetic acid derivative, formed as an intermediate and the compound of formula I is obtained directly in one step.
USE: Analgesic, antispasmodic, raw material of pyrethroid insecticide, etc.
COPYRIGHT: (C)1980,JPO&Japio
JP13936478A 1978-11-14 1978-11-14 Method for producing aromatic acetic acid Expired JPS5935370B2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP13936478A JPS5935370B2 (en) 1978-11-14 1978-11-14 Method for producing aromatic acetic acid
US06/093,818 US4268442A (en) 1978-11-14 1979-11-13 Process for preparing aromatic acetic acid
DE7979104475T DE2962737D1 (en) 1978-11-14 1979-11-13 Process for the preparation of aromatically substituted acetic acids
AT724679A AT370075B (en) 1978-11-14 1979-11-13 METHOD FOR PRODUCING ARYL ACETIC ACIDS
EP79104475A EP0011279B1 (en) 1978-11-14 1979-11-13 Process for the preparation of aromatically substituted acetic acids
CA339,768A CA1133916A (en) 1978-11-14 1979-11-13 Process for preparing aromatic acetic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13936478A JPS5935370B2 (en) 1978-11-14 1978-11-14 Method for producing aromatic acetic acid

Publications (2)

Publication Number Publication Date
JPS5566523A true JPS5566523A (en) 1980-05-20
JPS5935370B2 JPS5935370B2 (en) 1984-08-28

Family

ID=15243601

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13936478A Expired JPS5935370B2 (en) 1978-11-14 1978-11-14 Method for producing aromatic acetic acid

Country Status (3)

Country Link
JP (1) JPS5935370B2 (en)
AT (1) AT370075B (en)
CA (1) CA1133916A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652575A1 (en) * 1989-09-29 1991-04-05 Sanofi Sa PROCESS FOR THE PREPARATION OF ALPHA-BROMO PHENYLACETIC ACIDS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652575A1 (en) * 1989-09-29 1991-04-05 Sanofi Sa PROCESS FOR THE PREPARATION OF ALPHA-BROMO PHENYLACETIC ACIDS

Also Published As

Publication number Publication date
CA1133916A (en) 1982-10-19
JPS5935370B2 (en) 1984-08-28
AT370075B (en) 1983-02-25
ATA724679A (en) 1982-07-15

Similar Documents

Publication Publication Date Title
JPS5566523A (en) Preparation of aromatic acetic acid
JPS5566524A (en) Preparation of aromatic acetic acid
JPS5695142A (en) Preparation of aliphatic aldehyde
JPS5517349A (en) Production of diterpene derivative
JPS5615236A (en) Production of cyclopentenolone
JPS5572139A (en) Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid
JPS572276A (en) 1-methyl-5- n-alkyl-n-chloroacetylamino pyrazole-4- carboxylic acid ester derivative, its preparation, and herbicide for paddy rice field
JPS5738742A (en) Preparation of 1,4-dihydroanthraquinone
JPS5716840A (en) Phneylacetic acid derivative
JPS55153777A (en) Improved method of preparation of 3-methyl-3-(substituted phenyl)-glycidic ester
JPS5522617A (en) 2-chloro-5-trichloromethylpyridine and its preparation
JPS55120591A (en) Phosphinoethylmalonic acid derivative, and preparation thereof
JPS55143925A (en) Preparation of cyclopentenolone
JPS5785352A (en) Preparation of n-arylamidinecarboxylic acid
JPS5659727A (en) Preparation of substituted phenol
JPS57106645A (en) Preparation of 4-bromo-3-methylchrotonic acid ester
JPS55143962A (en) Novel aldehyde compound and its preparation
JPS5495533A (en) Preparation of derivative of anthranylaldehyde
JPS54106467A (en) Preparation of 2-alkyl-2,4-dihydro-5-methyl-3h-pyrazole- 3-one
JPS55127366A (en) Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole
JPS55100329A (en) Bis-(1-bromo-2,3,3-trichloro-2-propenyl) ether, its preparation, and preparation of trichloroacrolein
JPS572268A (en) Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid
JPS5750960A (en) Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone
JPS5742652A (en) Preparation of hydroxyphenylacetic acid and catalyst for preparing it
JPS5589354A (en) Preparation of aminothiofluoran compound