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JPS5559A - Preparation of immobilized bio-active substance - Google Patents

Preparation of immobilized bio-active substance

Info

Publication number
JPS5559A
JPS5559A JP7177078A JP7177078A JPS5559A JP S5559 A JPS5559 A JP S5559A JP 7177078 A JP7177078 A JP 7177078A JP 7177078 A JP7177078 A JP 7177078A JP S5559 A JPS5559 A JP S5559A
Authority
JP
Japan
Prior art keywords
collagen
carrier
bioactive substance
group
spacer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7177078A
Other languages
Japanese (ja)
Inventor
Hisao Kojima
Okiteru Suzuki
Kuniharu Iwamoto
Yasushi Okamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippi Inc
Original Assignee
Nippi Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippi Inc filed Critical Nippi Inc
Priority to JP7177078A priority Critical patent/JPS5559A/en
Publication of JPS5559A publication Critical patent/JPS5559A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

PURPOSE: To prepare an immobilized bioactive substance having the specific biological characteristics of collagen and the activity of the bioactive substance, by bonding collagen carrier with the bioactive substance through a compound (spacer) having a proper length.
CONSTITUTION: Bonding groups (e.g. azide group) are introduced into a coolagen carrier such as a molded soluble collagen, insolubilized collagen fiber, etc. e.g. by reacting with a cyan halide. The collagen carrier is pref. subjected to a proper pretreatment, e.g. methyl-esterification, to activate the functional groups of the carrier. A spacer having a functional group such as NH2 group is introduced to the collagen carrier having the bonding group, and the bioactive substance (e.g. enzyme, antibody) is chemically bonded and immobilized to the collagen carrier through the spacer.
COPYRIGHT: (C)1980,JPO&Japio
JP7177078A 1978-06-14 1978-06-14 Preparation of immobilized bio-active substance Pending JPS5559A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7177078A JPS5559A (en) 1978-06-14 1978-06-14 Preparation of immobilized bio-active substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7177078A JPS5559A (en) 1978-06-14 1978-06-14 Preparation of immobilized bio-active substance

Publications (1)

Publication Number Publication Date
JPS5559A true JPS5559A (en) 1980-01-05

Family

ID=13470112

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7177078A Pending JPS5559A (en) 1978-06-14 1978-06-14 Preparation of immobilized bio-active substance

Country Status (1)

Country Link
JP (1) JPS5559A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58192829A (en) * 1982-05-07 1983-11-10 Seikagaku Kogyo Co Ltd Immobilized physiologically active substance and its preparation
JPS61207340A (en) * 1985-03-13 1986-09-13 Koken:Kk Treatment of collagen substrate
JPS63304000A (en) * 1987-06-05 1988-12-12 Ube Ind Ltd Method for immobilizing substance derived from living body
JPH0222300A (en) * 1987-02-02 1990-01-25 Swiss Serum & Vaccine Inst Bern Immunogen conjugate, its production and generation of immune

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52139781A (en) * 1976-05-15 1977-11-21 Nippi Inc Production of fixed biologically active substance
JPS5341489A (en) * 1976-08-12 1978-04-14 Boehringer Sohn Ingelheim Production of enzyme preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52139781A (en) * 1976-05-15 1977-11-21 Nippi Inc Production of fixed biologically active substance
JPS5341489A (en) * 1976-08-12 1978-04-14 Boehringer Sohn Ingelheim Production of enzyme preparation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58192829A (en) * 1982-05-07 1983-11-10 Seikagaku Kogyo Co Ltd Immobilized physiologically active substance and its preparation
JPH0359080B2 (en) * 1982-05-07 1991-09-09 Seikagaku Kogyo Co Ltd
JPS61207340A (en) * 1985-03-13 1986-09-13 Koken:Kk Treatment of collagen substrate
JPH0586185B2 (en) * 1985-03-13 1993-12-10 Koken Kk
JPH0222300A (en) * 1987-02-02 1990-01-25 Swiss Serum & Vaccine Inst Bern Immunogen conjugate, its production and generation of immune
JPS63304000A (en) * 1987-06-05 1988-12-12 Ube Ind Ltd Method for immobilizing substance derived from living body

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