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JPS5527199A - Mercaptoacylproline derivative and its manufacture and use - Google Patents

Mercaptoacylproline derivative and its manufacture and use

Info

Publication number
JPS5527199A
JPS5527199A JP10272279A JP10272279A JPS5527199A JP S5527199 A JPS5527199 A JP S5527199A JP 10272279 A JP10272279 A JP 10272279A JP 10272279 A JP10272279 A JP 10272279A JP S5527199 A JPS5527199 A JP S5527199A
Authority
JP
Japan
Prior art keywords
mercaptoacylproline
derivative
manufacture
mercaptoacylproline derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10272279A
Other languages
Japanese (ja)
Other versions
JPH0134987B2 (en
Inventor
Enjieru Ondetsutei Miigeru
Kurapuchiyo Jiyon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of JPS5527199A publication Critical patent/JPS5527199A/en
Publication of JPH0134987B2 publication Critical patent/JPH0134987B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP10272279A 1978-08-11 1979-08-10 Mercaptoacylproline derivative and its manufacture and use Granted JPS5527199A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93288378A 1978-08-11 1978-08-11
KR1019790002731A KR830002450B1 (en) 1978-08-11 1979-08-10 Method for preparing mercaptoacyl derivative of substituted proline

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP63323204A Division JPH01287069A (en) 1978-08-11 1988-12-21 Production and use of mercaptoacyl proline derivative

Publications (2)

Publication Number Publication Date
JPS5527199A true JPS5527199A (en) 1980-02-27
JPH0134987B2 JPH0134987B2 (en) 1989-07-21

Family

ID=26626596

Family Applications (2)

Application Number Title Priority Date Filing Date
JP10272279A Granted JPS5527199A (en) 1978-08-11 1979-08-10 Mercaptoacylproline derivative and its manufacture and use
JP63323204A Pending JPH01287069A (en) 1978-08-11 1988-12-21 Production and use of mercaptoacyl proline derivative

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP63323204A Pending JPH01287069A (en) 1978-08-11 1988-12-21 Production and use of mercaptoacyl proline derivative

Country Status (30)

Country Link
JP (2) JPS5527199A (en)
KR (1) KR830002450B1 (en)
AR (1) AR229081A1 (en)
AT (1) AT379589B (en)
AU (1) AU530690B2 (en)
BE (1) BE878191A (en)
CA (1) CA1144930A (en)
CH (1) CH642064A5 (en)
CS (1) CS228118B2 (en)
DD (1) DD145749A5 (en)
DE (1) DE2932021C2 (en)
DK (1) DK154553C (en)
ES (1) ES483311A1 (en)
FI (1) FI69834C (en)
FR (1) FR2435469A1 (en)
GB (1) GB2028327B (en)
GR (1) GR72420B (en)
IE (1) IE48802B1 (en)
IN (1) IN152712B (en)
IT (1) IT1117782B (en)
LU (2) LU81593A1 (en)
NL (2) NL193374C (en)
NZ (1) NZ191036A (en)
PH (1) PH15030A (en)
PT (1) PT70049A (en)
RO (1) RO78870B (en)
SE (1) SE447477B (en)
SU (1) SU1066460A3 (en)
YU (1) YU41876B (en)
ZA (1) ZA793633B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5718611A (en) * 1980-03-05 1982-01-30 Uni Maiami Za Angiotensin converting enzyme inhibitor
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
JPH0882269A (en) * 1994-05-02 1996-03-26 Cummins Engine Co Inc Ball link motion for car-engine driving device
JP2006328078A (en) * 2002-10-31 2006-12-07 Pfizer Inc PROLINE DERIVATIVE HAVING AFFINITY FOR CALCIUM CHANNEL alpha2delta SUBUNIT
JP2011513292A (en) * 2008-02-27 2011-04-28 ジェネリクス・（ユーケー）・リミテッド New crystal form

