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JPS55154976A - Preparation of 5-fluorouracil derivative - Google Patents

Preparation of 5-fluorouracil derivative

Info

Publication number
JPS55154976A
JPS55154976A JP6363679A JP6363679A JPS55154976A JP S55154976 A JPS55154976 A JP S55154976A JP 6363679 A JP6363679 A JP 6363679A JP 6363679 A JP6363679 A JP 6363679A JP S55154976 A JPS55154976 A JP S55154976A
Authority
JP
Japan
Prior art keywords
fluorouracil
formula
solvent
furanyl
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6363679A
Other languages
Japanese (ja)
Other versions
JPS611030B2 (en
Inventor
Shuichi Ueda
Sanji Yasumoto
Sadao Hashimoto
Setsuo Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP6363679A priority Critical patent/JPS55154976A/en
Publication of JPS55154976A publication Critical patent/JPS55154976A/en
Publication of JPS611030B2 publication Critical patent/JPS611030B2/ja
Granted legal-status Critical Current

Links

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:2,3'-Anhydro-1-(tetrahydro-2'-furanyl)-5-fluorouracil shown by the formula I.
USE: A carcinostatic substance or its synthetic intermediate.
PROCESS: A trans-1-(3'-halogenotetrahydro-2'-furanyl)-5-fluorouracil shown by the formula II (X is halogen) is subjected to ring closure in water or an organic solvent, preferably in the presence of a reaction accelerator at 0W150°C, preferably at room temperature to 100°C for 10 minutesW24hrs to give a compond shown by the forula I in figh yields with ease. A basic substance, e.g., NaOH, sodium methoxide, or an acidic substance, e.g., acetic acid is used as the reaction accelerator. The starting material shown by the formula II is obtained by reacting 2,4-bis(trimethylsilyl)- 5-fluorouracil with a 2,3-dihalogenotetrahydrofuran in a solvent or in the absence of a solvent.
COPYRIGHT: (C)1980,JPO&Japio
JP6363679A 1979-05-22 1979-05-22 Preparation of 5-fluorouracil derivative Granted JPS55154976A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6363679A JPS55154976A (en) 1979-05-22 1979-05-22 Preparation of 5-fluorouracil derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6363679A JPS55154976A (en) 1979-05-22 1979-05-22 Preparation of 5-fluorouracil derivative

Publications (2)

Publication Number Publication Date
JPS55154976A true JPS55154976A (en) 1980-12-02
JPS611030B2 JPS611030B2 (en) 1986-01-13

Family

ID=13235030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6363679A Granted JPS55154976A (en) 1979-05-22 1979-05-22 Preparation of 5-fluorouracil derivative

Country Status (1)

Country Link
JP (1) JPS55154976A (en)

Also Published As

Publication number Publication date
JPS611030B2 (en) 1986-01-13

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