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JPS5538364A - Benzo ij quinolizine-2-carboxylic acid derivative and its preparation - Google Patents

Benzo ij quinolizine-2-carboxylic acid derivative and its preparation

Info

Publication number
JPS5538364A
JPS5538364A JP11345678A JP11345678A JPS5538364A JP S5538364 A JPS5538364 A JP S5538364A JP 11345678 A JP11345678 A JP 11345678A JP 11345678 A JP11345678 A JP 11345678A JP S5538364 A JPS5538364 A JP S5538364A
Authority
JP
Japan
Prior art keywords
formula
compound
quinolizine
benzo
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11345678A
Other languages
Japanese (ja)
Other versions
JPS6123797B2 (en
Inventor
Hiroshi Ishikawa
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP11345678A priority Critical patent/JPS5538364A/en
Publication of JPS5538364A publication Critical patent/JPS5538364A/en
Publication of JPS6123797B2 publication Critical patent/JPS6123797B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Benzo[ij]quinolizine-2-carboxylic acid derivative and its salt of formula I (R1 is lower alkyl, p-methylphenyl).
EXAMPLE: 8-Methanesulfonyloxy-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acic.
USE: Antibacterial agent or its synthetic intermediate; especially it is important as a synthetic intermediate of the compound of formula 6 that shows remarkable effectiveness against Pseudomonas aeruginosa, etc.
PROCESS: The compound of formula 2 derived from 5-hydroxy-3, 4-dihydrocarbostyril is made to react with a compound of formula 3 (R2, R3 are lower alkyls) to form the compound of formula 4, which is cyclized by heating or using POCl3 or the like and then hydrolyzed to produce the compound of formula I. The compound of formula 2 also is novel.
COPYRIGHT: (C)1980,JPO&Japio
JP11345678A 1978-09-13 1978-09-13 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation Granted JPS5538364A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11345678A JPS5538364A (en) 1978-09-13 1978-09-13 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11345678A JPS5538364A (en) 1978-09-13 1978-09-13 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5538364A true JPS5538364A (en) 1980-03-17
JPS6123797B2 JPS6123797B2 (en) 1986-06-07

Family

ID=14612689

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11345678A Granted JPS5538364A (en) 1978-09-13 1978-09-13 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5538364A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102887A (en) * 1980-12-18 1982-06-26 Otsuka Pharmaceut Co Ltd Preparation of benzo(ij)quinolizine-2-carboxylic acid derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102887A (en) * 1980-12-18 1982-06-26 Otsuka Pharmaceut Co Ltd Preparation of benzo(ij)quinolizine-2-carboxylic acid derivative

Also Published As

Publication number Publication date
JPS6123797B2 (en) 1986-06-07

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