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
CA1132985A (en) * 1978-12-22 1982-10-05 John Krapcho Ketal and thioketal derivatives of mercaptoacyl prolines
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
SE431331B (en) * 1980-03-21 1984-01-30 Squibb & Sons Inc NEW THERAPEUTICALLY ACTIVE SULFUR CONTAINING N-ACYLATED DERIVATIVES OF 4-OXO-L-PROLINE
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4390695A (en) * 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4578474A (en) * 1980-06-23 1986-03-25 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4332726A (en) * 1980-08-25 1982-06-01 E. R. Squibb & Sons, Inc. Purification of mercaptoacyl amino acids
US4307110A (en) * 1980-09-12 1981-12-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 3-substituted proline derivatives
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4312809A (en) 1980-10-31 1982-01-26 E. R. Squibb & Sons, Inc. Lactam derivatives of mercaptoacylamino acids
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4384123A (en) * 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4497953A (en) * 1981-06-01 1985-02-05 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4377701A (en) * 1981-09-21 1983-03-22 E. R. Squibb & Sons, Inc. 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
CA2021409A1 (en) * 1989-08-21 1991-02-22 Donald S. Karanewsky Phosphonate substituted amino or imino acids useful as antihypertensives
JPH05344844A (en) * 1992-06-12 1993-12-27 Suzumo Kiko Kk Method for producing roasted rice ball cracker
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
WO2006038119A1 (en) * 2004-10-08 2006-04-13 Warner-Lambert Company Llc Stereoselective synthesis of n-protected alkoxy prolines
GB0715626D0 (en) 2007-08-10 2007-09-19 Generics Uk Ltd Crystalline form of zofenopril calcium
US8853421B2 (en) 2008-02-27 2014-10-07 Generics [Uk] Limited Crystalline forms of zofenopril calcium
SI23949A (en) 2011-12-19 2013-06-28 Silverstone Pharma The new crystalline salts of zofenopril, the procedure for obtaining them and their use in therapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340092A2 (en) * 1976-02-09 1977-09-02 Roussel Uclaf Analgesic (N)-thiazolyl-quinoline carboxamides - prepd. from the corresp. quinoline carboxylic acid and (2)-amino-thiazole
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5718611A (en) * 1980-03-05 1982-01-30 Uni Maiami Za Angiotensin converting enzyme inhibitor
JPH0460986B2 (en) * 1980-03-05 1992-09-29 Univ Miami
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
JPH0882269A (en) * 1994-05-02 1996-03-26 Cummins Engine Co Inc Ball link motion for car-engine driving device
JP2006328078A (en) * 2002-10-31 2006-12-07 Pfizer Inc PROLINE DERIVATIVE HAVING AFFINITY FOR CALCIUM CHANNEL alpha2delta SUBUNIT
JP2011513292A (en) * 2008-02-27 2011-04-28 ジェネリクス・（ユーケー）・リミテッド New crystal form

Also Published As

Publication number Publication date
NL193374C (en) 1999-08-03
FI69834C (en) 1986-05-26
DE2932021C2 (en) 1994-05-19
KR830001269A (en) 1983-04-29
RO78870B (en) 1985-01-30
ZA793633B (en) 1980-07-30
GR72420B (en) 1983-11-03
JPH0134987B2 (en) 1989-07-21
KR830002450B1 (en) 1983-10-26
NL193374B (en) 1999-04-01
FR2435469B1 (en) 1983-02-11
BE878191A (en) 1980-02-11
DE2932021A1 (en) 1980-02-21
DK154553B (en) 1988-11-28
FI792498A (en) 1980-02-12
SE447477B (en) 1986-11-17
IT7949954A0 (en) 1979-08-03
GB2028327A (en) 1980-03-05
IT1117782B (en) 1986-02-24
YU192379A (en) 1983-02-28
LU81593A1 (en) 1979-12-07
FI69834B (en) 1985-12-31
ES483311A1 (en) 1980-04-16
SU1066460A3 (en) 1984-01-07
SE7906722L (en) 1980-02-12
ATA541679A (en) 1985-06-15
YU41876B (en) 1988-02-29
JPH01287069A (en) 1989-11-17
AR229081A1 (en) 1983-06-15
CA1144930A (en) 1983-04-19
PH15030A (en) 1982-05-13
NL7906120A (en) 1980-02-13
IN152712B (en) 1984-03-17
AU530690B2 (en) 1983-07-28
DK335879A (en) 1980-02-12
LU90403I2 (en) 2000-07-07
NL990024I1 (en) 1999-11-01
IE48802B1 (en) 1985-05-15
DK154553C (en) 1989-04-17
AT379589B (en) 1986-01-27
NZ191036A (en) 1984-05-31
CH642064A5 (en) 1984-03-30
DD145749A5 (en) 1981-01-07
FR2435469A1 (en) 1980-04-04
AU4919079A (en) 1980-02-14
PT70049A (en) 1979-09-01
CS228118B2 (en) 1984-05-14
NL990024I2 (en) 1999-11-01
RO78870A (en) 1982-07-06
IE791544L (en) 1980-02-11
GB2028327B (en) 1982-11-24

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